PDB-3u8n: Crystal structure of the acetylcholine binding protein (AChBP) fr...

Basic information

• Entry: Database: PDB / ID: 3u8n
• Title: Crystal structure of the acetylcholine binding protein (AChBP) from Lymnaea stagnalis in complex with NS3950 (1-(6-bromo-5-ethoxypyridin-3-yl)-1,4-diazepane)
• Components: Acetylcholine-binding protein
• Keywords: Acetylcholine-binding protein/agonist / Lymnaea stagnalis / agonist / Ligand-bindig domain / Acetylcholine / Acetylcholine-binding protein / Acetylcholine-binding protein-agonist complex

Function / homology

Function:

extracellular ligand-gated monoatomic ion channel activity / synaptic cleft / transmembrane signaling receptor activity / synapse / membrane

Domain/homology:

Acetylcholine Binding Protein; Chain: A, / Neurotransmitter-gated ion-channel ligand-binding domain / Neurotransmitter-gated ion-channel / Neurotransmitter-gated ion-channel ligand-binding domain / Neurotransmitter-gated ion-channel ligand-binding domain superfamily / Neurotransmitter-gated ion-channel ligand binding domain / Distorted Sandwich / Ig-like domain profile. / Immunoglobulin-like domain / Mainly Beta

Component:

1-(6-bromo-5-ethoxypyridin-3-yl)-1,4-diazepane / Acetylcholine-binding protein

• Biological species: Lymnaea stagnalis (great pond snail)
• Method: X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.35 Å
• Authors: Rohde, L.A.H. / Ahring, P.K. / Jensen, M.L. / Nielsen, E.O. / Peters, D. / Helgstrand, C. / Krintel, C. / Harpsoe, K. / Gajhede, M. / Kastrup, J.S. / Balle, T.
• Citation: Journal: J.Biol.Chem. / Year: 2012; Title: Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha 4 beta 2 receptors: unique role of halogen bonding revealed.; Authors: Rohde, L.A. / Ahring, P.K. / Jensen, M.L. / Nielsen, E. / Peters, D. / Helgstrand, C. / Krintel, C. / Harpse, K. / Gajhede, M. / Kastrup, J.S. / Balle, T.

History

Deposition	Oct 17, 2011	Deposition site: RCSB / Processing site: RCSB
Revision 1.0	Dec 14, 2011	Provider: repository / Type: Initial release
Revision 1.1	Sep 18, 2013	Group: Database references
Revision 1.2	Jan 24, 2018	Group: Data collection / Structure summary / Category: audit_author / diffrn_source Item: _audit_author.name / _diffrn_source.pdbx_synchrotron_site
Revision 1.3	Jul 29, 2020	Group: Data collection / Derived calculations / Structure summary Category: chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role Description: Carbohydrate remediation / Provider: repository / Type: Remediation
Revision 1.4	Sep 13, 2023	Group: Data collection / Database references / Refinement description / Structure summary Category: chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession

Assembly

Deposited unit

A: Acetylcholine-binding protein

B: Acetylcholine-binding protein

C: Acetylcholine-binding protein

D: Acetylcholine-binding protein

E: Acetylcholine-binding protein

F: Acetylcholine-binding protein

G: Acetylcholine-binding protein

H: Acetylcholine-binding protein

I: Acetylcholine-binding protein

J: Acetylcholine-binding protein

K: Acetylcholine-binding protein

L: Acetylcholine-binding protein

M: Acetylcholine-binding protein

N: Acetylcholine-binding protein

O: Acetylcholine-binding protein

P: Acetylcholine-binding protein

Q: Acetylcholine-binding protein

R: Acetylcholine-binding protein

S: Acetylcholine-binding protein

T: Acetylcholine-binding protein

hetero molecules

Summary:

• 484 kDa, 20 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	484,494	49
Polymers	477,250	20
Non-polymers	7,244	29
Water	32,877	1825

1

A: Acetylcholine-binding protein

B: Acetylcholine-binding protein

C: Acetylcholine-binding protein

D: Acetylcholine-binding protein

E: Acetylcholine-binding protein

hetero molecules

Summary:

• defined by author&software
• 121 kDa, 5 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	121,131	12
Polymers	119,313	5
Non-polymers	1,818	7
Water	90	5

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	14090 Å2
ΔGint	-66 kcal/mol
Surface area	42110 Å2
Method	PISA

2

F: Acetylcholine-binding protein

G: Acetylcholine-binding protein

H: Acetylcholine-binding protein

I: Acetylcholine-binding protein

J: Acetylcholine-binding protein

hetero molecules

Summary:

• defined by author&software
• 121 kDa, 5 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	121,131	12
Polymers	119,313	5
Non-polymers	1,818	7
Water	90	5

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	13900 Å2
ΔGint	-63 kcal/mol
Surface area	42250 Å2
Method	PISA

3

K: Acetylcholine-binding protein

L: Acetylcholine-binding protein

M: Acetylcholine-binding protein

N: Acetylcholine-binding protein

O: Acetylcholine-binding protein

hetero molecules

Summary:

• defined by author&software
• 121 kDa, 5 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	120,910	11
Polymers	119,313	5
Non-polymers	1,597	6
Water	90	5

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	13810 Å2
ΔGint	-67 kcal/mol
Surface area	41670 Å2
Method	PISA

4

P: Acetylcholine-binding protein

Q: Acetylcholine-binding protein

R: Acetylcholine-binding protein

S: Acetylcholine-binding protein

T: Acetylcholine-binding protein

hetero molecules

Summary:

• defined by author&software
• 121 kDa, 5 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	121,323	14
Polymers	119,313	5
Non-polymers	2,010	9
Water	90	5

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	14430 Å2
ΔGint	-93 kcal/mol
Surface area	42050 Å2
Method	PISA

Unit cell

Length a, b, c (Å)	239.120, 73.110, 271.840
Angle α, β, γ (deg.)	90.00, 97.45, 90.00
Int Tables number	5
Space group name H-M	C121

Noncrystallographic symmetry (NCS)

NCS domain:

ID	Ens-ID
1	1
2	1
3	1
4	1
5	1
6	1
7	1
8	1
9	1
10	1
11	1
12	1
13	1
14	1
15	1
16	1
17	1
18	1
19	1
20	1
1	2
2	2
3	2
4	2
5	2
6	2
7	2
8	2
9	2
10	2
11	2
12	2
13	2
14	2
15	2
16	2
17	2
18	2
19	2
20	2
1	3
2	3
3	3
4	3
5	3
6	3
7	3
8	3
9	3
10	3
11	3
12	3
13	3
14	3
15	3
16	3
17	3
18	3
19	3
20	3
1	4
2	4
3	4
4	4
5	4
6	4
7	4
8	4
9	4
10	4
11	4
12	4
13	4
14	4
15	4
16	4
17	4
18	4
1	5
2	5
1	6
2	6
3	6
4	6
5	6
6	6
7	6
8	6
9	6
10	6
11	6
12	6
13	6
14	6
15	6
16	6
17	6
18	6
19	6
20	6
1	7
2	7
3	7
4	7
5	7
6	7
7	7
8	7
9	7
10	7
11	7
12	7
13	7
14	7
15	7
16	7
17	7
18	7
19	7
20	7
1	8
2	8
3	8
4	8
5	8
6	8
7	8
8	8
9	8
10	8
11	8
12	8
13	8
14	8
15	8
16	8
17	8
18	8
19	8
20	8
1	9
2	9
3	9
4	9
5	9
6	9
7	9
8	9
9	9
10	9
11	9
12	9
13	9
14	9
15	9
16	9
17	9
1	10
2	10
3	10
1	11
2	11
3	11
4	11
5	11
6	11
7	11
8	11
9	11
10	11
11	11
12	11
13	11
14	11
15	11
16	11
17	11
18	11
19	11
20	11
1	12
2	12
3	12
1	13
2	13
3	13
4	13
5	13
6	13
7	13
8	13
9	13
10	13
11	13
12	13
13	13
14	13
15	13
16	13
17	13
1	14
2	14
3	14
4	14
5	14
6	14
7	14
8	14
9	14
10	14
11	14
12	14
13	14
14	14
15	14
16	14
17	14
18	14
19	14
20	14
1	15
2	15
3	15
4	15
5	15
6	15
7	15
8	15
9	15
10	15
11	15
12	15
13	15
14	15
15	15
16	15
17	15
1	16
2	16
3	16
1	17
2	17
3	17
4	17
5	17
1	18
2	18
3	18
4	18
5	18
6	18
7	18
8	18
9	18
10	18
1	19
2	19
3	19
4	19
1	20
2	20
3	20
4	20
5	20
6	20
7	20
8	20
9	20
10	20
11	20
12	20
13	20
14	20
15	20
16	20
17	20
18	20
19	20
20	20

NCS domain segments:

Dom-ID	Component-ID	Ens-ID	Selection details
1	1	1	chain A and resid 1:12
2	1	1	chain B and resid 1:12
3	1	1	chain C and resid 1:12
4	1	1	chain D and resid 1:12
5	1	1	chain E and resid 1:12
6	1	1	chain F and resid 1:12
7	1	1	chain G and resid 1:12
8	1	1	chain H and resid 1:12
9	1	1	chain I and resid 1:12
10	1	1	chain J and resid 1:12
11	1	1	chain K and resid 1:12
12	1	1	chain L and resid 1:12
13	1	1	chain M and resid 1:12
14	1	1	chain N and resid 1:12
15	1	1	chain O and resid 1:12
16	1	1	chain P and resid 1:12
17	1	1	chain Q and resid 1:12
18	1	1	chain R and resid 1:12
19	1	1	chain S and resid 1:12
20	1	1	chain T and resid 1:12
1	1	2	chain A and resid 16:22
2	1	2	chain B and resid 16:22
3	1	2	chain C and resid 16:22
4	1	2	chain D and resid 16:22
5	1	2	chain E and resid 16:22
6	1	2	chain F and resid 16:22
7	1	2	chain G and resid 16:22
8	1	2	chain H and resid 16:22
9	1	2	chain I and resid 16:22
10	1	2	chain J and resid 16:22
11	1	2	chain K and resid 16:22
12	1	2	chain L and resid 16:22
13	1	2	chain M and resid 16:22
14	1	2	chain N and resid 16:22
15	1	2	chain O and resid 16:22
16	1	2	chain P and resid 16:22
17	1	2	chain Q and resid 16:22
18	1	2	chain R and resid 16:22
19	1	2	chain S and resid 16:22
20	1	2	chain T and resid 16:22
1	1	3	chain A and resid 26:60
2	1	3	chain B and resid 26:60
3	1	3	chain C and resid 26:60
4	1	3	chain D and resid 26:60
5	1	3	chain E and resid 26:60
6	1	3	chain F and resid 26:60
7	1	3	chain G and resid 26:60
8	1	3	chain H and resid 26:60
9	1	3	chain I and resid 26:60
10	1	3	chain J and resid 26:60
11	1	3	chain K and resid 26:60
12	1	3	chain L and resid 26:60
13	1	3	chain M and resid 26:60
14	1	3	chain N and resid 26:60
15	1	3	chain O and resid 26:60
16	1	3	chain P and resid 26:60
17	1	3	chain Q and resid 26:60
18	1	3	chain R and resid 26:60
19	1	3	chain S and resid 26:60
20	1	3	chain T and resid 26:60
1	1	4	chain A and resid 61
2	1	4	chain B and resid 61
3	1	4	chain C and resid 61
4	1	4	chain D and resid 61
5	1	4	chain E and resid 61
6	1	4	chain F and resid 61
7	1	4	chain G and resid 61
8	1	4	chain H and resid 61
9	1	4	chain I and resid 61
10	1	4	chain J and resid 61
11	1	4	chain K and resid 61
12	1	4	chain L and resid 61
13	1	4	chain M and resid 61
14	1	4	chain N and resid 61
15	1	4	chain O and resid 61
16	1	4	chain Q and resid 61
17	1	4	chain S and resid 61
18	1	4	chain T and resid 61
1	1	5	chain P and resid 61
2	1	5	chain R and resid 61
1	1	6	chain A and resid 62:67
2	1	6	chain B and resid 62:67
3	1	6	chain C and resid 62:67
4	1	6	chain D and resid 62:67
5	1	6	chain E and resid 62:67
6	1	6	chain F and resid 62:67
7	1	6	chain G and resid 62:67
8	1	6	chain H and resid 62:67
9	1	6	chain I and resid 62:67
10	1	6	chain J and resid 62:67
11	1	6	chain K and resid 62:67
12	1	6	chain L and resid 62:67
13	1	6	chain M and resid 62:67
14	1	6	chain N and resid 62:67
15	1	6	chain O and resid 62:67
16	1	6	chain P and resid 62:67
17	1	6	chain Q and resid 62:67
18	1	6	chain R and resid 62:67
19	1	6	chain S and resid 62:67
20	1	6	chain T and resid 62:67
1	1	7	chain A and resid 68:69
2	1	7	chain B and resid 68:69
3	1	7	chain C and resid 68:69
4	1	7	chain D and resid 68:69
5	1	7	chain E and resid 68:69
6	1	7	chain F and resid 68:69
7	1	7	chain G and resid 68:69
8	1	7	chain H and resid 68:69
9	1	7	chain I and resid 68:69
10	1	7	chain J and resid 68:69
11	1	7	chain K and resid 68:69
12	1	7	chain L and resid 68:69
13	1	7	chain M and resid 68:69
14	1	7	chain N and resid 68:69
15	1	7	chain O and resid 68:69
16	1	7	chain P and resid 68:69
17	1	7	chain Q and resid 68:69
18	1	7	chain R and resid 68:69
19	1	7	chain S and resid 68:69
20	1	7	chain T and resid 68:69
1	1	8	chain A and resid 70:128
2	1	8	chain B and resid 70:128
3	1	8	chain C and resid 70:128
4	1	8	chain D and resid 70:128
5	1	8	chain E and resid 70:128
6	1	8	chain F and resid 70:128
7	1	8	chain G and resid 70:128
8	1	8	chain H and resid 70:128
9	1	8	chain I and resid 70:128
10	1	8	chain J and resid 70:128
11	1	8	chain K and resid 70:128
12	1	8	chain L and resid 70:128
13	1	8	chain M and resid 70:128
14	1	8	chain N and resid 70:128
15	1	8	chain O and resid 70:128
16	1	8	chain P and resid 70:128
17	1	8	chain Q and resid 70:128
18	1	8	chain R and resid 70:128
19	1	8	chain S and resid 70:128
20	1	8	chain T and resid 70:128
1	1	9	chain A and resid 129:131
2	1	9	chain B and resid 129:131
3	1	9	chain C and resid 129:131
4	1	9	chain D and resid 129:131
5	1	9	chain E and resid 129:131
6	1	9	chain F and resid 129:131
7	1	9	chain G and resid 129:131
8	1	9	chain H and resid 129:131
9	1	9	chain J and resid 129:131
10	1	9	chain K and resid 129:131
11	1	9	chain M and resid 129:131
12	1	9	chain N and resid 129:131
13	1	9	chain O and resid 129:131
14	1	9	chain Q and resid 129:131
15	1	9	chain R and resid 129:131
16	1	9	chain S and resid 129:131
17	1	9	chain T and resid 129:131
1	1	10	chain I and resid 129:131
2	1	10	chain P and resid 129:131
3	1	10	chain L and resid 129:131
1	1	11	chain A and resid 132:147
2	1	11	chain B and resid 132:147
3	1	11	chain C and resid 132:147
4	1	11	chain D and resid 132:147
5	1	11	chain E and resid 132:147
6	1	11	chain F and resid 132:147
7	1	11	chain G and resid 132:147
8	1	11	chain H and resid 132:147
9	1	11	chain I and resid 132:147
10	1	11	chain J and resid 132:147
11	1	11	chain K and resid 132:147
12	1	11	chain L and resid 132:147
13	1	11	chain M and resid 132:147
14	1	11	chain N and resid 132:147
15	1	11	chain O and resid 132:147
16	1	11	chain P and resid 132:147
17	1	11	chain Q and resid 132:147
18	1	11	chain R and resid 132:147
19	1	11	chain S and resid 132:147
20	1	11	chain T and resid 132:147
1	1	12	chain A and resid 148:155
2	1	12	chain I and resid 148:155
3	1	12	chain R and resid 148:155
1	1	13	chain B and resid 148:155
2	1	13	chain C and resid 148:155
3	1	13	chain D and resid 148:155
4	1	13	chain E and resid 148:155
5	1	13	chain F and resid 148:155
6	1	13	chain G and resid 148:155
7	1	13	chain H and resid 148:155
8	1	13	chain J and resid 148:155
9	1	13	chain K and resid 148:155
10	1	13	chain L and resid 148:155
11	1	13	chain M and resid 148:155
12	1	13	chain N and resid 148:155
13	1	13	chain O and resid 148:155
14	1	13	chain P and resid 148:155
15	1	13	chain Q and resid 148:155
16	1	13	chain S and resid 148:155
17	1	13	chain T and resid 148:155
1	1	14	chain A and resid 163:183
2	1	14	chain B and resid 163:183
3	1	14	chain C and resid 163:183
4	1	14	chain D and resid 163:183
5	1	14	chain E and resid 163:183
6	1	14	chain F and resid 163:183
7	1	14	chain G and resid 163:183
8	1	14	chain H and resid 163:183
9	1	14	chain I and resid 163:183
10	1	14	chain J and resid 163:183
11	1	14	chain K and resid 163:183
12	1	14	chain L and resid 163:183
13	1	14	chain M and resid 163:183
14	1	14	chain N and resid 163:183
15	1	14	chain O and resid 163:183
16	1	14	chain P and resid 163:183
17	1	14	chain Q and resid 163:183
18	1	14	chain R and resid 163:183
19	1	14	chain S and resid 163:183
20	1	14	chain T and resid 163:183
1	1	15	chain A and resid 184:186
2	1	15	chain C and resid 184:186
3	1	15	chain D and resid 184:186
4	1	15	chain E and resid 184:186
5	1	15	chain F and resid 184:186
6	1	15	chain G and resid 184:186
7	1	15	chain H and resid 184:186
8	1	15	chain I and resid 184:186
9	1	15	chain J and resid 184:186
10	1	15	chain K and resid 184:186
11	1	15	chain L and resid 184:186
12	1	15	chain N and resid 184:186
13	1	15	chain O and resid 184:186
14	1	15	chain Q and resid 184:186
15	1	15	chain R and resid 184:186
16	1	15	chain S and resid 184:186
17	1	15	chain T and resid 184:186
1	1	16	chain B and resid 184:186
2	1	16	chain M and resid 184:186
3	1	16	chain P and resid 184:186
1	1	17	chain B and resid 187:188
2	1	17	chain F and resid 187:188
3	1	17	chain G and resid 187:188
4	1	17	chain H and resid 187:188
5	1	17	chain O and resid 187:188
1	1	18	chain D and resid 187:188
2	1	18	chain E and resid 187:188
3	1	18	chain J and resid 187:188
4	1	18	chain K and resid 187:188
5	1	18	chain M and resid 187:188
6	1	18	chain N and resid 187:188
7	1	18	chain P and resid 187:188
8	1	18	chain Q and resid 187:188
9	1	18	chain R and resid 187:188
10	1	18	chain T and resid 187:188
1	1	19	chain C and resid 187:188
2	1	19	chain I and resid 187:188
3	1	19	chain L and resid 187:188
4	1	19	chain S and resid 187:188
1	1	20	chain A and resid 189:204
2	1	20	chain B and resid 189:204
3	1	20	chain C and resid 189:204
4	1	20	chain D and resid 189:204
5	1	20	chain E and resid 189:204
6	1	20	chain F and resid 189:204
7	1	20	chain G and resid 189:204
8	1	20	chain H and resid 189:204
9	1	20	chain I and resid 189:204
10	1	20	chain J and resid 189:204
11	1	20	chain K and resid 189:204
12	1	20	chain L and resid 189:204
13	1	20	chain M and resid 189:204
14	1	20	chain N and resid 189:204
15	1	20	chain O and resid 189:204
16	1	20	chain P and resid 189:204
17	1	20	chain Q and resid 189:204
18	1	20	chain R and resid 189:204
19	1	20	chain S and resid 189:204
20	1	20	chain T and resid 189:204

