登録情報 | データベース: PDB / ID: 4ie7 |
---|
タイトル | Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with citrate and rhein (RHN) |
---|
要素 | Alpha-ketoglutarate-dependent dioxygenase FTO |
---|
キーワード | OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / double-stranded beta helix / jelly-roll motif / oxidoreductase / dioxygenase / nucleic acid demethylase / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex |
---|
機能・相同性 | 機能・相同性情報
regulation of white fat cell proliferation / tRNA demethylase activity / Reversal of alkylation damage by DNA dioxygenases / mRNA N6-methyladenine demethylase / mRNA N6-methyladenosine dioxygenase activity / regulation of respiratory system process / regulation of lipid storage / regulation of brown fat cell differentiation / oxidative RNA demethylase activity / broad specificity oxidative DNA demethylase activity ...regulation of white fat cell proliferation / tRNA demethylase activity / Reversal of alkylation damage by DNA dioxygenases / mRNA N6-methyladenine demethylase / mRNA N6-methyladenosine dioxygenase activity / regulation of respiratory system process / regulation of lipid storage / regulation of brown fat cell differentiation / oxidative RNA demethylase activity / broad specificity oxidative DNA demethylase activity / snRNA processing / 酸化還元酵素; 電子対供与作用を持つ; 分子酸素を取り込むないしは分子酸素を還元する; 2-オキソグルタル酸類を片方の電子供与体とする; 酸素分をそれぞれの電子供与体に取り込む / RNA repair / DNA alkylation repair / temperature homeostasis / mRNA destabilization / regulation of multicellular organism growth / adipose tissue development / ferrous iron binding / transferase activity / nuclear speck / intracellular membrane-bounded organelle / nucleoplasm / nucleus / plasma membrane / cytosol / cytoplasm類似検索 - 分子機能 FTO C-terminal domain / Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal / Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain / Alpha-ketoglutarate-dependent dioxygenase FTO / FTO, C-terminal domain superfamily / FTO catalytic domain / FTO C-terminal domain / FTO catalytic domain / Alpha-ketoglutarate-dependent dioxygenase AlkB-like / Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily ...FTO C-terminal domain / Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal / Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain / