PDB-4um3: Engineered Ls-AChBP with alpha4-alpha4 binding pocket in complex ...

Basic information

• Entry: Database: PDB / ID: 4um3
• Title: Engineered Ls-AChBP with alpha4-alpha4 binding pocket in complex with NS3920
• Components: (ACETYLCHOLINE BINDING ...) x 3
• Keywords: SIGNALING PROTEIN / NICOTINIC ACETYLCHOLINE RECEPTOR / ION CHANNEL / RECEPTOR STOICHIOMETRY / CYS-LOOP RECEPTOR

Function / homology

Function:

excitatory extracellular ligand-gated monoatomic ion channel activity / synaptic cleft / transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential / transmembrane signaling receptor activity / postsynapse / neuron projection / membrane

Domain/homology:

Acetylcholine Binding Protein; Chain: A, / Neurotransmitter-gated ion-channel ligand-binding domain / Neurotransmitter-gated ion-channel / Neurotransmitter-gated ion-channel ligand-binding domain / Neurotransmitter-gated ion-channel ligand-binding domain superfamily / Neurotransmitter-gated ion-channel ligand binding domain / Distorted Sandwich / Ig-like domain profile. / Immunoglobulin-like domain / Mainly Beta

Component:

1-(6-bromopyridin-3-yl)-1,4-diazepane / Acetylcholine-binding protein

• Biological species: LYMNAEA STAGNALIS (great pond snail)
• Method: X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.703 Å
• Authors: Shahsavar, A. / Kastrup, J.S. / Balle, T. / Gajhede, M.
• Citation: Journal: Mol.Pharmacol. / Year: 2015; Title: Achbp Engineered to Mimic the Alpha4-Alpha4 Binding Pocket in Alpha4Beta2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity; Authors: Shahsavar, A. / Ahring, P.K. / Olsen, J.A. / Krintel, C. / Kastrup, J.S. / Balle, T. / Gajhede, M.

History

Deposition	May 14, 2014	Deposition site: PDBE / Processing site: PDBE
Revision 1.0	Jul 22, 2015	Provider: repository / Type: Initial release
Revision 1.1	Jul 29, 2015	Group: Database references
Revision 1.2	Sep 2, 2015	Group: Database references
Revision 2.0	Nov 15, 2017	Group: Advisory / Atomic model / Data collection / Derived calculations Category: atom_site / diffrn_source / pdbx_struct_assembly_gen / pdbx_struct_sheet_hbond / pdbx_validate_close_contact / struct_conf / struct_conn / struct_sheet / struct_sheet_order / struct_sheet_range / struct_site / struct_site_gen Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.occupancy / _atom_site.type_symbol / _diffrn_source.pdbx_synchrotron_site / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_validate_close_contact.auth_seq_id_2 / _struct_conf.pdbx_PDB_helix_id / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr2_auth_seq_id / _struct_sheet.id / _struct_sheet_order.sense / _struct_sheet_order.sheet_id / _struct_sheet_range.sheet_id / _struct_site.details / _struct_site.id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id / _struct_site.pdbx_num_residues / _struct_site_gen.auth_asym_id / _struct_site_gen.auth_comp_id / _struct_site_gen.auth_seq_id / _struct_site_gen.label_asym_id / _struct_site_gen.label_comp_id / _struct_site_gen.label_seq_id / _struct_site_gen.pdbx_num_res / _struct_site_gen.site_id
Revision 2.1	Jul 29, 2020	Group: Data collection / Derived calculations / Other / Structure summary Category: chem_comp / entity / pdbx_chem_comp_identifier / pdbx_database_status / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_database_status.status_code_sf / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_role Description: Carbohydrate remediation / Provider: repository / Type: Remediation
Revision 2.2	Jan 10, 2024	Group: Data collection / Database references / Refinement description / Structure summary Category: chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Revision 2.3	Nov 13, 2024	Group: Structure summary / Category: pdbx_entry_details / pdbx_modification_feature

Assembly

Deposited unit

A: ACETYLCHOLINE BINDING PROTEIN

B: ACETYLCHOLINE BINDING PROTEIN

C: ACETYLCHOLINE BINDING PROTEIN

D: ACETYLCHOLINE BINDING PROTEIN

E: ACETYLCHOLINE BINDING PROTEIN

F: ACETYLCHOLINE BINDING PROTEIN

G: ACETYLCHOLINE BINDING PROTEIN

H: ACETYLCHOLINE BINDING PROTEIN

I: ACETYLCHOLINE BINDING PROTEIN

J: ACETYLCHOLINE BINDING PROTEIN

K: ACETYLCHOLINE BINDING PROTEIN

L: ACETYLCHOLINE BINDING PROTEIN

M: ACETYLCHOLINE BINDING PROTEIN

N: ACETYLCHOLINE BINDING PROTEIN

O: ACETYLCHOLINE BINDING PROTEIN

P: ACETYLCHOLINE BINDING PROTEIN

Q: ACETYLCHOLINE BINDING PROTEIN

R: ACETYLCHOLINE BINDING PROTEIN

S: ACETYLCHOLINE BINDING PROTEIN

T: ACETYLCHOLINE BINDING PROTEIN

U: ACETYLCHOLINE BINDING PROTEIN

V: ACETYLCHOLINE BINDING PROTEIN

W: ACETYLCHOLINE BINDING PROTEIN

X: ACETYLCHOLINE BINDING PROTEIN

Y: ACETYLCHOLINE BINDING PROTEIN

Z: ACETYLCHOLINE BINDING PROTEIN

a: ACETYLCHOLINE BINDING PROTEIN

b: ACETYLCHOLINE BINDING PROTEIN

c: ACETYLCHOLINE BINDING PROTEIN

d: ACETYLCHOLINE BINDING PROTEIN

e: ACETYLCHOLINE BINDING PROTEIN

f: ACETYLCHOLINE BINDING PROTEIN

g: ACETYLCHOLINE BINDING PROTEIN

h: ACETYLCHOLINE BINDING PROTEIN

i: ACETYLCHOLINE BINDING PROTEIN

j: ACETYLCHOLINE BINDING PROTEIN

k: ACETYLCHOLINE BINDING PROTEIN

l: ACETYLCHOLINE BINDING PROTEIN

m: ACETYLCHOLINE BINDING PROTEIN

n: ACETYLCHOLINE BINDING PROTEIN

hetero molecules

Summary:

• 1.05 MDa, 40 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	1,053,015	84
Polymers	1,042,010	40
Non-polymers	11,005	44
Water	15,061	836

1

P: ACETYLCHOLINE BINDING PROTEIN

Q: ACETYLCHOLINE BINDING PROTEIN

R: ACETYLCHOLINE BINDING PROTEIN

S: ACETYLCHOLINE BINDING PROTEIN

T: ACETYLCHOLINE BINDING PROTEIN

hetero molecules

Summary:

• defined by software
• 131 kDa, 5 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	131,430	10
Polymers	130,150	5
Non-polymers	1,281	5
Water	90	5

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	13890 Å2
ΔGint	-37.2 kcal/mol
Surface area	40020 Å2
Method	PISA

2

U: ACETYLCHOLINE BINDING PROTEIN

V: ACETYLCHOLINE BINDING PROTEIN

W: ACETYLCHOLINE BINDING PROTEIN

X: ACETYLCHOLINE BINDING PROTEIN

Y: ACETYLCHOLINE BINDING PROTEIN

hetero molecules

Summary:

• defined by software
• 132 kDa, 5 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	131,642	11
Polymers	130,266	5
Non-polymers	1,377	6
Water	90	5

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	14220 Å2
ΔGint	-49 kcal/mol
Surface area	39700 Å2
Method	PISA

3

K: ACETYLCHOLINE BINDING PROTEIN

L: ACETYLCHOLINE BINDING PROTEIN

M: ACETYLCHOLINE BINDING PROTEIN

N: ACETYLCHOLINE BINDING PROTEIN

O: ACETYLCHOLINE BINDING PROTEIN

hetero molecules

Summary:

• defined by software
• 132 kDa, 5 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	131,768	11
Polymers	130,266	5
Non-polymers	1,502	6
Water	90	5

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	13900 Å2
ΔGint	-34 kcal/mol
Surface area	39250 Å2
Method	PISA

4

j: ACETYLCHOLINE BINDING PROTEIN

k: ACETYLCHOLINE BINDING PROTEIN

l: ACETYLCHOLINE BINDING PROTEIN

m: ACETYLCHOLINE BINDING PROTEIN

n: ACETYLCHOLINE BINDING PROTEIN

hetero molecules

Summary:

• defined by software
• 132 kDa, 5 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	131,546	10
Polymers	130,266	5
Non-polymers	1,281	5
Water	90	5

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	13810 Å2
ΔGint	-37.6 kcal/mol
Surface area	40370 Å2
Method	PISA

5

e: ACETYLCHOLINE BINDING PROTEIN

f: ACETYLCHOLINE BINDING PROTEIN

g: ACETYLCHOLINE BINDING PROTEIN

h: ACETYLCHOLINE BINDING PROTEIN

i: ACETYLCHOLINE BINDING PROTEIN

hetero molecules

Summary:

• defined by software
• 132 kDa, 5 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	131,546	10
Polymers	130,266	5
Non-polymers	1,281	5
Water	90	5

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	13830 Å2
ΔGint	-35.6 kcal/mol
Surface area	39700 Å2
Method	PISA

6

Z: ACETYLCHOLINE BINDING PROTEIN

a: ACETYLCHOLINE BINDING PROTEIN

b: ACETYLCHOLINE BINDING PROTEIN

c: ACETYLCHOLINE BINDING PROTEIN

d: ACETYLCHOLINE BINDING PROTEIN

hetero molecules

Summary:

• defined by software
• 132 kDa, 5 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	131,768	11
Polymers	130,266	5
Non-polymers	1,502	6
Water	90	5

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	14000 Å2
ΔGint	-33.3 kcal/mol
Surface area	40210 Å2
Method	PISA

7

A: ACETYLCHOLINE BINDING PROTEIN

B: ACETYLCHOLINE BINDING PROTEIN

C: ACETYLCHOLINE BINDING PROTEIN

D: ACETYLCHOLINE BINDING PROTEIN

E: ACETYLCHOLINE BINDING PROTEIN

hetero molecules

Summary:

• defined by software
• 132 kDa, 5 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	131,768	11
Polymers	130,266	5
Non-polymers	1,502	6
Water	90	5

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	14160 Å2
ΔGint	-34.6 kcal/mol
Surface area	40290 Å2
Method	PISA

8

F: ACETYLCHOLINE BINDING PROTEIN

G: ACETYLCHOLINE BINDING PROTEIN

H: ACETYLCHOLINE BINDING PROTEIN

I: ACETYLCHOLINE BINDING PROTEIN

J: ACETYLCHOLINE BINDING PROTEIN

hetero molecules

Summary:

• defined by software
• 132 kDa, 5 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	131,546	10
Polymers	130,266	5
Non-polymers	1,281	5
Water	90	5

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	13910 Å2
ΔGint	-34.6 kcal/mol
Surface area	39860 Å2
Method	PISA

Unit cell

Length a, b, c (Å)	135.490, 145.418, 234.906
Angle α, β, γ (deg.)	90.00, 101.29, 90.00
Int Tables number	4
Space group name H-M	P1211

Noncrystallographic symmetry (NCS)

NCS domain:

ID	Ens-ID
1	1
2	1
3	1
4	1
5	1
6	1
7	1
8	1
9	1
10	1
11	1
12	1
13	1
14	1
15	1
16	1
17	1
18	1
19	1
20	1
21	1
22	1
23	1
24	1
25	1
26	1
27	1
28	1
29	1
30	1
31	1
32	1
33	1
34	1
35	1
36	1
37	1
38	1
39	1
40	1

NCS domain segments:

Dom-ID	Component-ID	Ens-ID	Selection details
1	1	1	CHAIN A AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
2	1	1	CHAIN B AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
3	1	1	CHAIN C AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
4	1	1	CHAIN D AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
5	1	1	CHAIN E AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
6	1	1	CHAIN F AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
7	1	1	CHAIN G AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
8	1	1	CHAIN H AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
9	1	1	CHAIN I AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
10	1	1	CHAIN J AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
11	1	1	CHAIN K AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
12	1	1	CHAIN L AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
13	1	1	CHAIN M AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
14	1	1	CHAIN N AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
15	1	1	CHAIN O AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
16	1	1	CHAIN P AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
17	1	1	CHAIN Q AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
18	1	1	CHAIN R AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
19	1	1	CHAIN S AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
20	1	1	CHAIN T AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
21	1	1	CHAIN U AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
22	1	1	CHAIN V AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
23	1	1	CHAIN W AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
24	1	1	CHAIN X AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
25	1	1	CHAIN Y AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
26	1	1	CHAIN Z AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
27	1	1	CHAIN a AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
28	1	1	CHAIN b AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
29	1	1	CHAIN c AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
30	1	1	CHAIN d AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
31	1	1	CHAIN e AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
32	1	1	CHAIN f AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
33	1	1	CHAIN g AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
34	1	1	CHAIN h AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
35	1	1	CHAIN i AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
36	1	1	CHAIN j AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
37	1	1	CHAIN k AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
38	1	1	CHAIN l AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
39	1	1	CHAIN m AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...
40	1	1	CHAIN n AND (RESSEQ 1:21 OR RESSEQ 26:39 OR RESSEQ...

Components

ACETYLCHOLINE BINDING ... , 3 types, 40 molecules A B C D E F G H I J K L M N O Q R T U V W X Y Z a b c d e f ...

#1: Protein

A B C D E F G H I J K L M N O Q R T U ...
ACETYLCHOLINE BINDING PROTEIN / ACH-BINDING PROTEIN / ACHBP / ACETYLCHOLINE BINDING PROTEIN

Details:

Mass: 26053.143 Da / Num. of mol.: 38 / Mutation: YES
Source method: isolated from a genetically manipulated source
Details: 1-(6-BROMOPYRIDIN-3-YL)-1,4-DIAZEPANE (NS3920) BINDS AT THE INTERFACE OF EACH TWO MONOMERS
Source: (gene. exp.) LYMNAEA STAGNALIS (great pond snail) / Plasmid: PFASTBAC / Cell line (production host): SF9 / Production host: SPODOPTERA FRUGIPERDA (fall armyworm) / References: UniProt: P58154

#2: Protein

P ACETYLCHOLINE BINDING PROTEIN / ACH-BINDING PROTEIN / ACHBP / ACETYLCHOLINE BINDING PROTEIN

Details:

Mass: 25938.053 Da / Num. of mol.: 1 / Mutation: YES
Source method: isolated from a genetically manipulated source
Details: 1-(6-BROMOPYRIDIN-3-YL)-1,4-DIAZEPANE (NS3920) BINDS AT THE INTERFACE OF EACH TWO MONOMERS
Source: (gene. exp.) LYMNAEA STAGNALIS (great pond snail) / Plasmid: PFASTBAC / Cell line (production host): SF9 / Production host: SPODOPTERA FRUGIPERDA (fall armyworm) / References: UniProt: P58154

#3: Protein

S ACETYLCHOLINE BINDING PROTEIN / ACH-BINDING PROTEIN / ACHBP / ACETYLCHOLINE BINDING PROTEIN

Details:

Mass: 26052.158 Da / Num. of mol.: 1 / Mutation: YES
Source method: isolated from a genetically manipulated source
Details: 1-(6-BROMOPYRIDIN-3-YL)-1,4-DIAZEPANE (NS3920) BINDS AT THE INTERFACE OF EACH TWO MONOMERS
Source: (gene. exp.) LYMNAEA STAGNALIS (great pond snail) / Plasmid: PFASTBAC / Cell line (production host): SF9 / Production host: SPODOPTERA FRUGIPERDA (fall armyworm) / References: UniProt: P58154

Sugars , 1 types, 3 molecules

#5: Sugar

A-302 O-302 d-302 ChemComp-NAG / 2-acetamido-2-deoxy-beta-D-glucopyranose / N-acetyl-beta-D-glucosamine / 2-acetamido-2-deoxy-beta-D-glucose / 2-acetamido-2-deoxy-D-glucose / 2-acetamido-2-deoxy-glucose / N-ACETYL-D-GLUCOSAMINE

Details:

Type: D-saccharide, beta linking / Mass: 221.208 Da / Num. of mol.: 3
Source method: isolated from a genetically manipulated source
Formula: C₈H₁₅NO₆

Identifier:

Identifier	Type	Program
DGlcpNAcb	CONDENSED IUPAC CARBOHYDRATE SYMBOL	GMML 1.0
N-acetyl-b-D-glucopyranosamine	COMMON NAME	GMML 1.0
b-D-GlcpNAc	IUPAC CARBOHYDRATE SYMBOL	PDB-CARE 1.0
GlcNAc	SNFG CARBOHYDRATE SYMBOL	GMML 1.0

Non-polymers , 3 types, 877 molecules

#4: Chemical

A-301 B-301 C-301 D-301 E-301 F-301 G-301 H-301 I-301 J-301 K-301 L-301 M-301 N-301 O-301 P-301 Q-301 R-301 S-301 T-301 ...
ChemComp-09R / 1-(6-bromopyridin-3-yl)-1,4-diazepane

Details:

Mass: 256.142 Da / Num. of mol.: 40 / Source method: obtained synthetically / Formula: C₁₀H₁₄BrN₃

#6: Chemical

V-301 ChemComp-SO4 / SULFATE ION

Details:

Mass: 96.063 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: SO₄

#7: Water

ChemComp-HOH / water

Details:

Mass: 18.015 Da / Num. of mol.: 836 / Source method: isolated from a natural source / Formula: H₂O

Details

• Has protein modification: Y

Experimental details

Experiment

• Experiment: Method: X-RAY DIFFRACTION / Number of used crystals: 1

Sample preparation

• Crystal: Density Matthews: 2.52 ų/Da / Density % sol: 51.25 % / Description: NONE
• Crystal grow: pH: 8 ; Details: 0.1 M TRIS BASE (PH 8.0), 1-3% V/V POLYETHYLENE GLYCOL (PEG) 400 AND 1.8-2.3 M (NH4)2SO4

Data collection

• Diffraction: Mean temperature: 100 K
• Diffraction source: Source: SYNCHROTRON / Site: MAX II / Beamline: I911-3 / Wavelength: 1
• Detector: Type: MARMOSAIC 225 mm CCD / Detector: CCD / Details: MIRRORS
• Radiation: Monochromator: SI(111) / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
• Radiation wavelength: Wavelength: 1 Å / Relative weight: 1
• Reflection: Resolution: 2.7→30.07 Å / Num. obs: 242584 / % possible obs: 99.3 % / Observed criterion σ(I): 0 / Redundancy: 3.8 % / B_iso Wilson estimate: 44.79 Ų / R_merge(I) obs: 0.08 / Net I/σ(I): 15.6
• Reflection shell: Resolution: 2.7→2.85 Å / Redundancy: 3.7 % / R_merge(I) obs: 0.48 / Mean I/σ(I) obs: 2.9 / % possible all: 96.4

Processing

Software

Name	Version	Classification
PHENIX	(PHENIX.REFINE)	refinement
XDS		data reduction
SCALA		data scaling
PHASER		phasing

Refinement

Method to determine structure: MOLECULAR REPLACEMENT
Starting model: PDB ENTRY 3U8M

