登録情報 データベース : PDB / ID : 4ja7 構造の表示 ダウンロードとリンクタイトル Rat PP5 co-crystallized with P5SA-2 要素Serine/threonine-protein phosphatase 5 詳細 キーワード HYDROLASE / PP5 / activation / tau-dephosphorylation / neurodegenerative disease / Ser/Thr-Protein Phosphatase domain / Tetratricopeptide Repeat domain / Hsp90機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
ESR-mediated signaling / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / histone H2AXS139 phosphatase activity / RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity / RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity / MAP kinase serine/threonine phosphatase activity / myosin phosphatase activity / peptidyl-serine dephosphorylation / positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway / response to arachidonate ... ESR-mediated signaling / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / histone H2AXS139 phosphatase activity / RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity / RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity / MAP kinase serine/threonine phosphatase activity / myosin phosphatase activity / peptidyl-serine dephosphorylation / positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway / response to arachidonate / calmodulin-dependent protein phosphatase activity / Negative regulation of MAPK pathway / RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity / RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity / RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity / proximal dendrite / mitogen-activated protein kinase kinase kinase binding / protein folding chaperone complex / response to morphine / protein-serine/threonine phosphatase / protein serine/threonine phosphatase activity / phosphatase activity / cellular response to cadmium ion / phosphoprotein phosphatase activity / protein serine/threonine kinase inhibitor activity / G-protein alpha-subunit binding / negative regulation of MAPK cascade / heat shock protein binding / Hsp70 protein binding / Hsp90 protein binding / ADP binding / response to lead ion / cellular response to hydrogen peroxide / perikaryon / microtubule binding / neuronal cell body / negative regulation of apoptotic process / protein-containing complex binding / protein-containing complex / RNA binding / ATP binding / metal ion binding / identical protein binding / nucleus / plasma membrane / cytosol 類似検索 - 分子機能 PP5, C-terminal metallophosphatase domain / PPP domain / PPP5 TPR repeat region / : / Serine/threonine specific protein phosphatases signature. / Protein phosphatase 2A homologues, catalytic domain. / Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase / Metallo-dependent phosphatases / Purple Acid Phosphatase; chain A, domain 2 / Tetratricopeptide repeat ... PP5, C-terminal metallophosphatase domain / PPP domain / PPP5 TPR repeat region / : / Serine/threonine specific protein phosphatases signature. / Protein phosphatase 2A homologues, catalytic domain. / Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase / Metallo-dependent phosphatases / Purple Acid Phosphatase; chain A, domain 2 / Tetratricopeptide repeat / Tetratricopeptide repeat domain / Calcineurin-like phosphoesterase domain, ApaH type / Calcineurin-like phosphoesterase / Metallo-dependent phosphatase-like / TPR repeat region circular profile. / TPR repeat profile. / Tetratricopeptide repeats / Tetratricopeptide repeat / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / 4-Layer Sandwich / Alpha Horseshoe / Tetratricopeptide-like helical domain superfamily / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性生物種 Rattus norvegicus (ドブネズミ)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2 Å 詳細データ登録者 Haslbeck, V. / Helmuth, M. / Alte, F. / Popowicz, G. / Schmidt, W. / Weiwad, M. / Fischer, G. / Gemmecker, G. / Sattler, M. / Striggow, F. ...Haslbeck, V. / Helmuth, M. / Alte, F. / Popowicz, G. / Schmidt, W. / Weiwad, M. / Fischer, G. / Gemmecker, G. / Sattler, M. / Striggow, F. / Groll, M. / Richter, K. 引用ジャーナル : Biosci.Rep. / 年 : 2015タイトル : Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism.著者 : Haslbeck, V. / Drazic, A. / Eckl, J.M. / Alte, F. / Helmuth, M. / Popowicz, G. / Schmidt, W. / Braun, F. / Weiwad, M. / Fischer, G. / Gemmecker, G. / Sattler, M. / Striggow, F. / Groll, M. / Richter, K. 履歴 登録 2013年2月18日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2014年2月19日 Provider : repository / タイプ : Initial release改定 1.1 2015年11月11日 Group : Database references / Other改定 1.2 2016年2月10日 Group : Database references改定 1.3 2016年8月10日 Group : Database references改定 1.4 2023年9月20日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_seq_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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