Entry Database : PDB / ID : 4uak Structure visualization Downloads & linksTitle MRCK beta in complex with ADP ComponentsSerine/threonine-protein kinase MRCK beta Details Keywords TRANSFERASE / myotonic dystrophy kinase-related CDC42-binding kinase / metastasis / cell invasionFunction / homology Function and homology informationFunction Domain/homology Component
actomyosin / actomyosin structure organization / establishment or maintenance of cell polarity / RHOJ GTPase cycle / RHOQ GTPase cycle / cell leading edge / CDC42 GTPase cycle / cytoskeleton organization / small GTPase binding / cell-cell junction ... actomyosin / actomyosin structure organization / establishment or maintenance of cell polarity / RHOJ GTPase cycle / RHOQ GTPase cycle / cell leading edge / CDC42 GTPase cycle / cytoskeleton organization / small GTPase binding / cell-cell junction / cell migration / lamellipodium / actin cytoskeleton organization / cytoskeleton / non-specific serine/threonine protein kinase / protein kinase activity / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / protein-containing complex binding / magnesium ion binding / signal transduction / extracellular exosome / ATP binding / plasma membrane / cytoplasm / cytosol Similarity search - Function Serine/threonine-protein kinase MRCK beta, catalytic domain / KELK-motif containing domain / KELK-motif containing domain of MRCK Ser/Thr protein kinase / Myotonic dystrophy protein kinase, coiled coil / DMPK coiled coil domain like / Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 / CNH domain / Citron homology (CNH) domain / Citron homology (CNH) domain profile. / CRIB domain profile. ... Serine/threonine-protein kinase MRCK beta, catalytic domain / KELK-motif containing domain / KELK-motif containing domain of MRCK Ser/Thr protein kinase / Myotonic dystrophy protein kinase, coiled coil / DMPK coiled coil domain like / Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 / CNH domain / Citron homology (CNH) domain / Citron homology (CNH) domain profile. / CRIB domain profile. / P21-Rho-binding domain / CRIB domain / Diacylglycerol/phorbol-ester binding / Phorbol esters/diacylglycerol binding domain (C1 domain) / Zinc finger phorbol-ester/DAG-type signature. / Zinc finger phorbol-ester/DAG-type profile. / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain / C1-like domain superfamily / Extension to Ser/Thr-type protein kinases / AGC-kinase, C-terminal / AGC-kinase C-terminal domain profile. / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / PH-like domain superfamily / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.73 Å DetailsAuthors Schuettelkopf, A.W. CitationJournal : Cell Commun. Signal / Year : 2014Title : A novel small-molecule MRCK inhibitor blocks cancer cell invasion.Authors : Unbekandt, M. / Croft, D.R. / Crighton, D. / Mezna, M. / McArthur, D. / McConnell, P. / Schuttelkopf, A.W. / Belshaw, S. / Pannifer, A. / Sime, M. / Bower, J. / Drysdale, M. / Olson, M.F. History Deposition Aug 10, 2014 Deposition site : RCSB / Processing site : PDBERevision 1.0 Oct 22, 2014 Provider : repository / Type : Initial releaseRevision 1.1 Dec 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id
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