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Structure paper

TitleSelective activators of protein phosphatase 5 target the auto-inhibitory mechanism.
Journal, issue, pagesBiosci. Rep., Vol. 35, Year 2015
Publish dateFeb 18, 2013 (structure data deposition date)
AuthorsHaslbeck, V. / Drazic, A. / Eckl, J.M. / Alte, F. / Helmuth, M. / Popowicz, G. / Schmidt, W. / Braun, F. / Weiwad, M. / Fischer, G. ...Haslbeck, V. / Drazic, A. / Eckl, J.M. / Alte, F. / Helmuth, M. / Popowicz, G. / Schmidt, W. / Braun, F. / Weiwad, M. / Fischer, G. / Gemmecker, G. / Sattler, M. / Striggow, F. / Groll, M. / Richter, K.
External linksBiosci. Rep. / PubMed:26182372
MethodsX-ray diffraction
Resolution2 - 2.3 Å
Structure data

PDB-4ja7:
Rat PP5 co-crystallized with P5SA-2
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-4ja9:
Rat PP5 apo
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
KeywordsHYDROLASE / PP5 / activation / tau-dephosphorylation / neurodegenerative disease / Ser/Thr-Protein Phosphatase domain / Tetratricopeptide Repeat domain / Hsp90

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