Entry | Database: PDB / ID: 4nux |
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Title | Structure of receptor A |
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Components | Interleukin-17 receptor A |
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Keywords | IMMUNE SYSTEM / SEFIR domain / cytokine / receptor / autoimmune inflammatory |
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Function / homology | Function and homology information
interleukin-17 receptor activity / granulocyte chemotaxis / Interleukin-17 signaling / T-helper 17 type immune response / interleukin-17A-mediated signaling pathway / positive regulation of interleukin-23 production / positive regulation of chemokine (C-X-C motif) ligand 1 production / interleukin-17-mediated signaling pathway / positive regulation of interleukin-13 production / positive regulation of interleukin-5 production ...interleukin-17 receptor activity / granulocyte chemotaxis / Interleukin-17 signaling / T-helper 17 type immune response / interleukin-17A-mediated signaling pathway / positive regulation of interleukin-23 production / positive regulation of chemokine (C-X-C motif) ligand 1 production / interleukin-17-mediated signaling pathway / positive regulation of interleukin-13 production / positive regulation of interleukin-5 production / fibroblast activation / positive regulation of cytokine production involved in inflammatory response / defense response to fungus / response to virus / protein catabolic process / positive regulation of inflammatory response / positive regulation of interleukin-6 production / cell surface receptor signaling pathway / inflammatory response / innate immune response / signaling receptor binding / SARS-CoV-2 activates/modulates innate and adaptive immune responses / extracellular region / plasma membraneSimilarity search - Function Interleukin 17 receptor D / Interleukin-17 receptor, fibronectin-III-like domain 1 / Interleukin-17 receptor A/B, FnIII-like domain 1 superfamily / Interleukin-17 receptor A/B, FnIII-like domain 2 superfamily / Interleukin-17 receptor, fibronectin-III-like domain 1 / Interleukin-17 receptor-like / SEFIR domain / SEFIR domain / SEFIR domain profile.Similarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / SAD / Resolution: 2.295 Å |
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Authors | Zhang, B. / Han, Y. / Deng, J. |
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Citation | Journal: Acta Crystallogr.,Sect.D / Year: 2014 Title: Structure of the unique SEFIR domain from human interleukin 17 receptor A reveals a composite ligand-binding site containing a conserved alpha-helix for Act1 binding and IL-17 signaling. Authors: Zhang, B. / Liu, C. / Qian, W. / Han, Y. / Li, X. / Deng, J. |
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History | Deposition | Dec 4, 2013 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | May 14, 2014 | Provider: repository / Type: Initial release |
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Revision 1.1 | Sep 24, 2014 | Group: Database references |
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Revision 1.2 | Feb 28, 2024 | Group: Data collection / Database references / Category: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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