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| Title | Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 57, Page 3430-3449, Year 2014 |
| Publish date | Jun 20, 2014 (structure data deposition date) |
 Authors | Li, Z. / Wang, X. / Eksterowicz, J. / Gribble, M.W. / Alba, G.Q. / Ayres, M. / Carlson, T.J. / Chen, A. / Chen, X. / Cho, R. ...Li, Z. / Wang, X. / Eksterowicz, J. / Gribble, M.W. / Alba, G.Q. / Ayres, M. / Carlson, T.J. / Chen, A. / Chen, X. / Cho, R. / Connors, R.V. / DeGraffenreid, M. / Deignan, J.T. / Duquette, J. / Fan, P. / Fisher, B. / Fu, J. / Huard, J.N. / Kaizerman, J. / Keegan, K.S. / Li, C. / Li, K. / Li, Y. / Liang, L. / Liu, W. / Lively, S.E. / Lo, M.C. / Ma, J. / McMinn, D.L. / Mihalic, J.T. / Modi, K. / Ngo, R. / Pattabiraman, K. / Piper, D.E. / Queva, C. / Ragains, M.L. / Suchomel, J. / Thibault, S. / Walker, N. / Wang, Z. / Wanska, M. / Wehn, P.M. / Weidner, M.F. / Zhang, A.J. / Zhao, X. / Kamb, A. / Wickramasinghe, D. / Dai, K. / McGee, L.R. / Medina, J.C. |
 External links | J. Med. Chem. / PubMed:24641103 |
| Methods | X-ray diffraction |
| Resolution | 2.9 Å |
| Structure data |  PDB-4tth: |
| Chemicals |  ChemComp-24V:  ChemComp-HOH: |
| Source |
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 Keywords | TRANSFERASE/CELL CYCLE/INHIBITOR / Kinase / TRANSFERASE-CELL CYCLE-INHIBITOR complex |
saimiriine herpesvirus 2 (Herpesvirus saimiri)
homo sapiens (human)