- PDB-4km9: Crystal structure of human Suppressor of Fused -
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基本情報
登録情報
データベース: PDB / ID: 4km9
タイトル
Crystal structure of human Suppressor of Fused
要素
Suppressor of fused homolog
キーワード
PROTEIN BINDING / Suppressor of Fused
機能・相同性
機能・相同性情報
smoothened signaling pathway involved in ventral spinal cord interneuron specification / smoothened signaling pathway involved in spinal cord motor neuron cell fate specification / positive regulation of cellular response to drug / GLI-SUFU complex / ciliary tip / coronary vasculature development / Hedgehog 'off' state / aorta development / ventricular septum development / ciliary base ...smoothened signaling pathway involved in ventral spinal cord interneuron specification / smoothened signaling pathway involved in spinal cord motor neuron cell fate specification / positive regulation of cellular response to drug / GLI-SUFU complex / ciliary tip / coronary vasculature development / Hedgehog 'off' state / aorta development / ventricular septum development / ciliary base / skin development / negative regulation of protein import into nucleus / heart looping / spermatid development / negative regulation of osteoblast differentiation / negative regulation of ubiquitin-dependent protein catabolic process / negative regulation of smoothened signaling pathway / neural tube closure / Degradation of GLI1 by the proteasome / Hedgehog 'on' state / Degradation of GLI2 by the proteasome / GLI3 is processed to GLI3R by the proteasome / negative regulation of DNA-binding transcription factor activity / beta-catenin binding / transcription corepressor activity / regulation of DNA-templated transcription / protein kinase binding / negative regulation of transcription by RNA polymerase II / signal transduction / nucleoplasm / nucleus / cytosol / cytoplasm 類似検索 - 分子機能
Sufu, C-terminal domain / Suppressor of fused / Suppressor of fused, eukaryotic / Suppressor of fused C-terminal / Suppressor of fused, N-terminal / Suppressor of fused, C-terminal domain superfamily / Suppressor of Fused Gli/Ci N terminal binding domain / Suppressor of fused-like domain / Suppressor of fused protein (SUFU) / Gyrase A; domain 2 ...Sufu, C-terminal domain / Suppressor of fused / Suppressor of fused, eukaryotic / Suppressor of fused C-terminal / Suppressor of fused, N-terminal / Suppressor of fused, C-terminal domain superfamily / Suppressor of Fused Gli/Ci N terminal binding domain / Suppressor of fused-like domain / Suppressor of fused protein (SUFU) / Gyrase A; domain 2 / 2-Layer Sandwich / Alpha Beta 類似検索 - ドメイン・相同性
解像度: 3.19→50 Å / Cor.coef. Fo:Fc: 0.918 / Cor.coef. Fo:Fc free: 0.849 / Occupancy max: 1 / Occupancy min: 0.2 / SU B: 59.121 / SU ML: 0.471 / 交差検証法: THROUGHOUT / σ(F): 0 / ESU R Free: 0.589 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES: RESIDUAL ONLY
Rfactor
反射数
%反射
Selection details
Rfree
0.3053
426
4.8 %
RANDOM
Rwork
0.2434
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obs
0.2462
8939
98.76 %
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溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.4 Å / 溶媒モデル: MASK