3u8m

Resolution: 2.703→30.071 Å / SU ML: 0.37 / σ(F): 0 / Phase error: 24.82 / Stereochemistry target values: ML / Details: NUMBER OF TLS GROUPS IS 304

	Rfactor	Num. reflection	% reflection
Rfree	0.244	4882	2 %
Rwork	0.1981	-	-
obs	0.199	242584	99.46 %

• Solvent computation: Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
• Displacement parameters: B_iso mean: 46 Ų

Refinement step

Cycle: LAST / Resolution: 2.703→30.071 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	63211	0	607	836	64654

Refine LS restraints

Refine-ID	Type	Dev ideal	Number
X-RAY DIFFRACTION	f_bond_d	0.009	65741
X-RAY DIFFRACTION	f_angle_d	1.104	89566
X-RAY DIFFRACTION	f_dihedral_angle_d	13.976	23664
X-RAY DIFFRACTION	f_chiral_restr	0.065	10191
X-RAY DIFFRACTION	f_plane_restr	0.005	11475

Refine LS restraints NCS

Ens-ID	Dom-ID	Auth asym-ID	Number	Refine-ID	Type	Rms dev position (Å)
1	1	A	1426	X-RAY DIFFRACTION	POSITIONAL
1	2	B	1426	X-RAY DIFFRACTION	POSITIONAL	0.07
1	3	C	1434	X-RAY DIFFRACTION	POSITIONAL	0.07
1	4	D	1420	X-RAY DIFFRACTION	POSITIONAL	0.071
1	5	E	1448	X-RAY DIFFRACTION	POSITIONAL	0.064
1	6	F	1434	X-RAY DIFFRACTION	POSITIONAL	0.059
1	7	G	1434	X-RAY DIFFRACTION	POSITIONAL	0.066
1	8	H	1434	X-RAY DIFFRACTION	POSITIONAL	0.065
1	9	I	1434	X-RAY DIFFRACTION	POSITIONAL	0.067
1	10	J	1434	X-RAY DIFFRACTION	POSITIONAL	0.068
1	11	K	1434	X-RAY DIFFRACTION	POSITIONAL	0.058
1	12	L	1426	X-RAY DIFFRACTION	POSITIONAL	0.065
1	13	M	1434	X-RAY DIFFRACTION	POSITIONAL	0.063
1	14	N	1429	X-RAY DIFFRACTION	POSITIONAL	0.066
1	15	O	1434	X-RAY DIFFRACTION	POSITIONAL	0.06
1	16	P	1434	X-RAY DIFFRACTION	POSITIONAL	0.05
1	17	Q	1440	X-RAY DIFFRACTION	POSITIONAL	0.067
1	18	R	1434	X-RAY DIFFRACTION	POSITIONAL	0.067
1	19	S	1426	X-RAY DIFFRACTION	POSITIONAL	0.069
1	20	T	1422	X-RAY DIFFRACTION	POSITIONAL	0.066
1	21	U	1434	X-RAY DIFFRACTION	POSITIONAL	0.06
1	22	V	1426	X-RAY DIFFRACTION	POSITIONAL	0.072
1	23	W	1426	X-RAY DIFFRACTION	POSITIONAL	0.066
1	24	X	1434	X-RAY DIFFRACTION	POSITIONAL	0.065
1	25	Y	1434	X-RAY DIFFRACTION	POSITIONAL	0.055
1	26	Z	1434	X-RAY DIFFRACTION	POSITIONAL	0.055
1	27	A	1420	X-RAY DIFFRACTION	POSITIONAL	0.066
1	28	B	1448	X-RAY DIFFRACTION	POSITIONAL	0.066
1	29	C	1429	X-RAY DIFFRACTION	POSITIONAL	0.068
1	30	D	1434	X-RAY DIFFRACTION	POSITIONAL	0.059
1	31	E	1434	X-RAY DIFFRACTION	POSITIONAL	0.054
1	32	F	1420	X-RAY DIFFRACTION	POSITIONAL	0.065
1	33	G	1434	X-RAY DIFFRACTION	POSITIONAL	0.063
1	34	H	1434	X-RAY DIFFRACTION	POSITIONAL	0.063
1	35	I	1434	X-RAY DIFFRACTION	POSITIONAL	0.059
1	36	J	1426	X-RAY DIFFRACTION	POSITIONAL	0.059
1	37	K	1426	X-RAY DIFFRACTION	POSITIONAL	0.063
1	38	L	1434	X-RAY DIFFRACTION	POSITIONAL	0.064
1	39	M	1428	X-RAY DIFFRACTION	POSITIONAL	0.064
1	40	N	1426	X-RAY DIFFRACTION	POSITIONAL	0.052

LS refinement shell

Resolution (Å)	Rfactor Rfree	Num. reflection Rfree	Rfactor Rwork	Num. reflection Rwork	Refine-ID	% reflection obs (%)
2.7027-2.7334	0.3021	146	0.2498	6687	X-RAY DIFFRACTION	85
2.7334-2.7655	0.3572	197	0.2623	7935	X-RAY DIFFRACTION	100
2.7655-2.7992	0.3358	166	0.2644	7917	X-RAY DIFFRACTION	100
2.7992-2.8346	0.3528	147	0.2628	7897	X-RAY DIFFRACTION	100
2.8346-2.8719	0.3246	146	0.2568	7989	X-RAY DIFFRACTION	100
2.8719-2.9112	0.3284	141	0.2526	7928	X-RAY DIFFRACTION	100
2.9112-2.9527	0.3537	151	0.2477	7970	X-RAY DIFFRACTION	100
2.9527-2.9968	0.2688	153	0.2345	7913	X-RAY DIFFRACTION	100
2.9968-3.0436	0.319	163	0.2273	7942	X-RAY DIFFRACTION	100
3.0436-3.0934	0.2919	140	0.2207	7989	X-RAY DIFFRACTION	100
3.0934-3.1467	0.3034	151	0.2161	7957	X-RAY DIFFRACTION	100
3.1467-3.2039	0.2634	171	0.2153	7906	X-RAY DIFFRACTION	100
3.2039-3.2654	0.2534	179	0.2069	7928	X-RAY DIFFRACTION	100
3.2654-3.332	0.2743	158	0.2062	7946	X-RAY DIFFRACTION	100
3.332-3.4043	0.2639	165	0.1978	7953	X-RAY DIFFRACTION	100
3.4043-3.4834	0.2649	179	0.1922	7960	X-RAY DIFFRACTION	100
3.4834-3.5704	0.2384	163	0.1923	7929	X-RAY DIFFRACTION	100
3.5704-3.6668	0.2669	183	0.1979	7974	X-RAY DIFFRACTION	100
3.6668-3.7745	0.2471	178	0.1895	7905	X-RAY DIFFRACTION	100
3.7745-3.896	0.2098	151	0.1878	7997	X-RAY DIFFRACTION	100
3.896-4.035	0.2368	151	0.1793	7954	X-RAY DIFFRACTION	100
4.035-4.1961	0.2203	165	0.1716	7961	X-RAY DIFFRACTION	100
4.1961-4.3865	0.2034	185	0.1608	7986	X-RAY DIFFRACTION	100
4.3865-4.617	0.1928	154	0.1618	7963	X-RAY DIFFRACTION	100
4.617-4.9051	0.188	168	0.1643	7962	X-RAY DIFFRACTION	100
4.9051-5.282	0.1957	168	0.1676	8005	X-RAY DIFFRACTION	100
5.282-5.8101	0.2246	165	0.1827	8012	X-RAY DIFFRACTION	100
5.8101-6.6429	0.2578	172	0.2049	8024	X-RAY DIFFRACTION	100
6.6429-8.3397	0.1897	140	0.2008	8079	X-RAY DIFFRACTION	100
8.3397-30.0732	0.2305	186	0.2206	8134	X-RAY DIFFRACTION	100

