Entry Database : PDB / ID : 2c4c Structure visualization Downloads & linksTitle Crystal structure of the NADPH-treated monooxygenase domain of MICAL ComponentsNEDD9-INTERACTING PROTEIN WITH CALPONIN HOMOLOGY AND LIM DOMAINS Details Keywords TRANSPORT / CYTOSKELETON / FAD / FLAVOPROTEIN / LIM DOMAIN / METAL-BINDING / SIGNALING PROTEINFunction / homology Function and homology informationFunction Domain/homology Component
hippocampal mossy fiber expansion / NADPH oxidase H202-forming activity / F-actin monooxygenase / NAD(P)H oxidase (H2O2-forming) / sulfur oxidation / regulation of regulated secretory pathway / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen / actin filament depolymerization / intercellular bridge / monooxygenase activity ... hippocampal mossy fiber expansion / NADPH oxidase H202-forming activity / F-actin monooxygenase / NAD(P)H oxidase (H2O2-forming) / sulfur oxidation / regulation of regulated secretory pathway / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen / actin filament depolymerization / intercellular bridge / monooxygenase activity / FAD binding / negative regulation of protein phosphorylation / actin filament / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / small GTPase binding / SH3 domain binding / actin binding / midbody / endosome membrane / negative regulation of apoptotic process / protein kinase binding / metal ion binding / cytoplasm / cytosol Similarity search - Function DUF3585 / bMERB domain / Bivalent Mical/EHBP Rab binding domain / bMERB domain profile. / LIM zinc-binding domain signature. / Zinc-binding domain present in Lin-11, Isl-1, Mec-3. / Zinc finger, LIM-type / LIM domain profile. / FAD-binding domain / FAD binding domain ... DUF3585 / bMERB domain / Bivalent Mical/EHBP Rab binding domain / bMERB domain profile. / LIM zinc-binding domain signature. / Zinc-binding domain present in Lin-11, Isl-1, Mec-3. / Zinc finger, LIM-type / LIM domain profile. / FAD-binding domain / FAD binding domain / Calponin homology domain / Calponin homology (CH) domain / Calponin homology domain / CH domain superfamily / Calponin homology (CH) domain profile. / FAD/NAD(P)-binding domain / FAD/NAD(P)-binding domain / 3-Layer(bba) Sandwich / FAD/NAD(P)-binding domain superfamily / Alpha Beta Similarity search - Domain/homologyBiological species MUS MUSCULUS (house mouse)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 2.9 Å DetailsAuthors Siebold, C. / Berrow, N. / Walter, T.S. / Harlos, K. / Owens, R.J. / Terman, J.R. / Stuart, D.I. / Kolodkin, A.L. / Pasterkamp, R.J. / Jones, E.Y. CitationJournal : Proc.Natl.Acad.Sci.USA / Year : 2005Title : High-Resolution Structure of the Catalytic Region of Mical (Molecule Interacting with Casl), a Multidomain Flavoenzyme-Signaling Molecule.Authors : Siebold, C. / Berrow, N. / Walter, T.S. / Harlos, K. / Owens, R.J. / Stuart, D.I. / Terman, J.R. / Kolodkin, A.L. / Pasterkamp, R.J. / Jones, E.Y. History Deposition Oct 18, 2005 Deposition site : PDBE / Processing site : PDBERevision 1.0 Oct 26, 2005 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Advisory / Refinement description / Version format complianceRevision 1.2 Jun 28, 2017 Group : Data collection / Category : diffrn_source / Item : _diffrn_source.typeRevision 1.3 May 8, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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