NCS ensembles :

ID
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20

Components

#1: Protein

A B C D E F G H I J K L M N O P Q R S T
Acetylcholine-binding protein / ACh-binding protein / AchBP

Details:

Mass: 23862.523 Da / Num. of mol.: 20
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Lymnaea stagnalis (great pond snail) / Production host: Spodoptera frugiperda (fall armyworm) / Strain (production host): Sf9 / References: UniProt: P58154

#2: Chemical

A-211 B-211 C-211 D-211 E-211 F-211 G-211 H-211 I-211 J-211 K-211 L-211 M-211 N-211 O-211 P-211 Q-211 R-211 S-211 T-211
ChemComp-09S / 1-(6-bromo-5-ethoxypyridin-3-yl)-1,4-diazepane

Details:

Mass: 300.195 Da / Num. of mol.: 20 / Source method: obtained synthetically / Formula: C₁₂H₁₈BrN₃O

#3: Chemical

A-212 H-212 N-212 P-212 P-213 S-212
ChemComp-SO4 / SULFATE ION / Sulfate

Details:

Mass: 96.063 Da / Num. of mol.: 6 / Source method: obtained synthetically / Formula: SO₄

#4: Sugar

C-300 G-301 T-212 ChemComp-NAG / 2-acetamido-2-deoxy-beta-D-glucopyranose / N-acetyl-beta-D-glucosamine / 2-acetamido-2-deoxy-beta-D-glucose / 2-acetamido-2-deoxy-D-glucose / 2-acetamido-2-deoxy-glucose / N-ACETYL-D-GLUCOSAMINE / N-Acetylglucosamine

Details:

Type: D-saccharide, beta linking / Mass: 221.208 Da / Num. of mol.: 3
Source method: isolated from a genetically manipulated source
Formula: C₈H₁₅NO₆

Identifier:

Identifier	Type	Program
DGlcpNAcb	CONDENSED IUPAC CARBOHYDRATE SYMBOL	GMML 1.0
N-acetyl-b-D-glucopyranosamine	COMMON NAME	GMML 1.0
b-D-GlcpNAc	IUPAC CARBOHYDRATE SYMBOL	PDB-CARE 1.0
GlcNAc	SNFG CARBOHYDRATE SYMBOL	GMML 1.0

#5: Water

ChemComp-HOH / water / Water

Details:

Mass: 18.015 Da / Num. of mol.: 1825 / Source method: isolated from a natural source / Formula: H₂O

Experimental details

Experiment

• Experiment: Method: X-RAY DIFFRACTION / Number of used crystals: 1

Sample preparation

• Crystal: Density Matthews: 2.47 ų/Da / Density % sol: 50.17 %
• Crystal grow: Temperature: 293 K / pH: 8 ; Details: 50mM Tris, 1.9 M Ammonium sulfate, 3% PEG 400, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K

Data collection

• Diffraction: Mean temperature: 100 K
• Diffraction source: Source: SYNCHROTRON / Site: MAX II / Beamline: I911-2 / Wavelength: 1.038
• Detector: Type: MAR CCD 165 mm / Detector: CCD / Date: Mar 19, 2010
• Radiation: Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
• Radiation wavelength: Wavelength: 1.038 Å / Relative weight: 1
• Reflection: Resolution: 2.35→33.19 Å / Num. obs: 185432 / % possible obs: 95.3 % / Redundancy: 3.6 % / B_iso Wilson estimate: 25.2 Ų / R_merge(I) obs: 0.07 / R_sym value: 0.07 / Net I/σ(I): 12.7
• Reflection shell: Resolution: 2.35→2.48 Å / Redundancy: 3.5 % / R_merge(I) obs: 0.191 / Mean I/σ(I) obs: 5.7 / R_sym value: 0.191 / % possible all: 82.8

Processing

Software

Name	Version	Classification
PHASER		phasing
PHENIX	(phenix.refine: 1.6.4_486)	refinement
MOSFLM		data reduction
SCALA		data scaling

Refinement

Method to determine structure: MOLECULAR REPLACEMENT
Starting model: PDB ENTRY 1UW6: PENTAMER, CHAIN A-E

1uw6

Resolution: 2.35→33.05 Å / SU ML: 0.35 / Isotropic thermal model: Restrained / σ(F): 0 / Phase error: 21.78 / Stereochemistry target values: MLHL

	Rfactor	Num. reflection	% reflection
Rfree	0.23	3742	2.02 %
Rwork	0.197	-	-
obs	0.198	185370	95.3 %
all	-	194530	-

• Solvent computation: Shrinkage radii: 0.72 Å / VDW probe radii: 1 Å / Solvent model: FLAT BULK SOLVENT MODEL / B_sol: 34.29 Ų / k_sol: 0.39 e/ų

Displacement parameters

B_iso mean: 27.2 Ų

	Baniso -1	Baniso -2	Baniso -3
1-	-8.9971 Å2	0 Å2	3.2763 Å2
2-	-	4.1251 Å2	0 Å2
3-	-	-	4.872 Å2

Refinement step

Cycle: LAST / Resolution: 2.35→33.05 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	32294	0	412	1825	34531

Refine LS restraints

Refine-ID	Type	Dev ideal	Number
X-RAY DIFFRACTION	f_bond_d	0.008	33628
X-RAY DIFFRACTION	f_angle_d	1.045	45822
X-RAY DIFFRACTION	f_dihedral_angle_d	13.197	12458
X-RAY DIFFRACTION	f_chiral_restr	0.066	5182
X-RAY DIFFRACTION	f_plane_restr	0.004	5875

Refine LS restraints NCS

Ens-ID	Dom-ID	Auth asym-ID	Number	Refine-ID	Type	Rms dev position (Å)
1	1	A	104	X-RAY DIFFRACTION	POSITIONAL
1	2	B	104	X-RAY DIFFRACTION	POSITIONAL	0.034
1	3	C	104	X-RAY DIFFRACTION	POSITIONAL	0.033
1	4	D	104	X-RAY DIFFRACTION	POSITIONAL	0.032
1	5	E	104	X-RAY DIFFRACTION	POSITIONAL	0.032
1	6	F	104	X-RAY DIFFRACTION	POSITIONAL	0.034
1	7	G	104	X-RAY DIFFRACTION	POSITIONAL	0.031
1	8	H	104	X-RAY DIFFRACTION	POSITIONAL	0.033
1	9	I	104	X-RAY DIFFRACTION	POSITIONAL	0.028
1	10	J	104	X-RAY DIFFRACTION	POSITIONAL	0.031
1	11	K	104	X-RAY DIFFRACTION	POSITIONAL	0.032
1	12	L	104	X-RAY DIFFRACTION	POSITIONAL	0.032
1	13	M	104	X-RAY DIFFRACTION	POSITIONAL	0.029
1	14	N	104	X-RAY DIFFRACTION	POSITIONAL	0.033
1	15	O	104	X-RAY DIFFRACTION	POSITIONAL	0.032
1	16	P	104	X-RAY DIFFRACTION	POSITIONAL	0.032
1	17	Q	104	X-RAY DIFFRACTION	POSITIONAL	0.03
1	18	R	104	X-RAY DIFFRACTION	POSITIONAL	0.03
1	19	S	104	X-RAY DIFFRACTION	POSITIONAL	0.032
1	20	T	104	X-RAY DIFFRACTION	POSITIONAL	0.032
2	1	A	53	X-RAY DIFFRACTION	POSITIONAL
2	2	B	53	X-RAY DIFFRACTION	POSITIONAL	0.033
2	3	C	53	X-RAY DIFFRACTION	POSITIONAL	0.031
2	4	D	53	X-RAY DIFFRACTION	POSITIONAL	0.033
2	5	E	48	X-RAY DIFFRACTION	POSITIONAL	0.036
2	6	F	53	X-RAY DIFFRACTION	POSITIONAL	0.037
2	7	G	53	X-RAY DIFFRACTION	POSITIONAL	0.032
2	8	H	53	X-RAY DIFFRACTION	POSITIONAL	0.033
2	9	I	53	X-RAY DIFFRACTION	POSITIONAL	0.035
2	10	J	53	X-RAY DIFFRACTION	POSITIONAL	0.032
2	11	K	53	X-RAY DIFFRACTION	POSITIONAL	0.035
2	12	L	53	X-RAY DIFFRACTION	POSITIONAL	0.03
2	13	M	53	X-RAY DIFFRACTION	POSITIONAL	0.034
2	14	N	53	X-RAY DIFFRACTION	POSITIONAL	0.036
2	15	O	53	X-RAY DIFFRACTION	POSITIONAL	0.033
2	16	P	53	X-RAY DIFFRACTION	POSITIONAL	0.037
2	17	Q	53	X-RAY DIFFRACTION	POSITIONAL	0.043
2	18	R	53	X-RAY DIFFRACTION	POSITIONAL	0.029
2	19	S	53	X-RAY DIFFRACTION	POSITIONAL	0.035
2	20	T	53	X-RAY DIFFRACTION	POSITIONAL	0.036
3	1	A	284	X-RAY DIFFRACTION	POSITIONAL
3	2	B	284	X-RAY DIFFRACTION	POSITIONAL	0.041
3	3	C	284	X-RAY DIFFRACTION	POSITIONAL	0.042
3	4	D	284	X-RAY DIFFRACTION	POSITIONAL	0.043
3	5	E	284	X-RAY DIFFRACTION	POSITIONAL	0.053
3	6	F	284	X-RAY DIFFRACTION	POSITIONAL	0.048
3	7	G	284	X-RAY DIFFRACTION	POSITIONAL	0.042
3	8	H	284	X-RAY DIFFRACTION	POSITIONAL	0.044
3	9	I	284	X-RAY DIFFRACTION	POSITIONAL	0.044
3	10	J	284	X-RAY DIFFRACTION	POSITIONAL	0.038
3	11	K	284	X-RAY DIFFRACTION	POSITIONAL	0.056
3	12	L	284	X-RAY DIFFRACTION	POSITIONAL	0.042
3	13	M	284	X-RAY DIFFRACTION	POSITIONAL	0.045
3	14	N	284	X-RAY DIFFRACTION	POSITIONAL	0.046
3	15	O	284	X-RAY DIFFRACTION	POSITIONAL	0.042
3	16	P	284	X-RAY DIFFRACTION	POSITIONAL	0.039
3	17	Q	284	X-RAY DIFFRACTION	POSITIONAL	0.043
3	18	R	284	X-RAY DIFFRACTION	POSITIONAL	0.04
3	19	S	284	X-RAY DIFFRACTION	POSITIONAL	0.044
3	20	T	284	X-RAY DIFFRACTION	POSITIONAL	0.047
4	1	A	11	X-RAY DIFFRACTION	POSITIONAL
4	2	B	11	X-RAY DIFFRACTION	POSITIONAL	0.02
4	3	C	11	X-RAY DIFFRACTION	POSITIONAL	0.02
4	4	D	11	X-RAY DIFFRACTION	POSITIONAL	0.03
4	5	E	11	X-RAY DIFFRACTION	POSITIONAL	0.016
4	6	F	11	X-RAY DIFFRACTION	POSITIONAL	0.018
4	7	G	11	X-RAY DIFFRACTION	POSITIONAL	0.019
4	8	H	11	X-RAY DIFFRACTION	POSITIONAL	0.034
4	9	I	11	X-RAY DIFFRACTION	POSITIONAL	0.011
4	10	J	11	X-RAY DIFFRACTION	POSITIONAL	0.024
4	11	K	11	X-RAY DIFFRACTION	POSITIONAL	0.022
4	12	L	11	X-RAY DIFFRACTION	POSITIONAL	0.013
4	13	M	11	X-RAY DIFFRACTION	POSITIONAL	0.022
4	14	N	11	X-RAY DIFFRACTION	POSITIONAL	0.033
4	15	O	11	X-RAY DIFFRACTION	POSITIONAL	0.021
4	16	Q	11	X-RAY DIFFRACTION	POSITIONAL	0.024
4	17	S	11	X-RAY DIFFRACTION	POSITIONAL	0.024
4	18	T	11	X-RAY DIFFRACTION	POSITIONAL	0.016
5	1	P	11	X-RAY DIFFRACTION	POSITIONAL
5	2	R	11	X-RAY DIFFRACTION	POSITIONAL	0.024
6	1	A	48	X-RAY DIFFRACTION	POSITIONAL
6	2	B	48	X-RAY DIFFRACTION	POSITIONAL	0.031
6	3	C	48	X-RAY DIFFRACTION	POSITIONAL	0.032
6	4	D	48	X-RAY DIFFRACTION	POSITIONAL	0.036
6	5	E	48	X-RAY DIFFRACTION	POSITIONAL	0.027
6	6	F	48	X-RAY DIFFRACTION	POSITIONAL	0.031
6	7	G	48	X-RAY DIFFRACTION	POSITIONAL	0.031
6	8	H	48	X-RAY DIFFRACTION	POSITIONAL	0.031
6	9	I	48	X-RAY DIFFRACTION	POSITIONAL	0.035
6	10	J	48	X-RAY DIFFRACTION	POSITIONAL	0.033
6	11	K	48	X-RAY DIFFRACTION	POSITIONAL	0.031
6	12	L	48	X-RAY DIFFRACTION	POSITIONAL	0.027
6	13	M	48	X-RAY DIFFRACTION	POSITIONAL	0.028
6	14	N	48	X-RAY DIFFRACTION	POSITIONAL	0.036
6	15	O	48	X-RAY DIFFRACTION	POSITIONAL	0.038
6	16	P	48	X-RAY DIFFRACTION	POSITIONAL	0.036
6	17	Q	48	X-RAY DIFFRACTION	POSITIONAL	0.03
6	18	R	48	X-RAY DIFFRACTION	POSITIONAL	0.029
6	19	S	48	X-RAY DIFFRACTION	POSITIONAL	0.03
6	20	T	48	X-RAY DIFFRACTION	POSITIONAL	0.032
7	1	A	16	X-RAY DIFFRACTION	POSITIONAL
7	2	B	16	X-RAY DIFFRACTION	POSITIONAL	0.016
7	3	C	16	X-RAY DIFFRACTION	POSITIONAL	0.017
7	4	D	16	X-RAY DIFFRACTION	POSITIONAL	0.024
7	5	E	16	X-RAY DIFFRACTION	POSITIONAL	0.017
7	6	F	16	X-RAY DIFFRACTION	POSITIONAL	0.019
7	7	G	16	X-RAY DIFFRACTION	POSITIONAL	0.019
7	8	H	16	X-RAY DIFFRACTION	POSITIONAL	0.022
7	9	I	16	X-RAY DIFFRACTION	POSITIONAL	0.023
7	10	J	16	X-RAY DIFFRACTION	POSITIONAL	0.02
7	11	K	16	X-RAY DIFFRACTION	POSITIONAL	0.02
7	12	L	16	X-RAY DIFFRACTION	POSITIONAL	0.02
7	13	M	16	X-RAY DIFFRACTION	POSITIONAL	0.033
7	14	N	16	X-RAY DIFFRACTION	POSITIONAL	0.02
7	15	O	16	X-RAY DIFFRACTION	POSITIONAL	0.024
7	16	P	16	X-RAY DIFFRACTION	POSITIONAL	0.025
7	17	Q	16	X-RAY DIFFRACTION	POSITIONAL	0.027
7	18	R	16	X-RAY DIFFRACTION	POSITIONAL	0.026
7	19	S	16	X-RAY DIFFRACTION	POSITIONAL	0.024
7	20	T	16	X-RAY DIFFRACTION	POSITIONAL	0.027
8	1	A	448	X-RAY DIFFRACTION	POSITIONAL
8	2	B	448	X-RAY DIFFRACTION	POSITIONAL	0.045
8	3	C	448	X-RAY DIFFRACTION	POSITIONAL	0.043
8	4	D	448	X-RAY DIFFRACTION	POSITIONAL	0.043
8	5	E	440	X-RAY DIFFRACTION	POSITIONAL	0.044
8	6	F	448	X-RAY DIFFRACTION	POSITIONAL	0.041
8	7	G	448	X-RAY DIFFRACTION	POSITIONAL	0.042
8	8	H	448	X-RAY DIFFRACTION	POSITIONAL	0.041
8	9	I	440	X-RAY DIFFRACTION	POSITIONAL	0.047
8	10	J	448	X-RAY DIFFRACTION	POSITIONAL	0.042
8	11	K	448	X-RAY DIFFRACTION	POSITIONAL	0.048
8	12	L	448	X-RAY DIFFRACTION	POSITIONAL	0.043
8	13	M	440	X-RAY DIFFRACTION	POSITIONAL	0.039
8	14	N	448	X-RAY DIFFRACTION	POSITIONAL	0.046
8	15	O	448	X-RAY DIFFRACTION	POSITIONAL	0.044
8	16	P	448	X-RAY DIFFRACTION	POSITIONAL	0.04
8	17	Q	448	X-RAY DIFFRACTION	POSITIONAL	0.045
8	18	R	448	X-RAY DIFFRACTION	POSITIONAL	0.041
8	19	S	448	X-RAY DIFFRACTION	POSITIONAL	0.045
8	20	T	440	X-RAY DIFFRACTION	POSITIONAL	0.044
9	1	A	24	X-RAY DIFFRACTION	POSITIONAL
9	2	B	24	X-RAY DIFFRACTION	POSITIONAL	0.059
9	3	C	24	X-RAY DIFFRACTION	POSITIONAL	0.051
9	4	D	24	X-RAY DIFFRACTION	POSITIONAL	0.05
9	5	E	24	X-RAY DIFFRACTION	POSITIONAL	0.044
9	6	F	24	X-RAY DIFFRACTION	POSITIONAL	0.034
9	7	G	24	X-RAY DIFFRACTION	POSITIONAL	0.027
9	8	H	24	X-RAY DIFFRACTION	POSITIONAL	0.056
9	9	J	24	X-RAY DIFFRACTION	POSITIONAL	0.052
9	10	K	24	X-RAY DIFFRACTION	POSITIONAL	0.053
9	11	M	24	X-RAY DIFFRACTION	POSITIONAL	0.057
9	12	N	24	X-RAY DIFFRACTION	POSITIONAL	0.031
9	13	O	24	X-RAY DIFFRACTION	POSITIONAL	0.044
9	14	Q	24	X-RAY DIFFRACTION	POSITIONAL	0.062
9	15	R	24	X-RAY DIFFRACTION	POSITIONAL	0.064
9	16	S	24	X-RAY DIFFRACTION	POSITIONAL	0.068
9	17	T	24	X-RAY DIFFRACTION	POSITIONAL	0.054
10	1	I	24	X-RAY DIFFRACTION	POSITIONAL
10	2	P	24	X-RAY DIFFRACTION	POSITIONAL	0.053
10	3	L	24	X-RAY DIFFRACTION	POSITIONAL	0.029
11	1	A	121	X-RAY DIFFRACTION	POSITIONAL
11	2	B	121	X-RAY DIFFRACTION	POSITIONAL	0.048
11	3	C	121	X-RAY DIFFRACTION	POSITIONAL	0.041
11	4	D	121	X-RAY DIFFRACTION	POSITIONAL	0.041
11	5	E	121	X-RAY DIFFRACTION	POSITIONAL	0.044
11	6	F	121	X-RAY DIFFRACTION	POSITIONAL	0.039
11	7	G	121	X-RAY DIFFRACTION	POSITIONAL	0.039
11	8	H	121	X-RAY DIFFRACTION	POSITIONAL	0.042
11	9	I	121	X-RAY DIFFRACTION	POSITIONAL	0.045
11	10	J	121	X-RAY DIFFRACTION	POSITIONAL	0.037
11	11	K	121	X-RAY DIFFRACTION	POSITIONAL	0.048
11	12	L	121	X-RAY DIFFRACTION	POSITIONAL	0.042
11	13	M	121	X-RAY DIFFRACTION	POSITIONAL	0.033
11	14	N	121	X-RAY DIFFRACTION	POSITIONAL	0.041
11	15	O	121	X-RAY DIFFRACTION	POSITIONAL	0.043
11	16	P	121	X-RAY DIFFRACTION	POSITIONAL	0.039
11	17	Q	121	X-RAY DIFFRACTION	POSITIONAL	0.037
11	18	R	121	X-RAY DIFFRACTION	POSITIONAL	0.042
11	19	S	121	X-RAY DIFFRACTION	POSITIONAL	0.041
11	20	T	121	X-RAY DIFFRACTION	POSITIONAL	0.043
12	1	A	63	X-RAY DIFFRACTION	POSITIONAL
12	2	I	63	X-RAY DIFFRACTION	POSITIONAL	0.041
12	3	R	63	X-RAY DIFFRACTION	POSITIONAL	0.04
13	1	B	63	X-RAY DIFFRACTION	POSITIONAL
13	2	C	63	X-RAY DIFFRACTION	POSITIONAL	0.038
13	3	D	63	X-RAY DIFFRACTION	POSITIONAL	0.049
13	4	E	63	X-RAY DIFFRACTION	POSITIONAL	0.047
13	5	F	63	X-RAY DIFFRACTION	POSITIONAL	0.063
13	6	G	63	X-RAY DIFFRACTION	POSITIONAL	0.04
13	7	H	63	X-RAY DIFFRACTION	POSITIONAL	0.038
13	8	J	63	X-RAY DIFFRACTION	POSITIONAL	0.043
13	9	K	63	X-RAY DIFFRACTION	POSITIONAL	0.04
13	10	L	63	X-RAY DIFFRACTION	POSITIONAL	0.04
13	11	M	63	X-RAY DIFFRACTION	POSITIONAL	0.041
13	12	N	63	X-RAY DIFFRACTION	POSITIONAL	0.035
13	13	O	63	X-RAY DIFFRACTION	POSITIONAL	0.047
13	14	P	63	X-RAY DIFFRACTION	POSITIONAL	0.042
13	15	Q	63	X-RAY DIFFRACTION	POSITIONAL	0.039
13	16	S	63	X-RAY DIFFRACTION	POSITIONAL	0.051
13	17	T	63	X-RAY DIFFRACTION	POSITIONAL	0.055
14	1	A	182	X-RAY DIFFRACTION	POSITIONAL
14	2	B	182	X-RAY DIFFRACTION	POSITIONAL	0.061
14	3	C	182	X-RAY DIFFRACTION	POSITIONAL	0.045
14	4	D	182	X-RAY DIFFRACTION	POSITIONAL	0.049
14	5	E	182	X-RAY DIFFRACTION	POSITIONAL	0.058
14	6	F	174	X-RAY DIFFRACTION	POSITIONAL	0.044
14	7	G	182	X-RAY DIFFRACTION	POSITIONAL	0.046
14	8	H	182	X-RAY DIFFRACTION	POSITIONAL	0.042
14	9	I	182	X-RAY DIFFRACTION	POSITIONAL	0.051
14	10	J	182	X-RAY DIFFRACTION	POSITIONAL	0.04
14	11	K	182	X-RAY DIFFRACTION	POSITIONAL	0.05
14	12	L	182	X-RAY DIFFRACTION	POSITIONAL	0.048
14	13	M	182	X-RAY DIFFRACTION	POSITIONAL	0.041
14	14	N	182	X-RAY DIFFRACTION	POSITIONAL	0.051
14	15	O	182	X-RAY DIFFRACTION	POSITIONAL	0.04
14	16	P	182	X-RAY DIFFRACTION	POSITIONAL	0.04
14	17	Q	182	X-RAY DIFFRACTION	POSITIONAL	0.044
14	18	R	182	X-RAY DIFFRACTION	POSITIONAL	0.045
14	19	S	182	X-RAY DIFFRACTION	POSITIONAL	0.041
14	20	T	182	X-RAY DIFFRACTION	POSITIONAL	0.046
15	1	A	25	X-RAY DIFFRACTION	POSITIONAL
15	2	C	25	X-RAY DIFFRACTION	POSITIONAL	0.04
15	3	D	25	X-RAY DIFFRACTION	POSITIONAL	0.064
15	4	E	25	X-RAY DIFFRACTION	POSITIONAL	0.047
15	5	F	25	X-RAY DIFFRACTION	POSITIONAL	0.046
15	6	G	25	X-RAY DIFFRACTION	POSITIONAL	0.04
15	7	H	25	X-RAY DIFFRACTION	POSITIONAL	0.043
15	8	I	25	X-RAY DIFFRACTION	POSITIONAL	0.045
15	9	J	25	X-RAY DIFFRACTION	POSITIONAL	0.045
15	10	K	25	X-RAY DIFFRACTION	POSITIONAL	0.041
15	11	L	25	X-RAY DIFFRACTION	POSITIONAL	0.049
15	12	N	25	X-RAY DIFFRACTION	POSITIONAL	0.048
15	13	O	25	X-RAY DIFFRACTION	POSITIONAL	0.053
15	14	Q	25	X-RAY DIFFRACTION	POSITIONAL	0.041
15	15	R	25	X-RAY DIFFRACTION	POSITIONAL	0.054
15	16	S	25	X-RAY DIFFRACTION	POSITIONAL	0.05
15	17	T	25	X-RAY DIFFRACTION	POSITIONAL	0.051
16	1	B	25	X-RAY DIFFRACTION	POSITIONAL
16	2	M	25	X-RAY DIFFRACTION	POSITIONAL	0.048
16	3	P	25	X-RAY DIFFRACTION	POSITIONAL	0.07
17	1	B	12	X-RAY DIFFRACTION	POSITIONAL
17	2	F	12	X-RAY DIFFRACTION	POSITIONAL	0.032
17	3	G	12	X-RAY DIFFRACTION	POSITIONAL	0.083
17	4	H	12	X-RAY DIFFRACTION	POSITIONAL	0.041
17	5	O	12	X-RAY DIFFRACTION	POSITIONAL	0.038
18	1	D	18	X-RAY DIFFRACTION	POSITIONAL
18	2	E	18	X-RAY DIFFRACTION	POSITIONAL	0.029
18	3	J	12	X-RAY DIFFRACTION	POSITIONAL	0.035
18	4	K	12	X-RAY DIFFRACTION	POSITIONAL	0.03
18	5	M	12	X-RAY DIFFRACTION	POSITIONAL	0.047
18	6	N	18	X-RAY DIFFRACTION	POSITIONAL	0.033
18	7	P	12	X-RAY DIFFRACTION	POSITIONAL	0.056
18	8	Q	12	X-RAY DIFFRACTION	POSITIONAL	0.028
18	9	R	12	X-RAY DIFFRACTION	POSITIONAL	0.035
18	10	T	18	X-RAY DIFFRACTION	POSITIONAL	0.031
19	1	C	12	X-RAY DIFFRACTION	POSITIONAL
19	2	I	12	X-RAY DIFFRACTION	POSITIONAL	0.039
19	3	L	12	X-RAY DIFFRACTION	POSITIONAL	0.027
19	4	S	12	X-RAY DIFFRACTION	POSITIONAL	0.029
20	1	A	135	X-RAY DIFFRACTION	POSITIONAL
20	2	B	135	X-RAY DIFFRACTION	POSITIONAL	0.052
20	3	C	135	X-RAY DIFFRACTION	POSITIONAL	0.046
20	4	D	135	X-RAY DIFFRACTION	POSITIONAL	0.047
20	5	E	135	X-RAY DIFFRACTION	POSITIONAL	0.052
20	6	F	135	X-RAY DIFFRACTION	POSITIONAL	0.048
20	7	G	135	X-RAY DIFFRACTION	POSITIONAL	0.05
20	8	H	135	X-RAY DIFFRACTION	POSITIONAL	0.05
20	9	I	135	X-RAY DIFFRACTION	POSITIONAL	0.051
20	10	J	135	X-RAY DIFFRACTION	POSITIONAL	0.046
20	11	K	135	X-RAY DIFFRACTION	POSITIONAL	0.053
20	12	L	135	X-RAY DIFFRACTION	POSITIONAL	0.047
20	13	M	135	X-RAY DIFFRACTION	POSITIONAL	0.046
20	14	N	135	X-RAY DIFFRACTION	POSITIONAL	0.044
20	15	O	135	X-RAY DIFFRACTION	POSITIONAL	0.049
20	16	P	135	X-RAY DIFFRACTION	POSITIONAL	0.045
20	17	Q	135	X-RAY DIFFRACTION	POSITIONAL	0.041
20	18	R	135	X-RAY DIFFRACTION	POSITIONAL	0.05
20	19	S	135	X-RAY DIFFRACTION	POSITIONAL	0.05
20	20	T	135	X-RAY DIFFRACTION	POSITIONAL	0.042

