Entry Database : PDB / ID : 4o6z Structure visualization Downloads & linksTitle Crystal structure of serine hydroxymethyltransferase with covalently bound PLP Schiff-base from Plasmodium falciparum ComponentsSerine hydroxymethyltransferase Details Keywords TRANSFERASE / alpha/beta protein / methyltransferase activity / CytosolFunction / homology Function and homology informationFunction Domain/homology Component
cellular response to tetrahydrofolate / D-serine metabolic process / apicoplast / glycine metabolic process / glycine hydroxymethyltransferase / glycine hydroxymethyltransferase activity / glycine biosynthetic process from serine / serine binding / L-serine catabolic process / tetrahydrofolate metabolic process ... cellular response to tetrahydrofolate / D-serine metabolic process / apicoplast / glycine metabolic process / glycine hydroxymethyltransferase / glycine hydroxymethyltransferase activity / glycine biosynthetic process from serine / serine binding / L-serine catabolic process / tetrahydrofolate metabolic process / tetrahydrofolate interconversion / amino acid binding / cobalt ion binding / folic acid metabolic process / methyltransferase activity / pyridoxal phosphate binding / one-carbon metabolic process / methylation / mitochondrial matrix / protein homodimerization activity / mitochondrion / zinc ion binding / nucleus / cytoplasm Similarity search - Function Serine hydroxymethyltransferase / Serine hydroxymethyltransferase-like domain / Serine hydroxymethyltransferase / Aspartate Aminotransferase, domain 1 / Aspartate Aminotransferase, domain 1 / Aspartate Aminotransferase; domain 2 / Type I PLP-dependent aspartate aminotransferase-like (Major domain) / Pyridoxal phosphate-dependent transferase, small domain / Pyridoxal phosphate-dependent transferase, major domain / Pyridoxal phosphate-dependent transferase ... Serine hydroxymethyltransferase / Serine hydroxymethyltransferase-like domain / Serine hydroxymethyltransferase / Aspartate Aminotransferase, domain 1 / Aspartate Aminotransferase, domain 1 / Aspartate Aminotransferase; domain 2 / Type I PLP-dependent aspartate aminotransferase-like (Major domain) / Pyridoxal phosphate-dependent transferase, small domain / Pyridoxal phosphate-dependent transferase, major domain / Pyridoxal phosphate-dependent transferase / Alpha-Beta Complex / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Plasmodium falciparum (malaria parasite P. falciparum)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.98 Å DetailsAuthors Chitnumsub, P. / Jaruwat, A. / Leartsakulpanich, U. CitationJournal : Acta Crystallogr.,Sect.D / Year : 2014Title : The structure of Plasmodium falciparum serine hydroxymethyltransferase reveals a novel redox switch that regulates its activities.Authors : Chitnumsub, P. / Ittarat, W. / Jaruwat, A. / Noytanom, K. / Amornwatcharapong, W. / Pornthanakasem, W. / Chaiyen, P. / Yuthavong, Y. / Leartsakulpanich, U. History Deposition Dec 24, 2013 Deposition site : RCSB / Processing site : PDBJRevision 1.0 Jun 11, 2014 Provider : repository / Type : Initial releaseRevision 1.1 Dec 18, 2019 Group : Database references / Derived calculations / Category : citation / struct_conn / struct_ref_seq_difItem : _citation.country / _citation.journal_id_CSD ... _citation.country / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_PubMed / _citation.title / _struct_conn.pdbx_leaving_atom_flag / _struct_ref_seq_dif.details Revision 1.2 Nov 8, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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