Entry | Database: PDB / ID: 4uhi |
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Title | HUMAN STEROL 14-ALPHA DEMETHYLASE (CYP51) IN COMPLEX WITH VFV IN C121 SPACE GROUP |
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Components | STEROL 14-ALPHA DEMETHYLASE |
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Keywords | OXIDOREDUCTASE / MONOOXYGENASE / STEROL BIOSYNTHESIS / EUKARYOTIC MEMBRANES / CYTOCHROME P450 FOLD / ENDOPLASMIC RETICULUM |
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Function / homology | Function and homology information
sterol 14alpha-demethylase / sterol 14-demethylase activity / steroid 7-alpha-hydroxylase activity / oxysterol 7-alpha-hydroxylase activity / negative regulation of amyloid-beta clearance / sterol metabolic process / Cholesterol biosynthesis / bile acid biosynthetic process / EGR2 and SOX10-mediated initiation of Schwann cell myelination / steroid biosynthetic process ...sterol 14alpha-demethylase / sterol 14-demethylase activity / steroid 7-alpha-hydroxylase activity / oxysterol 7-alpha-hydroxylase activity / negative regulation of amyloid-beta clearance / sterol metabolic process / Cholesterol biosynthesis / bile acid biosynthetic process / EGR2 and SOX10-mediated initiation of Schwann cell myelination / steroid biosynthetic process / cholesterol biosynthetic process / negative regulation of protein secretion / Endogenous sterols / Activation of gene expression by SREBF (SREBP) / cholesterol homeostasis / negative regulation of protein catabolic process / oxidoreductase activity / iron ion binding / heme binding / endoplasmic reticulum membrane / membraneSimilarity search - Function Cytochrome P450, E-class, group IV / Cytochrome P450, conserved site / Cytochrome P450 cysteine heme-iron ligand signature. / Cytochrome P450 / Cytochrome P450 superfamily / Cytochrome P450Similarity search - Domain/homology |
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Biological species | HOMO SAPIENS (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.04 Å |
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Authors | Hargrove, T.Y. / Wawrzak, Z. / I Lepesheva, G. |
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Citation | Journal: J.Lipid Res. / Year: 2016 Title: Human Sterol 14Alpha-Demethylase (Cyp51) as a Target for Anticancer Chemotherapy: Towards Structure-Aided Drug Design. Authors: Hargrove, T.Y. / Friggeri, L. / Wawrzak, Z. / Sivakumaran, S. / Yazlovitskaya, E.M. / Hiebert, S.W. / Guengerich, F.P. / Waterman, M.R. / Lepesheva, G.I. |
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History | Deposition | Mar 24, 2015 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Jun 8, 2016 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jun 29, 2016 | Group: Database references |
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Revision 1.2 | Aug 10, 2016 | Group: Database references |
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Revision 1.3 | Jun 20, 2018 | Group: Advisory / Data collection / Derived calculations Category: pdbx_validate_symm_contact / struct_conn / struct_conn_type |
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Revision 1.4 | May 8, 2024 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Other Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / struct_conn / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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