登録情報 | データベース: PDB / ID: 4wae |
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タイトル | Phosphatidylinositol 4-kinase III beta crystallized with ATP |
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要素 | Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta |
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キーワード | TRANSFERASE |
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機能・相同性 | 機能・相同性情報
1-phosphatidylinositol 4-kinase / 1-phosphatidylinositol 4-kinase activity / rough endoplasmic reticulum membrane / Synthesis of PIPs at the Golgi membrane / phosphatidylinositol biosynthetic process / lysosome organization / phosphatidylinositol-mediated signaling / phosphatidylinositol phosphate biosynthetic process / inner ear development / 14-3-3 protein binding ...1-phosphatidylinositol 4-kinase / 1-phosphatidylinositol 4-kinase activity / rough endoplasmic reticulum membrane / Synthesis of PIPs at the Golgi membrane / phosphatidylinositol biosynthetic process / lysosome organization / phosphatidylinositol-mediated signaling / phosphatidylinositol phosphate biosynthetic process / inner ear development / 14-3-3 protein binding / receptor-mediated endocytosis / mitochondrial outer membrane / endosome / Golgi membrane / perinuclear region of cytoplasm / Golgi apparatus / signal transduction / ATP binding / membrane / cytosol / cytoplasm類似検索 - 分子機能 : / PI4KB/PIK1, accessory (PIK) domain / Phosphoinositide 3-kinase, accessory (PIK) domain / Phosphatidylinositol kinase / PIK helical domain profile. / Phosphatidylinositol 3- and 4-kinases signature 1. / Phosphatidylinositol 3/4-kinase, conserved site / Phosphatidylinositol 3- and 4-kinases signature 2. / Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily / Phosphoinositide 3-kinase, catalytic domain ...: / PI4KB/PIK1, accessory (PIK) domain / Phosphoinositide 3-kinase, accessory (PIK) domain / Phosphatidylinositol kinase / PIK helical domain profile. / Phosphatidylinositol 3- and 4-kinases signature 1. / Phosphatidylinositol 3/4-kinase, conserved site / Phosphatidylinositol 3- and 4-kinases signature 2. / Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily / Phosphoinositide 3-kinase, catalytic domain / Phosphatidylinositol 3- and 4-kinase / Phosphatidylinositol 3- and 4-kinases catalytic domain profile. / Phosphatidylinositol 3-/4-kinase, catalytic domain / Protein kinase-like domain superfamily類似検索 - ドメイン・相同性 ADENOSINE-5'-TRIPHOSPHATE / Phosphatidylinositol 4-kinase beta類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.318 Å |
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データ登録者 | Chalupska, D. / Boura, E. |
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資金援助 | チェコ, 1件 組織 | 認可番号 | 国 |
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Ministry of Education, Youth and Sports of the Czech Republic | LO1302 | チェコ |
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引用 | ジャーナル: J.Med.Chem. / 年: 2015 タイトル: Highly Selective Phosphatidylinositol 4-Kinase III beta Inhibitors and Structural Insight into Their Mode of Action. 著者: Mejdrova, I. / Chalupska, D. / Kogler, M. / Sala, M. / Plackova, P. / Baumlova, A. / Hrebabecky, H. / Prochazkova, E. / Dejmek, M. / Guillon, R. / Strunin, D. / Weber, J. / Lee, G. / Birkus, ...著者: Mejdrova, I. / Chalupska, D. / Kogler, M. / Sala, M. / Plackova, P. / Baumlova, A. / Hrebabecky, H. / Prochazkova, E. / Dejmek, M. / Guillon, R. / Strunin, D. / Weber, J. / Lee, G. / Birkus, G. / Mertlikova-Kaiserova, H. / Boura, E. / Nencka, R. |
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履歴 | 登録 | 2014年8月29日 | 登録サイト: RCSB / 処理サイト: PDBE |
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改定 1.0 | 2015年5月20日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2015年5月27日 | Group: Database references |
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改定 1.2 | 2017年9月6日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.3 | 2024年1月10日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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