cGMP-dependent protein kinase / cGMP-dependent protein kinase activity / cAMP-dependent protein kinase activity / cAMP-dependent protein kinase complex / cGMP binding / phosphorylation / endoplasmic reticulum membrane / signal transduction / ATP binding / metal ion binding Similarity search - Function
cGMP-dependent kinase / cGMP-dependent protein kinase, catalytic domain / Cyclic nucleotide-binding domain signature 2. / Cyclic nucleotide-binding domain signature 1. / Cyclic nucleotide-binding, conserved site / Cyclic nucleotide-monophosphate binding domain / Cyclic nucleotide-binding domain / cAMP/cGMP binding motif profile. / Cyclic nucleotide-binding domain / Cyclic nucleotide-binding domain superfamily ...cGMP-dependent kinase / cGMP-dependent protein kinase, catalytic domain / Cyclic nucleotide-binding domain signature 2. / Cyclic nucleotide-binding domain signature 1. / Cyclic nucleotide-binding, conserved site / Cyclic nucleotide-monophosphate binding domain / Cyclic nucleotide-binding domain / cAMP/cGMP binding motif profile. / Cyclic nucleotide-binding domain / Cyclic nucleotide-binding domain superfamily / AGC-kinase, C-terminal / AGC-kinase C-terminal domain profile. / RmlC-like jelly roll fold / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily Similarity search - Domain/homology
Method to determine structure: MOLECULAR REPLACEMENT / Resolution: 2.351→47.936 Å / SU ML: 0.26 / σ(F): 1.35 / Phase error: 26.31 / Stereochemistry target values: ML Details: ELECTRON DENSITY FAILS TO RESOLVE THE POSITIONS OF SOME LIGAND ATOMS. TRUNCATION OF THE LIGAND MODEL RESULTS IN AN APPARENT SYMMETRY THAT CANNOT BE RESOLVED BY THE ELECTRON DENSITY ALONE. ...Details: ELECTRON DENSITY FAILS TO RESOLVE THE POSITIONS OF SOME LIGAND ATOMS. TRUNCATION OF THE LIGAND MODEL RESULTS IN AN APPARENT SYMMETRY THAT CANNOT BE RESOLVED BY THE ELECTRON DENSITY ALONE. OUR CHOSEN LIGAND POSE IS SUPPORTED BY PRECEDENT FROM PDB ENTRIES 4IFG AND 4WJC. MOREOVER, OUR POSE ESTABLISHES ADDITIONAL HYDROGEN BONDS WHEN COMPARED TO THE MOST PLAUSIBLE ALTERNATIVE POSE.
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.238
3037
4.85 %
Random
Rwork
0.1938
-
-
-
all
0.1959
62639
-
-
obs
0.1959
62639
99.76 %
-
Solvent computation
Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
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