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°2)	L12 (°2)	L13 (°2)	L22 (°2)	L23 (°2)	L33 (°2)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å2)	T12 (Å2)	T13 (Å2)	T22 (Å2)	T23 (Å2)	T33 (Å2)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	0.0086	-0.0068	0.0029	0.0092	-0.0014	0.016	-0.1079	-0.0836	0.1766	0.0427	0.102	0.0172	0.0101	-0.0878	0.0001	0.395	-0.0104	0.0791	0.263	-0.0496	0.2702	-22.8904	10.6184	-108.6227
2	-0.001	-0.0031	0.0019	0.0052	-0.019	0.0615	-0.055	-0.0229	-0.0021	-0.0611	-0.0652	0.0691	0.04	0.0292	-0.1464	0.3068	0.146	-0.0227	0.0593	-0.0923	0.1441	-18.7933	-7.9334	-102.4577
3	0.0511	0.0611	0.0364	0.4557	0.1091	0.0549	0.127	-0.1489	-0.035	0.2717	-0.0816	-0.0085	0.1408	-0.1407	-0.0086	0.1125	-0.0035	0.008	0.2364	-0.0397	0.1561	-24.1568	0.7851	-77.5129
4	0.0015	-0.0041	0.0047	0.0059	0.0008	0.0147	0.0284	0.0673	-0.0283	-0.0434	0.0612	-0.105	0.0917	0.2099	0.0001	0.2934	-0.154	0.0353	0.2869	-0.0326	0.2172	-13.0299	8.3111	-105.7351
5	0.2079	0.0526	-0.1069	0.1356	-0.1211	0.3516	0.0395	0.1347	-0.1357	-0.1419	-0.0332	-0.068	0.1174	0.0533	-0.0648	0.1107	-0.005	0.0128	0.1223	0.0626	0.2289	-25.2683	2.5922	-89.0638
6	0.2053	0.0038	-0.1777	0.1968	0.0936	0.4107	0.0269	-0.0203	-0.05	0.0151	-0.1139	-0.1394	0.0755	0.139	-0.1199	0.2118	0.0952	0.0089	0.0641	0.0466	0.2953	-21.5326	-8.2226	-77.4641
7	0.0068	0.0092	-0.008	0.0256	-0.0051	0.0072	-0.0435	0.0488	-0.0179	0.0336	-0.1439	-0.0222	0.0862	0.1377	-0.0002	0.2637	-0.1	0.0404	0.3887	-0.0048	0.2873	-19.3529	9.3053	-72.0716
8	0.3234	0.0352	-0.2567	0.0825	0.0314	0.2798	0.0924	-0.0892	-0.1353	-0.147	-0.0639	0.0554	0.1577	0.2019	0.0148	0.343	0.1336	-0.1159	0.314	-0.035	0.2243	-19.147	-10.439	-78.3587
9	0.0647	0.0753	-0.0975	0.0843	-0.1101	0.1445	0.0625	-0.1415	-0.057	0.1388	-0.1598	-0.0704	0.0507	0.1987	-0.0681	0.1566	0.0109	-0.058	0.2177	-0.0143	0.1518	-20.6227	-2.2975	-70.5556
10	0.0454	-0.0042	-0.0251	0.0336	-0.0088	0.0138	0.0287	0.1683	0.2075	-0.071	0.1162	0.0451	-0.0112	-0.067	0.0007	0.2971	-0.0177	-0.0109	0.2537	-0.0227	0.1698	-36.8852	-16.0721	-107.2835
11	0.8163	0.0652	0.4876	0.1141	0.1012	0.319	-0.0933	-0.2441	0.0248	-0.0565	-0.0013	-0.0293	0.0452	-0.111	-0.0626	0.1924	0.0682	0.0452	0.048	0.0424	0.1748	-41.6214	-16.4892	-79.5127
12	0.0029	-0.0027	0.005	0.0085	-0.0022	0.0128	-0.0253	0.0408	-0.0589	-0.1329	0.0353	0.0896	0.0927	0.0653	0.0001	0.323	0.0358	0.0669	0.1802	-0.0267	0.3487	-28.5304	-22.1843	-107.3172
13	0.0575	0.0488	0.1012	0.1634	0.2431	0.3919	-0.0451	-0.0121	-0.1625	-0.1214	-0.1393	-0.0032	0.1903	-0.0141	-0.077	0.2002	0.0516	0.0835	0.0542	0.0679	0.2027	-39.4728	-13.5752	-90.4948
14	0.1503	-0.0638	-0.0259	0.0753	0.0097	0.0057	0.0203	-0.2981	-0.2644	0.0438	-0.1798	-0.0022	0.1815	0.016	-0.0414	0.2513	-0.0953	0.0796	0.1977	-0.0202	0.1903	-49.2354	-21.7965	-80.5999
15	0.0971	-0.0106	-0.1233	0.0333	0.0413	0.1358	0.1101	-0.0966	-0.1568	-0.0605	-0.1267	0.0107	0.1581	-0.0705	0.0001	0.2992	0.0182	0.0138	0.2016	0.0555	0.2109	-44.3823	-22.3498	-77.7147
16	0.0743	-0.0094	0.0323	0.0007	-0.0056	0.0137	-0.2009	0.0315	0.0482	0.0641	0.0029	-0.0868	0.0785	0.0648	0.0002	0.4954	0.0487	-0.0142	0.1616	-0.029	0.2273	-52.1265	-12.6973	-112.1097
17	0.0763	-0.0091	0.0718	0.1388	0.0726	0.11	-0.0538	-0.0499	0.058	-0.0352	-0.1637	-0.1549	0.0096	-0.0671	-0.0072	0.5003	0.1788	0.0076	0.309	0.0551	0.2949	-67.4655	-0.2892	-108.6427
18	0.0876	0.0158	-0.0121	0.0109	-0.0041	0.0172	-0.033	-0.1871	-0.0924	0.1267	-0.0341	-0.0557	0.0002	-0.1067	0	0.3284	0.0394	0.0107	0.2775	-0.0132	0.1852	-63.6369	-5.4762	-82.4094
19	0.0095	0.0086	0.005	0.0841	-0.0518	0.0453	-0.0135	0.0485	0.002	-0.0056	-0.0549	0.0618	0.1045	-0.0695	0.0243	0.1989	-0.0256	0.1177	0.187	-0.074	0.3792	-61.8688	-16.644	-111.5547
20	0.0361	-0.0327	-0.0226	0.0452	-0.0159	0.0527	-0.0339	0.0147	0.0238	0.0724	0.0567	0.1208	0.0357	-0.042	0.0102	0.0681	0.0007	0.0289	0.0871	0.0204	0.1555	-58.977	-5.4086	-93.0578
21	0.0776	-0.0387	0.0559	0.0387	-0.0902	0.2444	-0.0068	-0.024	-0.0231	0.0296	0.0092	0.0674	0.0151	-0.0115	0.0043	0.7855	0.0802	0.0506	0.1795	-0.0649	0.3473	-70.7435	-4.0503	-66.7757
22	0.0417	-0.0104	0.017	0.0266	-0.0039	0.0043	-0.1726	-0.0507	-0.0491	0.0587	-0.0115	-0.0667	-0.0047	-0.0136	0.0001	0.2417	0.1056	-0.0222	0.2198	-0.0656	0.2088	-70.9319	2.3768	-91.6176
23	0.0335	0.0432	0.0003	0.0514	-0.0054	-0.0008	-0.1847	0.0652	-0.0199	0.0257	0.0215	0.2152	0.1957	0.0234	-0.006	0.6237	-0.1036	0.112	0.3631	-0.0354	0.2703	-63.752	-15.4579	-77.3484
24	0.0145	-0.0192	-0.0198	0.0098	0.0106	0.0214	0.0475	0.1423	0.0412	0.0224	-0.076	0.169	0.0892	-0.0873	-0.0001	0.2634	0.0905	0.0105	0.3053	0.0199	0.1866	-73.818	0.8322	-85.2882
25	0.2397	0.2206	0.0099	0.3048	-0.0162	0.0274	0.0122	-0.1368	0.1488	0.0536	0.038	0.1159	0.0893	-0.0296	0.0202	0.2322	0.0433	0.1174	0.2798	-0.0609	0.1661	-69.8341	-4.6584	-77.5745
26	0.0028	-0.0058	0.012	0.0179	-0.0054	0.0285	-0.0206	0.1734	-0.021	-0.072	0.1154	0.0197	-0.0441	-0.111	0	0.3663	0.0521	0.0424	0.3292	0.0841	0.3452	-56.38	18.0478	-110.1881
27	0.4789	0.2602	-0.0236	0.1625	-0.0085	0.0146	0.1777	-0.1111	0.0505	-0.0729	-0.1662	0.0445	-0.1167	0.0194	-0.022	0.2218	0.1311	0.0472	0.1954	-0.0998	0.1727	-59.6156	18.7005	-82.0483
28	0.0039	-0.0054	0.0018	0.0188	-0.0181	0.0216	0.0498	0.2243	-0.0231	-0.1764	0.039	0.3035	-0.0413	-0.2973	0.0006	0.664	0.1556	-0.1191	0.5107	-0.1283	0.4293	-66.5314	17.2348	-112.4635
29	0.5797	0.3738	-0.3134	0.2505	-0.1864	0.167	0.2029	-0.2027	0.1629	-0.0649	-0.1387	0.034	-0.2933	-0.0748	0.0249	0.2135	0.1112	0.0383	0.1501	0.0179	0.21	-56.9931	15.6733	-92.8728
30	0.3173	0.0642	0.1302	0.3143	0.0437	0.1229	0.0934	-0.0859	0.2807	-0.1353	-0.1909	0.1497	-0.052	-0.1142	-0.326	0.548	0.1496	-0.0169	0.0386	-0.1218	0.2502	-56.291	27.4746	-81.8656
31	0.2241	-0.0908	0.3884	0.0938	-0.0922	0.7097	0.0779	-0.0245	0.1534	-0.0801	0.1099	0.0022	-0.106	-0.3086	0.0953	0.3845	0.1462	0.0921	0.1121	-0.0094	0.2988	-61.8667	24.8049	-80.4238
32	0.0139	0.0163	0.0028	0.0352	-0.0152	0.0136	0.1489	0.1489	-0.0063	-0.0998	-0.0075	-0.1017	-0.1656	-0.0159	0	0.2834	-0.0274	0.0513	0.2846	-0.0174	0.1977	-35.2141	22.1966	-107.7678
33	0.4648	0.1112	0.4015	0.0555	0.1794	0.5256	-0.197	-0.079	0.1126	0.1192	-0.052	0.2388	-0.1162	0.0149	-0.2165	0.2766	0.1792	0.1098	0.1732	-0.1095	0.1475	-35.4806	22.5759	-78.9252
34	0.1617	0.1146	0.1228	0.095	0.1036	0.1202	-0.0381	0.0621	0.0912	-0.0387	0.1342	-0.092	-0.0735	-0.0369	0.1246	0.4051	0.061	0.0533	0.1872	0.1621	0.4443	-36.6119	32.4573	-108.5639
35	0.0326	0.0062	-0.0099	0.0313	0.0918	0.2372	-0.1468	-0.1071	0.0167	0.093	-0.0063	-0.0247	-0.0989	0.0358	-0.0821	0.1727	0.0558	0.0412	0.0814	0.033	0.2418	-36.6166	20.6572	-90.441
36	0.1538	-0.1342	0.1083	0.1467	-0.1116	0.0815	-0.2676	-0.1814	0.1332	0.228	-0.0412	-0.0935	-0.1372	0.0021	-0.1035	0.2064	0.0265	0.0258	0.2383	0.0151	0.2408	-26.1594	22.325	-78.0814
37	0.0112	-0.0064	0.0002	0.0071	-0.0052	0.0015	-0.102	0.0816	0.067	-0.0789	0.0163	0.1764	-0.0797	0.1128	-0	0.572	0.0752	-0.0075	0.2704	-0.0578	0.4325	-42.4601	30.3165	-74.8325
38	0.2629	0.0055	-0.0008	0.1479	-0.2302	0.3464	-0.1035	0.0167	0.0177	0.0342	-0.0873	-0.0907	-0.0983	0.1381	-0.2513	0.1072	-0.0968	0.1124	0.1857	-0.0947	0.3133	-23.2072	23.8335	-78.8653
39	0.0172	0.019	0.0043	0.0187	0.0227	0.0123	-0.1795	-0.0417	0.0429	0.025	-0.0651	-0.0038	-0.1762	0.0137	0	0.3582	-0.0998	0.0162	0.3722	-0.0807	0.2818	-29.7056	25.5627	-74.0276
40	0.0083	-0.0032	-0.0018	0.0019	0.0006	0.014	-0.0152	-0.0365	0.0275	0.0361	-0.066	0.128	-0.0121	-0.0291	0.0001	0.3379	0.0731	0.0131	0.2593	-0.0577	0.1681	-21.5148	-2.3211	-116.4206
41	0.012	-0.0108	-0.0088	0.0101	0.0063	0.0215	-0.0277	0.018	-0.0146	0.0302	-0.0086	0.0185	0.0341	-0.0355	-0.0407	0.4743	-0.2406	0.1169	0.2249	0.0434	0.1993	-16.7485	16.5471	-121.7202
42	0.1811	-0.0904	0.0464	0.059	0.0411	0.3386	-0.2181	0.3294	-0.1184	-0.1328	-0.0431	-0.0144	0.0222	0.0859	-0.3466	0.1494	-0.1593	0.3109	0.1743	0.1245	-0.1188	-15.8484	7.4034	-147.0644
43	0.0141	-0.0001	0.0017	0.0017	0.0006	0.0129	0.2501	-0.1695	0.028	0.0684	0.0397	-0.0629	0.0154	0.1937	-0.0002	0.3499	-0.1036	-0.1106	0.3098	0.0942	0.2925	-11.3208	0.2746	-116.9666
44	0.091	0.0477	-0.0169	0.0698	0.0273	0.0601	0.0577	0.1315	-0.0159	-0.0715	-0.0876	-0.0696	-0.0906	0.2249	0.001	0.1891	-0.0378	0.0426	0.16	0.0182	0.2419	-19.9572	5.7613	-136.64
45	0.245	0.0512	0.0638	0.243	0.0702	0.1866	0.0182	0.103	0.0985	-0.1113	-0.0063	-0.1898	-0.1404	0.0938	-0.0497	0.3441	-0.1325	-0.0011	0.0234	-0.0003	0.2672	-13.5524	16.4925	-146.577
46	0.0055	0.0145	-0.0027	0.0102	0.0199	0.0725	0.0886	-0.0852	0.0988	0.0053	-0.0404	-0.0758	-0.0422	0.2165	0.0015	0.0703	0.0073	-0.0216	0.3361	0.0225	0.3089	-8.6887	-0.6132	-150.4684
47	0.1536	-0.038	0.1706	0.0159	-0.0544	0.202	-0.1202	0.0139	0.1193	0.043	-0.1308	-0.1527	-0.3079	0.1501	-0.257	0.4584	-0.1606	0.0517	0.1607	0.1487	0.3643	-11.4734	18.795	-145.2097
48	0.1865	-0.0546	0.0481	0.0219	-0.0222	0.018	0.0893	0.0808	0.1022	-0.0979	0.0659	0.1068	-0.0305	-0.0208	0.0487	0.3381	-0.0922	0.0469	0.1421	0.0456	0.1426	-10.8093	12.6095	-150.6691
49	0.0101	-0.0041	-0.0049	0.0044	0.0039	0.0051	-0.0496	0.035	-0.1746	0.1427	-0.0415	0.0635	0.104	-0.0879	0.0001	0.429	0.0453	-0.0572	0.4186	0.0242	0.1851	-28.4843	19.6915	-117.3604
50	0.0082	-0.0045	-0.0012	0.0017	0.0032	0.0067	-0.0128	-0.078	-0.1327	0.0016	0.073	-0.0136	0.0691	-0.0194	0.0003	0.4244	0.1143	0.0649	0.2625	0.0119	0.2757	-44.3679	29.1503	-125.0053
51	0.0377	0.0218	-0.0445	0.044	-0.0199	0.0878	-0.0343	0.0147	0.0612	-0.1253	0.1136	0.0076	-0.1473	-0.0366	0.3864	0.699	0.0593	0.0953	0.0295	0.1004	0.1503	-33.5387	24.3866	-149.2883
52	0.084	0.0006	0.0049	0.007	0.029	0.1573	-0.0658	0.0039	0.0425	0.0368	-0.1031	-0.0574	-0.1272	0.068	-0.0283	0.9314	0.1059	-0.0372	0.3129	0.0851	0.3755	-27.706	30.0456	-119.0945
53	0.0089	-0.0383	0.0253	0.0776	-0.047	0.0255	-0.046	0.0235	0.0081	-0.0178	-0.0283	-0.0243	-0.0281	-0.0645	-0.146	0.4116	-0.0299	0.0075	-0.2274	0.1062	0.2344	-34.0359	21.3491	-138.0641
54	0.0096	0.0042	0.001	0.0022	0.0008	0.0014	-0.0456	-0.0258	0.0907	-0.0253	-0.0345	-0.0387	-0.0546	0.0559	-0.0001	0.6488	0.0287	-0.0042	0.423	0.2291	0.3944	-34.2656	28.6286	-165.9847
55	0.0711	-0.0193	0.0167	0.1022	-0.0269	0.0338	-0.0581	-0.0141	0.1281	-0.1107	0.0225	-0.1592	-0.0748	-0.0362	-0.1445	0.6501	0.1822	0.0841	-0.0105	0.0337	0.2601	-44.778	29.7501	-142.5556
56	0.1368	0.2568	0.2307	0.491	0.4403	0.396	0.0766	0.0129	-0.0164	0.1382	0.2287	-0.1201	-0.0832	-0.0982	0.0464	0.7106	-0.1233	-0.0256	0.2661	0.0886	0.3082	-23.3245	27.2046	-152.9954
57	0.0241	-0.0048	0.0256	0.0071	-0.0013	0.0828	-0.1089	-0.0266	0.1239	-0.0221	0.1561	0.0028	-0.2168	-0.1103	0.0523	0.8312	0.1216	0.0328	0.1986	-0.0009	0.2866	-43.0469	32.1969	-149.0612
58	0.1144	-0.0415	-0.1219	0.1312	0.0231	0.1593	0.0673	0.1038	0.0301	-0.1982	0.0767	0.1055	-0.0123	-0.0017	0.0663	0.6925	0.1865	0.0138	0.1179	0.0837	0.292	-36.6442	30.2525	-153.8405
59	0.0652	0.0238	0.05	0.04	0.0247	0.0395	0.2037	-0.0481	-0.0319	0.0951	0.0498	0.0742	-0.0224	-0.1547	0.0037	0.3944	0.1143	0.0299	0.2154	-0	0.2911	-55.7273	14.3956	-123.2002
60	0.0343	-0.0172	0.0146	0.031	-0.0331	0.0267	-0.0339	0.0617	0.116	-0.169	-0.0098	-0.006	0.0096	-0.0055	-0.0004	0.3206	0.1077	-0.0104	0.225	0.0236	0.263	-55.1519	12.7567	-151.9586