LS refinement shell

Resolution (Å)	Rfactor Rfree	Num. reflection Rfree	Rfactor Rwork	Num. reflection Rwork	Refine-ID	% reflection obs (%)
2.35-2.3797	0.2962	107	0.2642	5713	X-RAY DIFFRACTION	82
2.3797-2.411	0.3296	109	0.2539	5771	X-RAY DIFFRACTION	82
2.411-2.4441	0.2779	114	0.2481	5830	X-RAY DIFFRACTION	83
2.4441-2.479	0.3005	126	0.2424	5860	X-RAY DIFFRACTION	85
2.479-2.516	0.3106	140	0.243	6032	X-RAY DIFFRACTION	85
2.516-2.5553	0.2893	137	0.2342	6057	X-RAY DIFFRACTION	87
2.5553-2.5971	0.3049	136	0.226	6350	X-RAY DIFFRACTION	90
2.5971-2.6419	0.2684	135	0.2273	6420	X-RAY DIFFRACTION	92
2.6419-2.6899	0.2754	152	0.2218	6662	X-RAY DIFFRACTION	95
2.6899-2.7416	0.265	138	0.2082	6748	X-RAY DIFFRACTION	96
2.7416-2.7976	0.2751	140	0.2082	6926	X-RAY DIFFRACTION	98
2.7976-2.8584	0.2594	136	0.2048	6899	X-RAY DIFFRACTION	99
2.8584-2.9248	0.2562	137	0.2109	7030	X-RAY DIFFRACTION	100
2.9248-2.9979	0.2457	127	0.2073	7027	X-RAY DIFFRACTION	100
2.9979-3.0789	0.2538	138	0.2138	7062	X-RAY DIFFRACTION	100
3.0789-3.1694	0.2383	138	0.2121	7052	X-RAY DIFFRACTION	100
3.1694-3.2717	0.2404	155	0.2088	6999	X-RAY DIFFRACTION	100
3.2717-3.3885	0.2272	131	0.2014	7079	X-RAY DIFFRACTION	100
3.3885-3.524	0.226	141	0.1915	7081	X-RAY DIFFRACTION	100
3.524-3.6842	0.2224	163	0.1834	7077	X-RAY DIFFRACTION	100
3.6842-3.8781	0.207	127	0.1793	7082	X-RAY DIFFRACTION	100
3.8781-4.1207	0.2089	161	0.164	7041	X-RAY DIFFRACTION	100
4.1207-4.4382	0.1601	148	0.1496	7086	X-RAY DIFFRACTION	100
4.4382-4.8835	0.1843	158	0.1431	7135	X-RAY DIFFRACTION	100
4.8835-5.5872	0.1686	137	0.1611	7149	X-RAY DIFFRACTION	100
5.5872-7.0282	0.2256	166	0.2196	7155	X-RAY DIFFRACTION	100
7.0282-33.0493	0.2046	145	0.2221	7305	X-RAY DIFFRACTION	99

