登録情報 | データベース: PDB / ID: 4pkt |
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タイトル | Anthrax toxin lethal factor with bound small molecule inhibitor 13 |
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要素 | Lethal factor |
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キーワード | HYDROLASE/HYDROLASE INHIBITOR / Anthrax toxin / lethal factor / metalloproteinase / metalloprotease / structural dynamics / ligand-induced conformational change / HYDROLASE-HYDROLASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
anthrax lethal factor endopeptidase / host cell cytosol / Uptake and function of anthrax toxins / metalloendopeptidase activity / metallopeptidase activity / toxin activity / proteolysis / zinc ion binding / extracellular region類似検索 - 分子機能 Anthrax toxin lethal factor, domain 3, chain A / Anthrax toxin lethal factor, domain 3, chain A / Anthrax toxin lethal factor, central domain / Anthrax toxin lethal factor, middle domain / Anthrax toxin, lethal/endema factor / : / Anthrax toxin lethal factor (ATLF)-like domain profile. / Anthrax toxin, lethal/endema factor, N-/C-terminal / Anthrax toxin lethal factor, N- and C-terminal domain / Toxin ADP-ribosyltransferase; Chain A, domain 1 ...Anthrax toxin lethal factor, domain 3, chain A / Anthrax toxin lethal factor, domain 3, chain A / Anthrax toxin lethal factor, central domain / Anthrax toxin lethal factor, middle domain / Anthrax toxin, lethal/endema factor / : / Anthrax toxin lethal factor (ATLF)-like domain profile. / Anthrax toxin, lethal/endema factor, N-/C-terminal / Anthrax toxin lethal factor, N- and C-terminal domain / Toxin ADP-ribosyltransferase; Chain A, domain 1 / Toxin ADP-ribosyltransferase; Chain A, domain 1 / Collagenase (Catalytic Domain) / Collagenase (Catalytic Domain) / Metallopeptidase, catalytic domain superfamily / Neutral zinc metallopeptidases, zinc-binding region signature. / Alpha-Beta Complex / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | ![](img/tx_bacteria.gif) Bacillus anthracis (炭疽菌) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.4 Å |
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データ登録者 | Maize, K.M. / De la Mora, T. / Finzel, B.C. |
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資金援助 | 米国, 3件 組織 | 認可番号 | 国 |
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Minnesota Dept. of Employment and Economic Development | SPAP-06-0014-P-FY07 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM08700 | 米国 | National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | AI091790-01 | 米国 |
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引用 | ジャーナル: Acta Crystallogr.,Sect.D / 年: 2014 タイトル: Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. 著者: Maize, K.M. / Kurbanov, E.K. / De La Mora-Rey, T. / Geders, T.W. / Hwang, D.J. / Walters, M.A. / Johnson, R.L. / Amin, E.A. / Finzel, B.C. |
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履歴 | 登録 | 2014年5月15日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2014年11月12日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2014年11月26日 | Group: Database references |
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改定 1.2 | 2015年2月4日 | Group: Derived calculations |
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改定 1.3 | 2017年9月27日 | Group: Author supporting evidence / Derived calculations ...Author supporting evidence / Derived calculations / Other / Refinement description / Source and taxonomy カテゴリ: entity_src_gen / pdbx_audit_support ...entity_src_gen / pdbx_audit_support / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list / software Item: _entity_src_gen.pdbx_alt_source_flag / _pdbx_audit_support.funding_organization ..._entity_src_gen.pdbx_alt_source_flag / _pdbx_audit_support.funding_organization / _pdbx_database_status.pdb_format_compatible / _pdbx_struct_assembly.oligomeric_details / _pdbx_struct_oper_list.symmetry_operation |
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改定 1.4 | 2019年12月11日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.5 | 2023年12月27日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / refine_hist Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _refine_hist.pdbx_number_atoms_nucleic_acid / _refine_hist.pdbx_number_atoms_protein |
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