61	0.0317	0.0212	-0.0294	0.0589	0.0044	0.0391	0.0376	-0.0056	0.1092	-0.0299	0.0093	0.0522	-0.1798	-0.1014	0.0195	0.5034	0.2914	0.0131	0.4364	-0.0864	0.3507	-60.8408	23.437	-123.1344
62	0.1047	0.0647	-0.0038	0.0825	-0.1017	0.3212	0.1893	-0.0072	-0.0088	0.0093	-0.0501	0.1098	-0.1693	-0.0768	0.3389	0.2716	0.287	-0.0763	0.1039	0.038	0.2212	-53.2837	12.5981	-140.4737
63	0.0267	0.0503	0.0124	0.1593	0.0379	0.0076	-0.071	0.0231	0.1048	-0.3839	0.0131	0.2642	-0.1584	-0.226	-0.0242	0.3971	0.1275	-0.0293	0.2918	-0.0701	0.1967	-62.3949	6.8195	-152.567
64	0.0012	0.0231	0.0066	0.0758	-0.0448	0.0773	-0.0696	0.0063	0.1652	-0.0036	-0.0322	0.0228	-0.2133	-0.2255	-0.2323	0.4247	0.3535	-0.1191	0.3517	-0.0014	0.2867	-61.2373	12.2873	-154.7489
65	0.2742	-0.2553	-0.0939	0.2394	0.0906	0.0286	0.0356	-0.0645	0.2554	0.0981	0.1141	-0.2128	-0.0631	-0.1274	0.0181	0.2954	0.1077	-0.0438	0.2567	-0.0177	0.1985	-54.882	-11.0403	-123.3197
66	0.0043	0.0732	0.0208	0.3714	0.1027	0.0323	-0.0965	0.1273	0.0068	-0.313	-0.0817	0.0745	-0.0314	-0.0842	-0.0278	0.2047	0.0363	-0.0458	0.1392	-0.006	0.2001	-50.7372	-11.408	-151.3145
67	0.0015	-0.002	0.0039	0.0238	-0.0225	0.023	-0.0409	-0.0234	-0.0135	0.0428	-0.1429	0.0794	0.0362	-0.1419	-0.0043	0.1563	-0.0035	0.0748	0.4322	0.0086	0.4502	-65.3132	-10.438	-123.6676
68	0.2036	-0.0199	-0.0278	0.1926	0.1236	0.0571	-0.0313	-0.1078	-0.0824	-0.1562	-0.0283	-0.0576	-0.1107	-0.1028	-0.0547	0.0509	0.141	0.0963	-0.0098	-0.1088	0.2075	-51.1085	-8.4162	-140.141
69	0.357	0.0525	-0.0976	0.3823	0.0456	0.0363	-0.0736	0.2466	-0.0769	-0.0042	0.0332	0.1733	0.0208	-0.0902	-0.0832	0.0162	0.0397	-0.0316	0.1	0.0043	0.2013	-47.4776	-20.019	-151.1712
70	0.2527	0.0973	-0.1025	0.0931	-0.0854	0.084	0.0634	0.1209	0.1581	0.0135	-0.0825	-0.0642	0.0984	-0.0938	0.0037	0.545	-0.0164	0.0332	0.393	-0.032	0.2115	-60.1279	-9.0072	-156.7605
71	0.2058	-0.1145	-0.0779	0.1404	-0.0402	0.1354	-0.0388	0.0586	-0.0908	-0.0012	-0.0813	-0.0106	0.0386	-0.0542	-0.0665	0.4924	0.1071	-0.0756	0.1152	-0.0441	0.283	-47.7834	-23.2344	-149.5339
72	0.4006	-0.0126	-0.1966	0.3144	-0.0113	0.0973	0.0687	0.1064	0.0674	-0.083	0.0475	0.0623	-0.024	-0.0847	0.1201	0.2588	0.0716	-0.0794	0.1016	-0.1058	0.1481	-50.767	-18.362	-155.5078
73	0.008	-0.0049	0.0087	0.0119	-0.011	0.014	-0.0206	0.0245	-0.0416	-0.0118	-0.079	-0.0035	-0.0266	0.0102	0.0001	0.392	-0.0279	0.0448	0.3881	0.0316	0.2667	-40.454	-15.7185	-118.701
74	0.0798	-0.0355	0.1229	0.0223	-0.0421	0.2234	0.0027	-0.0343	-0.013	0.024	0.0721	-0.1051	0.0895	-0.0922	0.0143	0.2813	-0.0667	-0.0853	0.1455	0.007	0.2793	-20.8918	-14.0313	-121.6788
75	0.2887	-0.0336	0.2147	0.1535	-0.1205	0.51	-0.0707	0.1106	-0.1822	-0.0054	-0.0414	-0.0165	-0.0355	0.0483	-0.1287	0.1955	0.0032	-0.0124	0.0459	-0.0151	0.1647	-26.4277	-14.6431	-148.2047
76	0.0346	0.0315	0.0045	0.04	-0.0092	0.0458	-0.0084	-0.0083	-0.0951	0.0091	-0.0704	0.017	0.0498	0.0094	-0.0217	0.5442	-0.0359	-0.0216	0.1438	0.0423	0.44	-34.6814	-24.4649	-119.7002
77	0.3089	0.1245	-0.0345	0.1831	-0.007	0.0597	-0.053	0.1244	0.0059	0.0528	0.0409	0.2143	0.0932	-0.0632	0.0997	-0.0517	-0.1228	0.0271	-0.1423	0.0287	0.1731	-30.3056	-12.397	-137.8023
78	0.0096	0.0504	-0.053	0.3539	-0.1026	0.2115	-0.0793	0.0637	-0.177	-0.0058	-0.0304	-0.2545	0.1068	0.1274	-0.178	0.0326	-0.0008	0.0254	0.1509	-0.0075	0.2203	-17.1282	-14.1185	-146.7018
79	0.198	0.2313	-0.2246	0.4397	-0.5065	0.6153	0.0599	0.1748	0.0736	-0.01	0.2948	0.112	0.1096	-0.0391	0.0986	0.191	0.0059	0.0042	0.1677	-0.1003	0.2769	-31.9399	-22.6139	-153.8412
80	0.0498	-0.0075	-0.0069	0.0604	-0.003	0.188	0.0047	0.1397	0.0819	-0.2729	-0.0987	-0.1649	-0.0359	0.2207	-0.0119	0.2858	0.0566	0.0282	0.1686	-0.0589	0.2911	-14.5063	-15.5106	-145.1534
81	0.0293	0.067	0.0309	0.2905	0.0315	0.0769	-0.004	0.0453	0.0719	-0.0875	-0.0297	0.0673	0.0075	-0.0248	0.0147	0.1171	-0.0052	0.041	0.3299	-0.1064	0.2243	-19.5318	-17.4478	-151.4753
82	0.0235	-0.0182	-0.0228	0.0159	0.0147	0.0185	-0.014	-0.0716	-0.0408	-0.0399	0.2295	0.1297	-0.1914	0.074	0.0001	0.277	-0.1097	-0.031	0.3862	-0.0277	0.367	39.1407	15.3366	-107.7303
83	0.0126	-0.0698	0.017	0.1844	-0.0413	0.0384	-0.1555	-0.0248	-0.218	-0.0143	-0.0986	0.003	-0.0195	0.1563	-0.0008	0.1215	-0.0744	0.0332	0.2067	0.0071	0.2441	38.2961	11.8941	-87.3055
84	0.0079	-0.004	0.0025	0.242	-0.1372	0.0767	0.0749	-0.0651	0.0848	-0.073	-0.1397	-0.2302	0.0696	0.0007	-0.1279	-0.1613	-0.0337	0.0309	0.2817	0.0352	0.2278	35.0521	15.5995	-90.2835
85	0.0603	-0.0352	-0.0785	0.1119	0.0256	0.0964	-0.0032	-0.1949	-0.2191	0.0958	-0.1283	-0.143	-0.0281	-0.1657	-0.0001	0.2544	0.0139	0.0035	0.3285	0.099	0.2809	32.0798	5.4471	-78.5854
86	0.0066	0.0053	0.0023	0.0031	0.002	0.0066	-0.0122	-0.1175	0.0577	-0.0377	-0.0088	-0.0758	-0.007	-0.0542	0.0001	0.2879	-0.1059	-0.0071	0.4656	0.0116	0.2392	23.1582	11.5578	-112.0365
87	0.0114	-0.0107	-0.0102	0.0085	0.0125	0.0207	0.0212	-0.0089	-0.0374	0.0252	0.0024	0.0425	0.0095	0.004	0.0246	0.1463	-0.1067	-0.0985	0.5754	0.1106	0.4131	6.1873	18.7849	-107.9898
88	0.4116	-0.1878	0.0536	0.1647	-0.0847	0.0456	-0.1639	-0.3937	-0.2879	0.0897	0.0703	0.1416	-0.1243	-0.1309	-0.0569	0.2503	-0.0607	-0.0321	0.3194	0.033	0.2371	10.0886	15.3524	-82.3422
89	0.0061	-0	0.0004	0.0035	0.0002	0.0021	-0.021	0.0985	-0.1144	-0.0645	0.0896	-0.0106	0.0588	-0.1582	-0	0.4617	0.0793	-0.0292	0.3319	-0.1287	0.5343	15.3355	4.5555	-111.2156
90	0.0067	0.0209	-0.0352	0.2268	-0.2607	0.411	-0.0496	0.0752	0.1855	-0.2	0.1821	-0.0808	0.3285	-0.0511	0.0739	0.1325	-0.0618	0.0265	0.3432	0.0286	0.2883	14.3222	16.7918	-92.7309
91	0.072	-0.0359	-0.0393	0.041	0.0149	0.0204	-0.0483	-0.0588	0.0126	0.0597	0.1431	0.1713	0.0762	-0.0333	0.0003	0.1901	-0.0031	0.0469	0.5317	0.0237	0.3062	1.3013	18.328	-83.6907
92	0.0256	-0.0394	0.017	0.0585	-0.0137	0.0183	-0.1663	-0.0017	-0.1314	-0.0055	-0.0344	-0.0866	0.0989	-0.0396	-0.005	0.3029	-0.1777	0.0493	0.6178	0.1629	0.366	13.9708	6.2534	-76.7892
93	0.0269	-0.0245	-0.0421	0.0694	0.072	0.0793	0.0061	-0.2138	-0.0572	0.1663	-0.0663	0.1482	-0.1007	-0.1528	0.0001	0.2378	-0.0051	0.0077	0.4555	0.0905	0.3019	0.0443	16.3738	-82.8839
94	0.0261	-0.058	0.0248	0.1666	0.0367	0.3258	0.1451	0.0313	0.1893	-0.1216	0.1238	-0.0712	0.2051	-0.1333	0.0251	0.2201	-0.1179	-0.0695	0.3573	0.1368	0.3403	8.5727	38.4019	-110.9099
95	0.1826	-0.0696	-0.0532	0.0901	-0.0377	0.0663	0.0336	-0.1313	0.1337	0.0361	0.1185	0.1524	-0.0264	-0.0017	0.1335	0.1006	-0.1543	0.05	0.4628	-0.0338	0.3253	5.1817	39.6607	-82.7959
96	0.0758	-0.0435	0.0187	0.1513	0.0934	0.0902	0.0655	0.0117	0.0161	-0.0375	0.08	-0.013	0.0713	-0.0845	0.1416	0.2525	-0.3219	-0.1667	0.4528	0.0421	0.4341	-0.8836	34.7773	-113.0714
97	0.0792	0.0603	0.064	0.1627	-0.0133	0.1118	0.1104	0.0074	0.0897	-0.0383	0.04	0.0953	0.0175	-0.0546	0.2672	-0.193	-0.1599	-0.0623	0.2234	0.0115	0.3176	8.7863	37.4168	-93.2909
98	0.0939	-0.0409	0.0681	0.0113	-0.0269	0.0456	-0.1069	0.0352	0.0166	0.1192	0.0772	0.2476	0.0093	-0.1419	-0.0001	0.2449	-0.0011	0.0439	0.3545	0.0097	0.332	2.6901	44.1121	-81.7455
99	0.1504	-0.0053	-0.0476	0.0513	0.1821	0.6912	-0.0984	-0.1203	0.2659	0.0599	0.0123	0.0087	-0.2573	-0.0514	-0.0979	-0.0061	0.0303	0.0374	0.3497	-0.0766	0.5989	2.862	49.4922	-82.3046
100	0.0056	0.0243	0.0173	0.2056	0.1128	0.0697	-0.0063	0.0604	-0.0598	-0.0022	0.1823	-0.0975	0.0043	0.0205	0.0539	0.0675	-0.0481	0.065	0.3296	0.0372	0.2861	27.1203	50.4209	-108.8395
101	0.3378	-0.1987	-0.2268	0.1944	0.0302	0.2706	-0.0165	-0.3365	0.2349	0.1932	0.0383	0.2368	-0.0218	0.1142	-0.1545	-0.0892	-0.1163	-0.0189	0.2005	-0.0316	0.2642	26.5123	51.5524	-80.0412
102	0.0036	0.0101	0.0083	0.0388	0.0337	0.0295	-0.0316	-0.0377	0.1296	-0.0422	0.0786	0.0423	-0.1101	-0.0924	0.0551	0.1916	0.0215	-0.1079	0.3158	0.1361	0.4725	22.4064	59.6271	-109.969
103	0.0479	0.0436	0.0182	0.0535	0.0621	0.0729	-0.0551	0.0516	0.2108	-0.0514	0.0503	-0.032	-0.1572	0.0733	0.0027	0.1031	-0.065	-0.0151	0.2874	-0.0267	0.2723	26.2848	48.9493	-91.3278
104	0.0581	0.0774	-0.08	0.1611	-0.1397	0.1303	-0.0167	-0.1753	0.1229	0.0181	0.0885	0.1237	-0.0028	-0.1373	0.1142	0.1887	0.0384	-0.1079	0.5908	-0.1877	0.4151	28.2193	54.7002	-63.1915
105	0.0385	0.0656	-0.0325	0.0902	-0.0673	0.1244	-0.0256	-0.1786	0.1455	0.1582	-0.0102	0.0511	-0.1861	0.1545	-0.0088	0.173	-0.0182	0.028	0.2429	-0.0884	0.2648	32.3771	56.2388	-80.2338
106	0.0263	0.02	-0.0217	0.0252	-0.0301	0.0197	0.0544	0.0521	0.0999	-0.1552	-0.1231	0.0711	-0.0317	0.1663	-0.0001	0.3423	0.0346	0.096	0.3345	-0.0116	0.3238	45.324	37.2546	-106.8953
107	0.2058	0.0177	-0.077	0.1951	0.041	0.0379	0.0055	-0.0654	0.2028	0.2257	-0.0925	-0.0465	0.0295	0.0216	-0.0544	-0.0586	-0.0967	-0.0321	0.3081	-0.0491	0.1124	44.4669	34.7151	-78.1809
108	0.0559	-0.0011	0.0381	0.0243	-0.0219	0.0588	0.1763	0.0508	0.1083	0.1566	-0.0599	0.0389	-0.1493	-0.0007	0.0007	0.1989	-0.0152	-0.0343	0.2252	0.0182	0.2532	44.7672	37.1659	-95.4923
109	0.1923	-0.0791	0.1224	0.6893	-0.097	0.3095	-0.0791	-0.1333	0.0218	0.2167	-0.23	-0.0916	-0.0246	0.1473	-0.2198	0.1067	-0.0607	-0.0168	0.4036	0.0588	0.23	47.7583	31.6493	-82.4868
110	0.4283	0.2046	-0.2654	0.3978	-0.2143	0.2762	0.2401	-0.1879	0.0863	0.1989	-0.0133	0.0235	-0.0263	0.08	0.0882	0.014	-0.1136	-0.0482	0.4147	0.0655	0.2963	49.9803	37.8124	-73.8502
111	0.0937	0.1227	-0.2193	0.1654	-0.2959	0.5194	-0.0999	-0.0753	-0.204	-0.0339	-0.0488	0.0517	0.2489	-0.0284	0.0567	0.1268	0.1492	0.0613	0.4351	0.0929	0.3902	50.6995	25.5213	-78.1179
112	0.0379	-0.0053	0.0004	0.0153	0.0006	0.002	-0.1154	-0.0888	-0.024	0.0561	-0.0176	0.1376	-0.1076	-0.0474	-0.0001	0.5784	-0.0359	-0.0448	0.2369	-0.0638	0.2424	-45.6078	37.7934	-6.6695
113	0.0638	0.0069	-0.0356	0.1546	-0.0136	0.0773	0.0179	-0.0307	-0.0242	0.0588	0.001	0.0661	0.1315	-0.0684	0.0744	0.3639	-0.4027	0.0791	0.09	-0.023	0.1472	-41.8547	55.698	-12.6885
114	0.067	0.0235	-0.025	0.0373	0.0273	0.0346	-0.0108	0.1065	0.2488	-0.0344	-0.1894	-0.1262	-0.1119	0.0481	-0.0016	0.2159	0.0461	-0.0088	0.1999	0.011	0.1548	-47.414	48.5561	-41.1594
115	0.1775	-0.093	-0.0922	0.1019	0.0622	0.0537	0.0026	0.2678	-0.0948	-0.196	-0.0107	0.089	-0.0355	-0.1649	-0.0132	0.1624	-0.0199	-0.0358	0.1936	0.0263	0.1586	-45.8954	46.6463	-33.1904
116	0.0068	0.0042	0.0061	0.0027	0.0061	0.0164	-0.0769	-0.0582	-0.1365	0.0401	0.0467	-0.2101	0.0673	0.2047	0.0003	0.4045	0.0895	-0.1056	0.3032	0.0229	0.2737	-35.7472	40.1354	-9.5146
117	0.3191	0.149	-0.1856	0.0601	-0.0795	0.101	0.1535	-0.1087	0.0325	-0.0407	-0.021	0.0862	0.0108	0.0624	0.0886	0.1599	0.0226	0.0367	0.0541	0.0074	0.1977	-48.269	46.0331	-26.4076
118	0.2407	-0.2855	0.0459	0.4962	0.044	0.1056	0.1164	0.0019	0.1034	-0.2345	-0.2132	-0.1669	-0.082	0.1413	-0.0755	0.298	-0.0867	0.025	0.1753	0.0523	0.1577	-44.1525	56.7518	-37.763
119	0.0058	0.0169	-0.0016	0.0184	0.0003	-0.0008	0.0376	-0.047	-0.0392	-0.0254	0.0139	-0.1331	0.0687	0.2061	0.0003	0.2847	0.02	0.0187	0.5162	0.0244	0.2554	-41.307	39.4657	-43.0465
120	0.0461	0.0122	0.0213	0.064	-0.0658	0.0737	0.0552	0.0277	0.205	0.1209	-0.0694	0.1252	-0.1507	0.1683	0.0001	0.2574	-0.0365	0.0027	0.2258	0.0161	0.2411	-41.7851	58.9753	-36.8699
121	0.0385	0.0059	0.0045	0.0859	-0.0342	0.1011	-0.021	0.0819	-0.0281	-0.1754	-0.0481	-0.0642	0.107	0.0831	-0.0801	0.3204	0.0234	0.0835	0.1491	0.0834	0.1219	-42.8472	51.8552	-44.0065
