Entry Database : PDB / ID : 4lee Structure visualization Downloads & linksTitle Structure of the Als3 adhesin from Candida albicans, residues 1-313 (mature sequence), triple mutant in the binding cavity: K59M, A116V, Y301F ComponentsAgglutinin-like protein 3 Details Keywords CELL ADHESION / adhesin / peptide binding protein / biofilm formation / cellular adhesion / peptides / cell surfaceFunction / homology Function and homology informationFunction Domain/homology Component
high molecular weight kininogen binding / reductive iron assimilation / cell adhesion involved in multi-species biofilm formation / filamentous growth of a population of unicellular organisms / yeast-form cell wall / cell adhesion involved in biofilm formation / single-species biofilm formation on inanimate substrate / hyphal cell wall / adhesion of symbiont to host / fungal-type cell wall ... high molecular weight kininogen binding / reductive iron assimilation / cell adhesion involved in multi-species biofilm formation / filamentous growth of a population of unicellular organisms / yeast-form cell wall / cell adhesion involved in biofilm formation / single-species biofilm formation on inanimate substrate / hyphal cell wall / adhesion of symbiont to host / fungal-type cell wall / symbiont entry into host / cell adhesion involved in single-species biofilm formation / intracellular copper ion homeostasis / side of membrane / cell adhesion molecule binding / cell-cell adhesion / endocytosis / extracellular vesicle / cell adhesion / cell surface / extracellular region / plasma membrane Similarity search - Function Agglutinin-like protein, N-terminal domain, N2 subdomain / Agglutinin-like protein repeat / Agglutinin-like protein, N-terminal / Agglutinin-like protein / Agglutinin-like protein, N-terminal, N2 subdomain / Candida agglutinin-like (ALS) / Agglutinin-like protein, N-terminal domain / Cell-wall agglutinin N-terminal ligand-sugar binding / Immunoglobulin-like - #1280 / Fibrogen-binding domain 1 ... Agglutinin-like protein, N-terminal domain, N2 subdomain / Agglutinin-like protein repeat / Agglutinin-like protein, N-terminal / Agglutinin-like protein / Agglutinin-like protein, N-terminal, N2 subdomain / Candida agglutinin-like (ALS) / Agglutinin-like protein, N-terminal domain / Cell-wall agglutinin N-terminal ligand-sugar binding / Immunoglobulin-like - #1280 / Fibrogen-binding domain 1 / Adhesion domain superfamily / Immunoglobulin-like / Sandwich / Mainly Beta Similarity search - Domain/homologyBiological species Candida albicans (yeast)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3 Å DetailsAuthors Lin, J. / Garnett, J.A. / Cota, E. CitationJournal : J.Biol.Chem. / Year : 2014Title : The Peptide-binding Cavity Is Essential for Als3-mediated Adhesion of Candida albicans to Human Cells.Authors : Lin, J. / Oh, S.H. / Jones, R. / Garnett, J.A. / Salgado, P.S. / Rusnakova, S. / Matthews, S.J. / Hoyer, L.L. / Cota, E. History Deposition Jun 25, 2013 Deposition site : RCSB / Processing site : RCSBRevision 1.0 May 14, 2014 Provider : repository / Type : Initial releaseRevision 1.1 Jun 18, 2014 Group : Database referencesRevision 1.2 Jul 16, 2014 Group : Database referencesRevision 1.3 Sep 20, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id / _struct_ref_seq_dif.details
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