登録情報 | データベース: PDB / ID: 4kel |
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タイトル | Atomic resolution crystal structure of Kallikrein-Related Peptidase 4 complexed with a modified SFTI inhibitor FCQR(N) |
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要素 | - Kallikrein-4
- Trypsin inhibitor 1
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キーワード | HYDROLASE/HYDROLASE INHIBITOR / Bowman-Birk Inhibitor / Protease / Protease Inhibitor / HYDROLASE-HYDROLASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
biomineral tissue development / amelogenesis / negative regulation of endopeptidase activity / endopeptidase inhibitor activity / 加水分解酵素; プロテアーゼ; ペプチド結合加水分解酵素; セリンエンドペプチターゼ / extracellular matrix disassembly / serine-type peptidase activity / secretory granule / serine-type endopeptidase inhibitor activity / protease binding ...biomineral tissue development / amelogenesis / negative regulation of endopeptidase activity / endopeptidase inhibitor activity / 加水分解酵素; プロテアーゼ; ペプチド結合加水分解酵素; セリンエンドペプチターゼ / extracellular matrix disassembly / serine-type peptidase activity / secretory granule / serine-type endopeptidase inhibitor activity / protease binding / serine-type endopeptidase activity / proteolysis / extracellular space / extracellular region / metal ion binding類似検索 - 分子機能 Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, histidine active site. / Serine proteases, trypsin domain profile. / Serine proteases, trypsin family, serine active site. / Trypsin-like serine protease / Serine proteases, trypsin domain / Trypsin / Trypsin-like serine proteases ...Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, histidine active site. / Serine proteases, trypsin domain profile. / Serine proteases, trypsin family, serine active site. / Trypsin-like serine protease / Serine proteases, trypsin domain / Trypsin / Trypsin-like serine proteases / Thrombin, subunit H / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / Beta Barrel / Mainly Beta類似検索 - ドメイン・相同性 Trypsin inhibitor 1 / Trypsin inhibitor 1 / Kallikrein-4類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト)
![](img/tx_plant.gif) Helianthus annuus (ヒグルマ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.148 Å |
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データ登録者 | Ilyichova, O.V. / Swedberg, J.E. / de Veer, S.J. / Sit, K.C. / Harris, J.M. / Buckle, A.M. |
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引用 | ジャーナル: Biochemistry / 年: 2019 タイトル: KLK4 Inhibition by Cyclic and Acyclic Peptides: Structural and Dynamical Insights into Standard-Mechanism Protease Inhibitors. 著者: Riley, B.T. / Ilyichova, O. / de Veer, S.J. / Swedberg, J.E. / Wilson, E. / Hoke, D.E. / Harris, J.M. / Buckle, A.M. |
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履歴 | 登録 | 2013年4月25日 | 登録サイト: RCSB / 処理サイト: PDBJ |
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改定 1.0 | 2014年4月30日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2016年3月9日 | Group: Other |
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改定 1.2 | 2017年11月15日 | Group: Refinement description / カテゴリ: software |
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改定 1.3 | 2019年9月4日 | Group: Data collection / Database references / Derived calculations カテゴリ: citation / citation_author / struct_conn Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _struct_conn.pdbx_leaving_atom_flag |
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改定 1.4 | 2023年11月8日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details |
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