122	0.1155	0.0036	0.0605	0.0338	-0.0067	0.0301	0.0227	-0.2232	-0.0199	0.1044	0.0358	0.0276	-0.1084	-0.0067	0.0018	0.4219	-0.0081	-0.001	0.2298	-0.0584	0.2462	-58.5131	63.1253	-7.6649
123	0.9682	0.1461	-0.252	0.1273	-0.0602	0.0711	-0.0496	0.366	0.0272	-0.1079	-0.0361	-0.0952	-0.0673	-0.1408	-0.0099	0.2846	0.1135	0.0449	0.1356	0.0693	0.2214	-64.2374	65.0295	-35.8289
124	0.0191	0.0129	-0.0292	0.0077	-0.0225	0.0466	-0.1239	-0.0039	0.0574	0.1765	-0.0569	-0.1099	-0.1086	0.1405	-0.0031	0.4175	-0.1224	-0.0327	0.1916	-0.0114	0.3813	-51.2903	70.6441	-7.934
125	0.1292	-0.0003	0.1505	0.0209	0.0438	0.3267	-0.0576	-0.1179	0.1036	-0.1244	-0.0756	0.0322	-0.246	-0.1769	0.0002	0.1896	0.0118	0.0113	0.1129	0.0065	0.2551	-62.12	62.0118	-25.0478
126	0.1354	0.0173	-0.0257	0.0083	-0.0125	0.1374	0.0839	0.0414	0.1678	-0.1668	-0.0091	0.052	-0.1947	0.0897	0.0081	0.3533	0.0479	0.0297	0.1457	0.0809	0.2997	-67.0177	69.3287	-36.809
127	0.0419	-0.004	0.0412	0.0073	0.009	0.0395	0.0545	-0.0503	0.1222	-0.1499	-0.131	0.1336	-0.0677	-0.1021	-0.0001	0.4036	-0.0798	-0.0415	0.3757	-0.0141	0.4014	-73.2556	73.0935	-33.4567
128	0.0927	-0.0055	-0.0346	0.1653	-0.0172	0.0505	-0.0011	0.0518	-0.0631	-0.1249	-0.0141	-0.0476	0.0148	0.0311	0.0279	0.476	0.0291	0.1377	0.1162	0.2171	0.372	-68.1408	71.0426	-39.6175
129	0.0242	-0.0028	0.0145	0.0319	-0.0172	0.0169	-0.1433	-0.0011	0.1201	-0.0389	-0.0789	-0.0716	-0.0612	0.0184	-0.0018	0.3111	-0.0525	0.0786	0.1663	-0.0553	0.2549	-74.8244	61.1599	-3.3214
130	0.0008	0.0039	0.0006	0.0093	0.0022	0.0034	-0.0624	-0.0344	0.0284	0.0019	-0.0978	-0.1074	-0.0535	-0.0147	-0.0001	0.261	-0.0952	0.0176	0.2519	-0.0488	0.3104	-90.1415	48.3999	-6.7883
131	0.0755	-0.0051	-0.0042	0.042	0.0142	0.0127	0.0848	0.0134	0.2158	-0.4436	-0.1616	0.1592	0.1838	-0.1792	0.0004	0.5514	0.0693	0.0058	0.2846	-0.0312	0.2415	-86.8676	53.1282	-36.5159
132	0.0273	0.0085	0.0005	0.0396	-0.0226	0.0122	-0.0183	-0.1002	-0.021	-0.1055	-0.0913	0.0403	0.0697	-0.0988	-0.0001	0.191	-0.0335	-0.0177	0.2185	-0.0464	0.2538	-85.2548	55.1094	-28.5496
133	0.0513	-0.0154	-0.0486	0.0156	0.0043	0.0537	-0.1824	-0.0689	-0.089	0.0354	-0.1061	0.0381	-0.0929	-0.0118	-0.0143	0.3074	-0.076	-0.0283	0.3886	-0.2403	0.481	-84.5888	65.0526	-3.9118
134	0.0364	-0.022	0.0347	0.0253	-0.0033	0.0354	0.0859	-0.0227	0.0548	-0.0288	0.0403	-0.0213	-0.06	-0.3392	0	0.3711	-0.048	-0.0319	0.2427	0.0079	0.3043	-81.5648	53.8934	-22.4175
135	0.0036	-0.0025	-0.0031	0.0093	0.0049	0.0039	0.1033	0.1462	-0.0409	0.0285	0.0744	-0.0081	0.0358	0.022	-0.0001	0.7494	-0.1921	-0.334	0.5908	0.1984	0.509	-93.1195	52.5274	-48.7906
136	0.0377	-0.0136	0.0017	0.023	0.0101	0.0049	-0.0008	0.0666	-0.0704	-0.1364	-0.2733	0.0149	0.0349	-0.2155	-0.0004	0.3001	-0.0264	0.0057	0.3819	-0.0221	0.2427	-93.4695	46.0289	-23.9551
137	0.0433	-0.0315	-0.0712	0.092	0.0163	0.2003	-0.0399	-0.0249	-0.0542	-0.1673	-0.1254	0.1564	-0.1229	-0.3157	-0.0078	0.3444	-0.086	-0.0851	0.3942	0.0229	0.4243	-92.796	53.4084	-34.0793
138	0.0062	0.0013	0.0064	0.008	-0.0036	0.0104	-0.0218	0.0004	-0.0591	0.0858	0.0427	-0.0282	-0.0413	-0.0949	-0	0.4106	-0.0479	-0.0861	0.264	0.1276	0.2983	-82.2374	39.0723	-2.196
139	0.0045	-0.0061	0.008	0.0053	-0.0064	0.0062	-0.04	-0.1406	-0.0646	0.0885	0.0613	0.0204	0.0531	-0.1418	0	0.3809	0.0063	-0.1581	0.2306	0.0678	0.4766	-75.5602	21.0963	-8.6467
140	0.0688	-0.0282	0.0284	0.0461	-0.0411	0.0399	0.0485	0.087	0.0432	0.0721	-0.0719	0.2824	0.2229	0.0555	0.0004	0.2418	-0.0804	0.0027	0.315	-0.0286	0.2581	-82.1019	29.7102	-33.4847
141	0.0173	0.0561	-0.0156	0.2162	-0.07	0.0234	0.1185	-0.0626	-0.0558	0.0442	0.0145	0.0966	0.0763	-0.1836	0.0035	0.4981	-0.2658	0.1012	0.6071	-0.1038	0.3165	-89.1086	31.135	-3.0501
142	0.0747	-0.0073	0.0392	0.0772	0.0094	0.0322	0.3231	-0.0443	-0.0453	0.0229	-0.1131	-0.2076	0.1016	-0.0292	0.0039	0.3802	-0.0492	-0.028	0.2086	0.0177	0.2827	-79.4925	32.7461	-22.547
143	0.0013	-0.0003	-0.0035	0.0111	0.0044	0.0116	0.0121	0.0825	0.0349	-0.0648	0.0216	0.1301	-0.0586	-0.1198	-0.0003	0.5537	0.099	-0.1274	0.6453	-0.1985	0.4065	-84.6256	24.5619	-49.7456
144	0.0616	0.0416	0.0528	0.2171	0.0992	0.196	-0.036	-0.0538	0.0362	0.1555	-0.1531	0.0724	0.1086	-0.0173	-0.3714	0.4721	-0.197	0.0121	0.051	-0.0028	0.2411	-82.7107	24.725	-30.3663
145	0.1736	-0.0297	-0.0458	0.0591	-0.1585	0.509	-0.0123	0.1229	-0.2109	0.101	0.0257	0.2543	0.146	-0.3219	-0.0161	0.4496	-0.0507	-0.1298	0.3021	-0.0095	0.3303	-79.1604	17.8193	-32.418
146	-0.0011	-0.0308	-0.0118	0.0375	0.0328	0.02	-0.0218	0.0706	-0.1146	0.076	-0.0687	-0.0232	0.154	-0.0422	-0.0026	0.4424	-0.0186	-0.0719	0.3061	-0.0395	0.1777	-83.3306	22.8199	-37.46
147	0.0023	-0.0042	-0.004	0.008	-0.0001	0.0081	-0.0313	-0.0241	0.0844	0.0197	0.0088	0.0213	-0.029	0.1352	0.0001	0.6445	-0.0396	-0.0261	0.296	0.0126	0.2558	-64.3955	24.7932	-4.4504
148	0.0094	-0.0041	-0.0045	0.0282	0.0123	0.0565	0.068	-0.1058	0.0502	0.0886	-0.0592	0.0558	-0.0171	-0.0285	0.0223	0.2043	-0.0972	0.0308	0.2627	-0.106	0.2808	-47.4268	27.1999	-11.8104
149	0.2821	-0.0487	-0.0838	0.0687	0.1331	0.3563	0.0004	0.1666	0.0549	-0.0978	0.016	0.1667	-0.1399	-0.0447	0.1359	0.2589	-0.0608	-0.0555	0.1637	-0.0114	0.1461	-58.0352	25.9409	-36.4981
150	0.0065	-0.0058	-0.0015	0.0056	0.0021	0.0027	-0.0037	-0.094	-0.0186	0.1085	0.1833	-0.0371	0.0212	0.0423	-0.0001	0.5635	-0.0054	0.0786	0.2858	0.0837	0.3721	-58.8704	16.6537	-7.2787
151	0.0391	0.0359	0.0161	0.0327	0.0164	0.0213	-0.0444	0.0438	0.0445	-0.0025	0.0302	0.0623	0.0631	0.0191	0.0051	0.3159	-0.0686	-0.0553	0.0087	-0.0283	0.1671	-58.6028	30.3812	-24.8071
152	0.0154	0.0142	-0.0036	0.0212	0.0184	0.0346	-0.0088	-0.0479	-0.0312	0.1965	0.0095	0.0516	0.1179	-0.0345	-0.0152	0.511	-0.0016	0.0198	0.0432	0.0274	0.1531	-59.8702	24.812	-25.4511
153	0.0727	0.003	-0.0677	0.1879	0.0261	0.0613	-0.1822	0.1327	-0.1032	0.0062	0.0181	-0.1111	0.1364	0.0184	-0.1459	0.3672	-0.0743	-0.0559	0.0971	-0.1072	0.2554	-48.7238	26.2376	-37.2938
154	0.0121	0.0023	-0.0107	0.0043	-0.0071	0.0141	-0.0106	0.0426	0.0254	0.0384	0.0222	0.1023	0.0898	0.0602	0	0.6327	-0.0178	-0.1105	0.3422	0.0072	0.3454	-64.9611	18.1518	-40.6313
155	0.0317	-0.01	-0.0947	0.0016	0.0085	0.2993	-0.1107	-0.0294	0.0978	0.0536	-0.0645	-0.0325	0.1641	0.1179	-0.0655	0.4082	0.1654	-0.033	0.2282	-0.0498	0.2355	-45.7778	24.735	-36.4907
156	0.0206	-0.022	-0.026	0.0152	0.0246	0.0334	-0.0389	0.0469	-0.0486	-0.0279	-0.0343	-0.2553	0.0812	0.0474	-0.0096	0.3586	0.1121	0.0182	0.2385	-0.0155	0.2473	-52.2258	23.0343	-41.35
157	0.0171	-0.0038	-0.0002	0.0026	0.0036	0.0052	-0.0369	0.0067	-0.1105	0.0585	0.0443	0.0226	-0.1074	0.0235	0.0311	0.4399	0.2885	0.0692	0.3289	-0.0839	0.2666	-57.9663	-13.3581	-7.9598
158	0.3278	0.1295	-0.1341	0.0568	-0.0493	0.0539	-0.3308	0.1749	0.0078	-0.0775	-0.0635	-0.172	0.0216	-0.0575	-0.0617	0.3575	0.0085	0.0374	0.1903	-0.0346	0.2227	-62.0432	-13.0362	-35.9627
159	0.0171	0.0367	0.0012	0.0798	0.0104	0.0405	-0.0194	-0.0716	0.1322	0.0395	-0.1104	-0.0871	-0.0769	0.1618	-0.0247	0.0658	0.0754	-0.086	0.2589	-0.0919	0.3486	-47.5772	-13.8779	-8.254
160	-0.0075	-0.0109	-0.0005	0.0924	0.0004	0.004	0.0676	-0.0489	0.0468	-0.0264	-0.0474	0.0233	0.0278	0.1451	0.0183	0.0071	0.2286	0.1071	0.1138	0.0004	0.2555	-62.0947	-14.6858	-29.2149
161	0.3425	0.1244	0.2019	0.0814	0.0362	0.1585	-0.0262	0.0248	0.1347	-0.2191	-0.2074	-0.0746	0.0184	0.0274	-0.1787	0.1916	0.0556	0.0124	0.0499	0.0735	0.1606	-67.5202	-2.9981	-28.2141
162	0.0844	-0.0261	0.0642	0.009	0.0055	0.198	0.0631	0.0708	-0.0716	-0.1013	-0.0814	-0.1596	-0.0118	0.3838	-0.0268	0.3221	-0.0648	0.0159	0.3858	-0.008	0.2263	-54.8642	-13.0599	-37.8854
163	0.1441	0.007	0.0957	0.0417	0.1516	0.6479	0.0683	0.0731	0.1195	0.001	-0.0588	-0.0272	-0.0321	0.21	-0.0025	0.3714	0.0468	0.0657	0.1578	0.0473	0.3287	-64.9264	-1.1865	-34.2724
164	0.4692	0.0611	0.0664	0.0602	0.1004	0.2022	-0.0555	0.2185	0.1059	-0.0013	-0.0998	-0.0299	-0.0577	0.0945	-0.1432	0.2379	0.0477	0.0494	0.0723	0.052	0.2068	-62.0885	-6.1501	-40.1257
165	0.004	-0.0038	0.0013	0.0102	-0.0016	0.0127	0.0139	-0.0061	-0.0783	-0.0449	-0.074	0.0901	0.0053	0.0438	0.0001	0.2258	0.0457	0.0457	0.3651	-0.0296	0.1559	-72.3162	-8.5084	-3.4438
166	0.0159	-0.0015	0.0041	-0.0002	-0.0034	0.0035	-0.1321	-0.0659	0.0048	-0.0718	0.0192	0.0441	-0.0441	0.0208	0.0003	0.2997	0.0388	0.1302	0.2396	0.0047	0.2642	-91.8759	-10.2307	-6.4362
167	0.2688	-0.145	-0.0074	0.2145	-0.0741	0.0411	-0.0001	0.0919	0.2737	-0.2058	-0.0599	-0.0023	0.0815	-0.1045	-0.0486	0.1749	0.0035	-0.0074	0.147	-0.0048	0.2272	-86.2865	-9.6669	-32.982
168	0.0108	-0.008	0.0088	0.0106	-0.0039	0.0053	-0.0764	-0.0514	0.0486	0.0675	0.0692	0.0115	-0.0161	-0.0435	-0	0.3924	-0.0263	-0.0187	0.2135	-0.0485	0.3984	-78.0871	0.2353	-4.4698
169	0.2036	0.1368	-0.0537	0.0819	-0.0378	0.0141	0.0529	-0.0688	0.027	0.0313	-0.0614	0.0552	-0.0689	-0.0278	-0.0053	0.1987	0.0323	0.0343	0.1222	-0.0089	0.2871	-82.3936	-11.6937	-22.2635
170	0.2842	0.093	-0.0114	0.0972	0.0065	0.003	-0.0884	0.1196	0.1096	-0.0379	0.0148	0.1479	-0.0404	-0.1483	-0.0027	0.2007	0.0942	0.0407	0.0895	-0.0489	0.1467	-95.5252	-10.2265	-31.502
171	0.0039	0.0061	-0.0051	0.0155	0.0237	0.0527	-0.147	0.0044	0.0923	0.0524	-0.0591	-0.0975	-0.0542	0.0374	-0.0014	0.3473	0.0669	-0.0073	0.1381	0.0618	0.3199	-80.2745	-2.0274	-38.8108
172	0.1924	0.0614	0.2129	0.0356	0.0405	0.3984	0.0851	-0.0496	-0.1261	-0.132	-0.018	0.1388	0.1371	-0.103	0.0277	0.1604	0.0209	0.0521	0.1258	0.033	0.2224	-98.2119	-8.8069	-29.9403
173	0.2577	0.1681	-0.0904	0.1392	0.0419	0.2541	0.1646	0.0187	-0.0547	-0.1746	-0.1485	-0.2672	0.0658	-0.0195	0.0403	0.2452	0.075	0.0206	0.2782	0.0607	0.2158	-93.1821	-6.893	-36.2226
174	0.0802	-0.0024	-0.0698	0.0232	0.0255	0.1004	-0.0575	0.0205	0.0079	-0.07	0.0571	-0.0669	-0.1818	-0.3519	-0.0048	0.377	0.0889	-0.0504	0.1472	-0.0037	0.2312	-92.8062	-29.7725	-3.7623
175	0.3845	-0.2233	-0.0938	0.2068	-0.0022	0.0635	0.1561	0.3119	0.0308	-0.2117	-0.153	0.1121	0.1062	-0.0225	-0.0293	0.1641	0.0089	-0.0104	0.1931	-0.0102	0.1893	-96.9212	-31.679	-31.7983
176	0.0102	0.0066	0.0133	0.0191	0.0108	0.0278	0.1743	-0.1742	0.062	0.0658	0.0039	0.0912	0.1171	-0.1257	0.0022	0.3899	-0.1193	0.0187	0.2172	-0.0629	0.2955	-101.3743	-24.4811	-1.7066
177	0.0698	0.0281	0.0612	0.0668	-0.0185	0.1204	-0.0444	0.059	-0.0587	-0.1266	-0.1074	-0.0122	-0.0272	-0.1947	-0.0014	0.2063	-0.0476	-0.0044	0.1304	-0.0467	0.2398	-92.9255	-30.022	-21.0726
178	0.0385	0.0238	0.0527	0.0462	0.008	0.0554	-0.0459	-0.007	0.1297	-0.0532	-0.2616	0.2656	0.1619	-0.1815	-0.0196	0.3553	0.023	-0.0259	0.2136	-0.0442	0.2122	-99.4905	-40.6733	-31.1115
179	0.0207	0.0094	-0.0128	0.0177	0.0003	0.0096	0.2591	-0.012	0.0126	-0.0975	-0.0145	-0.0305	0.1052	-0.0697	0.0008	0.2909	-0.0766	0.0251	0.3429	-0.0773	0.3119	-102.2607	-21.7779	-37.0728
180	0.0008	-0.0147	-0.0197	0.1549	0.1882	0.2182	-0.0038	0.0418	-0.1322	0.2426	-0.0877	0.0607	0.4535	-0.0663	-0.0032	0.3487	-0.0931	0.044	0.2789	-0.0594	0.3327	-101.3725	-43.0301	-29.9313
181	0.4754	-0.0666	-0.2571	0.1315	-0.111	0.3794	0.1878	0.0963	-0.0409	0.1446	-0.0125	-0.1293	0.073	-0.0633	0.0867	0.3638	-0.1032	-0.0504	0.2404	-0.1089	0.302	-101.9904	-36.919	-35.4017
182	0.0059	-0.0028	0.0004	0.0053	-0.0061	0.0069	0.021	0.005	0.1281	-0.021	-0.0208	0.0198	-0.0316	0.0372	0	0.4626	0.011	0.0132	0.3934	0.0783	0.2102	-84.5271	-43.9885	-2.042
