Entry Database : PDB / ID : 4j8s Structure visualization Downloads & linksTitle Crystal structure of human CNOT1 MIF4G domain in complex with a TTP peptide ComponentsCCR4-NOT transcription complex subunit 1 Tristetraprolin DetailsKeywords PROTEIN BINDING / MIF4G / protein-protein interaction / TTP / cytosolFunction / homology Function and homology informationFunction Domain/homology Component
regulation of keratinocyte apoptotic process / negative regulation of polynucleotide adenylyltransferase activity / nuclear-transcribed mRNA catabolic process, deadenylation-independent decay / positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA / positive regulation of intracellular mRNA localization / negative regulation of erythrocyte differentiation / positive regulation of cytoplasmic mRNA processing body assembly / regulation of keratinocyte proliferation / positive regulation of miRNA-mediated gene silencing / CCR4-NOT core complex ... regulation of keratinocyte apoptotic process / negative regulation of polynucleotide adenylyltransferase activity / nuclear-transcribed mRNA catabolic process, deadenylation-independent decay / positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA / positive regulation of intracellular mRNA localization / negative regulation of erythrocyte differentiation / positive regulation of cytoplasmic mRNA processing body assembly / regulation of keratinocyte proliferation / positive regulation of miRNA-mediated gene silencing / CCR4-NOT core complex / armadillo repeat domain binding / CCR4-NOT complex / regulation of keratinocyte differentiation / regulation of stem cell population maintenance / negative regulation of retinoic acid receptor signaling pathway / positive regulation of mRNA catabolic process / nuclear-transcribed mRNA poly(A) tail shortening / negative regulation of intracellular estrogen receptor signaling pathway / Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA / trophectodermal cell differentiation / 3'-UTR-mediated mRNA destabilization / miRNA-mediated post-transcriptional gene silencing / C-C chemokine binding / Deadenylation of mRNA / mRNA 3'-UTR AU-rich region binding / negative regulation of viral transcription / miRNA-mediated gene silencing by inhibition of translation / nuclear retinoic acid receptor binding / M-decay: degradation of maternal mRNAs by maternally stored factors / cellular response to granulocyte macrophage colony-stimulating factor stimulus / regulation of tumor necrosis factor production / cellular response to fibroblast growth factor stimulus / peroxisomal membrane / cellular response to glucocorticoid stimulus / nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / RNA polymerase binding / TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain / positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / negative regulation of interleukin-2 production / positive regulation of nuclear-transcribed mRNA poly(A) tail shortening / 3'-UTR-mediated mRNA stabilization / response to starvation / mRNA catabolic process / p38MAPK cascade / mRNA transport / positive regulation of fat cell differentiation / cellular response to epidermal growth factor stimulus / regulation of mRNA stability / heat shock protein binding / viral process / 14-3-3 protein binding / nuclear estrogen receptor binding / P-body / response to wounding / cytoplasmic stress granule / MAPK cascade / cellular response to tumor necrosis factor / cellular response to lipopolysaccharide / negative regulation of translation / molecular adaptor activity / ribonucleoprotein complex / protein domain specific binding / mRNA binding / protein kinase binding / negative regulation of transcription by RNA polymerase II / enzyme binding / DNA binding / extracellular space / RNA binding / membrane / metal ion binding / nucleus / cytosol / cytoplasm Similarity search - Function CCR4-NOT transcription complex subunit 1 TTP binding domain / CCR4-Not complex component, Not1, C-terminal / CCR4-NOT transcription complex subunit 1, domain 4 / CCR4-NOT transcription complex subunit 1, CAF1-binding domain / CCR4-NOT transcription complex subunit 1, TTP binding domain / CCR4-NOT transcription complex subunit 1, HEAT repeat / CCR4-NOT subunit 1, TTP binding domain superfamily / CCR4-NOT transcription complex subunit 1 / CCR4-Not complex component, Not1 / CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819 ... CCR4-NOT transcription complex subunit 1 TTP binding domain / CCR4-Not complex component, Not1, C-terminal / CCR4-NOT transcription complex subunit 1, domain 4 / CCR4-NOT transcription complex subunit 1, CAF1-binding domain / CCR4-NOT transcription complex subunit 1, TTP binding domain / CCR4-NOT transcription complex subunit 1, HEAT repeat / CCR4-NOT subunit 1, TTP binding domain superfamily / CCR4-NOT transcription complex subunit 1 / CCR4-Not complex component, Not1 / CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819 / CCR4-NOT transcription complex subunit 1 CAF1-binding domain / CCR4-NOT transcription complex subunit 1 TTP binding domain / CCR4-NOT transcription complex subunit 1 HEAT repeat / Zinc finger C-x8-C-x5-C-x3-H type (and similar) / Zinc finger, CCCH-type superfamily / zinc finger / Zinc finger, CCCH-type / Zinc finger C3H1-type profile. / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Alpha Horseshoe / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)HOMO SAPIENS (human)Method X-RAY DIFFRACTION / Sulfur SAD / Resolution : 1.55 Å DetailsAuthors Frank, F. / Fabian, M.R. / Rouya, C. / Siddiqui, N. / Lai, W.S. / Karetnikov, A. / Blackshear, P.J. / Sonenberg, N. / Nagar, B. CitationJournal : Nat.Struct.Mol.Biol. / Year : 2013Title : Structural basis for the recruitment of the human CCR4-NOT deadenylase complex by tristetraprolin.Authors : Fabian, M.R. / Frank, F. / Rouya, C. / Siddiqui, N. / Lai, W.S. / Karetnikov, A. / Blackshear, P.J. / Nagar, B. / Sonenberg, N. History Deposition Feb 14, 2013 Deposition site : RCSB / Processing site : RCSBRevision 1.0 May 8, 2013 Provider : repository / Type : Initial releaseRevision 1.1 Jul 24, 2013 Group : Database referencesRevision 1.2 May 25, 2016 Group : Structure summaryRevision 1.3 Feb 28, 2024 Group : Data collection / Database referencesCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details
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