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°2)	L12 (°2)	L13 (°2)	L22 (°2)	L23 (°2)	L33 (°2)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å2)	T12 (Å2)	T13 (Å2)	T22 (Å2)	T23 (Å2)	T33 (Å2)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	0.1738	-0.064	0.0692	0.0695	-0.0469	0.0447	0.0557	-0.0697	-0.0931	0.1391	0.0196	-0.0625	-0.0834	0.0366	-0	0.1387	-0.0859	0.0472	0.0894	-0.059	0.2671	70.0577	-0.6062	82.5191
2	0.0081	0.0075	0.0006	0.0058	0.0024	0.0045	0.1104	-0.0383	-0.0826	0.048	0.0724	-0.0383	0.0818	0.0319	0	0.1504	-0.0536	0.0185	0.1787	-0.0934	0.1963	73.4108	16.9208	97.6299
3	0.0112	-0.0009	0.0103	0.0048	-0.0095	0.0158	0.1988	-0.033	0.0315	-0.0532	0.1751	-0.0182	0.0338	0.0045	0.0004	0.0775	0.007	0.0335	0.0876	-0.0153	0.3021	77.6997	7.5891	118.4787
4	0.0106	-0.0045	-0.0072	-0.0009	0.0068	0.0099	-0.0349	0.0734	-0.0162	0.0396	-0.1185	-0.0912	-0.0292	0.0263	0.0001	0.0548	0.001	0.0155	0.2278	-0.0746	0.1739	76.9305	-15.6628	116.3919
5	0.0081	-0.0058	0.0012	0.0038	-0.0001	0.0008	0.0058	-0.0074	0.0641	0.0263	0.0287	-0.0226	-0.0371	0.0669	-0	0.1445	0.002	0.0424	0.2275	-0.0273	0.1843	72.1766	-20.6502	94.0574
6	0.0048	-0.0093	0.0007	0.0069	-0.0039	0.0038	0.1268	0.0282	-0.088	0.0812	-0.0337	0.0616	0.0226	0.0228	-0.0001	0.1008	-0.0071	-0.0181	0.2253	-0.0859	0.3295	84.4048	14.5847	109.3456
7	0.042	0.0001	-0.028	0.0044	0.0081	0.0257	0.1703	-0.0867	0.0293	-0.0067	0.0707	-0.0411	0.0577	0.0593	0.0015	0.1126	-0.1047	0.0192	0.2052	-0.1708	0.3639	79.721	11.7447	86.6316
8	0.0068	0.0089	0.0014	0.0085	-0.0044	0.003	-0.079	-0.0561	0.0465	-0.0161	-0.0149	0.0841	0.0157	-0.0329	-0	0.1006	-0.0722	0.0048	0.1592	-0.0568	0.1591	78.5469	-11.1733	82.4458
9	0.002	-0.0004	-0.0094	0	0.0046	0.0084	-0.0134	-0.0357	0.0327	-0.0175	-0.0363	0.0309	0.0273	-0.0359	0	0.1925	-0.0266	0.0394	0.2138	-0.0983	0.1767	82.5967	-22.2739	102.5723
10	0.0122	0.0088	-0.0069	0.005	-0.0033	0.0023	-0.0035	-0.0473	-0.0508	0.0453	0.0935	0.0099	0.1017	-0.004	0	0.1675	-0.0105	0.0341	0.2416	-0.048	0.1888	86.2333	-6.3811	119.1453
11	0.0116	0.0058	0.0089	0.0139	0.015	0.0106	0.0102	0.1517	-0.141	-0.0906	-0.0847	-0.0107	-0.0322	0.0072	-0	0.0862	-0.0337	-0.0157	0.1484	0.0029	0.2213	55.4486	-14.2785	19.4991
12	0.0079	-0.0004	0.0009	0.0084	-0.0081	0.0052	-0.0309	0.0032	0.0039	-0.0539	0.0393	0.0068	-0.13	0.0598	0	0.0857	-0.0403	-0.0037	0.2406	-0.1473	0.4226	60.5864	-9.2977	41.6538
13	-0.001	0.0021	-0.0019	0.0125	0.0041	0.0024	0.0538	0.1107	-0.0067	-0.0035	-0.0519	0.0333	0.0104	0.0227	-0.0001	0.1114	0.0182	-0.0219	0.1064	-0.0355	0.207	63.4437	-29.3694	52.9192
14	0.0139	-0.0068	0.0056	0.0043	0.0011	0.0039	-0.0518	0.0308	0.0559	-0.0583	-0.0276	-0.0652	-0.074	-0.0697	0	0.0729	-0.0423	-0.0023	0.1295	-0.0445	0.1278	60.0962	-46.7308	37.6599
15	0.003	0.0075	-0.0054	0.0056	-0.003	-0.0001	-0.1647	-0.0301	-0.0412	-0.018	-0.0338	0.0009	0.0121	0.0088	-0.0001	0.1291	-0.0333	0.0357	0.2474	0.0088	0.206	55.221	-37.3856	17.0648
16	0.001	-0.0047	-0.0062	0.0036	-0.0028	0.0173	-0.059	0.0187	0.0949	-0.005	-0.0157	0.0779	0.0816	-0.0052	0	0.0906	-0.0252	0.083	0.1397	-0.0941	0.1887	70.2432	-41.8191	44.8179
17	0.0494	-0.0768	0.0089	0.2001	0.0327	0.0514	-0.1145	-0.1517	-0.0714	0.2446	0.0123	-0.0015	0.075	-0.0533	0.0003	0.0628	-0.0215	-0.0289	0.1384	-0.0325	0.1707	71.2237	-19.038	49.6461
18	0.0085	-0.0015	0.012	0.0025	0.0072	0.0091	0.0724	-0.0394	0.1121	-0.0373	0.0841	0.0563	-0.0255	0.0166	0.0001	0.1173	-0.0211	-0.0015	0.2225	-0.0186	0.2702	66.5454	-7.6248	29.8581
19	0.0074	-0.0051	0.0009	0.0097	0.0017	0.0012	0.1205	-0.0378	0.08	0.1024	-0.0149	-0.0574	-0.0434	-0.0769	0	0.0932	-0.0984	0.0027	0.2798	0.0663	0.2322	62.6894	-23.2459	13.0198
20	0.013	0.0059	0.0136	0.098	-0.0509	0.0479	0.0714	0.012	-0.0573	0.0281	0.032	0.0546	-0.0104	-0.0092	0.0113	0.0897	-0.069	0.0033	0.2252	-0.1159	0.2055	64.9918	-44.3763	22.2061
21	0.0215	0.018	-0.0056	0.0165	-0.0102	0.0204	0.0267	0.0297	0.015	-0.1052	0.1049	-0.0426	-0.0528	0.0695	0.0213	0.1287	-0.0826	0.0708	0.1358	-0.1742	0.2647	65.4691	16.7356	89.8135
22	0.0457	0.0315	-0.0403	0.1382	0.0632	0.1049	-0.0822	-0.0892	0.0585	-0.0345	-0.0076	0.0151	0.011	-0.0002	-0.0351	0.0192	-0.038	-0.0721	0.2811	-0.0629	0.1783	71.0137	16.4469	116.8121
23	0.0016	0.0009	0.0104	0.0044	-0.0024	0.0312	-0.0376	0.0047	-0.0753	-0.0391	0.0143	-0.0797	-0.0207	0.0106	-0.0026	0.0481	0.0606	-0.0139	0.112	-0.0505	0.1778	72.3376	-9.8863	124.7347
24	0.0096	0.0166	0.0043	0.0519	-0.0074	0.0155	-0.0763	0.0104	0.0094	0.0166	-0.0175	-0.0028	0.0812	0.0333	-0.0068	0.1361	0.0066	0.0617	0.1755	-0.0747	0.1277	67.5743	-25.8907	102.8234
25	0.0035	0.0001	-0.0005	0.0005	-0.003	0.0017	-0.0209	0.0187	-0.0288	-0.0536	-0.0775	-0.0884	0.0263	0.0613	0	0.1051	-0.0491	0.1125	0.0188	-0.0416	0.2542	63.263	-8.7125	81.9795
26	0.0078	0.0066	-0.0019	0.0204	0.0011	0.0001	-0.0309	0.0092	0.0531	0.0308	-0.0182	-0.0204	-0.0508	0.0167	0.0027	0.0356	-0.0247	0.0083	0.2441	-0.1959	0.3266	86.974	19.1102	90.63
27	0.0022	0.0061	0.0008	0.0288	0.0048	0.0002	0.0342	0.0417	-0.0282	-0.0421	-0.0435	0.0454	-0.0274	-0.0207	0.0173	0.1082	-0.1436	-0.0314	0.2561	-0.1624	0.1326	83.7291	-3.7107	75.709
28	0.0319	-0.0153	0.0016	0.0104	0.0009	0.0022	0.0142	0.0607	-0.0781	0.0316	0.0016	0.0157	-0.0348	-0.0196	0.0302	0.1242	-0.0911	0.086	0.1881	-0.0509	0.0681	86.9389	-25.2753	92.601
29	0.0017	0.0014	0.0014	0.0086	-0.0085	0.0073	0.0401	-0.0737	-0.0877	0.0217	-0.0368	-0.0093	0.0159	-0.0103	0	0.2301	0.0205	0.106	0.292	-0.0717	0.0617	92.3091	-15.7004	117.9211
30	0.0032	-0.0025	0.0011	-0.0005	-0.0008	0.0009	0.0623	0.0051	-0	0.0346	0.0373	0.0468	-0.014	-0.0125	-0.0001	0.13	-0.0111	0.0983	0.1796	-0.0337	0.3243	92.3173	11.8382	116.7121
31	0.0043	-0.0007	-0.0026	0.0028	0.0051	0.0047	0.0651	0.016	0.0579	-0.0594	0.0162	-0.0058	-0.033	0.0063	0.0001	0.0812	-0.0224	-0.0571	0.1301	-0.0056	0.2968	52.7273	-4.018	35.6659
32	0.0032	-0.0004	0.0027	0.0071	0.002	0.0124	-0.0332	-0.0174	0.0675	-0.0795	-0.08	-0.0932	0.0362	0.0599	-0.0001	0.0654	0.0593	-0.0521	0.1298	-0.0198	0.2862	57.8505	-20.7837	56.8799
33	0.021	-0.0223	0.018	0.0238	-0.0194	0.0138	-0.0161	-0.0003	-0.0885	0.0244	0.1017	-0.0812	0.0009	0.0753	-0.0039	0.1524	0.0315	0.0266	0.0634	-0.113	0.2802	56.1494	-46.6031	48.1445
34	0.005	0.0063	-0.0029	0.0088	0.0042	0.0057	-0.0584	0.063	-0.0359	-0.0084	-0.1082	-0.0102	-0.0145	-0.0077	0	0.0754	-0.0077	0.0147	0.2861	-0.0108	0.0224	49.8775	-46.302	21.317
35	0.0062	-0.0187	-0.008	0.0605	0.0239	0.0094	-0.0228	0.0556	0.0215	0.0403	0.1069	-0.105	0.0477	0.0362	0.0004	0.0603	-0.0441	0.0657	0.2253	0.0345	0.0785	47.7512	-20.0397	13.6315
36	0.0008	-0.0014	0.0033	-0.0007	-0.0019	0.0088	-0.0049	-0.1372	-0.034	-0.024	-0.0372	0.0562	-0.0464	0.0231	0	0.0665	-0.0071	-0.0524	0.1855	-0.0421	0.2146	78.6118	-26.6544	53.3438
37	0.0419	-0.012	-0.0294	0.0236	0.0093	0.0237	0.0794	-0.0637	0.0635	-0.0252	0.0158	0.0079	0.0248	0.0427	-0.0009	0.2054	0.032	-0.0433	0.0359	-0.0209	0.2396	74.7132	-4.8503	37.0943
38	0.0161	-0.0136	0.0104	0.0539	-0.0331	0.0219	0.0276	0.1123	0.0564	0.0459	-0.0126	0.0298	0.0408	-0.0738	0.0123	0.0763	-0.1238	-0.048	0.3237	0.0048	0.1914	68.7709	-13.8438	11.7771
39	0.0019	0.0004	0.0054	0.0061	0.0089	0.0159	0.0347	-0.0332	-0.0887	0.0186	0.031	0.0864	0.002	-0.0033	0.0001	0.1869	-0.1327	-0.0267	0.222	-0.0893	0.1953	69.1952	-41.3606	12.2115
40	0.0029	-0.0004	0.0012	0.016	-0.0009	0.0001	-0.1296	-0.0172	-0.0358	0.0025	-0.0155	0.017	0.012	-0.0487	0	0.1527	-0.0388	0.0283	0.1896	-0.0821	0.1878	75.1331	-49.141	37.9674
41	0.4136	0.0709	0.267	0.0942	0.0006	0.217	0.0017	-0.2404	-0.0425	-0.0779	0.0244	0.1106	-0.1442	0.0375	0.2319	0.1017	-0.0074	-0.0109	0.0817	-0.0282	-0.0136	41.7275	10.9108	91.1377
42	0.2051	-0.052	0.1148	0.1932	0.1379	0.1723	0.1026	-0.2443	0.0196	0.12	-0.008	-0.086	-0.16	-0.1429	0.1816	0.1087	-0.0246	-0.0127	-0.0042	-0.1001	-0.0551	46.6594	18.0971	114.6407
43	0.0707	0.0299	0.0809	0.1637	0.1119	0.3897	-0.0008	-0.1309	-0.0257	0.0675	0.0564	-0.0292	-0.1214	-0.0613	0.1831	0.0793	-0.0213	0.0239	0.0335	-0.0441	-0.0412	49.351	-2.4969	128.7586
44	0.075	0.0556	-0.071	0.0272	-0.0797	0.2661	0.0754	0.0318	-0.0599	-0.0209	-0.0234	0.0084	-0.0051	-0.0902	0.132	0.0651	-0.0191	-0.0144	0.0542	-0.0095	0.0151	46.0452	-22.4387	114.0924
45	0.045	0.0036	0.0064	0.333	0.1946	0.0923	0.0931	0.0819	0.1194	-0.2109	0.0751	-0.0063	-0.0536	-0.0483	0.3735	0.0464	-0.0396	0.0081	-0.2968	-0.2455	-0.0919	41.1882	-14.1892	90.9952
46	0.0722	0.0887	-0.0706	0.1474	-0.0754	0.0583	0.0934	-0.1027	-0.0237	0.1104	-0.1125	0.0419	-0.0991	0.0876	-0.0054	0.0546	-0.0748	0.0382	0.1509	-0.1009	0.1458	111.3395	18.4306	92.9147
47	0.0531	0.0826	-0.0081	0.0932	-0.0915	0.0847	-0.0006	-0.0258	-0.1407	-0.147	0.005	-0.0045	-0.0552	0.033	-0.0543	0.113	-0.0761	0.0197	0.128	-0.07	0.1152	107.2862	2.5456	73.842
48	0.2219	0.2027	-0.1298	0.1517	-0.0633	0.1904	0.1094	-0.0936	-0.162	0.0325	-0.0976	-0.064	-0.0052	0.056	-0.0771	0.029	-0.022	0.0044	0.1016	-0.0512	0.0874	108.8345	-20.9051	82.5611
49	0.082	0.0315	-0.0077	0.0713	0.0406	0.0117	0.1683	-0.0564	-0.0713	0.1517	-0.0188	-0.1084	0.0279	0.0722	0.0591	0.0104	-0.0554	-0.0018	0.1673	-0.0561	0.1742	113.9488	-19.6454	107.1003
50	0.2542	0.0589	-0.1258	0.0366	0.0278	0.1711	0.1438	-0.1195	0.1256	0.1047	-0.0128	-0.1016	-0.0889	0.0762	0.0977	0.076	-0.0526	-0.034	0.1426	-0.0723	0.1322	115.4749	4.5559	113.481
51	0.1146	-0.0962	0.1146	0.1556	-0.054	0.1033	0.0216	-0.0835	0.1438	-0.1349	-0.0282	0.0259	-0.1553	-0.1082	-0.0287	0.0588	0.0329	-0.0148	0.1035	0.0015	0.0998	28.3557	-7.3167	34.5183
52	0.0124	-0.0534	-0.0384	0.1129	0.145	0.1435	-0.0315	-0.0937	-0.0683	0.1604	-0.0001	-0.0013	0.058	-0.0016	-0.0221	0.0978	-0.0078	0.0087	0.0763	-0.0252	0.1903	33.7681	-15.7089	57.3812
53	0.0298	-0.0023	-0.0648	0.0082	0.0549	0.1383	0.0999	0.0403	-0.0625	-0.0016	-0.0619	-0.0137	0.1362	-0.1164	0.1098	0.1258	-0.0353	-0.0105	0.1043	-0.0331	0.0783	34.0532	-40.8406	56.9307
54	0.2382	-0.079	-0.1666	0.136	0.0302	0.2208	0.0887	0.1028	-0.0806	-0.0452	-0.0879	0.0752	0.0717	-0.1243	0.0583	0.0698	-0.0194	-0.0068	0.0809	-0.0561	0.1267	28.683	-48.0503	33.5738
55	0.1615	0.0034	-0.0071	0.139	-0.0854	0.2472	0.1919	-0.0523	0.0982	-0.0245	-0.0532	0.1285	-0.1752	0.0525	0.0225	0.0362	0.022	0.0055	0.126	-0.0203	0.1162	25.2038	-27.495	19.6949
56	0.0404	-0.0589	0.0617	0.0276	-0.0756	0.0656	-0.0048	-0.0434	-0.1467	0.0977	-0.0461	-0.1693	0.0134	0.1341	-0.0001	0.0578	0.0104	0.0371	0.1844	-0.0315	0.179	100.7417	-33.1679	45.156
57	0.3062	-0.1518	0.0518	0.2307	0.0951	0.1573	0.1765	0.0985	0.1576	-0.1715	-0.1845	-0.117	-0.2025	0.0341	-0.1334	-0.1032	-0.1898	-0.0145	0.1151	-0.1213	0.13	98.801	-9.6499	36.8178
58	0.0538	0.0596	-0.0266	0.1335	0.0178	0.042	-0.0271	0.1606	0.0685	-0.158	-0.0019	-0.0828	-0.0334	0.0667	-0.0484	0.022	-0.0238	0.0417	0.1825	0.0213	0.1118	93.054	-10.1673	12.3931
59	0.0139	-0.0114	-0.0202	0.0705	-0.0101	0.1049	-0.0044	0.0703	-0.0587	-0.1348	-0.0066	-0.1285	0.0985	0.0785	0.0011	0.0336	-0.0326	0.0218	0.2312	-0.0632	0.1373	91.5614	-34.1689	5.3825
60	0.0163	-0.0333	0.0211	0.2444	-0.0872	0.4632	0.0837	-0.0184	-0.1448	0.1168	-0.1051	0.0412	0.1918	0.2971	-0.0072	0.0272	0.0268	0.0313	0.1725	-0.0876	0.2124	96.3012	-48.3345	25.601
61	5.1636	-2.2938	4.4083	7.5952	-1.6473	4.468	0.1951	0.207	-0.0105	-0.1975	-0.2168	-0.0544	0.1164	0.1671	0.0078	0.375	-0.0377	-0.0799	0.3621	-0.0449	0.4357	65.8082	15.7635	79.2563
62	5.0552	-4.0227	-3.2813	7.9861	1.0282	2.6537	0.0472	0.0028	0.0286	-0.064	0.0118	-0.08	-0.0339	0.0304	-0.0646	0.2577	-0.0593	0.0314	0.3238	-0.0638	0.3889	72.7415	25.8276	112.3315
63	0.3854	0.4061	-1.1326	0.8873	-1.6557	4.2762	0.0099	-0.0126	0.0071	0.0252	-0.0215	-0.0133	-0.0212	0.0534	0.0098	0.1564	-0.079	0.0299	0.2667	0.0454	0.3743	76.383	-3.1339	131.734
64	2.7491	4.9106	-2.6374	8.7987	-4.6702	2.5949	-0.0069	-0.0269	-0.0561	0.0312	-0.0161	-0.0727	-0.0238	0.0038	-0.0065	0.2443	-0.1051	0.0757	0.3515	-0.0977	0.3626	71.7516	-31.2162	111.1298
65	5.7574	6.274	6.213	6.9681	6.606	6.9109	0.0759	0.057	-0.1431	0.0314	0.0269	-0.0919	0.0843	0.0766	-0.1246	0.0578	0.0953	-0.1249	0.3568	0.0895	0.1881	64.9667	-19.3731	78.7042
66	6.2444	5.0027	-5.7262	4.5992	-3.3248	7.9507	0.1045	-0.0111	0.0652	0.2048	0.0039	0.148	-0.086	-0.0029	-0.0949	0.486	0.0586	-0.0403	0.3388	-0.0437	0.5827	85.806	27.0166	97.5529
67	2.464	0.8157	-4.3034	0.2713	-1.426	7.5183	0.0299	0.0232	0.0153	-0.0068	-0.0128	0.0025	-0.0774	-0.0941	-0.028	0.1836	-0.0156	-0.0211	0.4826	-0.0362	0.2662	80.2815	4.9314	70.8028
68	4.5051	-5.6504	-3.6175	7.7576	3.9417	6.1364	0.0284	0.0323	-0.0388	-0.0702	-0.0757	0.1173	-0.0124	-0.0235	0.0244	0.0542	-0.0685	0.0032	0.4171	0.054	0.4591	82.53	-27.9498	83.595
69	3.5054	0.3385	4.0202	4.2348	0.1313	4.7309	0.074	-0.0732	-0.1551	-0.0614	0.0407	0.1508	0.0329	-0.0847	-0.1305	0.212	-0.0066	-0.0118	0.2228	0.0392	0.3337	89.6769	-26.0233	117.7522
