登録情報 | データベース: PDB / ID: 4jb8 |
---|
タイトル | Caspase-7 in Complex with DARPin C7_16 |
---|
要素 | - Caspase-7 subunit p11Caspase 7
- Caspase-7 subunit p20Caspase 7
- DARPin C7_16
|
---|
キーワード | Hydrolase/DE NOVO PROTEIN / Complex structure / selected DARPin C7_16 / Hydrolase-DE NOVO PROTEIN complex |
---|
機能・相同性 | 機能・相同性情報
caspase-7 / lymphocyte apoptotic process / positive regulation of plasma membrane repair / cellular response to staurosporine / cysteine-type endopeptidase activity involved in execution phase of apoptosis / SMAC, XIAP-regulated apoptotic response / Activation of caspases through apoptosome-mediated cleavage / SMAC (DIABLO) binds to IAPs / SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes / cysteine-type endopeptidase activity involved in apoptotic process ...caspase-7 / lymphocyte apoptotic process / positive regulation of plasma membrane repair / cellular response to staurosporine / cysteine-type endopeptidase activity involved in execution phase of apoptosis / SMAC, XIAP-regulated apoptotic response / Activation of caspases through apoptosome-mediated cleavage / SMAC (DIABLO) binds to IAPs / SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes / cysteine-type endopeptidase activity involved in apoptotic process / fibroblast apoptotic process / execution phase of apoptosis / Apoptotic cleavage of cellular proteins / protein maturation / Caspase-mediated cleavage of cytoskeletal proteins / cysteine-type peptidase activity / response to UV / striated muscle cell differentiation / protein catabolic process / protein processing / heart development / peptidase activity / neuron apoptotic process / cellular response to lipopolysaccharide / aspartic-type endopeptidase activity / defense response to bacterium / cysteine-type endopeptidase activity / apoptotic process / タンパク質分解 / extracellular space / RNA binding / 核質 / 細胞核 / 細胞質基質 / 細胞質類似検索 - 分子機能 Caspase-like / Rossmann fold - #1460 / Ankyrin repeat-containing domain / Peptidase family C14A, His active site / Caspase family histidine active site. / Peptidase C14, caspase non-catalytic subunit p10 / Peptidase family C14A, cysteine active site / Caspase family cysteine active site. / Caspase family p10 domain profile. / Peptidase C14A, caspase catalytic domain ...Caspase-like / Rossmann fold - #1460 / Ankyrin repeat-containing domain / Peptidase family C14A, His active site / Caspase family histidine active site. / Peptidase C14, caspase non-catalytic subunit p10 / Peptidase family C14A, cysteine active site / Caspase family cysteine active site. / Caspase family p10 domain profile. / Peptidase C14A, caspase catalytic domain / Caspase, interleukin-1 beta converting enzyme (ICE) homologues / Peptidase C14, p20 domain / Caspase family p20 domain profile. / : / Caspase domain / Caspase-like domain superfamily / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Αソレノイド / Alpha-Beta Plaits / ロスマンフォールド / 2-Layer Sandwich / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 |
---|
生物種 | Homo sapiens (ヒト) synthetic construct (人工物) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.7 Å |
---|
データ登録者 | Fluetsch, A. / Seeger, M.A. / Gruetter, M.G. |
---|
引用 | ジャーナル: Protein Sci. / 年: 2013 タイトル: Design, construction, and characterization of a second-generation DARPin library with reduced hydrophobicity. 著者: Seeger, M.A. / Zbinden, R. / Flutsch, A. / Gutte, P.G. / Engeler, S. / Roschitzki-Voser, H. / Grutter, M.G. |
---|
履歴 | 登録 | 2013年2月19日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2013年8月21日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2013年10月9日 | Group: Database references |
---|
改定 1.2 | 2017年11月15日 | Group: Refinement description / カテゴリ: software |
---|
改定 1.3 | 2023年9月20日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details |
---|
|
---|