登録情報 | データベース: PDB / ID: 4tth |
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タイトル | Crystal structure of a CDK6/Vcyclin complex with inhibitor bound |
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要素 | - Cyclin homolog
- Cyclin-dependent kinase 6
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キーワード | TRANSFERASE/CELL CYCLE/INHIBITOR / Kinase / TRANSFERASE-CELL CYCLE-INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
cyclin D2-CDK6 complex / cyclin D3-CDK6 complex / cyclin D1-CDK6 complex / cell dedifferentiation / Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 / Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 / Drug-mediated inhibition of CDK4/CDK6 activity / FBXO family protein binding / lateral ventricle development / symbiont-mediated perturbation of host cell cycle progression ...cyclin D2-CDK6 complex / cyclin D3-CDK6 complex / cyclin D1-CDK6 complex / cell dedifferentiation / Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 / Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 / Drug-mediated inhibition of CDK4/CDK6 activity / FBXO family protein binding / lateral ventricle development / symbiont-mediated perturbation of host cell cycle progression / negative regulation of myeloid cell differentiation / type B pancreatic cell development / negative regulation of monocyte differentiation / astrocyte development / dentate gyrus development / regulation of cell motility / gliogenesis / Regulation of RUNX1 Expression and Activity / regulation of hematopoietic stem cell differentiation / positive regulation of cell-matrix adhesion / generation of neurons / Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) / negative regulation of cell cycle / negative regulation of cellular senescence / negative regulation of cell differentiation / negative regulation of osteoblast differentiation / hematopoietic stem cell differentiation / cyclin-dependent kinase / cyclin-dependent protein serine/threonine kinase activity / cyclin-dependent protein kinase holoenzyme complex / regulation of G2/M transition of mitotic cell cycle / ruffle / Notch signaling pathway / cyclin binding / regulation of erythrocyte differentiation / Oncogene Induced Senescence / response to virus / G1/S transition of mitotic cell cycle / positive regulation of fibroblast proliferation / negative regulation of epithelial cell proliferation / Cyclin D associated events in G1 / T cell differentiation in thymus / regulation of gene expression / Senescence-Associated Secretory Phenotype (SASP) / Oxidative Stress Induced Senescence / regulation of cell cycle / negative regulation of cell population proliferation / cell division / protein serine kinase activity / centrosome / DNA damage response / positive regulation of gene expression / negative regulation of transcription by RNA polymerase II / signal transduction / nucleoplasm / ATP binding / nucleus / cytosol / cytoplasm類似検索 - 分子機能 Cyclin domain, herpesvirus / Herpesviridae viral cyclin / Cyclin, herpesvirus / Cyclin-dependent kinase 6 / : / Cyclins signature. / Cyclin / Cyclin-like / Cyclin A; domain 1 / Cyclin, N-terminal ...Cyclin domain, herpesvirus / Herpesviridae viral cyclin / Cyclin, herpesvirus / Cyclin-dependent kinase 6 / : / Cyclins signature. / Cyclin / Cyclin-like / Cyclin A; domain 1 / Cyclin, N-terminal / Cyclin, N-terminal domain / Cyclin-like / domain present in cyclins, TFIIB and Retinoblastoma / Cyclin-like superfamily / : / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Chem-24V / Cyclin-dependent kinase 6 / Cyclin homolog類似検索 - 構成要素 |
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生物種 | Saimiriine herpesvirus 2 (ヘルペスウイルス)
Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.9 Å |
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データ登録者 | Piper, D.E. / Walker, N. / Wang, Z. |
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引用 | ジャーナル: J.Med.Chem. / 年: 2014 タイトル: Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3. 著者: Li, Z. / Wang, X. / Eksterowicz, J. / Gribble, M.W. / Alba, G.Q. / Ayres, M. / Carlson, T.J. / Chen, A. / Chen, X. / Cho, R. / Connors, R.V. / DeGraffenreid, M. / Deignan, J.T. / Duquette, J. ...著者: Li, Z. / Wang, X. / Eksterowicz, J. / Gribble, M.W. / Alba, G.Q. / Ayres, M. / Carlson, T.J. / Chen, A. / Chen, X. / Cho, R. / Connors, R.V. / DeGraffenreid, M. / Deignan, J.T. / Duquette, J. / Fan, P. / Fisher, B. / Fu, J. / Huard, J.N. / Kaizerman, J. / Keegan, K.S. / Li, C. / Li, K. / Li, Y. / Liang, L. / Liu, W. / Lively, S.E. / Lo, M.C. / Ma, J. / McMinn, D.L. / Mihalic, J.T. / Modi, K. / Ngo, R. / Pattabiraman, K. / Piper, D.E. / Queva, C. / Ragains, M.L. / Suchomel, J. / Thibault, S. / Walker, N. / Wang, X. / Wang, Z. / Wanska, M. / Wehn, P.M. / Weidner, M.F. / Zhang, A.J. / Zhao, X. / Kamb, A. / Wickramasinghe, D. / Dai, K. / McGee, L.R. / Medina, J.C. |
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履歴 | 登録 | 2014年6月20日 | 登録サイト: RCSB / 処理サイト: RCSB |
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置き換え | 2014年8月6日 | ID: 4P41 |
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改定 1.0 | 2014年8月6日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2014年10月1日 | Group: Database references |
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改定 1.2 | 2017年11月22日 | Group: Database references / Derived calculations ...Database references / Derived calculations / Other / Refinement description / Source and taxonomy カテゴリ: citation / entity_src_gen ...citation / entity_src_gen / pdbx_database_status / pdbx_struct_oper_list / software Item: _citation.journal_id_CSD / _entity_src_gen.pdbx_alt_source_flag ..._citation.journal_id_CSD / _entity_src_gen.pdbx_alt_source_flag / _pdbx_database_status.pdb_format_compatible / _pdbx_struct_oper_list.symmetry_operation / _software.classification |
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改定 1.3 | 2023年9月27日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / refine_hist Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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