Entry Database : PDB / ID : 4tkn Structure visualization Downloads & linksTitle Structure of the SNX17 FERM domain bound to the second NPxF motif of KRIT1 ComponentsKrev interaction trapped protein 1 Sorting nexin-17 DetailsKeywords PROTEIN TRANSPORT/SIGNALING PROTEIN / FERM domain / NPxY motif / NPxF motif / PROTEIN TRANSPORT-SIGNALING PROTEIN complexFunction / homology Function and homology informationFunction Domain/homology Component
GTPase regulator activity / cardiac septum development / endothelium development / integrin activation / coronary vasculature development / endocytic recycling / aorta development / regulation of establishment of cell polarity / negative regulation of endothelial cell migration / endosomal transport ... GTPase regulator activity / cardiac septum development / endothelium development / integrin activation / coronary vasculature development / endocytic recycling / aorta development / regulation of establishment of cell polarity / negative regulation of endothelial cell migration / endosomal transport / low-density lipoprotein particle receptor binding / small GTPase-mediated signal transduction / negative regulation of endothelial cell proliferation / regulation of endocytosis / regulation of angiogenesis / cholesterol catabolic process / negative regulation of endothelial cell apoptotic process / phosphatidylinositol-4,5-bisphosphate binding / negative regulation of angiogenesis / phosphatidylinositol binding / receptor-mediated endocytosis / cell redox homeostasis / kidney development / intracellular protein transport / cell-cell junction / cytoplasmic vesicle / microtubule binding / angiogenesis / early endosome / cytoskeleton / endosome membrane / endosome / intracellular membrane-bounded organelle / signaling receptor binding / Golgi apparatus / signal transduction / protein-containing complex / extracellular space / membrane / plasma membrane / cytoplasm / cytosol Similarity search - Function Acyl-CoA Binding Protein - #60 / Sorting nexin-17 / SNX17, atypical FERM-like domain / Sorting nexin-17/31, FERM domain / : / : / Sorting Nexin 17 FERM C-terminal domain / Sortin nexin 17/31, FERM domain, F2 lobe / Sortin nexin 17/27/31, FERM domain, F1 lobe / KRIT, N-terminal NPxY motif-rich region ... Acyl-CoA Binding Protein - #60 / Sorting nexin-17 / SNX17, atypical FERM-like domain / Sorting nexin-17/31, FERM domain / : / : / Sorting Nexin 17 FERM C-terminal domain / Sortin nexin 17/31, FERM domain, F2 lobe / Sortin nexin 17/27/31, FERM domain, F1 lobe / KRIT, N-terminal NPxY motif-rich region / Krev interaction trapped protein 1, FERM domain C-lobe / KRIT, N-terminal NPxY motif-rich domain superfamily / NUDIX, or N-terminal NPxY motif-rich, region of KRIT / SNX17/27/31 / Ankyrin repeats (many copies) / Ras-associating (RA) domain profile. / Acyl-CoA Binding Protein / Ras-associating (RA) domain / PhoX homologous domain, present in p47phox and p40phox. / PX domain profile. / PX domain / Phox homology / PX domain superfamily / FERM central domain / FERM/acyl-CoA-binding protein superfamily / Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) / PH-domain like / FERM central domain / FERM superfamily, second domain / FERM domain / FERM domain profile. / Band 4.1 domain / Band 4.1 homologues / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / Ubiquitin-like (UB roll) / PH-like domain superfamily / Roll / Roll / Up-down Bundle / Mainly Beta / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 3 Å DetailsAuthors Stiegler, A.L. / Zhang, R. / Liu, W. / Boggon, T.J. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS) R01 NS085078 United States
CitationJournal : J.Biol.Chem. / Year : 2014Title : Structural Determinants for Binding of Sorting Nexin 17 (SNX17) to the Cytoplasmic Adaptor Protein Krev Interaction Trapped 1 (KRIT1).Authors : Stiegler, A.L. / Zhang, R. / Liu, W. / Boggon, T.J. History Deposition May 27, 2014 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jul 30, 2014 Provider : repository / Type : Initial releaseRevision 1.1 Aug 13, 2014 Group : Database referencesRevision 1.2 Oct 1, 2014 Group : Database referencesRevision 1.3 Sep 20, 2017 Group : Author supporting evidence / Database references ... Author supporting evidence / Database references / Derived calculations / Other / Refinement description / Source and taxonomy Category : citation / entity_src_gen ... citation / entity_src_gen / pdbx_audit_support / pdbx_database_status / pdbx_struct_oper_list / software Item : _citation.journal_id_CSD / _entity_src_gen.pdbx_alt_source_flag ... _citation.journal_id_CSD / _entity_src_gen.pdbx_alt_source_flag / _pdbx_audit_support.funding_organization / _pdbx_database_status.pdb_format_compatible / _pdbx_struct_oper_list.symmetry_operation Revision 1.4 Dec 18, 2019 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.5 Sep 27, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / refine_hist Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _refine_hist.number_atoms_total / _refine_hist.pdbx_number_atoms_nucleic_acid / _refine_hist.pdbx_number_atoms_protein
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