登録情報 データベース : PDB / ID : 4wo1 構造の表示 ダウンロードとリンクタイトル Crystal structure of the DAP12 transmembrane domain in lipid cubic phase 要素TYRO protein tyrosine kinase-binding protein 詳細 キーワード SIGNALING PROTEIN / alpha-helix Transmembrane Signaling機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
myeloid leukocyte activation / stimulatory killer cell immunoglobulin-like receptor signaling pathway / positive regulation of receptor localization to synapse / positive regulation of macrophage fusion / positive regulation of osteoclast development / microglial cell activation involved in immune response / positive regulation of natural killer cell activation / negative regulation of transforming growth factor beta1 production / Other semaphorin interactions / positive regulation of microglial cell mediated cytotoxicity ... myeloid leukocyte activation / stimulatory killer cell immunoglobulin-like receptor signaling pathway / positive regulation of receptor localization to synapse / positive regulation of macrophage fusion / positive regulation of osteoclast development / microglial cell activation involved in immune response / positive regulation of natural killer cell activation / negative regulation of transforming growth factor beta1 production / Other semaphorin interactions / positive regulation of microglial cell mediated cytotoxicity / neutrophil activation involved in immune response / positive regulation of protein localization to cell surface / apoptotic cell clearance / Signal regulatory protein family interactions / negative regulation of type I interferon production / negative regulation of interleukin-10 production / negative regulation of B cell proliferation / stimulatory C-type lectin receptor signaling pathway / negative regulation of long-term synaptic potentiation / response to axon injury / cellular defense response / forebrain development / osteoclast differentiation / positive regulation of superoxide anion generation / secretory granule membrane / positive regulation of interleukin-1 beta production / DAP12 interactions / positive regulation of interleukin-6 production / positive regulation of tumor necrosis factor production / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / DAP12 signaling / actin cytoskeleton organization / molecular adaptor activity / protein stabilization / intracellular signal transduction / signaling receptor binding / Neutrophil degranulation / positive regulation of gene expression / cell surface / signal transduction / protein homodimerization activity / identical protein binding / membrane / metal ion binding / plasma membrane 類似検索 - 分子機能 (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate / TYRO protein tyrosine kinase-binding protein 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.14 Å 詳細データ登録者 Call, M.J. / Call, M.E. / Knoblich, K. 資金援助 オーストラリア, 3件 詳細 詳細を隠す組織 認可番号 国 National Health and Medical Research Council (NHMRC, Australia) GNT1011352 オーストラリア veski VIF12 オーストラリア Australian Research Council (ARC) DP110104369, FT120100145 オーストラリア
引用ジャーナル : Cell Rep / 年 : 2015タイトル : Transmembrane Complexes of DAP12 Crystallized in Lipid Membranes Provide Insights into Control of Oligomerization in Immunoreceptor Assembly.著者 : Knoblich, K. / Park, S. / Lutfi, M. / van 't Hag, L. / Conn, C.E. / Seabrook, S.A. / Newman, J. / Czabotar, P.E. / Im, W. / Call, M.E. / Call, M.J. 履歴 登録 2014年10月15日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2015年6月3日 Provider : repository / タイプ : Initial release改定 1.1 2015年6月10日 Group : Database references改定 1.2 2017年9月27日 Group : Advisory / Author supporting evidence ... Advisory / Author supporting evidence / Data collection / Derived calculations / Other / Source and taxonomy カテゴリ : diffrn_source / entity_src_gen ... diffrn_source / entity_src_gen / pdbx_audit_support / pdbx_database_status / pdbx_struct_oper_list / pdbx_validate_close_contact Item : _diffrn_source.pdbx_synchrotron_site / _entity_src_gen.pdbx_alt_source_flag ... _diffrn_source.pdbx_synchrotron_site / _entity_src_gen.pdbx_alt_source_flag / _pdbx_audit_support.funding_organization / _pdbx_database_status.pdb_format_compatible / _pdbx_struct_oper_list.symmetry_operation 改定 1.3 2020年1月1日 Group : Author supporting evidence / Derived calculationsカテゴリ : pdbx_audit_support / pdbx_struct_special_symmetryItem : _pdbx_audit_support.funding_organization改定 1.4 2023年9月27日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_alt_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_alt_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_ptnr1_label_alt_id / _struct_conn.pdbx_ptnr2_label_alt_id / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id
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