70	4.9951	4.9352	6.3295	4.9349	6.2767	8.7297	0.1487	-0.1865	-0.0161	0.1041	-0.1776	0.0304	0.1159	-0.1778	0.0033	0.4834	0.018	-0.0146	0.5167	-0.0304	0.4599	91.79	7.9702	126.5559
71	1.79	2.0366	0.0092	2.3415	-0.029	0.0639	0.0695	0.0496	0.0167	-0.1227	-0.0621	-0.1026	-0.0022	0.0102	-0.0199	0.2857	0.0527	-0.1229	0.2558	0.1108	0.4013	53.0188	1.2053	26.4526
72	9.3463	-3.8707	-9.6662	4.1437	3.8532	2	0.0848	-0.0257	0.051	-0.0927	0.0553	-0.0809	-0.1936	0.1224	-0.1486	0.4502	0.0303	0.0248	0.4585	-0.1327	0.3047	60.6071	-10.6249	58.6785
73	3.5396	3.9208	-3.6758	5.7847	-2.1897	6.2765	0.0202	-0.0524	-0.0434	0.042	-0.0949	-0.0948	-0.0345	0.0455	0.048	0.2714	0.0436	-0.0636	0.2828	-0.1306	0.3205	60.7149	-45.8365	57.5352
74	8.5851	7.7761	5.6248	7.9108	5.9225	4.4747	0.0579	0.0138	-0.0587	0.0328	0.0183	-0.1413	0.0117	0.0014	-0.0374	0.1241	0.0063	0.0426	0.12	-0.0118	0.3157	53.431	-55.6529	24.7391
75	3.6155	-2.9579	2.344	3.1197	-2.6827	2.3556	0.05	0.0972	-0.0229	-0.0347	-0.0739	0.0037	0.0535	0.1181	-0.007	0.2806	0.0614	0.0653	0.4909	0.0889	0.3305	48.5074	-26.7176	5.6104
76	6.0802	2.1998	6.4685	2.0217	2.4767	6.8972	0.1436	-0.14	0.0178	0.1709	-0.2047	0.0934	0.0039	-0.0552	0.0099	0.2533	0.1014	0.1906	0.3365	-0.1149	0.4748	74.7138	-2.529	47.3126
77	1.7071	-2.0281	-2.4771	8.3841	1.3478	4.3755	0.0297	0.0352	-0.0257	-0.0147	-0.0827	0.0418	-0.0511	-0.0944	0.047	0.304	0.051	-0.0638	0.4441	0.0951	0.3378	64.5098	-37.2395	3.5576
78	2.3245	1.3978	1.0203	3.1872	-1.0246	1.5914	0.0496	0.0186	-0.1221	-0.0466	-0.0185	0.1521	0.0047	-0.0128	-0.03	0.3822	0.1436	0.0539	0.4117	0.0859	0.4053	71.2836	-56.9308	31.971
79	5.7777	-3.8177	5.2954	2.9431	-4.2675	6.5985	0.1407	-0.1957	-0.1476	-0.0199	-0.0051	0.0384	0.129	-0.2358	-0.1439	0.2934	-0.0662	0.0768	0.3505	-0.0665	0.2979	77.303	-35.3956	59.158
80	2.0002	2.4631	-5.2492	2.4401	0.3045	4.1263	0.0949	0.0043	0.0457	0.1291	0.0279	0.1029	-0.1628	-0.0746	-0.1312	0.2597	-0.0556	0.0104	0.3637	0.0509	0.403	66.5845	-3.7128	13.161
81	0.0423	-0.0017	0.0415	0.0069	-0.0019	0.0415	-0.0851	0.0677	0.0398	-0.1202	-0.0658	-0.0015	0.0805	0.0692	-0.0015	0.1677	-0.0377	-0.0167	0.0891	-0.0714	0.1572	68.1699	7.6465	77.1998
82	0.001	-0.0088	-0.0053	0.0839	0.0478	0.0265	-0.0281	-0.0049	-0.0137	-0.082	0.0626	-0.0304	-0.0572	0.0418	-0.0026	0.0552	-0.0636	-0.0248	0.1129	-0.0145	0.1761	74.0131	24.6617	103.8239
83	0.0067	-0.0031	-0.0036	0.0024	-0.0014	0.0035	-0.0411	0.0197	-0.0356	0.0484	0.0048	-0.0399	-0.0735	0.041	0	0.0575	-0.0176	-0.0323	0.0665	-0.0103	0.2664	78.6838	4.1955	127.7711
84	0.0321	-0.0058	0.0119	0.0023	0.0026	0.0175	0.022	0.0192	-0.0117	0.0346	-0.0312	-0.0177	0.0706	0.0191	-0.0295	0.0749	0.0844	-0.0578	0.2339	-0.165	0.1264	75.8534	-25.5875	116.2764
85	0.0054	0.0007	-0.0051	0.0058	-0.0045	0.0018	0.048	0.0097	-0.0346	-0.0134	0.0303	-0.0708	0.1335	0.0111	-0	0.1009	-0.047	0.0485	0.0847	-0.0595	0.1882	69.2382	-23.3507	84.9707
86	0.004	-0.0008	-0.0009	0.0009	0.0025	0.0043	-0.0021	0.0401	0.0421	0.0613	0.0108	0.023	-0.0388	0.0145	-0	0.109	0.078	0.0019	0.1856	-0.0907	0.1738	84.4675	23.7185	105.5237
87	0.0019	0.0005	-0.005	0.0009	0.0008	0.0005	-0.0916	0.0007	0.0873	0.0074	0.0093	0.0292	-0.0615	-0.1022	0.0001	0.068	-0.0446	0.0094	0.2644	-0.2383	0.3899	78.5273	11.059	76.7256
88	0.004	0.0015	-0.0031	-0.0026	-0.003	0.001	-0.0407	0.0776	-0.0372	-0.1767	-0.0252	0.1027	-0.0378	-0.0865	-0.0002	0.1391	-0.084	-0.0468	0.4014	-0.0982	0.1402	78.8837	-20.8408	79.9262
89	0.0071	0.0063	0.0041	0.02	0.0123	0.0042	-0.0478	-0.0738	-0.009	-0.0048	0.0152	0.0656	0.1509	0.0016	-0	0.2034	-0.0386	0.0814	0.2425	-0.0226	0.2869	85.1687	-27.626	110.6964
90	0.0051	-0.0017	-0.0021	0.0021	0.0037	0.0019	-0.0217	0.0025	0.0653	0.1248	0.0207	0.0439	0.0667	-0.0583	0	0.2424	0.0553	-0.0233	0.1202	-0.1204	0.2703	88.7226	-0.0691	126.3903
91	0.0054	-0.0039	-0.0003	0.0047	0.0025	0.0016	-0.1149	-0.0009	0.0393	-0.0814	0.0447	-0.0404	-0.0493	0.0348	-0	0.1134	-0.1007	0.0409	0.196	-0.0198	0.269	54.5697	-4.3976	19.9805
92	0.0049	0.006	-0.0051	0.0164	-0.0029	0.0045	0.0119	-0.0153	0.0398	-0.0226	0.0739	-0.0612	-0.084	0.0956	0.0001	0.1709	-0.0796	-0.0728	0.1594	-0.0106	0.2965	61.7404	-6.5823	51.1384
93	0.0125	0.002	-0.0054	0.0037	0.0154	0.0498	-0.0481	-0.0364	-0.0325	0.0683	-0.0294	-0.0198	0.0116	0.0691	-0.0265	0.1675	-0.0185	-0.0532	0.1123	-0.1194	0.1455	63.9373	-37.717	58.4985
94	0.0144	0.0005	-0.0104	-0.0012	-0.0015	0.0053	0.0589	0.0261	-0.0283	0.1189	0.0651	-0.0845	0.0785	0.0489	0.0073	0.1038	0.0389	-0.0502	0.2459	0.0169	0.1025	58.0584	-54.4801	31.8344
95	0.0092	0.0043	-0.0001	0.002	0.0001	-0.0018	0.0365	0.0367	0.0624	-0.0958	0.0573	0.0034	0.1078	0.0157	0.0001	0.0727	0.0488	0.0352	0.1572	0.0532	0.1382	52.2492	-34.0776	8.2152
96	0.018	-0.0017	0.0074	0.0158	-0.0224	0.0406	0.036	-0.0577	-0.0911	0.0265	0.0411	0.0649	0.0855	-0.0423	0.0008	0.1318	0.0139	0.1535	0.1606	0.0452	0.2693	73.2928	-41.4067	54.3118
97	0.0073	-0.0034	-0.006	0.0051	-0.0031	0.0221	0.0071	-0.018	0.0298	0.1262	-0.0832	0.0371	0.0004	-0.0778	-0.0089	0.1073	0.0117	0.0617	0.1957	-0.0966	-0.0118	72.7318	-9.4284	51.8915
98	0.0067	-0.0029	-0.0065	0.0113	0.006	0.0058	-0.058	-0.0099	0.0896	0.0373	0.0112	0.058	-0.0999	-0.0475	0.0001	0.254	-0.0259	-0.0688	0.1963	-0.1201	0.3949	65.5281	-2.125	21.5487
99	0.0109	-0.0006	0.0045	0.007	-0.0071	0.0016	-0.0599	-0.0003	-0.0914	-0.0826	-0.052	0.0376	-0.0772	-0.0745	-0.0001	0.222	-0.1511	-0.0523	0.2797	-0.0459	0.3877	61.8853	-29.3669	5.2463
100	0.0076	-0.003	0.0021	0.0033	0.0028	0.012	-0.0584	0.0138	-0.046	-0.0043	0.0398	0.0988	0.0681	-0.057	-0	0.1355	-0.0637	-0.0073	0.1133	0.0037	0.3435	66.7299	-53.6309	25.4808
101	0.0002	-0.0001	-0.0001	0.0009	0.0007	0.0009	-0.0131	0.0087	0.0195	-0.0113	-0.0097	-0.0024	0.0087	0.0045	0.0001	0.3885	0.0246	0.2323	0.5002	-0.0655	0.516	70.2684	1.5027	67.0527
102	0.001	0.0037	0.0115	0.042	0.0218	0.1632	0.0091	-0.0089	0.0024	0.0023	0.0012	-0.0043	0.0053	-0.0017	-0.0004	0.4087	-0.1282	0.0613	0.7134	-0.0015	0.5402	76.6954	31.8374	94.6262
103	0.08	0.0403	0.0012	0.4469	-0.1232	0.0363	0.0035	-0.0099	0.0037	0.0008	-0.0026	-0.0025	-0.005	-0.006	-0.0017	0.4197	-0.0868	-0.2013	0.6375	0.0236	0.5976	83.8761	14.5071	130.9147
104	0.0718	-0.0067	0.0536	0.0667	0.0434	0.1007	-0.0099	0.0007	0.0079	0.014	-0.0012	-0.0076	-0.0044	0.0016	-0.0002	0.6062	0.0916	-0.136	0.7173	-0.0623	0.8094	82.4209	-26.3814	126.1003
105	0.0609	-0.0531	0.0182	0.0651	-0.038	0.1326	-0.0071	-0.0014	-0.0061	-0.0016	0.0089	-0.0021	0.0006	-0.0066	-0.0002	0.6538	0.3468	0.0472	0.538	-0.0999	0.5189	73.8546	-34.1961	86.7108
106	0.0032	0.0019	0.0013	0.0012	-0	0.0052	0.0037	0.0104	0.0073	0.0135	-0.0042	0.0145	0.0137	-0.0063	0	0.3786	0.1101	0.1375	0.3607	0.1005	0.4633	82.5338	28.2185	116.5723
107	0	-0.0001	0	0.0003	-0.0001	0.0001	0.0007	0.0063	-0.009	-0.0017	0.0015	-0.0028	0.0099	-0.0011	-0.0001	0.493	0.1723	-0.0466	0.5336	-0.1861	0.6136	74.2053	22.2582	76.7142
108	0.0006	-0.0007	0.0007	0.0009	-0.0008	0.0009	-0.0105	-0.0024	-0.0125	-0.0108	-0.0186	0.0086	-0.0087	-0.003	0.0001	0.4904	0.0073	-0.1546	0.4749	-0.0249	0.3872	72.4525	-18.511	70.1767
109	0.0012	0.001	0.0012	0.0012	0.0016	0.0015	-0.0043	-0.0072	-0.0024	-0.0099	-0.0032	0.0122	-0.024	0.0077	-0.0002	0.2917	-0.1778	0.0935	0.4837	-0.0131	0.4455	79.3771	-36.8154	106.2034
110	0.0001	-0.0001	-0.0002	0.0002	-0	0.0001	0.0036	-0.0036	-0.0047	0.0082	0.0114	-0.0062	0.0069	0.0038	-0.0001	0.5664	0.0874	0.3988	0.6747	-0.0515	0.6182	85.8903	-8.4566	134.4974
111	0.0001	0.0001	0.0002	0.0003	0.0004	0.0014	0.0007	0.0028	0.0107	-0.0034	-0.0074	-0.0068	0.0075	-0.0024	0	0.6712	-0.2493	0.1999	0.6497	-0.1736	0.7271	56.3183	-3.7304	8.1423
112	0.0003	0.0009	-0.0008	0.005	-0.0039	0.0032	0.0062	-0.001	-0.0013	-0.0169	-0.0051	-0.0032	-0.0166	0.0055	0	0.3509	-0.2768	0.0373	0.5826	-0.1306	0.4763	65.1261	4.3683	47.5082
113	0.0533	0.0518	0.0226	0.2351	-0.0003	0.0551	-0.0035	-0.0032	0.002	0.0032	-0.0017	-0.0024	0.0114	-0.0073	-0.0007	0.3746	0.0793	-0.1127	0.6393	-0.0875	0.5661	70.2222	-31.9317	66.6186
114	0.1058	0.0101	0.1046	0.0598	0.0148	0.1509	-0.0026	0.0129	0.004	-0.0145	-0.0026	-0.0031	0.0031	-0.0066	-0.0008	0.6538	0.2885	0.0423	0.811	-0.0566	0.8056	64.3248	-61.6373	39.4177
115	0.0051	-0.0104	0.002	0.0693	-0.0094	0.0024	0.0097	0.0075	0.0004	0.0005	0.0113	0.0052	-0.0098	-0.0042	-0.0003	0.5164	0.1696	0.1971	0.6453	0.017	0.589	55.8753	-44.4056	3.3647
116	0.0421	0.0597	-0.0258	0.1855	0.0194	0.0902	0.0007	-0.006	0.0114	0.0101	0.0139	0.0056	-0.0138	0.0003	-0.0004	0.4371	-0.2734	0.1416	0.559	-0.0981	0.6731	69.4426	-52.7313	56.0029
117	0.059	-0.0351	-0.0081	0.098	0.0295	0.2874	0.0122	0.0072	-0.0033	0.0097	0.0048	0.006	-0.0049	0.0037	-0.0009	0.7209	0.0999	0.0462	0.8915	-0.0039	0.9332	62.4043	7.1018	28.2991
118	0.0642	-0.0018	-0.0214	0.1807	0.0065	0.0368	0.0011	-0.0096	-0.0071	0.0028	-0.0029	-0.0056	-0.0014	-0.011	-0.0006	0.586	0.1455	-0.0703	0.7172	0.0122	0.8061	56.0468	-20.7441	-0.9177
119	0.0547	0.0207	0.0559	0.0478	-0.0195	0.099	-0.021	-0.0081	-0.0019	0.0017	-0.0077	0.0064	0.0019	0.0055	-0.0005	0.3518	-0.2914	-0.0982	0.6796	0.0389	0.6472	60.1977	-58.0214	16.4332
120	0.0401	-0.0024	0.0357	0.1135	-0.0274	0.0489	-0.0748	0.0761	0.0051	0.1175	-0.0101	-0.1702	-0.1874	-0.1004	-0.0634	0.0993	-0.1055	-0.0454	-0.6895	-0.6346	-0.4852	50.2329	8.0367	90.3793
121	0.1002	0.0664	-0.0993	0.2261	-0.0963	0.3345	0.0034	-0.0736	0.0123	0.0611	0.2156	0.0685	-0.0046	-0.1568	0.3381	0.11	-0.066	-0.0194	-0.1694	-0.2148	-0.0749	54.5643	16.2542	110.6477
122	0.0551	-0.0349	-0.1144	0.3386	-0.0426	0.0887	0.0109	-0.1612	-0.1679	0.1195	0.1287	0.4056	0.0541	-0.0064	0.0107	0.0822	-0.0558	-0.0911	0.0043	-0.1887	-0.3793	57.2613	-0.9345	124.6771
123	0.1451	0.1926	-0.0079	0.3474	0.1102	0.1674	-0.0743	0.1489	-0.0343	-0.122	0.155	-0.1811	0.0228	0.0308	0.4468	0.0797	0.0061	-0.02	-0.0298	0.0388	-0.0592	54.5959	-19.8171	113.1434
124	0.0578	-0.0662	0.0313	0.0994	-0.0154	0.0809	-0.0922	-0.0196	-0.035	-0.0416	0.0957	0.0658	0.0502	-0.0622	0.0598	0.1096	-0.0253	-0.0126	0.0196	-0.0685	0.0271	49.9707	-14.1337	92.1406
125	0.1724	0.1168	-0.1344	0.2072	-0.0876	0.206	0.1166	0.0002	0.2637	-0.0353	0.0394	0.0805	-0.137	0.0137	0.0714	0.0865	-0.0932	0.0394	0.1126	-0.1156	0.1319	103.3029	16.1192	96.3544
126	0.0582	0.0406	-0.0599	0.1449	0.0243	0.1395	-0.0497	-0.001	0.0437	-0.033	0.0179	0.0151	0.0138	0.001	-0.1985	0.0649	-0.0432	-0.0056	0.1201	-0.0596	0.0602	99.4405	3.5609	78.2154
127	0.076	0.0321	-0.0151	0.1095	-0.0819	0.1062	-0.0884	0.0182	-0.2385	-0.1093	-0.0814	-0.2074	0.136	0.1344	-0.3331	-0.0093	-0.1095	-0.1041	-0.0411	-0.2513	-0.0819	100.4552	-17.8978	84.2458
128	0.1841	-0.0032	0.1107	0.1016	0.035	0.1066	-0.077	-0.088	-0.1188	-0.0283	0.0533	-0.0451	0.0079	-0.0368	-0.0181	0.0778	-0.0449	-0.0336	0.105	-0.0191	0.0949	105.2163	-18.5168	106.1004
129	0.1277	0.0147	0.0902	0.0846	0.0484	0.0916	-0.0109	-0.2167	0.1053	0.0415	0.0168	0.0868	-0.1165	-0.0038	0.0945	0.0818	-0.0481	0.0036	0.1634	-0.0906	0.0797	106.7591	2.284	113.6091
130	0.0546	-0.0324	0.0429	0.1559	0.139	0.1424	0.0451	0.0806	0.1783	0.0339	0.044	-0.0712	-0.0714	-0.01	0.0303	0.0644	-0.0123	0.0124	0.0255	0.011	0.1046	36.5513	-10.0138	31.7418
131	0.1243	-0.0086	-0.1275	0.2904	-0.0179	0.0834	-0.0947	-0.1417	0.2373	0.1776	0.211	0.073	0.0722	-0.0126	0.0969	0.0252	-0.1587	-0.0719	-0.5093	-0.273	-0.0112	41.4676	-15.6234	52.6848
132	0.0877	0.0403	-0.1969	0.3919	-0.0455	0.2912	0.1047	-0.2178	0.0246	-0.0148	-0.2382	-0.0642	0.371	0.4582	-0.345	0.0296	-0.0943	-0.0474	-0.3286	-0.1262	0.0052	41.8603	-37.9563	53.9513
133	0.0184	0.0423	0.0635	0.1475	0.1457	0.1935	0.0065	0.2757	-0.1876	-0.142	0.237	0.211	0.0549	-0.1941	0.3918	0.0669	-0.01	-0.0123	-0.6648	-0.5063	-0.2194	37.5229	-46.2234	33.8535
134	0.4235	0.0118	0.1044	0.2079	-0.054	0.1553	-0.057	0.341	0.1932	0.0281	-0.0169	0.0966	0.0163	-0.073	-0.0118	0.0752	0.0161	-0.0082	0.0922	-0.0403	-0.0347	34.073	-29.0288	20.0428
135	0.0598	-0.027	0.1114	0.0651	0.0412	0.4997	-0.1655	-0.0878	-0.1587	0.1253	0.0886	0.0733	-0.0629	0.228	-0.1783	-0.3276	-0.1757	-0.129	0.0276	-0.0944	0.0351	91.7821	-34.0112	44.3862
136	0.2163	0.1182	0.0203	0.0861	-0.0852	0.4056	0.0504	-0.1438	0.2321	-0.1054	-0.0817	0.0275	-0.0597	0.2211	-0.1833	0.0598	-0.0844	-0.0185	0.049	-0.1179	0.05	90.4411	-12.502	38.8006
137	0.7248	-0.0191	0.1149	0.1603	0.0139	0.1161	-0.0564	0.2743	0.1884	-0.0487	0.0289	-0.0047	-0.0435	-0.0168	-0.0424	0.0504	-0.0193	-0.0024	0.0029	0.0255	0.0469	85.3383	-11.177	16.9977
138	0.2474	0.1806	-0.1229	0.2758	0.0158	0.3	-0.2097	0.3382	-0.114	-0.1433	0.1698	0.1833	0.2481	-0.0446	-0.0522	0.0604	-0.0312	0.0066	0.1557	-0.0776	0.0058	83.6328	-31.8848	9.0524
139	0.0894	0.0021	0.0325	0.1017	0.0355	0.1237	-0.0753	0.144	-0.2824	0.0416	0.0904	-0.0949	0.2158	0.0589	-0.0003	0.0917	0.0222	-0.012	0.1269	-0.0836	0.1973	87.8252	-45.859	25.947
