- PDB-4rhw: Crystal structure of Apaf-1 CARD and caspase-9 CARD complex -
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基本情報
登録情報
データベース: PDB / ID: 4rhw
タイトル
Crystal structure of Apaf-1 CARD and caspase-9 CARD complex
要素
Apoptotic protease-activating factor 1
Caspase-9
キーワード
APOPTOSIS / death domain superfamily
機能・相同性
機能・相同性情報
caspase-9 / response to G1 DNA damage checkpoint signaling / caspase complex / Formation of apoptosome / regulation of apoptotic DNA fragmentation / apoptosome / activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c / leukocyte apoptotic process / glial cell apoptotic process / response to cobalt ion ...caspase-9 / response to G1 DNA damage checkpoint signaling / caspase complex / Formation of apoptosome / regulation of apoptotic DNA fragmentation / apoptosome / activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c / leukocyte apoptotic process / glial cell apoptotic process / response to cobalt ion / cysteine-type endopeptidase activity involved in apoptotic signaling pathway / Caspase activation via Dependence Receptors in the absence of ligand / Activation of caspases through apoptosome-mediated cleavage / Regulation of the apoptosome activity / cysteine-type endopeptidase activity involved in apoptotic process / SMAC (DIABLO) binds to IAPs / SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes / AKT phosphorylates targets in the cytosol / fibroblast apoptotic process / epithelial cell apoptotic process / platelet formation / TP53 Regulates Transcription of Caspase Activators and Caspases / Transcriptional Regulation by E2F6 / Constitutive Signaling by AKT1 E17K in Cancer / cysteine-type endopeptidase activator activity involved in apoptotic process / protein maturation / intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress / signal transduction in response to DNA damage / forebrain development / cardiac muscle cell apoptotic process / enzyme activator activity / cellular response to transforming growth factor beta stimulus / heat shock protein binding / intrinsic apoptotic signaling pathway / cellular response to dexamethasone stimulus / response to nutrient / kidney development / neural tube closure / response to ischemia / positive regulation of apoptotic signaling pathway / NOD1/2 Signaling Pathway / protein processing / ADP binding / SH3 domain binding / activation of cysteine-type endopeptidase activity involved in apoptotic process / intrinsic apoptotic signaling pathway in response to DNA damage / cellular response to UV / positive regulation of neuron apoptotic process / response to estradiol / nervous system development / peptidase activity / regulation of apoptotic process / secretory granule lumen / neuron apoptotic process / ficolin-1-rich granule lumen / response to lipopolysaccharide / cell differentiation / response to hypoxia / positive regulation of apoptotic process / cysteine-type endopeptidase activity / nucleotide binding / apoptotic process / DNA damage response / Neutrophil degranulation / protein kinase binding / protein-containing complex / mitochondrion / extracellular exosome / extracellular region / ATP binding / identical protein binding / nucleus / cytoplasm / cytosol 類似検索 - 分子機能
AUTHOR STATED THE BIOLOGICAL UNIT CONTAINS 7 APAF-1 CARDS AND 4 CASPASE-9 CARDS. BASED ON THEIR EXPERIMENTAL RESULTS, APAF-1 FORMS A HEPTAMER IN THE APOPTOSOME, AND IN THE HOLOENZYME FORMED BY THE APOPTOSOME AND CASPASE-9, THE MOLAR RATIO BETWEEN APAF-1 AND CASPASE-9 IS 7:4. HOWEVER, FURTHER VALIDATION IS REQUIRED.