登録情報 | データベース: PDB / ID: 4oth |
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タイトル | Crystal Structure of PRK1 Catalytic Domain in Complex with Ro-31-8220 |
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要素 | Serine/threonine-protein kinase N1 |
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キーワード | TRANSFERASE/TRANSFERASE INHIBITOR / PRK1 / PKN1 / Protein kinase C related kinase 1 / KINASE / PROTEIN KINASE / ATP BINDING / PHOSPHORYLATION / TRANSFERASE-TRANSFERASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
epithelial cell migration / protein kinase C / diacylglycerol-dependent serine/threonine kinase activity / renal system process / regulation of germinal center formation / B cell apoptotic process / histone H3T11 kinase activity / hyperosmotic response / regulation of cell motility / regulation of androgen receptor signaling pathway ...epithelial cell migration / protein kinase C / diacylglycerol-dependent serine/threonine kinase activity / renal system process / regulation of germinal center formation / B cell apoptotic process / histone H3T11 kinase activity / hyperosmotic response / regulation of cell motility / regulation of androgen receptor signaling pathway / regulation of immunoglobulin production / nuclear androgen receptor binding / RHOB GTPase cycle / RHOC GTPase cycle / negative regulation of B cell proliferation / cleavage furrow / B cell homeostasis / RHOA GTPase cycle / RHO GTPases activate PKNs / spleen development / RAC1 GTPase cycle / post-translational protein modification / nuclear receptor coactivator activity / negative regulation of protein phosphorylation / protein kinase C binding / Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / small GTPase binding / histone deacetylase binding / midbody / histone binding / protein kinase activity / intracellular signal transduction / endosome / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / chromatin binding / regulation of transcription by RNA polymerase II / signal transduction / protein-containing complex / nucleoplasm / ATP binding / nucleus / cytoplasm / cytosol類似検索 - 分子機能 Serine/threonine-protein kinase N1, second HR1 domain / Serine/threonine-protein kinase N, first HR1 domain / Serine/threonine-protein kinase N, C2 domain / Hr1 repeat / Rho effector or protein kinase C-related kinase homology region 1 homologues / HR1 repeat superfamily / HR1 rho-binding domain / REM-1 domain profile. / Protein kinase, C-terminal / Protein kinase C terminal domain ...Serine/threonine-protein kinase N1, second HR1 domain / Serine/threonine-protein kinase N, first HR1 domain / Serine/threonine-protein kinase N, C2 domain / Hr1 repeat / Rho effector or protein kinase C-related kinase homology region 1 homologues / HR1 repeat superfamily / HR1 rho-binding domain / REM-1 domain profile. / Protein kinase, C-terminal / Protein kinase C terminal domain / C2 domain / C2 domain profile. / Extension to Ser/Thr-type protein kinases / AGC-kinase, C-terminal / AGC-kinase C-terminal domain profile. / C2 domain superfamily / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 BISINDOLYLMALEIMIDE IX / Serine/threonine-protein kinase N1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.8 Å |
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データ登録者 | Chamberlain, P.P. / Delker, S. / Pagarigan, B. / Mahmoudi, A. / Jackson, P. / Abbassian, M. / Muir, J. / Raheja, N. / Cathers, B. |
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引用 | ジャーナル: Plos One / 年: 2014 タイトル: Crystal Structures of PRK1 in Complex with the Clinical Compounds Lestaurtinib and Tofacitinib Reveal Ligand Induced Conformational Changes. 著者: Chamberlain, P. / Delker, S. / Pagarigan, B. / Mahmoudi, A. / Jackson, P. / Abbasian, M. / Muir, J. / Raheja, N. / Cathers, B. |
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履歴 | 登録 | 2014年2月13日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2014年8月27日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年1月24日 | Group: Structure summary / カテゴリ: audit_author / Item: _audit_author.name |
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