登録情報 データベース : PDB / ID : 4jmh 構造の表示 ダウンロードとリンクタイトル Crystal structure of synthetic protein in complex with double pY peptide 要素Clamp Shc1_pY239/240 SHC-transforming protein 1 詳細キーワード DE NOVO PROTEIN / Synthetic protein / binding to double pY containing sequence機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
regulation of superoxide metabolic process / positive regulation of cell proliferation in bone marrow / XBP1(S) activates chaperone genes / neurotrophin TRKA receptor binding / transmembrane receptor protein tyrosine kinase adaptor activity / Interleukin-15 signaling / Interleukin-2 signaling / Shc-EGFR complex / Signaling by LTK / epidermal growth factor binding ... regulation of superoxide metabolic process / positive regulation of cell proliferation in bone marrow / XBP1(S) activates chaperone genes / neurotrophin TRKA receptor binding / transmembrane receptor protein tyrosine kinase adaptor activity / Interleukin-15 signaling / Interleukin-2 signaling / Shc-EGFR complex / Signaling by LTK / epidermal growth factor binding / epidermal growth factor receptor binding / Signaling by ALK / RET signaling / Activated NTRK3 signals through RAS / Activated NTRK2 signals through RAS / Interleukin-3, Interleukin-5 and GM-CSF signaling / SHC1 events in ERBB4 signaling / Signalling to RAS / SHC-related events triggered by IGF1R / Role of LAT2/NTAL/LAB on calcium mobilization / Interleukin receptor SHC signaling / Signal attenuation / SHC-mediated cascade:FGFR3 / MET activates RAS signaling / SHC-mediated cascade:FGFR2 / SHC-mediated cascade:FGFR4 / Erythropoietin activates RAS / SHC-mediated cascade:FGFR1 / Signaling by CSF3 (G-CSF) / Tie2 Signaling / insulin-like growth factor receptor binding / SHC1 events in EGFR signaling / ephrin receptor binding / phosphotyrosine residue binding / SHC1 events in ERBB2 signaling / Integrin signaling / Constitutive Signaling by Overexpressed ERBB2 / FCERI mediated Ca+2 mobilization / Insulin receptor signalling cascade / negative regulation of angiogenesis / insulin-like growth factor receptor signaling pathway / FCERI mediated MAPK activation / Signaling by ERBB2 TMD/JMD mutants / insulin receptor binding / Constitutive Signaling by EGFRvIII / Signaling by ERBB2 ECD mutants / epidermal growth factor receptor signaling pathway / Signaling by ERBB2 KD Mutants / phospholipid binding / receptor tyrosine kinase binding / cellular response to growth factor stimulus / cell-cell adhesion / Signaling by CSF1 (M-CSF) in myeloid cells / GPER1 signaling / Signaling by ALK fusions and activated point mutants / insulin receptor signaling pathway / DAP12 signaling / Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants / heart development / actin cytoskeleton organization / RAF/MAP kinase cascade / angiogenesis / positive regulation of MAPK cascade / Extra-nuclear estrogen signaling / positive regulation of ERK1 and ERK2 cascade / intracellular signal transduction / mitochondrial matrix / defense response to bacterium / focal adhesion / negative regulation of DNA-templated transcription / positive regulation of cell population proliferation / negative regulation of apoptotic process / positive regulation of DNA-templated transcription / plasma membrane / cytosol 類似検索 - 分子機能 Phosphotyrosine interaction domain, Shc-like / SH2 adaptor protein C, SH2 domain / : / Phosphotyrosine interaction domain (PTB/PID) / Phosphotyrosine interaction domain (PID) profile. / Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain / PTB/PI domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains ... Phosphotyrosine interaction domain, Shc-like / SH2 adaptor protein C, SH2 domain / : / Phosphotyrosine interaction domain (PTB/PID) / Phosphotyrosine interaction domain (PID) profile. / Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain / PTB/PI domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / SH2 domain superfamily / PH-like domain superfamily / Immunoglobulins / Immunoglobulin-like / Sandwich / Mainly Beta 類似検索 - ドメイン・相同性生物種 synthetic construct (人工物) Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.408 Å 詳細データ登録者 Yasui, N. / Smith, L. / Koide, S. 引用ジャーナル : Mol.Cell / 年 : 2014タイトル : Directed network wiring identifies a key protein interaction in embryonic stem cell differentiation.著者 : Yasui, N. / Findlay, G.M. / Gish, G.D. / Hsiung, M.S. / Huang, J. / Tucholska, M. / Taylor, L. / Smith, L. / Boldridge, W.C. / Koide, A. / Pawson, T. / Koide, S. 履歴 登録 2013年3月14日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2014年4月23日 Provider : repository / タイプ : Initial release改定 1.1 2014年7月30日 Group : Database references改定 1.2 2014年8月6日 Group : Data collection改定 1.3 2023年9月20日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag改定 1.4 2023年12月6日 Group : Data collection / カテゴリ : chem_comp_atom / chem_comp_bond / Item : _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_2
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