Entry Database : PDB / ID : 4o1v Structure visualization Downloads & linksTitle SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer ComponentsPhosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Speckle-type POZ protein DetailsKeywords PROTEIN BINDING / UBL conjugation pathway / ligase / ubiquitin / E3 / SPOP / MATH / PTENFunction / homology Function and homology informationFunction Domain/homology Component
inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity / PTEN Loss of Function in Cancer / phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase / regulation of cellular component size / negative regulation of keratinocyte migration / phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity / negative regulation of synaptic vesicle clustering / phosphatidylinositol phosphate phosphatase activity / rhythmic synaptic transmission / inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity ... inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity / PTEN Loss of Function in Cancer / phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase / regulation of cellular component size / negative regulation of keratinocyte migration / phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity / negative regulation of synaptic vesicle clustering / phosphatidylinositol phosphate phosphatase activity / rhythmic synaptic transmission / inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity / central nervous system myelin maintenance / negative regulation of wound healing, spreading of epidermal cells / phosphatidylinositol-3-phosphate phosphatase activity / central nervous system neuron axonogenesis / postsynaptic density assembly / neuron-neuron synaptic transmission / negative regulation of dendritic spine morphogenesis / Regulation of PTEN mRNA translation / synapse maturation / presynaptic membrane assembly / Negative regulation of the PI3K/AKT network / cellular response to electrical stimulus / negative regulation of cell cycle G1/S phase transition / negative regulation of axonogenesis / Transcriptional Regulation by MECP2 / myelin sheath adaxonal region / phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity / negative regulation of excitatory postsynaptic potential / negative regulation of organ growth / forebrain morphogenesis / negative regulation of focal adhesion assembly / Schmidt-Lanterman incisure / anaphase-promoting complex binding / Hydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases / phosphatidylinositol dephosphorylation / dentate gyrus development / negative regulation of cyclin-dependent protein serine/threonine kinase activity / positive regulation of ubiquitin protein ligase activity / spindle assembly involved in female meiosis / positive regulation of ubiquitin-dependent protein catabolic process / regulation of proteolysis / negative regulation of cell size / phosphatidylinositol biosynthetic process / dendritic spine morphogenesis / negative regulation of epithelial to mesenchymal transition / brain morphogenesis / regulation of neuron projection development / myosin phosphatase activity / negative regulation of G1/S transition of mitotic cell cycle / Cul3-RING ubiquitin ligase complex / protein serine/threonine phosphatase activity / molecular function inhibitor activity / protein-serine/threonine phosphatase / ubiquitin-specific protease binding / Synthesis of IP3 and IP4 in the cytosol / regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / negative regulation of peptidyl-serine phosphorylation / locomotor rhythm / negative regulation of vascular associated smooth muscle cell proliferation / negative regulation of cellular senescence / Synthesis of PIPs at the plasma membrane / positive regulation of excitatory postsynaptic potential / phosphoprotein phosphatase activity / social behavior / localization / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / canonical Wnt signaling pathway / prepulse inhibition / multicellular organismal response to stress / synapse assembly / Regulation of PTEN localization / protein dephosphorylation / negative regulation of cell migration / protein-tyrosine-phosphatase / phosphatidylinositol 3-kinase/protein kinase B signal transduction / negative regulation of protein phosphorylation / protein tyrosine phosphatase activity / locomotory behavior / central nervous system development / cell projection / PDZ domain binding / cell motility / TP53 Regulates Metabolic Genes / Hedgehog 'on' state / regulation of protein stability / cytoplasmic side of plasma membrane / PML body / positive regulation of DNA-binding transcription factor activity / Regulation of PTEN stability and activity / protein polyubiquitination / Ovarian tumor domain proteases / cell migration / Downstream TCR signaling / negative regulation of neuron projection development / heart development / proteasome-mediated ubiquitin-dependent protein catabolic process / dendritic spine / postsynaptic density / learning or memory / protein stabilization Similarity search - Function PTEN, phosphatase domain / Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN / Inositol hexakisphosphate / SPOP, C-terminal BACK domain / Tensin phosphatase, C2 domain / Tensin-type phosphatase domain / C2 domain of PTEN tumour-suppressor protein / Phosphatase tensin-type domain profile. / C2 tensin-type domain profile. / C2 domain of PTEN tumour-suppressor protein ... PTEN, phosphatase domain / Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN / Inositol hexakisphosphate / SPOP, C-terminal BACK domain / Tensin phosphatase, C2 domain / Tensin-type phosphatase domain / C2 domain of PTEN tumour-suppressor protein / Phosphatase tensin-type domain profile. / C2 tensin-type domain profile. / C2 domain of PTEN tumour-suppressor protein / Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A / Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A / MATH domain / MATH/TRAF domain / MATH/TRAF domain profile. / meprin and TRAF homology / TRAF-like / BTB/POZ domain / BTB domain profile. / Broad-Complex, Tramtrack and Bric a brac / BTB/POZ domain / Protein-tyrosine phosphatase / Tyrosine-specific protein phosphatase, PTPase domain / Protein-tyrosine phosphatase, catalytic / Protein tyrosine phosphatase, catalytic domain motif / Protein-tyrosine phosphatase, active site / SKP1/BTB/POZ domain superfamily / Tyrosine-specific protein phosphatases domain / Tyrosine specific protein phosphatases domain profile. / Protein-tyrosine phosphatase-like / C2 domain superfamily / Sandwich / Mainly Beta Similarity search - Domain/homology Speckle-type POZ protein / Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Similarity search - ComponentBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2 Å DetailsAuthors Calabrese, M.F. / Watson, E.R. / Schulman, B.A. CitationJournal : Cancer Cell / Year : 2014Title : SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer.Authors: Li, G. / Ci, W. / Karmakar, S. / Chen, K. / Dhar, R. / Fan, Z. / Guo, Z. / Zhang, J. / Ke, Y. / Wang, L. / Zhuang, M. / Hu, S. / Li, X. / Zhou, L. / Li, X. / Calabrese, M.F. / Watson, E.R. / ... Authors : Li, G. / Ci, W. / Karmakar, S. / Chen, K. / Dhar, R. / Fan, Z. / Guo, Z. / Zhang, J. / Ke, Y. / Wang, L. / Zhuang, M. / Hu, S. / Li, X. / Zhou, L. / Li, X. / Calabrese, M.F. / Watson, E.R. / Prasad, S.M. / Rinker-Schaeffer, C. / Eggener, S.E. / Stricker, T. / Tian, Y. / Schulman, B.A. / Liu, J. / White, K.P. History Deposition Dec 16, 2013 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Apr 30, 2014 Provider : repository / Type : Initial releaseRevision 1.1 Sep 20, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details
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