登録情報 データベース : PDB / ID : 4kmd 構造の表示 ダウンロードとリンクタイトル Crystal structure of Sufud60-Gli1p 要素Sufu Zinc finger protein GLI1 詳細キーワード PROTEIN BINDING/TRANSCRIPTION / protein peptide complex / PROTEIN BINDING-TRANSCRIPTION complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
notochord regression / regulation of hepatocyte proliferation / GLI proteins bind promoters of Hh responsive genes to promote transcription / smoothened signaling pathway involved in ventral spinal cord interneuron specification / smoothened signaling pathway involved in spinal cord motor neuron cell fate specification / positive regulation of cellular response to drug / GLI-SUFU complex / ventral midline development / pituitary gland development / epidermal cell differentiation ... notochord regression / regulation of hepatocyte proliferation / GLI proteins bind promoters of Hh responsive genes to promote transcription / smoothened signaling pathway involved in ventral spinal cord interneuron specification / smoothened signaling pathway involved in spinal cord motor neuron cell fate specification / positive regulation of cellular response to drug / GLI-SUFU complex / ventral midline development / pituitary gland development / epidermal cell differentiation / proximal/distal pattern formation / prostate gland development / ciliary tip / positive regulation of cell cycle G1/S phase transition / cerebellar cortex morphogenesis / coronary vasculature development / regulation of smoothened signaling pathway / positive regulation of smoothened signaling pathway / dorsal/ventral pattern formation / aorta development / ventricular septum development / skin development / smoothened signaling pathway / negative regulation of protein import into nucleus / regulation of osteoblast differentiation / digestive tract morphogenesis / ciliary base / heart looping / axoneme / negative regulation of ubiquitin-dependent protein catabolic process / spermatid development / negative regulation of osteoblast differentiation / Hedgehog 'off' state / positive regulation of cardiac muscle cell proliferation / liver regeneration / lung development / positive regulation of DNA replication / Degradation of GLI1 by the proteasome / Hedgehog 'on' state / negative regulation of smoothened signaling pathway / Degradation of GLI2 by the proteasome / GLI3 is processed to GLI3R by the proteasome / RNA polymerase II transcription regulatory region sequence-specific DNA binding / neural tube closure / negative regulation of canonical Wnt signaling pathway / beta-catenin binding / response to wounding / osteoblast differentiation / transcription corepressor activity / DNA-binding transcription activator activity, RNA polymerase II-specific / microtubule binding / sequence-specific DNA binding / DNA-binding transcription factor activity, RNA polymerase II-specific / transcription cis-regulatory region binding / ciliary basal body / cilium / positive regulation of cell migration / RNA polymerase II cis-regulatory region sequence-specific DNA binding / positive regulation of cell population proliferation / chromatin binding / regulation of transcription by RNA polymerase II / protein kinase binding / regulation of DNA-templated transcription / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / signal transduction / positive regulation of transcription by RNA polymerase II / DNA binding / zinc ion binding / nucleoplasm / nucleus / plasma membrane / cytosol / cytoplasm 類似検索 - 分子機能 C2H2-type zinc-finger protein GLI-like / Sufu, C-terminal domain / Suppressor of fused / Suppressor of fused, eukaryotic / Suppressor of fused C-terminal / Suppressor of fused, N-terminal / Suppressor of fused, C-terminal domain superfamily / Suppressor of Fused Gli/Ci N terminal binding domain / Suppressor of fused-like domain / Suppressor of fused protein (SUFU) ... C2H2-type zinc-finger protein GLI-like / Sufu, C-terminal domain / Suppressor of fused / Suppressor of fused, eukaryotic / Suppressor of fused C-terminal / Suppressor of fused, N-terminal / Suppressor of fused, C-terminal domain superfamily / Suppressor of Fused Gli/Ci N terminal binding domain / Suppressor of fused-like domain / Suppressor of fused protein (SUFU) / : / C2H2 zinc finger / Gyrase A; domain 2 / Zinc finger, C2H2 type / zinc finger / Zinc finger C2H2 type domain profile. / Zinc finger C2H2 superfamily / Zinc finger C2H2 type domain signature. / Zinc finger C2H2-type / 2-Layer Sandwich / Alpha Beta 類似検索 - ドメイン・相同性 2,3-DIHYDROXY-1,4-DITHIOBUTANE / Zinc finger protein GLI1 / Suppressor of fused homolog 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.7 Å 詳細データ登録者 Zhang, Y. / Qi, X. / Zhang, Z. / Wu, G. 引用ジャーナル : Nat Commun / 年 : 2013タイトル : Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.著者 : Zhang, Y. / Fu, L. / Qi, X. / Zhang, Z. / Xia, Y. / Jia, J. / Jiang, J. / Zhao, Y. / Wu, G. 履歴 登録 2013年5月8日 登録サイト : RCSB / 処理サイト : PDBJ改定 1.0 2013年11月20日 Provider : repository / タイプ : Initial release改定 1.1 2013年11月27日 Group : Experimental preparation改定 1.2 2014年2月12日 Group : Database references改定 1.3 2017年8月23日 Group : Refinement description / Source and taxonomy / カテゴリ : entity_src_gen / software改定 1.4 2017年11月15日 Group : Refinement description / カテゴリ : softwareItem : _software.classification / _software.contact_author ... _software.classification / _software.contact_author / _software.contact_author_email / _software.date / _software.language / _software.location / _software.name / _software.type / _software.version 改定 1.5 2023年11月8日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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