183	0.0102	-0.0044	0.0059	0	-0.0014	0.005	0.0673	-0.1371	0.1053	0.045	0.0709	-0.0385	-0.0286	0.0026	0.0002	0.4382	0.1056	-0.0184	0.4711	-0.1098	0.331	-68.3448	-53.7413	-9.7055
184	0.1833	-0.0802	0.2105	0.1187	-0.1364	0.4958	0.1229	0.0443	-0.113	-0.0393	0.0947	0.0218	0.2233	0.0395	0.2031	0.5575	0.0222	-0.0194	0.082	-0.0209	0.1422	-79.3517	-48.7718	-33.9326
185	0.0022	-0.0025	0.0057	0.0058	-0.01	0.0148	-0.0677	-0.0064	-0.051	0.1094	-0.0153	0.0688	0.0632	-0.1175	-0	0.8206	0.0295	-0.0533	0.389	-0.0385	0.3599	-85.3314	-54.3467	-3.7486
186	0.0897	0.0203	-0.0077	0.0844	0.086	0.1066	0.0696	0.0324	0.1403	-0.073	0.0138	-0.0561	0.1458	-0.0532	-0.0003	0.4501	0.0764	-0.0069	0.1306	-0.0059	0.2942	-78.874	-45.7067	-22.715
187	0.0683	-0.0452	0.0427	0.0693	-0.057	0.181	-0.0954	0.0534	-0.0366	-0.0692	-0.0892	-0.1365	0.0038	0.0128	-0.346	0.8023	0.3537	0.0777	0.2055	0.1129	0.2543	-71.4642	-53.8054	-34.5992
188	0.0172	0.0123	-0.0016	0.1024	0.0771	0.0635	0.0263	-0.014	0.0038	0.1074	0.0031	0.0945	0.1077	0.0177	-0.0442	0.5935	-0.0843	-0.0358	0.1563	-0.0401	0.2846	-89.4595	-52.6381	-37.1028
189	0.014	0.0151	-0.0031	0.1419	-0.0941	0.056	-0.083	0.0113	-0.0879	-0.1099	-0.025	-0.0205	0.0036	0.0415	-0.1305	0.6393	0.1939	-0.0692	0.0558	-0.0058	0.3213	-69.8752	-56.6049	-33.6434
190	0.084	-0.0316	0.0122	0.0038	0.0016	0.0853	0.0377	0.0981	-0.0393	-0.0891	-0.0204	0.0737	-0.0606	-0.0876	0.0054	0.819	0.2473	0.0622	0.2148	-0.1219	0.2523	-76.2777	-54.781	-38.472
191	0.0165	-0.0005	-0.0077	0.0029	0.0051	0.0084	-0.0694	-0.0005	0.0734	0.0589	-0.0192	0.0508	0.0066	-0.0676	0.0002	0.4349	-0.0249	0.0024	0.1163	0.015	0.1908	-61.5478	-43.9739	-4.7335
192	0.0006	-0.0069	0.0054	0.0999	-0.0969	0.0886	-0.0404	-0.1263	0.0638	0.1179	-0.2922	-0.0169	0.1138	0.0019	-0.0216	0.3134	0.1057	0.1648	0.3505	-0.122	0.3341	-51.0503	-31.1957	-11.9012
193	0.0265	-0.0249	0.0091	0.0362	0.0436	0.0359	-0.0438	0.0591	-0.1511	-0.1636	-0.1109	0.0586	0.0152	-0.0018	-0.3337	0.4832	0.5554	0.1974	-0.0367	-0.1719	0.1267	-57.7075	-37.2076	-36.4535
194	0.0122	-0.0043	0.0006	0.0025	0.0009	0.0027	-0.024	-0.1373	-0.1522	-0.0511	0.0461	-0.0165	0.0645	0.0232	-0.0002	0.4873	0.1359	-0.0203	0.5031	0.1199	0.5288	-52.1671	-47.8181	-7.569
195	0.0282	0.0191	-0.0087	0.0152	0.0166	0.1155	0.0502	-0.0024	0.1221	-0.1889	-0.0275	-0.0994	-0.0429	0.0361	0.0133	0.4436	0.3114	0.112	0.0781	-0.1204	0.108	-60.6225	-34.7355	-24.55
196	0.1232	0.0349	0.0381	0.2738	-0.0211	0.1601	-0.1417	-0.091	-0.0494	-0.1544	-0.0982	-0.0232	0.1608	0.0705	-0.3476	0.5116	0.364	0.1581	-0.0086	0.0853	0.2875	-57.1496	-38.7554	-34.1007
197	0.0519	0.0237	-0.0247	0.0752	0.013	0.0375	0.0134	0.0196	-0.2314	-0.1026	0.0245	-0.1746	0.2644	0.1695	-0.1771	0.4901	0.3785	0.0236	0.2942	0.0331	0.3407	-52.4881	-36.2556	-34.0849
198	0.029	-0.0215	0.0137	0.0574	0.0274	0.0181	0.0388	0.0157	-0.0473	-0.053	-0.0559	0.0173	-0.0045	0.1134	-0.2314	0.196	0.3282	0.0107	0.4591	0.0103	0.3014	-47.2058	-30.7614	-36.2584
199	0.1482	-0.0987	0.0382	0.0806	-0.0495	0.0466	-0.0853	0.0722	-0.0443	-0.0739	-0.1245	-0.0643	0.1024	-0.0299	-0.439	0.5737	0.2144	0.2722	0.3136	-0.0084	0.3193	-51.4213	-35.684	-41.322
200	0.0328	0.0167	0.0011	0.0063	0.0028	0.0017	0.0266	-0.1114	0.1316	-0.0358	0.0877	0.1709	-0.0029	0.0756	0.0002	0.3543	0.0186	-0.0161	0.4493	-0.0874	0.2773	16.2046	34.3804	-8.2548
201	-0	0.0279	-0.0073	0.6062	-0.2489	0.1012	-0.0788	0.0505	0.1075	-0.3235	-0.0162	-0.1269	0.1097	-0.0358	-0.0141	0.204	0.0325	0.0464	0.43	0.0187	0.1758	11.3268	35.9743	-36.2117
202	0.0037	0.0078	-0.0006	0.0213	0.0037	0.0085	0.0371	-0.0021	0.0671	0.1326	0.0227	-0.0198	-0.0054	0.1357	-0	0.4449	-0.0775	-0.177	0.4972	-0.0505	0.5451	25.8793	37.7168	-8.5927
203	0.1432	0.0205	0.06	0.0554	0.0381	0.0515	0.0594	-0.0067	0.0257	0.0068	0.0106	-0.088	-0.2946	-0.0215	-0.0005	0.1984	0.0702	0.0149	0.3243	-0.0127	0.2618	9.9678	36.9709	-28.9703
204	0.0007	0.0001	-0.0053	0.0014	-0.0025	0.0034	-0.0404	0.1888	0.0974	-0.0139	-0.0839	-0.1428	0.0511	0.1115	0.0001	0.4741	-0.0818	-0.0621	0.429	0.153	0.3103	20.9206	35.4127	-42.1787
205	0.0551	-0.0216	0.063	0.001	-0.0147	0.0613	-0.1881	0.1813	0.0036	-0.1632	-0.0511	0.1793	-0.2087	-0.0095	-0.0003	0.5107	-0.0323	-0.0631	0.3823	0.0752	0.3049	7.5381	45.0663	-36.7789
206	0.0069	0.0025	-0.0053	0.0069	0.0074	0.0133	0.0008	-0.0753	-0.103	0.0251	0.0375	-0.1352	0.0018	-0.0382	0	0.4485	0.068	0.0631	0.3247	0.0536	0.313	0.7081	37.1444	-3.5099
207	0.0051	0.0198	-0.0226	0.0782	-0.0884	0.0965	0.0623	-0.0569	-0.0733	0.0457	-0.0244	-0.0306	-0.0146	0.0228	-0.0218	0.1282	0.1351	-0.0013	0.5139	0.1068	0.3619	-17.2156	30.144	-7.0374
208	0.0333	-0.0587	0.0013	0.0489	-0.009	0.0388	-0.0353	0.0472	0.1323	-0.2386	0.205	-0.1566	-0.0303	-0.0581	-0	0.3797	0.0201	0.0116	0.2893	-0.0162	0.235	-12.8125	33.1503	-32.9785
209	0.0039	0.0029	0.0036	0.006	0.0004	0.0033	-0.0906	-0.1329	0.2182	0.0051	0.0374	-0.0604	-0.1445	-0.0898	-0	0.6091	0.0522	0.0057	0.4252	-0.0558	0.3578	-7.0558	44.2024	-4.3018
210	0.0526	0.0921	0.0208	0.1987	-0.0136	0.0479	-0.0455	-0.0596	-0.0806	-0.1144	0.0505	-0.2034	-0.0751	0.0305	0.0044	0.156	0.0736	0.0357	0.2135	-0.0343	0.2546	-8.441	31.949	-22.3388
211	0.0956	-0.0322	0.0408	0.1642	0.1111	0.1147	-0.0014	0.0542	0.0949	-0.0669	-0.0094	0.1607	-0.1088	-0.1222	0.0001	0.2811	0.0617	-0.0563	0.2655	-0.0191	0.2933	-20.1541	33.1495	-33.1046
212	0.0054	0.0277	0.0219	0.1483	0.2422	0.5091	0.1746	-0.0995	0.0001	0.1179	0.1455	-0.0054	-0.0821	-0.1363	0.1031	0.2194	0.1395	0.107	0.3805	0.1607	0.3742	-14.5081	9.6161	-4.0342
213	0.0392	0.0716	0.0105	0.1905	0.1625	0.2899	0.1342	0.2217	-0.1517	-0.2521	0.0684	0.0712	-0.0998	0.1159	-0.0028	0.1929	0.0633	-0.0161	0.2919	0.0317	0.2463	-17.9902	8.8628	-32.0936
214	0.08	0.0574	0.0096	0.0541	-0.0186	0.1502	0.0561	-0.0576	-0.0248	-0.0161	0.0156	0.0856	-0.0104	-0.0804	0.0704	0.115	0.1668	-0.0871	0.2442	-0.026	0.2389	-15.652	11.777	-15.0007
215	0.218	-0.0808	0.052	0.1222	0.1314	0.4086	-0.0051	-0.0878	-0.0266	0.058	0.0513	0.143	0.1595	-0.1021	-0.0164	0.2577	0.1354	-0.0142	0.2171	0.0104	0.2664	-17.9298	4.9349	-27.1861
216	-0.0001	-0.003	0.0038	0.0065	-0.0058	0.0141	0.0814	0.0545	0.0337	0.0329	-0.1139	0.0885	0.1031	-0.1233	-0	0.2682	0.1461	-0.0501	0.4303	-0.0342	0.3343	-26.0354	15.642	-35.9501
217	0.1181	-0.087	0.1243	0.4269	0.2478	0.3933	0.0589	-0.1317	0.0156	0.1728	0.0344	-0.0726	0.2248	-0.1068	-0.1045	0.1905	0.0931	-0.1137	0.312	-0.0302	0.2543	-20.4896	-0.7072	-32.6576
218	0.0769	-0.0338	-0.0178	0.0237	-0.005	0.0249	-0.0068	-0.0232	0.0811	0.043	0.1268	-0.0757	0.0309	-0.0425	0.1388	0.0911	0.079	-0.1339	0.4737	0.0801	0.2391	-2.3671	-0.7474	-2.8475
219	0.371	-0.0084	-0.3501	0.1277	-0.046	0.3501	0.0942	-0.114	0.1476	-0.0043	0.0182	0.0622	-0.0134	0.0003	0.0606	0.2434	0.0089	-0.1309	0.3843	-0.1301	0.3303	14.7542	-4.5	-11.3873
220	0.3358	0.0844	0.2843	0.4975	-0.0335	0.3097	0.2076	0.3347	-0.2269	-0.3092	0.0551	0.2435	0.0341	0.0215	0.0896	0.1621	0.2521	-0.1855	0.2458	-0.0238	0.2545	3.1703	-3.2261	-34.936
221	0.0044	0.003	0.0062	0.0008	0.0004	0.0081	-0.0097	0.0353	-0.0946	0.1569	0.0551	0.0774	0.1027	-0.0794	-0.0001	0.3318	-0.0723	-0.0431	0.1675	0.0751	0.3512	-0.5833	-10.917	-4.858
222	0.0282	0.0458	0.0036	0.3705	0.0567	0.0905	0.1652	0.0191	-0.1046	0.1259	-0.0272	-0.0799	0.067	0.1227	0.0356	0.1054	0.1198	-0.0378	0.3472	0.0082	0.3193	3.0979	-0.3345	-23.9809
223	0.055	0.0735	0.0206	0.1599	0.0579	0.0706	-0.0214	0.2037	-0.3493	-0.0099	0.0222	-0.1359	0.1886	-0.0293	-0.03	0.211	0.0743	-0.0176	0.2981	-0.0892	0.1949	12.013	-6.3524	-35.6563
224	0.1032	-0.1018	0.0179	0.1259	-0.0462	0.0387	-0.1337	-0.044	-0.0386	0.0634	-0.1554	0.1491	0.0909	-0.0288	-0.0116	0.6307	0.0818	-0.2227	0.4506	-0.0974	0.5477	-5.6967	-9.4255	-38.0838
225	0.158	0.0456	0.0645	0.08	0.0265	0.0392	-0.0039	0.0731	-0.0907	-0.1459	-0.0041	0.1225	0.0751	0.094	-0.1145	0.2202	0.2003	-0.0969	0.4078	-0.0196	0.283	14.3417	-8.4499	-35.0467
226	0.0492	-0.0018	-0.0508	0.0029	0.0007	0.0494	0.0243	-0.0689	-0.0507	-0.0539	-0.0328	0.1118	-0.0024	0.0654	0.0443	0.3126	0.2546	-0.0951	0.505	-0.0913	0.2812	7.6015	-8.1636	-39.7302
227	0.0129	0.0074	0.0049	0.0076	0.0046	0.0125	0.0371	-0.0316	0.0359	-0.0162	0.0018	0.1365	0.0007	-0.0199	-0	0.2657	0.0741	-0.0803	0.292	-0.0286	0.339	19.6618	5.0984	-5.7029
228	0.0032	0.0041	0.0008	0.0016	0.0006	0.0016	0.0445	0.0244	0.0205	0.2304	-0.1191	0.1008	0.0727	-0.0789	-0.0001	0.3906	-0.0961	-0.0306	0.3185	0.0227	0.3065	27.9025	20.4888	-12.1269
229	0.2209	-0.0927	0.0199	0.0654	0.0355	0.1384	0.019	0.2414	-0.1178	-0.1123	-0.1032	-0.0497	-0.0276	0.0063	-0.0827	0.2142	0.1531	-0.0079	0.5398	-0.0074	0.2166	21.1968	13.4921	-37.2571
230	0.0181	0.0085	0.0135	0.0062	0.0013	0.0113	-0.0066	-0.0358	-0.2671	0.0197	-0.0561	-0.1021	0.1414	-0.0081	0	0.3431	0.1603	0.0182	0.4052	0.0187	0.4168	29.6522	3.7943	-8.7632
231	0.0324	0.0026	-0.0468	0.0406	-0.003	0.0549	0.0709	0.0145	0.0595	-0.168	-0.0605	0.0325	0.0847	0.1888	0	0.2958	0.0867	-0.0118	0.2868	-0.0239	0.2746	19.4888	12.8933	-25.8225
232	0.2108	-0.1007	-0.024	0.181	-0.0071	0.1391	0.1827	0.3892	0.1432	-0.1328	-0.074	-0.2624	-0.1732	0.1821	0.0058	0.4151	0.0669	0.0139	0.5091	0.0368	0.2881	26.8806	17.5795	-39.1421
233	0.0057	0.0021	0.0014	0.0067	-0.0082	0.0085	0.1543	-0.0775	-0.0041	-0.0143	0.0987	0.0698	0.0536	0.0969	-0.0001	0.3663	-0.108	-0.1619	0.3727	0.0288	0.3953	-11.3564	-73.9235	-3.7454
234	0.0472	0.0038	-0.0447	0.0009	-0.0058	0.047	0.032	-0.1208	0.1931	-0.057	0.0235	0.0622	-0.0028	-0.1019	0.0112	0.3899	0.0849	-0.1619	0.4917	-0.2588	0.5206	6.9068	-77.0053	-11.8055
235	0.4181	-0.1943	-0.0956	0.1258	0.0991	0.0974	-0.0697	0.0818	-0.1609	-0.077	0.2144	-0.127	0.0588	0.1957	-0.1275	0.2053	-0.168	-0.0182	0.5774	-0.1811	0.3348	-5.175	-74.8893	-35.8013
236	0.0109	-0.0069	0.0063	0.0057	-0.0085	0.0222	0.0165	-0.0072	-0.1063	0.0371	0.0316	0.0058	0.0532	-0.0128	0.0575	0.2815	-0.2273	-0.0837	0.3	0.0125	0.6689	-8.4443	-83.7791	-6.0155
237	0.2904	0.0285	0.0416	0.0986	-0.0121	0.2467	0.0811	0.4456	-0.182	-0.1204	0.2907	-0.1999	0.1838	0.1005	0.5421	-0.0794	-0.3217	-0.1016	0.3582	-0.2649	0.3615	-5.7025	-72.494	-24.5018
238	0.1565	0.0078	-0.0347	0.1101	-0.0332	0.0265	-0.0446	0.365	-0.1192	-0.1438	0.0247	-0.1387	0.023	-0.0439	-0.0435	0.1095	-0.1708	0.0445	0.7599	-0.3515	0.4491	3.9311	-76.8263	-36.7194
239	0.0293	-0.0278	-0.0605	0.0277	0.0634	0.1327	-0.0664	0.0161	0.0187	0.0595	-0.0177	0.0593	0.0801	0.05	-0.2939	0.3694	-0.2184	-0.0138	0.6229	-0.2583	0.2995	-13.5372	-81.4936	-39.6278
240	0.0361	0.0029	-0.0371	0.0089	-0.0115	0.0305	0.0421	0.0296	-0.0001	-0.1307	0.2043	-0.3078	0.0296	0.0803	0.0001	0.3958	-0.1522	0.0583	0.6761	-0.26	0.494	3.5955	-78.9739	-37.9466
241	0.1493	0.0349	-0.1395	0.008	-0.0305	0.1324	0.0677	-0.0393	-0.0042	0.0143	0.0306	0.0634	-0.0128	0.0433	0.2028	0.4358	-0.0314	-0.1936	0.3627	-0.1508	0.4347	10.1325	-65.9017	-6.3237
242	0.0073	0.0013	0.0093	0.0053	-0.0064	0.0143	0.1086	0.0496	0.0059	0.0545	0.034	-0.059	0.0559	0.1225	0.0001	0.4281	-0.1478	0.0017	0.6601	-0.1442	0.2346	16.6264	-49.3329	-12.8367
243	0.1076	0.0747	0.0099	0.073	0.065	0.1421	-0.1357	0.0117	-0.0375	-0.0761	0.0332	-0.0167	-0.0434	0.0425	-0.1197	0.2963	-0.2869	0.0349	0.6983	-0.3903	0.4028	10.7229	-56.0716	-37.4753
