Entry Database : PDB / ID : 4wh9 Structure visualization Downloads & linksTitle Structure of the CDC25B Phosphatase Catalytic Domain with Bound Inhibitor ComponentsM-phase inducer phosphatase 2 Details Keywords HYDROLASE/HYDROLASE Inhibitor / Phosphatase / Inhibitor / Fragment / HYDROLASE-HYDROLASE Inhibitor complexFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of G2/MI transition of meiotic cell cycle / female meiosis I / oocyte maturation / Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models / positive regulation of cytokinesis / phosphoprotein phosphatase activity / Cyclin A/B1/B2 associated events during G2/M transition / Cyclin A:Cdk2-associated events at S phase entry / positive regulation of G2/M transition of mitotic cell cycle / positive regulation of mitotic cell cycle ... positive regulation of G2/MI transition of meiotic cell cycle / female meiosis I / oocyte maturation / Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models / positive regulation of cytokinesis / phosphoprotein phosphatase activity / Cyclin A/B1/B2 associated events during G2/M transition / Cyclin A:Cdk2-associated events at S phase entry / positive regulation of G2/M transition of mitotic cell cycle / positive regulation of mitotic cell cycle / protein-tyrosine-phosphatase / protein tyrosine phosphatase activity / spindle pole / G2/M transition of mitotic cell cycle / mitotic cell cycle / cell division / protein phosphorylation / centrosome / positive regulation of cell population proliferation / protein kinase binding / nucleoplasm / nucleus / cytoplasm / cytosol Similarity search - Function M-phase inducer phosphatase / M-phase inducer phosphatase / Rhodanese-like domain / Oxidized Rhodanese; domain 1 / Rhodanese Homology Domain / Rhodanese-like domain / Rhodanese domain profile. / Rhodanese-like domain superfamily / Rhodanese-like domain / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.5 Å DetailsAuthors Lund, G.L. / Dudkin, S. / Borkin, D. / Ni, W. / Grembecka, J. / Cierpicki, T. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Cancer Institute (NIH/NCI) CA181185 United States
CitationJournal : Acs Chem.Biol. / Year : 2015Title : Inhibition of CDC25B Phosphatase Through Disruption of Protein-Protein Interaction.Authors : Lund, G. / Dudkin, S. / Borkin, D. / Ni, W. / Grembecka, J. / Cierpicki, T. History Deposition Sep 20, 2014 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Dec 10, 2014 Provider : repository / Type : Initial releaseRevision 1.1 Feb 4, 2015 Group : Derived calculationsRevision 1.2 Mar 4, 2015 Group : Database referencesRevision 1.3 Sep 27, 2017 Group : Author supporting evidence / Derived calculations / Source and taxonomyCategory : entity_src_gen / pdbx_audit_support / pdbx_struct_oper_listItem : _entity_src_gen.pdbx_alt_source_flag / _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operationRevision 1.4 Dec 4, 2019 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.5 Sep 27, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / diffrn_radiation_wavelength / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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