140	0.0027	-0.0037	0.0153	0.0189	-0.0343	0.1033	-0.0505	0.0132	0.0115	0.0212	0.0121	0.0255	0.0011	0.0278	-0.0003	0.0612	0.0437	-0.152	0.2396	-0.1325	0.4133	19.0601	13.8928	90.8882
141	0.006	-0.0009	0.0029	0.0203	-0.0092	0.0055	0.028	0.0263	-0.0516	-0.0317	0.0243	0.0214	0.0499	-0.0383	0.0001	0.1762	0.0607	0.0306	0.2506	-0.0254	0.1242	25.315	23.636	119.7716
142	0.0169	0.0182	0.0381	0.0253	0.0596	0.1599	-0.0006	-0.0034	0.022	-0.0316	-0.0136	0.0382	-0.0395	0.0079	0.0001	0.343	0.0754	0.1049	0.2576	0.0485	0.0893	28.8272	-1.3678	138.5249
143	0.0267	-0.0333	0.0012	0.0613	-0.0131	0.008	-0.0483	-0.0068	-0.0055	0.0211	-0.0318	0.0044	0.0253	0.0245	-0.0244	0.081	-0.1552	0.0902	0.3409	0.0574	0.1356	24.8913	-27.1587	121.1818
144	0.0053	0.0008	-0.0005	0.097	0.0792	0.0642	0.0187	-0.0274	0.0197	-0.0111	-0.0154	-0.0033	0.0309	0.0223	-0.0028	0.1513	-0.1865	-0.0058	0.2767	-0.0368	0.1869	18.8567	-17.7907	91.9291
145	0.0062	0.0249	0.0097	0.2076	0.0145	0.0207	-0.0663	0.0091	0.0469	-0.0127	-0.0541	0.0075	-0.0412	0.0173	-0.0182	0.0609	-0.3312	-0.0749	0.3562	-0.0766	0.3225	133.1525	23.9163	89.1077
146	0	-0.0036	0.0052	0.0411	-0.0772	0.1594	-0.0123	-0.0054	0.0033	-0.0295	0.0133	0.0299	-0.0065	0.0198	-0.0072	0.1491	-0.2052	0.4887	0.3363	-0.1715	0.1478	128.067	4.406	64.5047
147	0.004	-0.0002	0.0067	0.0117	-0.0017	0.0103	-0.0773	0.0125	0.0212	-0.0144	-0.0248	-0.0279	0.0067	0.006	0.0001	0.331	0.1487	0.0083	0.5967	-0.123	0.3103	129.6739	-25.3042	74.49
148	0.0041	-0.0012	0.0004	0.0022	-0.0032	0.0041	-0.0146	0.0044	-0.0548	-0.0337	-0.0058	-0.0308	0.0629	0.003	-0.0001	0.0908	-0.0167	0.0938	0.4145	-0.0251	0.239	138.313	5.5065	114.1052
149	0.0036	-0.0008	-0.0008	0.0013	-0.0003	0.0001	-0.0085	0.0199	-0.0563	-0.0016	-0.0143	0.0015	0.0006	0.0063	-0.0002	0.1569	0.159	-0.0817	0.2558	-0.0343	0.3468	6.3497	-2.4173	36.9872
150	0.0085	-0.0133	0.0178	0.0259	-0.0275	0.0645	-0.0205	0.0096	0.0322	0.0619	-0.0053	-0.0099	-0.0058	0.0171	-0.0005	0.0631	0.0161	0.1582	0.4797	-0.0054	0.2184	13.7973	-43.6943	66.7559
151	0.0001	-0.0045	0.0006	0.1201	-0.0033	-0.0009	-0.0259	-0.0055	0.0416	-0.0169	-0.0266	-0.0076	0.0106	-0.0097	-0.0093	0.1282	-0.3053	0.0501	0.3738	-0.0966	0.3414	7.0494	-53.9784	37.6057
152	0.0065	0.0084	0.0288	0.0202	0.0607	0.1875	-0.0273	-0.0017	-0.0112	0.0144	0.0094	0.0084	0.0348	-0.0011	-0.0005	0.0377	-0.0396	-0.0483	0.5205	-0.0635	0.4914	2.489	-28.5876	19.4727
153	0.0053	-0.0042	-0.0004	0.013	0.0113	0.0213	-0.0631	0.0059	-0.0051	0.0346	-0.029	-0.0362	0.0134	0.017	-0.0001	0.1351	-0.1511	-0.1057	0.3971	0.0335	0.5053	121.0494	-5.8458	35.4229
154	0.0002	0.0001	0.0003	0.0006	-0.0002	0.0004	-0.0225	-0.0136	0.0004	0.0246	0.0137	-0.0162	-0.0349	0.0065	0.0002	0.1797	-0.1802	0.055	0.2984	0.066	0.3577	113.8651	-5.116	4.817
155	0.0029	0.0001	-0.0013	0.0003	0.001	0.0017	-0.0295	0.0039	0.0123	-0.0397	-0.0132	-0.0252	-0.0012	0.0077	-0.0003	0.3162	-0.0092	0.2258	0.7202	-0.0538	0.4583	111.763	-34.8927	-4.8587
156	0.0011	0.0094	0.0024	0.0927	0.0263	0.0079	-0.0183	0.0101	-0.0066	-0.0239	-0.0027	0.0147	-0.0113	0.0035	-0	0.3961	0.1937	0.1574	0.4825	-0.2182	0.5853	117.6798	-53.6984	19.8974
157	0.0038	0.0023	0.0004	0.048	-0.0127	0.0088	0.0019	0.0217	-0.0235	-0.0184	0.0337	0.0078	0.0131	0.0145	-0.0001	0.0334	0.1208	-0.0689	0.3253	-0.0553	0.2613	135.9426	-24.6277	105.0715
158	0.0021	-0.001	0.0007	0.0047	-0.0046	0.0185	-0.0351	0.0141	-0.007	0.0358	-0.0012	0.0131	0.0407	-0.0067	-0.0004	0.1002	0.0777	-0.1518	0.6429	0.0331	0.5331	123.243	-35.938	44.9282
159	0.002	0.0015	-0.0019	0.0032	-0.0004	0.003	-0.026	0.0133	0.0081	0.004	0.0407	0.015	-0.0099	-0.037	0.0002	0.2567	0.0613	0.0146	0.2561	-0.2111	0.311	13.0651	-12.2724	66.1377
160	0.0169	-0.0341	0.0347	0.1834	0.1396	0.3169	0.0967	0.0253	0.0398	-0.0899	0.1095	-0.0752	-0.1317	0.1351	0.0878	0.152	0.0195	0.0172	-0.0074	0.091	0.0455	44.3574	20.1907	94.5029
161	0.2495	-0.0675	-0.0144	0.0932	0.0258	0.0098	-0.0097	-0.0267	0.1628	0.0589	0.0223	-0.0363	-0.0577	0.0218	0.0442	0.1899	-0.0396	0.0134	0.0715	-0.0813	0.0796	50.3522	17.2696	124.0446
162	0.0184	0.0464	-0.0137	0.1062	-0.0449	0.0155	0.0623	0.0228	0.0528	-0.0026	-0.0298	0.0134	-0.0553	0.0085	-0.0225	0.1347	-0.0177	-0.0201	0.0716	0.0443	0.0255	51.4235	-12.1957	130.7783
163	0.0297	0.0027	0.0598	0.0513	-0.0068	0.0968	0.027	-0.0142	-0.0227	0.0766	0.0579	-0.0222	0.0641	0.0244	0.0113	0.14	0.0151	-0.0087	0.0205	-0.0114	0.1182	45.8577	-27.783	105.46
164	0.0352	-0.0734	0.0071	0.1356	0.01	0.0893	-0.0454	-0.0753	-0.0602	-0.0488	0.0544	0.0411	-0.0231	0.0275	0.1129	0.2201	0.0164	0.0205	0.0753	-0.0131	0.0257	41.4532	-7.7449	83.1538
165	0.0283	-0.0163	-0.0126	0.0123	-0.0032	0.0232	-0.0188	0.0376	0.0291	-0.079	0.0336	0.0308	-0.0698	0.0128	-0.0165	0.1103	-0.1005	-0.0151	0.0518	-0.083	0.1496	107.6685	20.4465	83.6087
166	0.0089	0.0099	-0.0226	0.1452	-0.0524	0.0664	0.0831	0.0726	0.0402	-0.1229	0.0581	0.1354	-0.0352	0.0597	0.1589	0.1186	-0.093	-0.0289	0.1405	-0.1827	-0.0301	104.4846	-6.1258	69.2509
167	0.0244	-0.0346	0.0276	0.0064	-0.017	0.0224	0.1065	0.03	-0.0421	-0.1103	0.0453	-0.0765	0.0756	-0.0022	0	0.133	0.0096	-0.0057	0.1371	-0.0434	0.2169	108.3796	-28.3257	89.5071
168	0.0153	0.026	0.019	0.0298	0.0098	0.0217	0.0463	-0.0101	-0.085	0.1426	-0.0815	-0.0353	0.0725	0.0375	-0	0.1918	-0.0544	-0.0233	0.2775	0.0161	0.1532	114.1485	-15.593	116.3993
169	0.0616	0.0059	-0.0169	0.081	-0.0906	0.2232	0.0361	-0.1072	0.0192	0.0296	-0.0948	0.0512	-0.1728	0.1415	-0.1541	0.1843	-0.0751	-0.0093	0.2256	-0.1104	0.1343	113.6722	14.5826	112.7273
170	0.0153	0.0197	-0.0627	0.0897	-0.0733	0.2313	0.1057	0.0188	0.0744	-0.089	0.0298	0.2014	-0.2904	-0.0543	0.0429	0.1978	0.0064	0.0288	0.0386	0.016	0.2988	31.9592	-2.009	42.4287
171	0.024	0.0533	-0.0117	0.0982	-0.0124	0.0436	0.035	-0.0769	0.0218	0.2494	-0.0396	-0.1139	-0.073	0.016	0.0726	0.1644	-0.0013	-0.0081	0.1076	-0.0787	0.0849	37.2564	-22.229	64.3835
172	0.0661	0.0464	0.0543	0.1043	-0.0695	0.1431	0.0972	-0.0071	-0.0883	0.09	0.0458	0.0517	0.0235	-0.0134	0.0652	0.1827	-0.0121	-0.0103	0.033	0.0192	0.1503	35.0912	-50.0803	52.8669
173	0.3076	-0.0315	-0.0578	0.0686	0.0168	0.0428	0.1264	0.0423	-0.2328	0.071	-0.0485	0.0674	0.1754	0.011	0.1022	0.1198	0.0079	-0.0679	0.1066	-0.1264	0.009	28.0923	-47.3234	23.4141
174	0.0136	-0.0375	-0.0221	0.0585	0.0418	0.0126	-0.0289	-0.0083	-0.025	-0.0121	0.0877	0.0769	0.0598	-0.0575	0.0041	0.1266	0.0116	-0.0438	0.1403	0.0511	0.0887	26.239	-17.7412	17.0488
175	0.2768	-0.0312	-0.0207	0.0921	-0.0118	0.1817	0.0457	-0.1169	0.0083	-0.0555	-0.0177	0.102	-0.0199	0.3006	-0.1021	0.0891	-0.0646	-0.0222	0.3157	-0.0358	0.0245	100.203	-24.6078	50.6126
176	0.0097	0.0217	-0.024	0.026	-0.0318	0.0437	-0.0586	-0.0304	0.0097	0.0028	-0.0067	0.0019	-0.1677	0.0604	-0.0074	0.1654	-0.0851	-0.0157	0.1446	-0.0342	0.2339	95.5377	-2.0852	30.8672
177	0.0136	0.0062	-0.0154	0.2488	0.0436	0.0123	0.0054	0.003	-0.0045	-0.0235	-0.0786	0.0366	-0.0121	0.2292	-0.0114	0.1376	-0.0645	-0.0086	0.1936	0.0319	0.0407	89.2458	-13.9479	3.7876
178	0.0273	-0.0698	0.0484	0.1921	-0.0967	0.0985	0.1095	0.1372	-0.0782	-0.1292	-0.0453	0.1938	-0.1118	0.1425	0.0422	0.1654	-0.032	0.0553	0.3094	-0.1673	0.1368	90.1149	-44.1456	6.6332
179	0.0174	0.0013	0.0264	0.0392	-0.0147	0.0241	0.0492	0.0427	-0.0616	-0.0788	-0.075	0.0189	0.0862	0.1161	-0.0001	0.121	0.0557	0.0307	0.1218	-0.013	0.2776	96.7559	-50.6069	35.5674
180	0.0006	-0.0112	-0.0181	0.055	0.067	0.0957	0.1013	0.0421	0.0273	-0.0661	0.1127	-0.0296	0.0299	-0.0059	0.0047	0.1271	-0.0122	-0.0177	0.0301	0.013	0.0729	53.6688	22.93	87.2906
181	0.0045	0.0014	-0.005	0.0064	-0.002	0.0032	0.0347	-0.0873	0.003	0.1286	-0.0025	0.0163	-0.0888	-0.0613	-0.0001	0.213	0.0147	0.0083	0.2977	0.0623	0.0669	104.4204	-20.5589	121.6289
182	-0.0018	0.0036	-0.0003	0.0037	-0.0013	-0.0026	-0.0359	0.0036	0.1024	0.0147	0.049	-0.0749	0.0735	-0.1524	-0.0003	0.0479	-0.0371	-0.023	0.2068	0.1108	0.1326	78.2507	-8.8601	3.3924
183	0.2091	-0.0151	0.2635	0.1384	0.1747	0.5751	0.0981	0.02	0.1251	0.0241	0.1693	-0.0415	0.1181	0.1337	0.1536	0.0405	-0.0576	0.0175	-0.0602	-0.1898	0.0636	60.9838	22.9047	123.1717
184	0.0339	0.0345	-0.0121	0.0388	-0.0123	0.0246	0.0349	-0.1382	0.0044	0.0639	-0.0993	0.0214	0.1303	-0.0238	-0.0141	0.1348	0.0314	-0.0212	0.0956	-0.0137	-0.0046	62.964	-11.706	134.3766
185	0.0099	-0.0206	0.017	0.0372	-0.0238	0.0403	0.0171	0.0621	-0.0249	-0.0772	0.0726	-0.0007	0.0454	0.0578	0.0841	0.1074	0.17	0.082	-0.3756	-0.0037	0.0441	56.5712	-33.3107	105.6181
186	0.132	0.0098	0.0691	0.0515	0.011	0.0458	-0.0347	0.0564	0.0553	-0.122	0.0143	-0.0668	-0.0507	0.0223	-0.0121	0.1546	-0.0338	0.0841	0.0317	-0.0606	0.0774	50.7503	-11.8856	76.7089
187	0.0115	-0.0013	0.0074	0.0149	-0.0029	0.0054	-0.0787	0.1062	0.0233	0.0522	-0.0772	0.0119	-0.0572	-0.0833	-0.0001	0.1376	-0.0836	-0.0102	0.2025	0.0442	0.2099	97.5191	26.3776	86.1663
188	0.1776	0.0171	-0.0155	0.0963	-0.0641	0.05	-0.0459	0.0875	0.0936	-0.0156	-0.0423	-0.0673	0.0574	-0.0396	-0.0338	0.079	-0.0405	-0.0482	0.1223	-0.0819	0.0645	93.0795	-3.7068	65.972
189	0.0127	0.0047	-0.0038	0.0002	0.0008	0.018	0.1242	-0.0361	-0.0211	0.0369	0.065	0.0533	0.0676	-0.0349	-0	0.1862	-0.0819	0.067	0.14	-0.0803	0.1199	97.2479	-32.6885	87.8926
190	0.0144	0.016	-0.015	0.0133	-0.0171	0.0304	-0.1345	-0.0556	0.1178	-0.0479	0.0069	0.1505	0.0455	0.1573	-0.0013	0.215	-0.0382	0.0038	0.1779	-0.123	0.1347	104.5779	16.0629	120.5975
191	0.0391	-0.0094	-0.094	0.0314	-0.0135	0.2338	0.0862	-0.0161	0.0604	-0.0039	0.1315	-0.0008	-0.0368	0.0413	0.0132	0.0902	0.0089	0.0041	0.0158	-0.0116	0.1563	41.6011	3.4901	37.7972
192	0.011	0.0122	-0.0123	0.0327	-0.0283	0.0344	0.045	-0.0336	-0.0092	0.0622	-0.036	-0.0347	0.0255	0.036	-0.0012	0.0924	-0.0143	-0.0402	0.1696	-0.1739	0.2449	48.4338	-18.1328	66.4022
193	0.0379	-0.012	-0.0204	0.0059	0.0015	0.0131	0.0467	-0.1088	-0.0807	-0.0194	-0.0152	-0.0051	0.0635	-0.0403	0.0105	0.1405	-0.0007	0.0108	0.0501	-0.0291	0.1447	46.6155	-52.8425	55.4872
194	0.0171	-0.0016	0.0039	0.0149	-0.0139	0.0129	0.0058	0.0207	0.03	-0.1137	0.0505	0.0268	-0.0666	-0.0025	0.0043	0.1087	-0.0438	0.0126	0.1112	0.0046	0.0092	38.1485	-52.9506	19.8419
195	0.0972	-0.0849	0.0509	0.0954	-0.0347	0.0249	-0.0268	0.0792	0.0673	0.0269	-0.1098	-0.2039	-0.0891	-0.0313	-0.0051	0.2081	-0.0194	0.0058	0.1322	-0.009	0.046	35.1241	-18.2363	8.9032
196	0.1851	0.0735	0.1223	0.0279	0.0503	0.5337	-0.0902	-0.0858	0.0572	0.0028	-0.0866	-0.0013	-0.0171	0.0458	-0.259	0.0804	-0.1103	-0.011	0.1586	-0.0161	-0.0852	91.2432	-26.8662	58.3302
197	0.0139	-0.0024	0.0085	0.0081	0.0066	0.0133	-0.0183	0.0192	0.0385	-0.0679	0.0689	0.053	-0.0378	-0.0254	0.0001	0.076	0.0105	-0.0152	0.2966	-0.1515	0.2633	86.2289	2.3583	37.1386
198	0.2604	-0.0952	-0.1049	0.0459	0.0515	0.0639	-0.0645	-0.0442	-0.0811	0.1916	-0.0003	0.1201	0.1479	0.0076	-0.0165	0.137	-0.0699	0.0334	0.1522	-0.1177	0.1413	78.5867	-45.4944	3.3542
199	0.0074	-0.0117	0.001	0.0134	-0.0002	0.0076	-0.0305	0.0018	-0.0221	0.0596	0.1034	0.074	0.0331	-0.0475	0.0001	0.0947	-0.0157	0.0007	0.0799	-0.0045	0.3702	86.4821	-56.6078	37.4289
200	0.0316	-0.0393	0.0116	0.0326	-0.0104	0.006	-0.0684	0.0825	-0.0246	-0.1044	0.1023	-0.0364	0.0414	-0.0355	0.0162	0.1422	-0.0105	-0.0348	0.0425	0.0117	0.0949	34.319	11.7901	86.4087
201	0.0329	0.0128	0.0563	0.082	-0.0026	0.0264	0.0646	0.1037	0.1454	-0.1088	0.1249	-0.1313	-0.0333	-0.0724	0.1816	0.1896	0.0083	-0.0129	-0.2215	-0.3158	-0.0627	40.4013	24.2525	114.8192
202	0.0473	0.017	-0.1189	0.0158	-0.0472	0.1267	0.0021	0.1437	0.0604	0.0424	0.0864	0.0987	-0.1851	-0.0269	0.16	0.2036	0.0018	0.0177	0.0515	0.0202	-0.3681	44.3841	0.6051	135.3779
203	0.0383	-0.0613	-0.0258	0.0901	0.014	0.0483	-0.0442	0.0473	-0.263	-0.0628	-0.0364	-0.0667	-0.0574	-0.0573	-0.0512	0.1323	-0.0281	0.0195	-0.353	0.1522	0.0201	40.7835	-26.5684	119.8291
204	0.0046	-0.0037	0.0119	0.1367	-0.0327	0.0629	-0.064	-0.0303	-0.1787	0.147	0.1102	0.0594	-0.0585	-0.0057	0.0665	0.0873	-0.1015	-0.024	0.0717	-0.1021	0.0402	34.5091	-19.8169	89.7208
205	-0.0066	-0.0016	0.0141	-0.0043	0.0069	-0.0216	-0.0121	-0.2445	0.2234	0.1469	0.0414	0.0261	-0.0466	0.1296	0.101	0.0047	-0.2379	-0.0814	-0.0902	-0.2014	0.0902	118.4195	23.4603	94.4753
206	0.4239	-0.0071	0.1929	0.0596	0.0228	0.1409	-0.1007	-0.0066	0.1963	-0.052	-0.0364	-0.0809	-0.1467	-0.1132	-0.0231	0.1384	-0.0825	0.0216	0.1523	-0.0272	0.0643	112.6683	6.8765	68.2757
207	0.0746	-0.0401	0.0678	0.0792	0.0311	0.0825	0.0598	0.1158	-0.0543	0.0521	-0.1022	0.0816	0.0332	0.152	-0.0018	0.1689	-0.0519	0.0141	0.1523	-0.1064	0.2166	113.797	-23.8147	75.8578
208	0.0605	-0.0271	-0.0197	-0.0072	-0.0151	0.1066	-0.1127	-0.0083	-0.2133	-0.1283	0.0361	-0.0779	0.1253	-0.0109	-0.0066	0.1234	0.0086	-0.0461	0.2207	-0.0157	0.1436	120.2074	-25.9252	106.7776
