Entry Database : PDB / ID : 4orm Structure visualization Downloads & linksTitle Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM338 (N-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine) ComponentsDihydroorotate dehydrogenase (quinone), mitochondrial Details Keywords OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / alpha/beta barrel / Oxidoreductase / FMN / mitochondrial membrane / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complexFunction / homology Function and homology informationFunction Domain/homology Component
Pyrimidine biosynthesis / pyrimidine ribonucleotide biosynthetic process / dihydroorotate dehydrogenase (quinone) activity / dihydroorotate dehydrogenase (quinone) / dihydroorotate dehydrogenase activity / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / mitochondrial inner membrane Similarity search - Function Dihydroorotate dehydrogenase, class 2 / Dihydroorotate dehydrogenase signature 1. / Dihydroorotate dehydrogenase signature 2. / Dihydroorotate dehydrogenase, conserved site / : / Dihydroorotate dehydrogenase domain / Dihydroorotate dehydrogenase / Aldolase class I / Aldolase-type TIM barrel / TIM Barrel ... Dihydroorotate dehydrogenase, class 2 / Dihydroorotate dehydrogenase signature 1. / Dihydroorotate dehydrogenase signature 2. / Dihydroorotate dehydrogenase, conserved site / : / Dihydroorotate dehydrogenase domain / Dihydroorotate dehydrogenase / Aldolase class I / Aldolase-type TIM barrel / TIM Barrel / Alpha-Beta Barrel / Alpha Beta Similarity search - Domain/homologyBiological species Plasmodium falciparum (malaria parasite P. falciparum)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.07 Å DetailsAuthors Deng, X. / Phillips, M.A. CitationJournal : J.Med.Chem. / Year : 2014Title : Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors.Authors : Deng, X. / Kokkonda, S. / El Mazouni, F. / White, J. / Burrows, J.N. / Kaminsky, W. / Charman, S.A. / Matthews, D. / Rathod, P.K. / Phillips, M.A. History Deposition Feb 11, 2014 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jun 4, 2014 Provider : repository / Type : Initial releaseRevision 1.1 Jul 9, 2014 Group : Database referencesRevision 1.2 Aug 23, 2017 Group : Refinement description / Source and taxonomy / Category : entity_src_gen / softwareRevision 1.3 Feb 28, 2024 Group : Data collection / Database references / Derived calculationsCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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