244	0.0093	-0.0053	-0.0109	0.0078	-0.0031	0.0127	-0.0327	-0.0658	-0.0134	-0.066	-0.0783	-0.0074	-0.0679	0.1156	-0.0001	0.3504	0.0008	0.0646	0.7314	-0.3831	0.7282	20.2188	-65.8994	-9.3492
245	0.0749	0.0538	-0.059	0.1084	-0.0078	0.0522	-0.0226	0.1116	-0.1461	0.0409	0.0316	-0.0192	0.0321	0.0082	0.0696	0.0684	-0.1688	-0.0154	0.2868	-0.3877	0.293	9.0703	-57.3512	-26.0047
246	0.0214	0.0056	0.003	0.0005	-0.0008	0.0006	-0.124	0.2667	-0.1736	-0.2107	0.1214	-0.0829	0.0257	0.0262	-0.062	0.3391	-0.4968	0.0302	0.6369	-0.4635	0.4067	15.3536	-47.8905	-37.5748
247	0.1094	0.0762	0.148	0.1707	0.1278	0.2034	-0.1747	0.209	-0.0649	-0.0411	-0.0876	0.1175	-0.0392	0.0579	-0.2454	0.3603	-0.3334	0.1081	0.6171	-0.3126	0.3973	16.1086	-52.8449	-40.0445
248	0.0027	0.001	0.0003	0.0023	0.0071	0.0104	-0.0008	-0.0803	-0.1261	-0.0122	-0.0166	0.0574	0.076	0.0673	0	0.4605	-0.0556	0.0112	0.3668	-0.0619	0.2298	9.1222	-42.4747	-5.8313
249	0.0103	-0.0072	-0.0016	0.0068	0.0077	0.0116	-0.0399	-0.0327	0.1063	-0.0526	-0.0003	-0.0308	-0.0681	0.0161	0.0001	0.4845	0.1868	-0.0307	0.7451	-0.0263	0.4096	-4.7978	-28.4628	-9.6096
250	0.0431	0.0788	-0.0266	0.1711	-0.0017	0.0217	-0.0648	0.2488	0.0723	-0.2479	0.1548	0.0186	-0.0033	-0.1028	0.0049	0.475	-0.4144	-0.0484	0.5944	0.0366	0.2729	-1.8207	-34.95	-35.6676
251	0.0705	-0.0594	0.0381	0.0553	-0.0278	0.0431	0.005	-0.0175	0.0164	-0.024	0.0676	-0.0342	-0.0239	0.0768	0.1001	0.4891	-0.1514	-0.2222	0.3581	0.0035	0.3177	12.2502	-32.6302	-7.8486
252	0.1219	-0.1626	0.1649	0.2407	-0.177	0.348	-0.0783	0.1993	0.0553	-0.1112	0.2116	-0.0931	-0.0846	-0.1773	0.0431	0.3251	-0.2685	0.064	0.3405	-0.0345	0.2734	-0.4571	-38.3376	-24.6296
253	0.0033	0.0015	0.0022	0.0007	-0.001	0.0052	0.0924	0.0133	0.0169	-0.1137	0.0521	0.0411	0.0533	-0.0083	0	0.5787	0.0657	-0.1095	0.6804	0.1446	0.4738	-5.2754	-29.7956	-51.7522
254	0.0405	-0.0013	0.012	0.0009	-0.0014	0.0037	-0.2595	-0.0171	0.1451	-0.0574	-0.0681	0.1367	0.014	-0.0598	-0.0016	0.5433	-0.139	-0.049	0.3519	0.0885	0.3398	-9.2717	-27.1297	-26.5406
255	0.1386	-0.1489	0.1603	0.1498	-0.1877	0.392	-0.1777	0.144	0.0747	-0.073	0.2318	0.069	-0.2745	-0.1743	0.0426	0.7688	-0.4084	-0.0206	0.5123	0.0083	0.338	-2.9354	-28.4768	-37.2866
256	0.0044	0.005	0.0119	0.0119	0.0208	0.018	0.0227	-0.1441	0.0468	0.0504	-0.065	-0.0834	-0.1159	0.1852	-0.0002	0.3685	0.0151	0.0174	0.3794	0.0057	0.3169	-19.9323	-40.1148	-4.9752
257	0.1092	-0.106	-0.0383	0.1119	0.0437	0.0577	-0.3818	0.1913	0.2313	-0.3134	0.3522	0.0868	-0.0492	-0.0457	0.0169	0.5351	-0.192	-0.0901	0.3725	0.065	0.307	-25.4516	-40.5912	-32.8541
258	0.1057	-0.0659	0.1777	0.0418	-0.1103	0.3116	-0.266	-0.0168	0.0014	-0.0007	0.02	0.0671	-0.363	-0.0737	-0.0225	0.2491	-0.0747	-0.0272	0.2754	0.0637	0.2649	-20.7747	-39.5485	-16.0285
259	0.357	-0.2273	-0.024	0.1586	0.0062	0.0525	-0.2093	0.084	0.4226	-0.019	0.2949	0.3181	-0.1996	-0.1107	0.0341	0.2774	-0.0733	-0.0751	0.3185	0.145	0.2544	-28.665	-42.1297	-28.0202
260	0.0082	0.0066	-0.0035	0.0178	0.0062	0.0151	-0.2124	0.0005	0.0743	-0.1179	-0.1825	-0.0624	0.0081	-0.0404	-0.0003	0.6483	-0.1352	-0.0806	0.5074	0.0987	0.7376	-24.1282	-30.3478	-37.2864
261	0.0379	0.0534	0.0374	0.034	0.0236	0.0433	-0.2243	-0.0596	0.3467	-0.1438	0.0775	0.2065	-0.0691	-0.0767	-0.0013	0.2845	-0.1241	-0.0671	0.544	0.0888	0.3763	-35.3203	-42.7202	-32.3531
262	0.0105	-0.0006	-0.0066	0.0072	0.0001	0.0075	-0.0778	-0.062	0.1489	-0.0369	-0.0695	-0.0138	-0.0129	-0.1112	0.0001	0.4424	0.1114	-0.0171	0.3182	0.1739	0.362	-25.4021	-55.6794	-1.7736
263	0.0347	-0.0051	-0.0344	0.001	0.0051	0.0332	-0.1199	-0.0197	0.1001	0.1247	0.0185	-0.1717	-0.0404	0.0198	-0.0049	0.2816	0.0099	-0.0999	0.1932	0.0832	0.2491	-21.738	-72.0396	-8.4793
264	0.1144	0.058	0.095	0.1523	-0.0084	0.1129	-0.0039	0.096	-0.1126	0.0235	0.1981	0.0143	-0.0099	-0.0037	0.269	0.2175	-0.2712	0.07	0.4173	0.0699	0.1566	-27.5877	-65.2231	-32.931
265	0.0082	0.0059	0.0047	0.0126	-0.0007	0.0157	0.0385	-0.1195	-0.1267	0.0182	-0.0647	0.1072	0.1582	-0.0729	0.0003	0.3977	0.0721	-0.0282	0.3722	-0.0435	0.3853	-34.1156	-61.5513	-2.5664
266	-0.0001	-0.001	0.0257	0.4962	-0.2175	0.1848	-0.0174	0.0016	-0.0929	0.0968	0.3008	0.0115	0.0026	-0.0744	0.1028	0.0767	0.0102	0.0268	0.2094	0.012	0.2758	-24.3306	-62.7899	-22.0097
267	0.0429	-0.0382	-0.0328	0.0885	0.0691	0.0593	-0.1301	0.1496	-0.3031	-0.3148	0.1623	0.0779	0.0114	-0.041	-0.0004	0.3091	-0.151	0.0135	0.4134	-0.0024	0.3177	-26.9353	-74.5606	-32.694
268	0.0168	0.0316	0.0358	0.0541	0.0508	0.0344	-0.0817	0.033	-0.0267	-0.1447	0.0886	0.0615	-0.0149	0.0656	-0	0.2305	-0.0483	-0.0091	0.4058	0.0042	0.3016	-31.0332	-70.2179	-33.8638
269	0.1848	-0.2543	-0.0227	0.3323	0.0379	0.1803	-0.1052	0.0548	-0.2338	0.0207	0.1574	0.0218	0.1409	0.0352	0.031	0.3028	-0.1986	-0.0175	0.295	-0.0147	0.256	-30.5398	-71.614	-36.8471
270	0.0809	0.0446	0.013	0.3026	-0.2884	0.459	-0.0439	-0.0634	0.0368	0.1745	0.017	-0.0787	-0.0494	0.1489	-0.1854	0.5515	0.2377	-0.1677	0.5285	-0.1944	0.2078	32.4393	-53.9951	-109.2234
271	0.0075	-0.0034	0.0028	0.003	0.0041	0.0086	-0.0592	0.06	-0.1454	-0.0034	0.0836	-0.0039	0.1101	-0.0489	-0	0.5148	-0.0421	-0.067	0.4606	-0.0887	0.4547	18.6343	-68.1537	-105.1281
272	0.0174	0.0128	-0.0131	0.0211	-0.0277	0.0332	-0.0902	-0.1614	0.2195	0.3041	0.0958	-0.0646	-0.1107	-0.0966	-0.0671	0.6245	0.5594	-0.075	0.3618	-0.1388	0.4281	21.9476	-61.4778	-79.2054
273	-0.0082	0.0505	-0.0257	0.2014	0.0046	0.2541	0.0612	-0.077	0.0014	0.2322	0.2087	-0.0954	0.0795	-0.1575	0.1741	0.4335	0.4268	-0.1164	0.2578	0.0175	0.2256	22.5552	-62.3166	-89.4387
274	0.2276	0.185	-0.0924	0.239	-0.289	0.4354	-0.1062	-0.1415	0.0041	0.2962	0.4223	0.0523	0.4114	-0.0052	0.089	0.8138	0.4674	-0.0368	0.6427	-0.0364	0.4677	20.7229	-67.8991	-77.5858
275	0.0154	0.0047	-0.0195	0.023	-0.0036	0.0183	-0.1069	0.0309	-0.0291	-0.0285	0.0558	0.1716	0.222	0.1796	0	0.3504	0.1129	-0.0603	0.3553	0.0589	0.3798	2.6956	-56.5325	-109.7989
276	0.5729	0.1249	-0.1232	0.0683	-0.0463	0.1078	-0.2504	-0.0294	-0.0748	0.2878	0.1853	0.0569	-0.1253	-0.1512	-0.1451	0.4141	0.3128	0.0908	0.5911	0.2296	0.3329
277	0.173	0.1567	-0.0765	0.1544	-0.059	0.1106	-0.2449	0.1804	-0.0806	-0.013	0.356	0.0643	0.1665	-0.0581	0.0074	0.2781	0.0746	0.0062	0.4845	0.0795	0.3231	2.7018	-57.1418	-98.7058
278	0.1636	0.125	0.0699	0.1354	0.0274	0.0368	-0.2174	-0.2323	-0.4588	0.2446	0.4108	0.4455	0.1545	-0.142	0.042	0.2674	0.1446	0.0767	0.4914	0.2212	0.4529	-5.2793	-54.659	-86.92
279	0.0631	0.0371	0.0476	0.0594	-0.0181	0.1045	-0.2182	0.1867	-0.1359	0.032	0.0367	0.0422	0.1084	-0.0594	-0.0129	0.5531	0.3086	0.0932	0.7538	0.3131	0.4744	-7.9251	-57.2603	-81.5697
280	0.0165	0.0064	0.0153	0.0021	0.0121	0.0522	-0.162	-0.0954	0.0115	0.1051	0.0431	0.1061	0.0527	0.0272	-0.0649	0.3088	0.3252	0.2077	0.6581	0.3827	0.6516	-9.274	-56.1877	-78.5158
281	0.0581	-0.0194	0.028	0.0166	0.0011	0.0189	-0.0161	-0.1742	-0.0199	-0.0652	-0.0162	-0.0062	0.1105	-0.1341	0	0.2575	-0.0204	0.0157	0.361	0.0553	0.2684	-1.4522	-31.8159	-110.221
282	0.0792	0.0255	0.0583	0.0338	-0.0041	0.1016	-0.1151	-0.2026	0.0534	0.1089	0.0307	0.0901	0.0037	-0.0085	-0.1941	0.2924	0.4196	0.0065	0.7112	0.1173	0.2159	-4.2538	-31.2911	-82.1325
283	0.0139	0.0101	0.0023	0.0283	-0.0064	0.0114	0.0958	-0.0217	0.0645	0.0058	-0.0416	0.0267	-0.1785	-0.0625	0.0002	0.2439	0.1362	-0.0315	0.5464	0.0002	0.4462	-10.9103	-35.4105	-112.4172
284	-0.0023	-0.0163	-0.0071	0.1146	-0.0716	0.0639	-0.0742	-0.1907	-0.0336	0.0654	0.1934	0.1627	0.0954	-0.0542	0.2872	0.0025	0.3969	-0.1011	0.2356	0.2011	0.0619	-1.0454	-33.8205	-93.0443
285	0.1341	-0.0377	0.0417	0.1453	-0.0986	0.2504	-0.1769	-0.1922	0.1196	0.2633	0.0642	0.0629	-0.0393	-0.0554	-0.3939	0.4462	0.4902	-0.0758	0.7266	-0.0972	0.2819	-3.3823	-21.8554	-82.23
286	0.0111	0.0104	0.0269	0.024	0.0063	0.0861	-0.0195	0.0126	-0.1213	0.1426	-0.0163	-0.0386	0.0878	-0.0495	-0.0062	0.4983	0.3566	0.0045	0.8725	0.134	0.537	-12.859	-37.3278	-78.2194
287	0.0044	-0.0017	0.0143	0.0276	0.022	0.0404	-0.1866	-0.3289	0.2184	0.1566	0.1672	-0	0.0031	-0.1191	-0.0001	0.4366	0.2195	-0.0016	0.6237	0.0052	0.3915	-4.6351	-19.0673	-83.5462
288	0.0188	0.0144	-0.0426	0.2013	-0.173	0.1766	-0.048	-0.1996	0.0011	-0.0088	0.0037	-0.0352	-0.07	-0.0618	0.0424	0.4551	0.4219	0.0426	0.7529	0.0777	0.2771	-7.3129	-24.8942	-78.29
289	0.0072	0.0054	-0.0088	0.0069	-0.0101	0.0144	0.1107	0.036	-0.0668	0.092	0.1478	0.0123	-0.041	0.0379	-0.0002	0.2011	0.0686	-0.0403	0.3768	0.0403	0.4101	11.7163	-22.8041	-111.5737
290	0.2551	-0.0645	0.339	0.0507	-0.0588	0.4778	-0.0676	0.1093	0.0066	-0.0068	0.0145	0.0006	-0.1419	0.0901	-0.1302	0.3046	0.1232	0.0156	0.6919	-0.2045	0.3884	30.3315	-19.4272	-104.0038
291	0.0355	0.0297	-0.0545	0.0145	-0.0336	0.0763	-0.1558	-0.372	0.0597	0.1524	0.137	-0.0032	-0.0096	-0.0216	0.0202	0.4737	0.3926	-0.2315	0.831	-0.2387	0.2478	18.1018	-21.4451	-79.5647
292	0.0071	-0.0196	0.0106	0.0426	-0.0196	0.0087	-0.0172	0.0179	0.0923	-0.0065	0.0126	0.078	-0.0473	-0.001	-0.0015	0.1136	-0.0483	-0.016	0.2305	0.0368	0.6187	14.548	-12.9006	-109.4256
293	0.052	0.0411	-0.031	0.1638	-0.2269	0.3554	0.0159	-0.1046	0.0977	0.1352	0.1709	-0.1055	-0.0531	-0.1155	0.3111	0.1187	0.5779	-0.2076	0.4031	-0.1441	0.2602	18.6279	-26.2371	-91.0613
294	0.0422	0.0548	-0.0096	0.1457	-0.1644	0.2048	-0.1878	-0.5307	0.2413	0.2727	0.3018	-0.0608	-0.0651	-0.018	0.4858	0.1386	0.3796	-0.5223	0.6485	-0.2831	0.0401
295	0.2272	0.06	0.1295	0.0144	0.0381	0.0806	-0.1528	-0.0614	0.0309	0.1043	0.0989	0.0124	-0.057	-0.0117	-0.0443	0.7531	0.3537	-0.1353	0.7938	-0.1814	0.571	9.9122	-14.5292	-75.9576
296	0.0175	-0.0218	-0.0004	0.1664	0.1673	0.1784	0.0237	-0.0558	0.1033	0.1579	0.1808	-0.2363	-0.1121	0.055	0.1471	0.5525	0.4015	-0.2073	0.6536	-0.3545	0.5693	26.8304	-17.2661	-77.5091
297	0.0078	-0.0041	-0.0018	0.002	0.0031	0.0059	-0.0396	-0.0322	0.1487	0.0005	-0.0283	0.0001	-0.011	-0.0411	-0	0.2882	0.1736	-0.0641	0.3745	-0.1545	0.4603	33.2484	-30.6377	-109.0596
298	0.006	0.0043	-0.0052	0.0067	-0.0023	0.0056	-0.0045	0.0341	0.0282	-0.0412	-0.0622	-0.0499	-0.0167	0.0304	-0.0001	0.4875	0.1373	-0.1455	0.5596	-0.2006	0.3728	38.4438	-46.5598	-102.8062
299	0.0543	-0.0412	-0.0411	0.0483	0.0562	0.0595	0.0104	-0.0123	0.0615	0.1069	0.1169	-0.1446	0.0009	-0.0193	0.2987	0.4183	0.4859	-0.1691	0.7307	-0.2322	0.3472	34.3092	-40.0369	-77.7862
300	0.0441	0.0018	-0.0729	0.0001	-0.0035	0.129	-0.2374	-0.0707	0.1671	0.0079	-0.12	-0.0462	-0.0405	0.2432	-0.0129	0.4387	0.2173	-0.2374	0.7558	-0.1111	0.6026	43.3687	-30.509	-106.157
301	0.0599	-0.0869	0.0625	0.1498	-0.0583	0.0788	-0.0633	-0.1181	-0.0179	0.1759	0.1376	-0.0893	0.023	0.0068	0.3256	0.1677	0.5649	-0.1836	0.2319	-0.2721	0.3207	32.4963	-38.9242	-89.2279
302	0.0053	-0.017	0.0035	0.0867	0.0247	0.0087	0.0178	-0.0669	-0.0516	0.1816	0.0574	-0.1646	-0.0045	0.075	0.0153	0.5774	0.7827	-0.2248	0.6061	-0.2626	0.4612	38.2499	-42.978	-76.1276
303	-0.0033	0.0058	-0.0042	0.0213	-0.0235	0.0258	-0.1329	-0.256	0.0254	0.1105	-0.0672	-0.1038	0.0539	-0.0331	0.0002	0.693	0.3814	-0.1073	0.6882	-0.1247	0.4565	41.8369	-49.7556	-78.4798
304	0.0586	-0.0244	-0.0552	0.1484	0.1391	0.1621	-0.1579	-0.1351	0.1488	0.1057	-0.0438	-0.0932	-0.0529	0.0543	-0.4616	0.6592	0.5365	-0.344	0.766	-0.2365	0.4421	39.631	-43.9025	-73.0892