209	0.0096	-0.0128	-0.0118	0.0159	0.0132	0.0586	0.087	-0.1568	-0.0208	-0.0136	-0.0298	-0.0217	0.1378	0.0265	0.0105	0.1917	-0.095	-0.1064	0.2161	-0.1955	0.1087	122.9413	3.5735	118.1935
210	0.0527	0.003	-0.0285	0.0386	0.0127	0.0992	0.0646	0.0515	0.1162	-0.2069	-0.0638	0.032	-0.0931	-0.0473	0.0008	0.108	0.0562	-0.0214	0.0501	0.0334	0.2258	21.2662	-3.1504	31.4681
211	0.03	0.0257	-0.0443	0.0051	-0.0247	0.0194	0.0869	-0.2639	0.2854	-0.0519	0.0366	-0.0462	-0.1155	0.15	0.0198	0.1487	-0.0123	0.033	0.1474	-0.1238	0.1881	28.1718	-10.1641	61.4974
212	0.0533	0.0925	0.0349	0.1984	0.1212	0.1558	-0.0456	-0.0973	-0.0575	0.1235	-0.1134	0.0842	0.0146	-0.0724	-0.0831	0.1869	0.0045	0.0146	0.1295	-0.0066	0.041	29.4066	-41.6589	64.3707
213	0.0319	-0.0491	0.0298	0.1118	0.0078	0.0438	-0.0943	-0.1257	0.0534	0.0638	0.0118	0.0667	-0.0782	0.0021	-0.0575	0.1146	-0.0837	-0.0032	0.0613	-0.0987	0.1389	22.9629	-54.3506	36.0901
214	0.0135	-0.0268	-0.0346	0.0334	0.056	0.0545	0.0478	0.1247	-0.0413	-0.0662	-0.0764	0.133	0.0277	-0.0798	0	0.1507	-0.0074	-0.0584	0.184	-0.0031	0.1355	17.8441	-30.5551	15.7753
215	0.0422	0.0066	0.0012	0.0155	-0.0226	0.0103	-0.1004	-0.0236	-0.0317	0.0715	-0.0414	0.019	0.0658	0.1405	-0.0001	0.1014	0.1005	0.0076	0.2623	0.0292	0.1383	107.7509	-37.6958	47.8825
216	0.0619	0.0515	-0.0446	0.0242	-0.0155	0.0673	-0.0064	-0.1693	0.0964	0.2138	-0.113	0.0597	-0.0041	0.1119	-0.0172	0.1612	-0.0993	-0.0053	0.2921	-0.0989	0.2161	106.1723	-6.9604	40.8123
217	-0.0022	-0.0141	0.0033	0.0375	-0.0185	-0.001	-0.0285	-0.1034	0.1379	-0.0118	0.0294	-0.0454	-0.2294	0.0236	-0.0001	0.2543	-0.0906	-0.0117	0.2644	0.0417	0.154	98.9251	-3.9193	10.1325
218	0.0638	-0.0005	0.0467	0.0141	-0.0139	0.0416	-0.0981	0.174	0.0139	0.0126	-0.0074	0.0301	-0.1283	0.1051	-0.0412	0.2317	-0.1264	0.0212	0.4442	-0.1098	0.0332	96.2346	-32.9744	-2.0398
219	0.0133	-0.0044	0.0017	-0.0008	0.009	0.0137	-0.0782	0.0325	-0.0797	0.0519	0.0888	-0.1454	-0.0234	0.1214	-0	0.1504	0.0734	0.0302	0.243	-0.1749	0.3416	101.7338	-53.777	21.2849
220	0.0043	0.0049	0.0207	0.0053	0.0206	0.1054	-0.0008	-0.0039	-0.0077	-0.0659	0.0121	0.007	0.0018	0.0292	0.0004	0.3016	-0.0008	0.002	0.1806	-0.0825	0.1118	49.651	30.136	101.0259
221	0.0018	-0.0042	-0.0013	0.0628	0.0225	0.0096	0.0258	0.0273	0.0163	-0.0091	-0.0192	0.0634	-0.0278	0.0269	0.0036	0.2351	-0.0382	0.033	0.0645	-0.0168	0.0519	54.6627	-24.7063	130.0632
222	0.0084	-0.0026	0.0068	0.0065	-0.0018	0.0114	0.0524	0.0515	0.0435	0.0136	-0.0278	-0.0155	-0.0292	-0.028	0.0002	0.4065	-0.1336	0.028	0.0977	-0.0749	0.1989	46.5728	-31.5579	92.9451
223	-0	0.0002	-0.0002	0.0002	0.0007	0.0012	0.0595	0.0101	0.0393	-0.0008	0.0303	0.0054	0.0032	-0.0221	-0.0002	0.3925	0.0773	0.0749	0.2964	0.0257	0.192	43.4629	2.3686	75.0582
224	0.0041	-0.0019	0.0024	0.0085	0.011	0.0219	0.0357	-0.0103	-0.0051	0.007	0.0027	0.0074	-0.0102	0.0291	-0.0001	0.297	0.045	-0.0192	0.408	-0.1116	0.1023	101.7422	20.0021	72.0331
225	0.1044	0.0484	-0.0738	0.0901	-0.0496	0.0572	0.0457	-0.0371	0.022	0.0006	0.036	-0.0275	-0.0142	0.0119	0.0101	0.243	-0.0323	-0.0787	0.2127	-0.1746	0.1665	100.3116	-18.1702	67.0169
226	0.0041	0.0023	0.01	0.0054	-0.0045	0.0504	0.0353	0.0269	0.0092	-0.0156	-0.0141	0.0157	-0.014	-0.0135	0.0002	0.3023	-0.0889	-0.0671	0.3081	0.0355	0.3819	106.9912	-35.229	100.5132
227	0.0062	0.0042	-0.0007	0.0204	-0.0038	0.0091	0.012	-0.0142	0.0293	-0.0053	0.0137	-0.0263	0.0317	-0.0105	-0.0001	0.5153	-0.1411	0.0438	0.3498	-0.0873	0.1615	112.8998	-7.8697	126.9539
228	0.0058	-0.0019	0.009	0.024	-0.0392	0.0724	0.0749	0.0347	0.0204	-0.0052	0.0061	-0.0237	-0.006	-0.0015	0.0001	0.5809	-0.1281	0.1749	0.2965	-0.2169	0.3834	109.5073	26.562	109.3396
229	0.0011	-0.0009	0.0067	0.0041	-0.0133	0.05	-0.0056	-0.0176	-0.0151	-0.025	-0.0002	0.0071	0.0158	-0.0189	-0.0036	0.447	-0.0256	-0.0805	0.0326	-0.2273	0.4059	37.9623	1.6043	53.4604
230	0.0011	0.0007	-0.0016	0.0489	-0.0063	0.0022	0.0107	0.0188	-0.066	0.0212	-0.005	-0.0124	-0.0333	0.0017	-0.0004	0.405	0.0345	-0.1636	0.2639	0.0017	0.157	42.4126	-32.4926	70.7053
231	0.0117	0.0046	-0.0072	0.044	-0.0388	0.0349	0.0129	0.033	0.0035	0.0185	0.021	-0.013	0.0392	-0.0231	0.003	0.3011	0.1182	-0.1016	0.3363	-0.0186	0.0593	28.7298	-43.3524	11.0006
232	0.0093	-0.0029	-0.0017	0.0296	0.0104	0.0108	0.091	-0.0156	0.0281	0.0379	0.0489	0.0288	-0.0177	0.0115	-0.0001	0.51	0.1062	0.0231	0.1505	0.0674	0.2227	29.3271	-5.0984	16.3143
233	0.0035	0.0006	0.0188	0.0006	0.0033	0.1086	0.0182	0.0475	-0.0122	0.0061	-0.0175	0.0033	0.0148	-0.0309	0	0.4028	-0.0477	-0.0217	0.3008	0.1202	0.2579	89.7045	4.9129	21.5526
234	0.0056	-0.0009	0.004	0.0294	0.0083	0.0052	-0.0457	0.0337	-0.0403	0.0184	-0.0221	-0.0107	0.0005	-0.0116	-0.0002	0.2431	-0.0231	-0.0527	0.3561	0.0839	0.1972	83.6837	-21.2093	-5.4977
235	0.0027	-0.0069	0.0084	0.0172	-0.0216	0.0271	0.0516	-0.026	-0.0249	0.0027	-0.0238	-0.0066	-0.0287	0.009	-0	0.4368	0.0296	0.0556	0.1285	-0.115	0.3871	87.8182	-56.1124	11.303
236	0.0062	0.0009	0.01	0.0043	0.0138	0.0525	0.0379	-0.0003	0.0024	0.0429	0.0135	0.0012	-0.0115	0.0292	0.0002	0.4501	-0.1367	-0.0967	0.4044	0.0992	0.3853	96.3639	-50.5519	48.6552
237	0.0153	0.0201	-0.0221	0.0915	-0.0259	0.0288	0.0182	-0.0107	0.002	-0.0323	0.0155	0.0141	0.0001	0.018	0.0088	0.1642	-0.0766	-0.0922	-0.0327	-0.2891	0.0282	56.1082	13.1438	135.1524
238	0.0042	-0.0024	0.0078	0.0141	0.0104	0.0355	0.0266	0.0012	0.0008	0.0122	-0.0087	-0.0005	-0.0323	0.018	-0	0.2639	-0.0087	0.0183	0.0944	-0.1745	0.4572	37.1874	-60.0796	44.7486
239	0.0954	-0.056	0.0198	0.057	-0.0082	0.0046	0.0523	0.0338	-0.0388	0.0157	0.0333	-0.0475	0.015	0.0016	0.0099	0.3198	-0.2016	-0.0274	0.216	-0.3067	0.0759	97.5321	-12.488	54.5637
240	0.2366	0.2118	0.0108	0.242	-0.0182	0.0168	-0.0178	0.0069	-0.0059	0.009	-0.0092	0.0117	0.006	-0.0043	-0.006	0.2789	0.0338	0.0333	0.1479	-0.0827	-0.0649	59.8713	9.4844	134.4659
241	0.0007	-0.0009	0	0.0016	-0.0004	-0.0001	0.0107	-0.0241	-0.0029	0.0154	-0.0123	-0.0102	-0.0163	0.008	0.0002	0.4831	-0.0629	0.0397	0.3773	0.1477	0.2779	98.2579	16.2038	71.2836
242	0.2523	-0.0567	0.125	0.0561	0.0325	0.1855	-0.0024	-0.0065	-0.0129	-0.001	-0.0077	0.0131	0.0082	-0.0029	-0.0016	0.1532	-0.1416	0.0936	0.1896	-0.3791	0.0013	97.404	-20.6391	70.6538
243	0.0001	-0	-0.0002	0.0001	0.0002	0.0001	0.0245	0.0082	-0.0086	0.005	0.022	0.0056	0.004	-0.0081	-0	0.6067	-0.0686	-0.0432	0.3513	-0.012	0.2418	104.5683	-32.9036	104.3801
244	0.0668	0.0057	-0.0927	0.1015	-0.022	0.3262	0.004	-0.012	-0.0069	-0.004	0.0067	0.0033	-0.0028	0.0067	0.0053	0.2533	0.0673	-0.234	0.1372	0.2605	0.3381	33.3219	-3.6261	19.2311
245	0.3981	-0.3199	0.048	0.3324	-0.0567	0.0871	0.0116	0.0119	-0.0007	-0.0076	-0.0084	0.0073	-0.0117	0.0093	0.0009	0.4063	-0.1045	-0.0315	0.1947	-0.1569	0.1502	49.9855	-28.9132	90.0206
246	0.0864	-0.0489	-0.0845	0.068	0.0699	0.1016	0.0012	-0.0229	0.0159	0.002	0.0001	0.0024	-0.0186	-0.0035	0.0001	0.2563	0.0995	-0.0678	0.1767	0.0026	0.2941	47.516	5.362	76.2135
247	0.2115	0.0207	-0.298	0.057	0.0459	0.5214	0.0046	-0.0021	-0.0091	0.0074	0.0016	0.0043	0.0052	0.01	0.0005	0.5343	-0.1964	-0.0221	0.3856	-0.2453	0.5091	105.5205	26.7265	105.9325
248	0.0711	0.0303	0.0012	0.173	-0.0012	0.0589	0.0023	0.0036	-0.0194	0.0025	-0.0005	-0.0092	0.0142	0.007	0	0.4422	-0.0164	0.0084	0.3122	-0.1725	0.3053	41.7689	-1.4476	55.1366
249	0.4614	-0.2022	0.181	0.177	-0.0961	0.1259	-0.0018	0.0127	0.0112	0.0079	0.0201	-0.0167	-0.0011	0.003	0.0031	0.3743	-0.1582	0.0472	0.1054	-0.0815	0.2204	39.5364	-59.029	40.2283
250	0.2236	-0.2618	-0.0866	0.3301	0.0981	0.0526	-0.0235	-0.0021	-0.0037	0.0064	-0.0268	-0.0079	-0.001	-0.0068	0.0006	0.2637	0.009	-0.0896	0.3207	-0.0066	0.14	32.4972	-39.8253	9.9491
251	0.0512	0.0286	-0.1241	0.0399	-0.0283	0.387	0.0079	-0.0079	-0.0014	0.0059	-0.0022	0.0088	0.0058	0.0023	0.0032	0.2894	-0.0425	-0.0226	0.1977	-0.2322	0.2663	93.4391	-9.9508	52.4382
252	0.2638	-0.3319	-0.2224	0.5993	0.2366	0.3364	-0.0085	-0.0035	-0.0109	-0.0048	0.0053	0.0048	0.0039	-0.0023	-0	0.5402	0.091	0.1088	0.4014	0.2032	0.2786	85.691	2.7926	19.1333
253	0.6615	-0.3708	0.2245	0.3317	-0.1008	0.1952	-0.0066	-0.003	-0.0034	0.0057	-0.0194	-0.0084	-0.0107	-0.0052	0.0012	0.495	-0.0523	-0.0808	0.5069	-0.0765	0.2575	80.8459	-25.1598	-3.7401
254	0.2228	0.2256	-0.0112	0.2434	-0.0294	0.0206	0.0016	0.0032	-0.0112	-0.0018	-0.0137	-0.0041	0.0023	0.0034	0.0006	0.3205	0.1088	0.0224	0.3519	0.1512	0.5773	92.9284	-47.2063	50.6826
255	0.2554	0.023	0.1691	0.0465	-0.025	0.165	-0.0015	-0.0023	0.0034	0.0125	0.0029	0.0042	-0.0032	0.0007	0.0001	0.1733	0.0437	0.086	0.1266	0.1338	0.3196	57.2591	-26.1439	125.7776
256	0.2685	0.2876	-0.1993	0.404	-0.2324	0.2247	-0.0097	0.0101	0.0194	0.0076	-0.008	0.0042	-0.0045	-0.0024	0.0005	0.5423	-0.0307	-0.0025	0.4106	-0.17	0.1853	108.9461	-4.4869	126.6724
257	0.5399	0.1987	0.2119	0.2259	0.1325	0.1025	0.0364	-0.0069	-0.0067	-0.011	0.013	0.0005	0.0012	0.0117	0.0003	0.2641	0.0933	0.0388	0.2583	0.1957	0.2228	45.7255	-35.319	67.9536
258	0.73	0.1156	0.4301	0.0362	0.0349	0.3162	0.0067	-0.0115	-0.0014	-0.0005	-0.0204	-0.0117	0.0003	0.004	0.0013	0.2135	0.0777	0.105	0.1	-0.2444	0.4161	84.8908	-56.2326	15.6049
259	0.179	-0.1403	-0.0817	0.3079	-0.024	0.3705	0.055	-0.0276	0.0505	0.0621	0.1429	0.0755	-0.1937	-0.1573	0.2404	0.1143	0.033	-0.0255	-0.0247	0.0023	0.0471	39.1684	19.465	91.6029
260	0.009	-0.0584	-0.0065	0.0368	0.052	0.0031	0.2052	0.0219	-0.015	0.0452	0.0257	0.0809	-0.0972	-0.0029	0.2434	0.1541	-0.0743	-0.0406	-0.0119	-0.1829	-0.053	45.6302	20.7761	123.0949
261	0.0242	-0.0038	-0.0364	0.0229	-0.0356	0.0819	0.0108	-0.0219	0.0277	0.131	-0.025	-0.069	0.0849	-0.0946	0.0043	0.1405	0.022	0.0123	0.0547	-0.0067	0.0766	47.6274	-9.2164	134.3348
262	0.0742	0.0468	-0.0261	0.0203	0.0226	0.0299	0.0854	-0.0612	-0.1273	0.0638	-0.0193	-0.0315	0.0064	-0.0738	0.011	0.0843	-0.0347	0.0341	0.0579	-0.0053	0.0497	42.1949	-29.3208	109.8969
263	0.0606	-0.1006	0.0364	0.1558	-0.0647	0.0433	-0.0421	-0.0351	0.0791	-0.0107	-0.0391	-0.1279	0.07	-0.0516	-0.0445	0.0713	-0.0558	0.0383	0.0769	-0.0251	-0.0018	36.9148	-11.6225	83.6413
264	0.0162	0.0288	-0.0408	0.0945	-0.0863	0.116	0.0716	0.0314	0.0496	-0.0487	0.1198	-0.0403	-0.123	0.0316	0.0812	0.1492	-0.0592	-0.0348	0.0766	-0.0596	0.1747	112.5788	23.2341	85.4392
265	0.0312	0.0099	0.0176	0.0426	-0.1354	0.2448	0.062	0.0335	-0.0762	0.0402	-0.0947	-0.0143	0.0071	0.4165	-0.0998	0.1269	-0.1176	-0.019	0.1293	-0.1011	0.0769	108.5966	-2.6321	66.6979
266	0.014	0.0013	0.0134	0.0529	0.0409	0.0367	0.1646	0.0809	-0.0088	0.1106	0.0462	-0.0791	0.0566	0.1386	0.0031	0.1147	-0.0403	0.0477	0.1446	-0.0519	0.1537	111.9648	-28.974	84.7526
267	0.0773	0.0232	0.0025	0.0655	0.0888	0.0641	0.1488	-0.1061	-0.1113	0.2414	-0.0874	-0.1532	0.1218	0.1002	0.0016	0.1431	0.0299	-0.0259	0.2701	-0.056	0.1707	118.4072	-19.4932	114.8345
268	0.0667	0.0439	0.0222	0.0371	0.0357	0.0497	0.0674	-0.0613	-0.0997	-0.0119	0.0142	-0.1092	-0.0931	0.1763	0.0755	0.1247	-0.0868	-0.0087	0.192	-0.1353	0.1301	118.826	12.6928	115.2744
269	0.0637	0.0271	-0.0219	0.0663	-0.0684	0.3427	0.0178	0.0714	-0.0872	0.1865	0.1275	0.3182	-0.0877	-0.1976	0.0445	0.1145	0.0644	-0.0144	-0.0154	0.0024	0.296	26.8	-0.3852	39.9654
270	0.0353	0.0392	-0.0091	0.0584	-0.0257	-0.0035	0.1748	-0.162	0.0305	0.1451	-0.1137	0.1865	-0.0109	-0.1136	0.0031	0.1817	0.0294	-0.0429	0.1571	-0.0616	0.1001	32.9047	-18.3338	65.8944
271	0.0393	-0.006	0.0019	0.1258	0.0027	0.1786	-0.0747	0.0213	0.0082	0.0372	0.2298	0.1646	0.082	-0.219	0.059	0.1208	-0.0107	0.0345	0.0544	-0.0456	0.0318	31.6175	-49.317	57.6625
272	0.0349	-0.0233	-0.0587	0.0289	0.0292	0.0592	0.0112	-0.0318	-0.0631	0.0129	-0.0608	0.2727	0.1018	-0.0692	-0.0086	0.0733	-0.059	-0.0128	0.0944	-0.0522	0.0694	24.2128	-50.8815	26.3365
273	0.0467	-0.029	-0.0422	0.0942	0.0882	0.0854	0.11	0.0565	0.0346	-0.0825	-0.0808	0.0012	-0.1265	-0.0209	0.0125	0.2038	-0.005	-0.0705	0.1815	0.0147	0.1859	21.2491	-20.7246	15.4486
274	0.0911	-0.0331	-0.1065	0.2228	0.0311	0.1981	0.0595	-0.0135	0.0098	0.1417	-0.1671	-0.0758	0.0304	0.1966	-0.0729	0.0787	-0.001	-0.0322	0.2002	-0.0468	0.1246	104.912	-28.2031	51.2612
275	0.0529	0.0374	-0.0974	0.0532	-0.0162	0.1893	-0.0109	-0.0392	0.076	-0.0023	0.0644	0.1064	-0.1403	0.2645	0.0193	0.0908	-0.0884	-0.0482	0.161	-0.0296	0.2443	100.8148	-1.5711	33.6209
276	0.1517	0.0592	0.0567	0.0635	0.0508	0.0879	-0.0956	0.031	0.0103	-0.0739	-0.0757	-0.0375	-0.1239	0.1444	-0.0047	0.141	-0.0883	-0.0135	0.2491	0.0536	0.1133	93.7667	-10.0399	3.4809
277	0.0913	0.0215	-0.0166	0.0597	-0.0257	0.0299	-0.0054	0.0692	-0.201	-0.0955	0.0201	0.1856	0.0048	0.2053	-0.0024	0.1832	-0.0964	0.0812	0.2602	-0.1836	0.2691	93.6863	-42.1999	2.1975
278	0.0479	0.0905	0.0866	0.1035	0.1361	0.1682	0.0918	0.0591	-0.226	-0.0629	0.1728	-0.1326	-0.0047	0.1455	0.0527	0.1169	0.1046	0.0671	0.1338	-0.0534	0.3098	100.5304	-53.3393	31.6668

