登録情報 | データベース: PDB / ID: 4wjg |
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タイトル | Structure of T. brucei haptoglobin-hemoglobin receptor binding to human haptoglobin-hemoglobin |
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要素 | - (Hemoglobin subunit ...) x 2
- Haptoglobin
- Haptoglobin-hemoglobin receptor
- Iron-regulated surface determinant protein H
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キーワード | ENDOCYTOSIS / Trypanosome / Receptor |
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機能・相同性 | 機能・相同性情報
negative regulation of hydrogen peroxide catabolic process / negative regulation of oxidoreductase activity / cell wall / nitric oxide transport / hemoglobin binding / immune system process / hemoglobin alpha binding / haptoglobin binding / haptoglobin-hemoglobin complex / organic acid binding ...negative regulation of hydrogen peroxide catabolic process / negative regulation of oxidoreductase activity / cell wall / nitric oxide transport / hemoglobin binding / immune system process / hemoglobin alpha binding / haptoglobin binding / haptoglobin-hemoglobin complex / organic acid binding / renal absorption / hemoglobin complex / antioxidant activity / oxygen transport / Scavenging of heme from plasma / endocytic vesicle lumen / blood vessel diameter maintenance / acute-phase response / hydrogen peroxide catabolic process / oxygen carrier activity / Late endosomal microautophagy / Heme signaling / carbon dioxide transport / response to hydrogen peroxide / Erythrocytes take up oxygen and release carbon dioxide / Erythrocytes take up carbon dioxide and release oxygen / Cytoprotection by HMOX1 / defense response / oxygen binding / regulation of blood pressure / platelet aggregation / Chaperone Mediated Autophagy / peroxidase activity / specific granule lumen / positive regulation of nitric oxide biosynthetic process / tertiary granule lumen / Factors involved in megakaryocyte development and platelet production / ficolin-1-rich granule lumen / blood microparticle / defense response to bacterium / iron ion binding / serine-type endopeptidase activity / heme binding / Neutrophil degranulation / extracellular space / extracellular exosome / extracellular region / membrane / metal ion binding / cytosol類似検索 - 分子機能 Ferritin - #80 / Iron-regulated surface determinant protein H / Immunoglobulin-like - #1850 / NEAT domain / Iron Transport-associated domain / NEAT domain profile. / NEAr Transporter domain / NEAT domain superfamily / Complement Module, domain 1 / Complement Module; domain 1 ...Ferritin - #80 / Iron-regulated surface determinant protein H / Immunoglobulin-like - #1850 / NEAT domain / Iron Transport-associated domain / NEAT domain profile. / NEAr Transporter domain / NEAT domain superfamily / Complement Module, domain 1 / Complement Module; domain 1 / YSIRK type signal peptide / Sushi/SCR/CCP domain / Sushi/CCP/SCR domain profile. / Sushi/SCR/CCP superfamily / Hemoglobin, pi / YSIRK Gram-positive signal peptide / Hemoglobin, alpha-type / Hemoglobin, beta-type / Ferritin / Gram-positive cocci surface proteins LPxTG motif profile. / LPXTG cell wall anchor domain / Globin/Protoglobin / Globins / Globin domain profile. / Globin-like / Globin / Globin / Globin-like superfamily / Ribbon / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin domain profile. / Trypsin-like serine protease / Serine proteases, trypsin domain / Trypsin / Trypsin-like serine proteases / Thrombin, subunit H / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / Up-down Bundle / Immunoglobulin-like / Beta Barrel / Sandwich / Orthogonal Bundle / Mainly Beta / Mainly Alpha類似検索 - ドメイン・相同性 PROTOPORPHYRIN IX CONTAINING FE / OXYGEN MOLECULE / Haptoglobin-hemoglobin receptor / Haptoglobin / Hemoglobin subunit beta / Hemoglobin subunit alpha / Iron-regulated surface determinant protein H類似検索 - 構成要素 |
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生物種 | Staphylococcus aureus subsp. aureus N315 (黄色ブドウ球菌)
![](img/tx_eukaryote.gif) Trypanosoma brucei brucei (トリパノソーマ)
Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.1 Å |
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データ登録者 | Stoedkilde, K. / Torvund-Jensen, M. / Moestrup, S.K. / Andersen, C.B.F. |
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資金援助 | デンマーク, 4件 組織 | 認可番号 | 国 |
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The Lundbeck Foundation | | デンマーク | The Novo Nordisk Foundation | | デンマーク | The European Research Council | | デンマーク | The Danish Council for Independent Research | | デンマーク |
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引用 | ジャーナル: Nat Commun / 年: 2014 タイトル: Structural basis for trypanosomal haem acquisition and susceptibility to the host innate immune system. 著者: Stdkilde, K. / Torvund-Jensen, M. / Moestrup, S.K. / Andersen, C.B. |
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履歴 | 登録 | 2014年9月30日 | 登録サイト: RCSB / 処理サイト: PDBE |
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改定 1.0 | 2014年11月26日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2014年12月3日 | Group: Database references |
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改定 1.2 | 2018年2月28日 | Group: Source and taxonomy / カテゴリ: entity_src_gen / entity_src_nat Item: _entity_src_gen.gene_src_strain / _entity_src_gen.pdbx_gene_src_scientific_name ..._entity_src_gen.gene_src_strain / _entity_src_gen.pdbx_gene_src_scientific_name / _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id / _entity_src_gen.pdbx_host_org_scientific_name / _entity_src_gen.pdbx_host_org_strain / _entity_src_nat.common_name |
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改定 2.0 | 2020年7月29日 | Group: Advisory / Atomic model ...Advisory / Atomic model / Data collection / Derived calculations / Source and taxonomy / Structure summary カテゴリ: atom_site / chem_comp ...atom_site / chem_comp / entity / entity_src_gen / entity_src_nat / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_struct_conn_angle / pdbx_validate_close_contact / struct_asym / struct_conn / struct_conn_type / struct_site / struct_site_gen Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ..._atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.type_symbol / _chem_comp.name / _chem_comp.type / _entity_src_nat.entity_id / _pdbx_entity_nonpoly.entity_id / _pdbx_entity_nonpoly.name / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_validate_close_contact.auth_asym_id_1 / _pdbx_validate_close_contact.auth_asym_id_2 / _pdbx_validate_close_contact.auth_seq_id_1 / _pdbx_validate_close_contact.auth_seq_id_2 / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn_type.id 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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