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Selection details
1	X-RAY DIFFRACTION	1	CHAIN A AND (RESID 1 THROUGH 13 )
2	X-RAY DIFFRACTION	2	CHAIN A AND (RESID 14 THROUGH 26 )
3	X-RAY DIFFRACTION	3	CHAIN A AND (RESID 27 THROUGH 59 )
4	X-RAY DIFFRACTION	4	CHAIN A AND (RESID 60 THROUGH 72 )
5	X-RAY DIFFRACTION	5	CHAIN A AND (RESID 73 THROUGH 122 )
6	X-RAY DIFFRACTION	6	CHAIN A AND (RESID 123 THROUGH 153 )
7	X-RAY DIFFRACTION	7	CHAIN A AND (RESID 154 THROUGH 170 )
8	X-RAY DIFFRACTION	8	CHAIN A AND (RESID 171 THROUGH 190 )
9	X-RAY DIFFRACTION	9	CHAIN A AND (RESID 191 THROUGH 207 )
10	X-RAY DIFFRACTION	10	CHAIN B AND (RESID 1 THROUGH 26 )
11	X-RAY DIFFRACTION	11	CHAIN B AND (RESID 27 THROUGH 59 )
12	X-RAY DIFFRACTION	12	CHAIN B AND (RESID 60 THROUGH 72 )
13	X-RAY DIFFRACTION	13	CHAIN B AND (RESID 73 THROUGH 122 )
14	X-RAY DIFFRACTION	14	CHAIN B AND (RESID 123 THROUGH 153 )
15	X-RAY DIFFRACTION	15	CHAIN B AND (RESID 154 THROUGH 205 )
16	X-RAY DIFFRACTION	16	CHAIN C AND (RESID 1 THROUGH 13 )
17	X-RAY DIFFRACTION	17	CHAIN C AND (RESID 14 THROUGH 26 )
18	X-RAY DIFFRACTION	18	CHAIN C AND (RESID 27 THROUGH 59 )
19	X-RAY DIFFRACTION	19	CHAIN C AND (RESID 60 THROUGH 72 )
20	X-RAY DIFFRACTION	20	CHAIN C AND (RESID 73 THROUGH 122 )
21	X-RAY DIFFRACTION	21	CHAIN C AND (RESID 123 THROUGH 133 )
22	X-RAY DIFFRACTION	22	CHAIN C AND (RESID 134 THROUGH 153 )
23	X-RAY DIFFRACTION	23	CHAIN C AND (RESID 154 THROUGH 170 )
24	X-RAY DIFFRACTION	24	CHAIN C AND (RESID 171 THROUGH 190 )
25	X-RAY DIFFRACTION	25	CHAIN C AND (RESID 191 THROUGH 206 )
26	X-RAY DIFFRACTION	26	CHAIN D AND (RESID 1 THROUGH 26 )
27	X-RAY DIFFRACTION	27	CHAIN D AND (RESID 27 THROUGH 59 )
28	X-RAY DIFFRACTION	28	CHAIN D AND (RESID 60 THROUGH 72 )
29	X-RAY DIFFRACTION	29	CHAIN D AND (RESID 73 THROUGH 122 )
30	X-RAY DIFFRACTION	30	CHAIN D AND (RESID 123 THROUGH 153 )
31	X-RAY DIFFRACTION	31	CHAIN D AND (RESID 154 THROUGH 205 )
32	X-RAY DIFFRACTION	32	CHAIN E AND (RESID 1 THROUGH 26 )
33	X-RAY DIFFRACTION	33	CHAIN E AND (RESID 27 THROUGH 59 )
34	X-RAY DIFFRACTION	34	CHAIN E AND (RESID 60 THROUGH 72 )
35	X-RAY DIFFRACTION	35	CHAIN E AND (RESID 73 THROUGH 122 )
36	X-RAY DIFFRACTION	36	CHAIN E AND (RESID 123 THROUGH 153 )
37	X-RAY DIFFRACTION	37	CHAIN E AND (RESID 154 THROUGH 170 )
38	X-RAY DIFFRACTION	38	CHAIN E AND (RESID 171 THROUGH 190 )
39	X-RAY DIFFRACTION	39	CHAIN E AND (RESID 191 THROUGH 205 )
40	X-RAY DIFFRACTION	40	CHAIN F AND (RESID 1 THROUGH 13 )
41	X-RAY DIFFRACTION	41	CHAIN F AND (RESID 14 THROUGH 26 )
42	X-RAY DIFFRACTION	42	CHAIN F AND (RESID 27 THROUGH 59 )
43	X-RAY DIFFRACTION	43	CHAIN F AND (RESID 60 THROUGH 72 )
44	X-RAY DIFFRACTION	44	CHAIN F AND (RESID 73 THROUGH 122 )
45	X-RAY DIFFRACTION	45	CHAIN F AND (RESID 123 THROUGH 153 )
46	X-RAY DIFFRACTION	46	CHAIN F AND (RESID 154 THROUGH 170 )
47	X-RAY DIFFRACTION	47	CHAIN F AND (RESID 171 THROUGH 190 )
48	X-RAY DIFFRACTION	48	CHAIN F AND (RESID 191 THROUGH 205 )
49	X-RAY DIFFRACTION	49	CHAIN G AND (RESID 1 THROUGH 13 )
50	X-RAY DIFFRACTION	50	CHAIN G AND (RESID 14 THROUGH 26 )
51	X-RAY DIFFRACTION	51	CHAIN G AND (RESID 27 THROUGH 59 )
52	X-RAY DIFFRACTION	52	CHAIN G AND (RESID 60 THROUGH 72 )
53	X-RAY DIFFRACTION	53	CHAIN G AND (RESID 73 THROUGH 122 )
54	X-RAY DIFFRACTION	54	CHAIN G AND (RESID 123 THROUGH 133 )
55	X-RAY DIFFRACTION	55	CHAIN G AND (RESID 134 THROUGH 153 )
56	X-RAY DIFFRACTION	56	CHAIN G AND (RESID 154 THROUGH 170 )
57	X-RAY DIFFRACTION	57	CHAIN G AND (RESID 171 THROUGH 190 )
58	X-RAY DIFFRACTION	58	CHAIN G AND (RESID 191 THROUGH 205 )
59	X-RAY DIFFRACTION	59	CHAIN H AND (RESID 1 THROUGH 26 )
60	X-RAY DIFFRACTION	60	CHAIN H AND (RESID 27 THROUGH 59 )
61	X-RAY DIFFRACTION	61	CHAIN H AND (RESID 60 THROUGH 72 )
62	X-RAY DIFFRACTION	62	CHAIN H AND (RESID 73 THROUGH 122 )
63	X-RAY DIFFRACTION	63	CHAIN H AND (RESID 123 THROUGH 153 )
64	X-RAY DIFFRACTION	64	CHAIN H AND (RESID 154 THROUGH 205 )
65	X-RAY DIFFRACTION	65	CHAIN I AND (RESID 1 THROUGH 26 )
66	X-RAY DIFFRACTION	66	CHAIN I AND (RESID 27 THROUGH 59 )
67	X-RAY DIFFRACTION	67	CHAIN I AND (RESID 60 THROUGH 72 )
68	X-RAY DIFFRACTION	68	CHAIN I AND (RESID 73 THROUGH 122 )
69	X-RAY DIFFRACTION	69	CHAIN I AND (RESID 123 THROUGH 153 )
70	X-RAY DIFFRACTION	70	CHAIN I AND (RESID 154 THROUGH 170 )
71	X-RAY DIFFRACTION	71	CHAIN I AND (RESID 171 THROUGH 190 )
72	X-RAY DIFFRACTION	72	CHAIN I AND (RESID 191 THROUGH 205 )
73	X-RAY DIFFRACTION	73	CHAIN J AND (RESID 1 THROUGH 13 )
74	X-RAY DIFFRACTION	74	CHAIN J AND (RESID 14 THROUGH 26 )
75	X-RAY DIFFRACTION	75	CHAIN J AND (RESID 27 THROUGH 59 )
76	X-RAY DIFFRACTION	76	CHAIN J AND (RESID 60 THROUGH 72 )
77	X-RAY DIFFRACTION	77	CHAIN J AND (RESID 73 THROUGH 122 )
78	X-RAY DIFFRACTION	78	CHAIN J AND (RESID 123 THROUGH 153 )
79	X-RAY DIFFRACTION	79	CHAIN J AND (RESID 154 THROUGH 170 )
80	X-RAY DIFFRACTION	80	CHAIN J AND (RESID 171 THROUGH 190 )
81	X-RAY DIFFRACTION	81	CHAIN J AND (RESID 191 THROUGH 205 )
82	X-RAY DIFFRACTION	82	CHAIN K AND (RESID 1 THROUGH 26 )
83	X-RAY DIFFRACTION	83	CHAIN K AND (RESID 27 THROUGH 72 )
84	X-RAY DIFFRACTION	84	CHAIN K AND (RESID 73 THROUGH 122 )
85	X-RAY DIFFRACTION	85	CHAIN K AND (RESID 123 THROUGH 205 )
86	X-RAY DIFFRACTION	86	CHAIN L AND (RESID 1 THROUGH 13 )
87	X-RAY DIFFRACTION	87	CHAIN L AND (RESID 14 THROUGH 26 )
88	X-RAY DIFFRACTION	88	CHAIN L AND (RESID 27 THROUGH 59 )
89	X-RAY DIFFRACTION	89	CHAIN L AND (RESID 60 THROUGH 72 )
90	X-RAY DIFFRACTION	90	CHAIN L AND (RESID 73 THROUGH 122 )
91	X-RAY DIFFRACTION	91	CHAIN L AND (RESID 123 THROUGH 153 )
92	X-RAY DIFFRACTION	92	CHAIN L AND (RESID 154 THROUGH 170 )
93	X-RAY DIFFRACTION	93	CHAIN L AND (RESID 171 THROUGH 204 )
94	X-RAY DIFFRACTION	94	CHAIN M AND (RESID 1 THROUGH 26 )
95	X-RAY DIFFRACTION	95	CHAIN M AND (RESID 27 THROUGH 59 )
96	X-RAY DIFFRACTION	96	CHAIN M AND (RESID 60 THROUGH 72 )
97	X-RAY DIFFRACTION	97	CHAIN M AND (RESID 73 THROUGH 122 )
98	X-RAY DIFFRACTION	98	CHAIN M AND (RESID 123 THROUGH 170 )
99	X-RAY DIFFRACTION	99	CHAIN M AND (RESID 171 THROUGH 204 )
100	X-RAY DIFFRACTION	100	CHAIN N AND (RESID 1 THROUGH 26 )
101	X-RAY DIFFRACTION	101	CHAIN N AND (RESID 27 THROUGH 59 )
102	X-RAY DIFFRACTION	102	CHAIN N AND (RESID 60 THROUGH 72 )
103	X-RAY DIFFRACTION	103	CHAIN N AND (RESID 73 THROUGH 122 )
104	X-RAY DIFFRACTION	104	CHAIN N AND (RESID 123 THROUGH 133 )
105	X-RAY DIFFRACTION	105	CHAIN N AND (RESID 134 THROUGH 205 )
106	X-RAY DIFFRACTION	106	CHAIN O AND (RESID 1 THROUGH 26 )
107	X-RAY DIFFRACTION	107	CHAIN O AND (RESID 27 THROUGH 59 )
108	X-RAY DIFFRACTION	108	CHAIN O AND (RESID 60 THROUGH 101 )
109	X-RAY DIFFRACTION	109	CHAIN O AND (RESID 102 THROUGH 153 )
110	X-RAY DIFFRACTION	110	CHAIN O AND (RESID 154 THROUGH 184 )
111	X-RAY DIFFRACTION	111	CHAIN O AND (RESID 185 THROUGH 204 )
112	X-RAY DIFFRACTION	112	CHAIN P AND (RESID 1 THROUGH 13 )
113	X-RAY DIFFRACTION	113	CHAIN P AND (RESID 14 THROUGH 26 )
114	X-RAY DIFFRACTION	114	CHAIN P AND (RESID 27 THROUGH 46 )
115	X-RAY DIFFRACTION	115	CHAIN P AND (RESID 47 THROUGH 59 )
116	X-RAY DIFFRACTION	116	CHAIN P AND (RESID 60 THROUGH 72 )
117	X-RAY DIFFRACTION	117	CHAIN P AND (RESID 73 THROUGH 122 )
118	X-RAY DIFFRACTION	118	CHAIN P AND (RESID 123 THROUGH 153 )
119	X-RAY DIFFRACTION	119	CHAIN P AND (RESID 154 THROUGH 170 )
120	X-RAY DIFFRACTION	120	CHAIN P AND (RESID 171 THROUGH 190 )
121	X-RAY DIFFRACTION	121	CHAIN P AND (RESID 191 THROUGH 206 )
122	X-RAY DIFFRACTION	122	CHAIN Q AND (RESID 1 THROUGH 26 )
123	X-RAY DIFFRACTION	123	CHAIN Q AND (RESID 27 THROUGH 59 )
124	X-RAY DIFFRACTION	124	CHAIN Q AND (RESID 60 THROUGH 72 )
125	X-RAY DIFFRACTION	125	CHAIN Q AND (RESID 73 THROUGH 122 )
126	X-RAY DIFFRACTION	126	CHAIN Q AND (RESID 123 THROUGH 170 )
127	X-RAY DIFFRACTION	127	CHAIN Q AND (RESID 171 THROUGH 190 )
128	X-RAY DIFFRACTION	128	CHAIN Q AND (RESID 191 THROUGH 205 )
129	X-RAY DIFFRACTION	129	CHAIN R AND (RESID 1 THROUGH 13 )
130	X-RAY DIFFRACTION	130	CHAIN R AND (RESID 14 THROUGH 26 )
131	X-RAY DIFFRACTION	131	CHAIN R AND (RESID 27 THROUGH 46 )
132	X-RAY DIFFRACTION	132	CHAIN R AND (RESID 47 THROUGH 59 )
133	X-RAY DIFFRACTION	133	CHAIN R AND (RESID 60 THROUGH 72 )
134	X-RAY DIFFRACTION	134	CHAIN R AND (RESID 73 THROUGH 122 )
135	X-RAY DIFFRACTION	135	CHAIN R AND (RESID 123 THROUGH 133 )
136	X-RAY DIFFRACTION	136	CHAIN R AND (RESID 134 THROUGH 153 )
137	X-RAY DIFFRACTION	137	CHAIN R AND (RESID 154 THROUGH 204 )
138	X-RAY DIFFRACTION	138	CHAIN S AND (RESID 1 THROUGH 13 )
139	X-RAY DIFFRACTION	139	CHAIN S AND (RESID 14 THROUGH 26 )
140	X-RAY DIFFRACTION	140	CHAIN S AND (RESID 27 THROUGH 59 )
141	X-RAY DIFFRACTION	141	CHAIN S AND (RESID 60 THROUGH 72 )
142	X-RAY DIFFRACTION	142	CHAIN S AND (RESID 73 THROUGH 122 )
143	X-RAY DIFFRACTION	143	CHAIN S AND (RESID 123 THROUGH 133 )
144	X-RAY DIFFRACTION	144	CHAIN S AND (RESID 134 THROUGH 170 )
145	X-RAY DIFFRACTION	145	CHAIN S AND (RESID 171 THROUGH 190 )
146	X-RAY DIFFRACTION	146	CHAIN S AND (RESID 191 THROUGH 205 )
147	X-RAY DIFFRACTION	147	CHAIN T AND (RESID 1 THROUGH 13 )
148	X-RAY DIFFRACTION	148	CHAIN T AND (RESID 14 THROUGH 26 )
149	X-RAY DIFFRACTION	149	CHAIN T AND (RESID 27 THROUGH 59 )
150	X-RAY DIFFRACTION	150	CHAIN T AND (RESID 60 THROUGH 72 )
151	X-RAY DIFFRACTION	151	CHAIN T AND (RESID 73 THROUGH 101 )
152	X-RAY DIFFRACTION	152	CHAIN T AND (RESID 102 THROUGH 122 )
153	X-RAY DIFFRACTION	153	CHAIN T AND (RESID 123 THROUGH 153 )
154	X-RAY DIFFRACTION	154	CHAIN T AND (RESID 154 THROUGH 170 )
155	X-RAY DIFFRACTION	155	CHAIN T AND (RESID 171 THROUGH 190 )
156	X-RAY DIFFRACTION	156	CHAIN T AND (RESID 191 THROUGH 205 )
157	X-RAY DIFFRACTION	157	CHAIN U AND (RESID 1 THROUGH 26 )
158	X-RAY DIFFRACTION	158	CHAIN U AND (RESID 27 THROUGH 59 )
159	X-RAY DIFFRACTION	159	CHAIN U AND (RESID 60 THROUGH 72 )
160	X-RAY DIFFRACTION	160	CHAIN U AND (RESID 73 THROUGH 133 )
161	X-RAY DIFFRACTION	161	CHAIN U AND (RESID 134 THROUGH 149 )
162	X-RAY DIFFRACTION	162	CHAIN U AND (RESID 150 THROUGH 170 )
163	X-RAY DIFFRACTION	163	CHAIN U AND (RESID 171 THROUGH 190 )
164	X-RAY DIFFRACTION	164	CHAIN U AND (RESID 191 THROUGH 205 )
165	X-RAY DIFFRACTION	165	CHAIN V AND (RESID 1 THROUGH 13 )
166	X-RAY DIFFRACTION	166	CHAIN V AND (RESID 14 THROUGH 26 )
167	X-RAY DIFFRACTION	167	CHAIN V AND (RESID 27 THROUGH 59 )
168	X-RAY DIFFRACTION	168	CHAIN V AND (RESID 60 THROUGH 72 )
169	X-RAY DIFFRACTION	169	CHAIN V AND (RESID 73 THROUGH 122 )
170	X-RAY DIFFRACTION	170	CHAIN V AND (RESID 123 THROUGH 153 )
171	X-RAY DIFFRACTION	171	CHAIN V AND (RESID 154 THROUGH 170 )
172	X-RAY DIFFRACTION	172	CHAIN V AND (RESID 171 THROUGH 190 )
173	X-RAY DIFFRACTION	173	CHAIN V AND (RESID 191 THROUGH 205 )
174	X-RAY DIFFRACTION	174	CHAIN W AND (RESID 1 THROUGH 26 )
175	X-RAY DIFFRACTION	175	CHAIN W AND (RESID 27 THROUGH 59 )
176	X-RAY DIFFRACTION	176	CHAIN W AND (RESID 60 THROUGH 72 )
177	X-RAY DIFFRACTION	177	CHAIN W AND (RESID 73 THROUGH 122 )
178	X-RAY DIFFRACTION	178	CHAIN W AND (RESID 123 THROUGH 154 )
179	X-RAY DIFFRACTION	179	CHAIN W AND (RESID 155 THROUGH 170 )
180	X-RAY DIFFRACTION	180	CHAIN W AND (RESID 171 THROUGH 190 )
181	X-RAY DIFFRACTION	181	CHAIN W AND (RESID 191 THROUGH 205 )
182	X-RAY DIFFRACTION	182	CHAIN X AND (RESID 1 THROUGH 13 )
183	X-RAY DIFFRACTION	183	CHAIN X AND (RESID 14 THROUGH 26 )
184	X-RAY DIFFRACTION	184	CHAIN X AND (RESID 27 THROUGH 59 )
185	X-RAY DIFFRACTION	185	CHAIN X AND (RESID 60 THROUGH 72 )
186	X-RAY DIFFRACTION	186	CHAIN X AND (RESID 73 THROUGH 122 )
187	X-RAY DIFFRACTION	187	CHAIN X AND (RESID 123 THROUGH 153 )
188	X-RAY DIFFRACTION	188	CHAIN X AND (RESID 154 THROUGH 170 )
189	X-RAY DIFFRACTION	189	CHAIN X AND (RESID 171 THROUGH 190 )
190	X-RAY DIFFRACTION	190	CHAIN X AND (RESID 191 THROUGH 205 )
191	X-RAY DIFFRACTION	191	CHAIN Y AND (RESID 1 THROUGH 13 )
192	X-RAY DIFFRACTION	192	CHAIN Y AND (RESID 14 THROUGH 26 )
193	X-RAY DIFFRACTION	193	CHAIN Y AND (RESID 27 THROUGH 59 )
194	X-RAY DIFFRACTION	194	CHAIN Y AND (RESID 60 THROUGH 72 )
195	X-RAY DIFFRACTION	195	CHAIN Y AND (RESID 73 THROUGH 101 )
196	X-RAY DIFFRACTION	196	CHAIN Y AND (RESID 102 THROUGH 133 )
197	X-RAY DIFFRACTION	197	CHAIN Y AND (RESID 134 THROUGH 170 )
198	X-RAY DIFFRACTION	198	CHAIN Y AND (RESID 171 THROUGH 190 )
199	X-RAY DIFFRACTION	199	CHAIN Y AND (RESID 191 THROUGH 205 )
200	X-RAY DIFFRACTION	200	CHAIN Z AND (RESID 1 THROUGH 26 )
201	X-RAY DIFFRACTION	201	CHAIN Z AND (RESID 27 THROUGH 59 )
202	X-RAY DIFFRACTION	202	CHAIN Z AND (RESID 60 THROUGH 72 )
203	X-RAY DIFFRACTION	203	CHAIN Z AND (RESID 73 THROUGH 153 )
204	X-RAY DIFFRACTION	204	CHAIN Z AND (RESID 154 THROUGH 170 )
205	X-RAY DIFFRACTION	205	CHAIN Z AND (RESID 171 THROUGH 205 )
206	X-RAY DIFFRACTION	206	CHAIN a AND (RESID 1 THROUGH 13 )
207	X-RAY DIFFRACTION	207	CHAIN a AND (RESID 14 THROUGH 26 )
208	X-RAY DIFFRACTION	208	CHAIN a AND (RESID 27 THROUGH 59 )
209	X-RAY DIFFRACTION	209	CHAIN a AND (RESID 60 THROUGH 72 )
210	X-RAY DIFFRACTION	210	CHAIN a AND (RESID 73 THROUGH 122 )
211	X-RAY DIFFRACTION	211	CHAIN a AND (RESID 123 THROUGH 205 )
212	X-RAY DIFFRACTION	212	CHAIN b AND (RESID 1 THROUGH 26 )
213	X-RAY DIFFRACTION	213	CHAIN b AND (RESID 27 THROUGH 59 )
214	X-RAY DIFFRACTION	214	CHAIN b AND (RESID 60 THROUGH 101 )
215	X-RAY DIFFRACTION	215	CHAIN b AND (RESID 102 THROUGH 153 )
216	X-RAY DIFFRACTION	216	CHAIN b AND (RESID 154 THROUGH 170 )
217	X-RAY DIFFRACTION	217	CHAIN b AND (RESID 171 THROUGH 205 )
218	X-RAY DIFFRACTION	218	CHAIN b AND (RESID 1 THROUGH 13 )
219	X-RAY DIFFRACTION	219	CHAIN c AND (RESID 14 THROUGH 26 )
220	X-RAY DIFFRACTION	220	CHAIN c AND (RESID 27 THROUGH 59 )
221	X-RAY DIFFRACTION	221	CHAIN c AND (RESID 60 THROUGH 72 )
222	X-RAY DIFFRACTION	222	CHAIN c AND (RESID 73 THROUGH 122 )
223	X-RAY DIFFRACTION	223	CHAIN c AND (RESID 123 THROUGH 153 )
224	X-RAY DIFFRACTION	224	CHAIN c AND (RESID 154 THROUGH 170 )
225	X-RAY DIFFRACTION	225	CHAIN c AND (RESID 171 THROUGH 190 )
226	X-RAY DIFFRACTION	226	CHAIN c AND (RESID 191 THROUGH 205 )
227	X-RAY DIFFRACTION	227	CHAIN d AND (RESID 1 THROUGH 13 )
228	X-RAY DIFFRACTION	228	CHAIN d AND (RESID 14 THROUGH 26 )
229	X-RAY DIFFRACTION	229	CHAIN d AND (RESID 27 THROUGH 59 )
230	X-RAY DIFFRACTION	230	CHAIN d AND (RESID 60 THROUGH 72 )
231	X-RAY DIFFRACTION	231	CHAIN d AND (RESID 73 THROUGH 122 )
232	X-RAY DIFFRACTION	232	CHAIN d AND (RESID 123 THROUGH 205 )
233	X-RAY DIFFRACTION	233	CHAIN e AND (RESID 1 THROUGH 13 )
234	X-RAY DIFFRACTION	234	CHAIN e AND (RESID 14 THROUGH 26 )
235	X-RAY DIFFRACTION	235	CHAIN e AND (RESID 27 THROUGH 59 )
236	X-RAY DIFFRACTION	236	CHAIN e AND (RESID 60 THROUGH 72 )
237	X-RAY DIFFRACTION	237	CHAIN e AND (RESID 73 THROUGH 122 )
238	X-RAY DIFFRACTION	238	CHAIN e AND (RESID 123 THROUGH 153 )
239	X-RAY DIFFRACTION	239	CHAIN e AND (RESID 154 THROUGH 170 )
240	X-RAY DIFFRACTION	240	CHAIN e AND (RESID 171 THROUGH 205 )
241	X-RAY DIFFRACTION	241	CHAIN f AND (RESID 1 THROUGH 13 )
242	X-RAY DIFFRACTION	242	CHAIN f AND (RESID 14 THROUGH 26 )
243	X-RAY DIFFRACTION	243	CHAIN f AND (RESID 27 THROUGH 59 )
244	X-RAY DIFFRACTION	244	CHAIN f AND (RESID 60 THROUGH 72 )
245	X-RAY DIFFRACTION	245	CHAIN f AND (RESID 73 THROUGH 122 )
246	X-RAY DIFFRACTION	246	CHAIN f AND (RESID 123 THROUGH 153 )
247	X-RAY DIFFRACTION	247	CHAIN f AND (RESID 154 THROUGH 205 )
248	X-RAY DIFFRACTION	248	CHAIN g AND (RESID 1 THROUGH 13 )
249	X-RAY DIFFRACTION	249	CHAIN g AND (RESID 14 THROUGH 26 )
250	X-RAY DIFFRACTION	250	CHAIN g AND (RESID 27 THROUGH 59 )
251	X-RAY DIFFRACTION	251	CHAIN g AND (RESID 60 THROUGH 72 )
252	X-RAY DIFFRACTION	252	CHAIN g AND (RESID 73 THROUGH 122 )
253	X-RAY DIFFRACTION	253	CHAIN g AND (RESID 123 THROUGH 133 )
254	X-RAY DIFFRACTION	254	CHAIN g AND (RESID 134 THROUGH 153 )
255	X-RAY DIFFRACTION	255	CHAIN g AND (RESID 154 THROUGH 204 )
256	X-RAY DIFFRACTION	256	CHAIN h AND (RESID 1 THROUGH 26 )
257	X-RAY DIFFRACTION	257	CHAIN h AND (RESID 27 THROUGH 59 )
258	X-RAY DIFFRACTION	258	CHAIN h AND (RESID 60 THROUGH 101 )
259	X-RAY DIFFRACTION	259	CHAIN h AND (RESID 102 THROUGH 153 )
260	X-RAY DIFFRACTION	260	CHAIN h AND (RESID 154 THROUGH 170 )
261	X-RAY DIFFRACTION	261	CHAIN h AND (RESID 171 THROUGH 204 )
262	X-RAY DIFFRACTION	262	CHAIN i AND (RESID 1 THROUGH 13 )
263	X-RAY DIFFRACTION	263	CHAIN i AND (RESID 14 THROUGH 26 )
264	X-RAY DIFFRACTION	264	CHAIN i AND (RESID 27 THROUGH 59 )
265	X-RAY DIFFRACTION	265	CHAIN i AND (RESID 60 THROUGH 72 )
266	X-RAY DIFFRACTION	266	CHAIN i AND (RESID 73 THROUGH 122 )
267	X-RAY DIFFRACTION	267	CHAIN i AND (RESID 123 THROUGH 154 )
268	X-RAY DIFFRACTION	268	CHAIN i AND (RESID 155 THROUGH 190 )
269	X-RAY DIFFRACTION	269	CHAIN i AND (RESID 191 THROUGH 205 )
270	X-RAY DIFFRACTION	270	CHAIN j AND (RESID 1 THROUGH 13 )
271	X-RAY DIFFRACTION	271	CHAIN j AND (RESID 14 THROUGH 26 )
272	X-RAY DIFFRACTION	272	CHAIN j AND (RESID 27 THROUGH 59 )
273	X-RAY DIFFRACTION	273	CHAIN j AND (RESID 60 THROUGH 153 )
274	X-RAY DIFFRACTION	274	CHAIN j AND (RESID 154 THROUGH 204 )
275	X-RAY DIFFRACTION	275	CHAIN k AND (RESID 1 THROUGH 26 )
276	X-RAY DIFFRACTION	276	CHAIN k AND (RESID 27 THROUGH 59 )
277	X-RAY DIFFRACTION	277	CHAIN k AND (RESID 60 THROUGH 101 )
278	X-RAY DIFFRACTION	278	CHAIN k AND (RESID 102 THROUGH 153 )
279	X-RAY DIFFRACTION	279	CHAIN k AND (RESID 154 THROUGH 190 )
280	X-RAY DIFFRACTION	280	CHAIN k AND (RESID 191 THROUGH 205 )
281	X-RAY DIFFRACTION	281	CHAIN l AND (RESID 1 THROUGH 26 )
282	X-RAY DIFFRACTION	282	CHAIN l AND (RESID 27 THROUGH 59 )
283	X-RAY DIFFRACTION	283	CHAIN l AND (RESID 60 THROUGH 72 )
284	X-RAY DIFFRACTION	284	CHAIN l AND (RESID 73 THROUGH 122 )
285	X-RAY DIFFRACTION	285	CHAIN l AND (RESID 123 THROUGH 153 )
286	X-RAY DIFFRACTION	286	CHAIN l AND (RESID 154 THROUGH 170 )
287	X-RAY DIFFRACTION	287	CHAIN l AND (RESID 171 THROUGH 190 )
288	X-RAY DIFFRACTION	288	CHAIN l AND (RESID 191 THROUGH 205 )
289	X-RAY DIFFRACTION	289	CHAIN m AND (RESID 1 THROUGH 13 )
290	X-RAY DIFFRACTION	290	CHAIN m AND (RESID 14 THROUGH 26 )
291	X-RAY DIFFRACTION	291	CHAIN M AND (RESID 27 THROUGH 59 )
292	X-RAY DIFFRACTION	292	CHAIN m AND (RESID 60 THROUGH 72 )
293	X-RAY DIFFRACTION	293	CHAIN m AND (RESID 73 THROUGH 101 )
294	X-RAY DIFFRACTION	294	CHAIN m AND (RESID 102 THROUGH 153 )
295	X-RAY DIFFRACTION	295	CHAIN M AND (RESID 154 THROUGH 170 )
296	X-RAY DIFFRACTION	296	CHAIN m AND (RESID 171 THROUGH 205 )
297	X-RAY DIFFRACTION	297	CHAIN n AND (RESID 1 THROUGH 13 )
298	X-RAY DIFFRACTION	298	CHAIN n AND (RESID 14 THROUGH 26 )
299	X-RAY DIFFRACTION	299	CHAIN n AND (RESID 27 THROUGH 59 )
300	X-RAY DIFFRACTION	300	CHAIN n AND (RESID 60 THROUGH 72 )
301	X-RAY DIFFRACTION	301	CHAIN n AND (RESID 73 THROUGH 122 )
302	X-RAY DIFFRACTION	302	CHAIN n AND (RESID 123 THROUGH 170 )
303	X-RAY DIFFRACTION	303	CHAIN n AND (RESID 171 THROUGH 190 )
304	X-RAY DIFFRACTION	304	CHAIN n AND (RESID 191 THROUGH 205 )