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Selection details
1	X-RAY DIFFRACTION	1	chain A and resid 1:12
2	X-RAY DIFFRACTION	2	chain B and resid 1:12
3	X-RAY DIFFRACTION	3	chain C and resid 1:12
4	X-RAY DIFFRACTION	4	chain D and resid 1:12
5	X-RAY DIFFRACTION	5	chain E and resid 1:12
6	X-RAY DIFFRACTION	6	chain F and resid 1:12
7	X-RAY DIFFRACTION	7	chain G and resid 1:12
8	X-RAY DIFFRACTION	8	chain H and resid 1:12
9	X-RAY DIFFRACTION	9	chain I and resid 1:12
10	X-RAY DIFFRACTION	10	chain J and resid 1:12
11	X-RAY DIFFRACTION	11	chain K and resid 1:12
12	X-RAY DIFFRACTION	12	chain L and resid 1:12
13	X-RAY DIFFRACTION	13	chain M and resid 1:12
14	X-RAY DIFFRACTION	14	chain N and resid 1:12
15	X-RAY DIFFRACTION	15	chain O and resid 1:12
16	X-RAY DIFFRACTION	16	chain P and resid 1:12
17	X-RAY DIFFRACTION	17	chain Q and resid 1:12
18	X-RAY DIFFRACTION	18	chain R and resid 1:12
19	X-RAY DIFFRACTION	19	chain S and resid 1:12
20	X-RAY DIFFRACTION	20	chain T and resid 1:12
21	X-RAY DIFFRACTION	21	chain A and resid 16:22
22	X-RAY DIFFRACTION	22	chain B and resid 16:22
23	X-RAY DIFFRACTION	23	chain C and resid 16:22
24	X-RAY DIFFRACTION	24	chain D and resid 16:22
25	X-RAY DIFFRACTION	25	chain E and resid 16:22
26	X-RAY DIFFRACTION	26	chain F and resid 16:22
27	X-RAY DIFFRACTION	27	chain G and resid 16:22
28	X-RAY DIFFRACTION	28	chain H and resid 16:22
29	X-RAY DIFFRACTION	29	chain I and resid 16:22
30	X-RAY DIFFRACTION	30	chain J and resid 16:22
31	X-RAY DIFFRACTION	31	chain K and resid 16:22
32	X-RAY DIFFRACTION	32	chain L and resid 16:22
33	X-RAY DIFFRACTION	33	chain M and resid 16:22
34	X-RAY DIFFRACTION	34	chain N and resid 16:22
35	X-RAY DIFFRACTION	35	chain O and resid 16:22
36	X-RAY DIFFRACTION	36	chain P and resid 16:22
37	X-RAY DIFFRACTION	37	chain Q and resid 16:22
38	X-RAY DIFFRACTION	38	chain R and resid 16:22
39	X-RAY DIFFRACTION	39	chain S and resid 16:22
40	X-RAY DIFFRACTION	40	chain T and resid 16:22
41	X-RAY DIFFRACTION	41	chain A and resid 26:60
42	X-RAY DIFFRACTION	42	chain B and resid 26:60
43	X-RAY DIFFRACTION	43	chain C and resid 26:60
44	X-RAY DIFFRACTION	44	chain D and resid 26:60
45	X-RAY DIFFRACTION	45	chain E and resid 26:60
46	X-RAY DIFFRACTION	46	chain F and resid 26:60
47	X-RAY DIFFRACTION	47	chain G and resid 26:60
48	X-RAY DIFFRACTION	48	chain H and resid 26:60
49	X-RAY DIFFRACTION	49	chain I and resid 26:60
50	X-RAY DIFFRACTION	50	chain J and resid 26:60
51	X-RAY DIFFRACTION	51	chain K and resid 26:60
52	X-RAY DIFFRACTION	52	chain L and resid 26:60
53	X-RAY DIFFRACTION	53	chain M and resid 26:60
54	X-RAY DIFFRACTION	54	chain N and resid 26:60
55	X-RAY DIFFRACTION	55	chain O and resid 26:60
56	X-RAY DIFFRACTION	56	chain P and resid 26:60
57	X-RAY DIFFRACTION	57	chain Q and resid 26:60
58	X-RAY DIFFRACTION	58	chain R and resid 26:60
59	X-RAY DIFFRACTION	59	chain S and resid 26:60
60	X-RAY DIFFRACTION	60	chain T and resid 26:60
61	X-RAY DIFFRACTION	61	chain A and resid 61
62	X-RAY DIFFRACTION	62	chain B and resid 61
63	X-RAY DIFFRACTION	63	chain C and resid 61
64	X-RAY DIFFRACTION	64	chain D and resid 61
65	X-RAY DIFFRACTION	65	chain E and resid 61
66	X-RAY DIFFRACTION	66	chain F and resid 61
67	X-RAY DIFFRACTION	67	chain G and resid 61
68	X-RAY DIFFRACTION	68	chain H and resid 61
69	X-RAY DIFFRACTION	69	chain I and resid 61
70	X-RAY DIFFRACTION	70	chain J and resid 61
71	X-RAY DIFFRACTION	71	chain K and resid 61
72	X-RAY DIFFRACTION	72	chain L and resid 61
73	X-RAY DIFFRACTION	73	chain M and resid 61
74	X-RAY DIFFRACTION	74	chain N and resid 61
75	X-RAY DIFFRACTION	75	chain O and resid 61
76	X-RAY DIFFRACTION	76	chain Q and resid 61
77	X-RAY DIFFRACTION	77	chain S and resid 61
78	X-RAY DIFFRACTION	78	chain T and resid 61
79	X-RAY DIFFRACTION	79	chain P and resid 61
80	X-RAY DIFFRACTION	80	chain R and resid 61
81	X-RAY DIFFRACTION	81	chain A and resid 62:67
82	X-RAY DIFFRACTION	82	chain B and resid 62:67
83	X-RAY DIFFRACTION	83	chain C and resid 62:67
84	X-RAY DIFFRACTION	84	chain D and resid 62:67
85	X-RAY DIFFRACTION	85	chain E and resid 62:67
86	X-RAY DIFFRACTION	86	chain F and resid 62:67
87	X-RAY DIFFRACTION	87	chain G and resid 62:67
88	X-RAY DIFFRACTION	88	chain H and resid 62:67
89	X-RAY DIFFRACTION	89	chain I and resid 62:67
90	X-RAY DIFFRACTION	90	chain J and resid 62:67
91	X-RAY DIFFRACTION	91	chain K and resid 62:67
92	X-RAY DIFFRACTION	92	chain L and resid 62:67
93	X-RAY DIFFRACTION	93	chain M and resid 62:67
94	X-RAY DIFFRACTION	94	chain N and resid 62:67
95	X-RAY DIFFRACTION	95	chain O and resid 62:67
96	X-RAY DIFFRACTION	96	chain P and resid 62:67
97	X-RAY DIFFRACTION	97	chain Q and resid 62:67
98	X-RAY DIFFRACTION	98	chain R and resid 62:67
99	X-RAY DIFFRACTION	99	chain S and resid 62:67
100	X-RAY DIFFRACTION	100	chain T and resid 62:67
101	X-RAY DIFFRACTION	101	chain A and resid 68:69
102	X-RAY DIFFRACTION	102	chain B and resid 68:69
103	X-RAY DIFFRACTION	103	chain C and resid 68:69
104	X-RAY DIFFRACTION	104	chain D and resid 68:69
105	X-RAY DIFFRACTION	105	chain E and resid 68:69
106	X-RAY DIFFRACTION	106	chain F and resid 68:69
107	X-RAY DIFFRACTION	107	chain G and resid 68:69
108	X-RAY DIFFRACTION	108	chain H and resid 68:69
109	X-RAY DIFFRACTION	109	chain I and resid 68:69
110	X-RAY DIFFRACTION	110	chain J and resid 68:69
111	X-RAY DIFFRACTION	111	chain K and resid 68:69
112	X-RAY DIFFRACTION	112	chain L and resid 68:69
113	X-RAY DIFFRACTION	113	chain M and resid 68:69
114	X-RAY DIFFRACTION	114	chain N and resid 68:69
115	X-RAY DIFFRACTION	115	chain O and resid 68:69
116	X-RAY DIFFRACTION	116	chain P and resid 68:69
117	X-RAY DIFFRACTION	117	chain R and resid 68:69
118	X-RAY DIFFRACTION	118	chain S and resid 68:69
119	X-RAY DIFFRACTION	119	chain T and resid 68:69
120	X-RAY DIFFRACTION	120	chain A and resid 70:128
121	X-RAY DIFFRACTION	121	chain B and resid 70:128
122	X-RAY DIFFRACTION	122	chain C and resid 70:128
123	X-RAY DIFFRACTION	123	chain D and resid 70:128
124	X-RAY DIFFRACTION	124	chain E and resid 70:128
125	X-RAY DIFFRACTION	125	chain F and resid 70:128
126	X-RAY DIFFRACTION	126	chain G and resid 70:128
127	X-RAY DIFFRACTION	127	chain H and resid 70:128
128	X-RAY DIFFRACTION	128	chain I and resid 70:128
129	X-RAY DIFFRACTION	129	chain J and resid 70:128
130	X-RAY DIFFRACTION	130	chain K and resid 70:128
131	X-RAY DIFFRACTION	131	chain L and resid 70:128
132	X-RAY DIFFRACTION	132	chain M and resid 70:128
133	X-RAY DIFFRACTION	133	chain N and resid 70:128
134	X-RAY DIFFRACTION	134	chain O and resid 70:128
135	X-RAY DIFFRACTION	135	chain P and resid 70:128
136	X-RAY DIFFRACTION	136	chain Q and resid 70:128
137	X-RAY DIFFRACTION	137	chain R and resid 70:128
138	X-RAY DIFFRACTION	138	chain S and resid 70:128
139	X-RAY DIFFRACTION	139	chain T and resid 70:128
140	X-RAY DIFFRACTION	140	chain A and resid 129:131
141	X-RAY DIFFRACTION	141	chain B and resid 129:131
142	X-RAY DIFFRACTION	142	chain C and resid 129:131
143	X-RAY DIFFRACTION	143	chain D and resid 129:131
144	X-RAY DIFFRACTION	144	chain E and resid 129:131
145	X-RAY DIFFRACTION	145	chain F and resid 129:131
146	X-RAY DIFFRACTION	146	chain G and resid 129:131
147	X-RAY DIFFRACTION	147	chain H and resid 129:131
148	X-RAY DIFFRACTION	148	chain J and resid 129:131
149	X-RAY DIFFRACTION	149	chain K and resid 129:131
150	X-RAY DIFFRACTION	150	chain M and resid 129:131
151	X-RAY DIFFRACTION	151	chain N and resid 129:131
152	X-RAY DIFFRACTION	152	chain O and resid 129:131
153	X-RAY DIFFRACTION	153	chain Q and resid 129:131
154	X-RAY DIFFRACTION	154	chain R and resid 129:131
155	X-RAY DIFFRACTION	155	chain S and resid 129:131
156	X-RAY DIFFRACTION	156	chain T and resid 129:131
157	X-RAY DIFFRACTION	157	chain I and resid 129:131
158	X-RAY DIFFRACTION	158	chain P and resid 129:131
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160	X-RAY DIFFRACTION	160	chain A and resid 132:147
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162	X-RAY DIFFRACTION	162	chain C and resid 132:147
163	X-RAY DIFFRACTION	163	chain D and resid 132:147
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165	X-RAY DIFFRACTION	165	chain F and resid 132:147
166	X-RAY DIFFRACTION	166	chain G and resid 132:147
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