Entry Database : PDB / ID : 4px3 Structure visualization Downloads & linksTitle Human GKRP bound to AMG-3295 and Sorbitol-6-phosphate ComponentsGlucokinase regulatory protein Details Keywords sugar binding protein/inhibitor / SIS domain containing protein / Regulatory protein - binds to and inhibits glucokinase / sugar binding protein-inhibitor complexFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of glucokinase activity / glucose sensor activity / fructose-6-phosphate binding / carbohydrate derivative metabolic process / urate metabolic process / kinase inhibitor activity / Regulation of Glucokinase by Glucokinase Regulatory Protein / Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) / response to fructose / triglyceride homeostasis ... negative regulation of glucokinase activity / glucose sensor activity / fructose-6-phosphate binding / carbohydrate derivative metabolic process / urate metabolic process / kinase inhibitor activity / Regulation of Glucokinase by Glucokinase Regulatory Protein / Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) / response to fructose / triglyceride homeostasis / enzyme inhibitor activity / response to glucose / protein import into nucleus / glucose homeostasis / carbohydrate binding / enzyme binding / mitochondrion / nucleoplasm / cytoplasm / cytosol Similarity search - Function C-terminal lid domain of glucokinase regulatory protein / Glucokinase regulatory protein, conserved site / N-acetylmuramic acid 6-phosphate etherase/glucokinase regulatory protein / Glucokinase regulatory protein family signature. / SIS domain / SIS domain profile. / SIS domain superfamily / Glucose-6-phosphate isomerase like protein; domain 1 / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.43 Å DetailsAuthors Jordan, S.R. / Chmait, S. CitationJournal : To be Published Title : Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disruptors of GK-GKRP BindingAuthors : Pennington, L.D. / Bartberger, M.D. / Croghan, M.D. / Andrews, K.L. / Ashton, K.S. / Bourbeau, M.P. / Chen, J. / Chmait, S. / Cupples, R. / Fotsch, C. History Deposition Mar 21, 2014 Deposition site : RCSB / Processing site : RCSBRevision 1.0 May 13, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Sep 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ... _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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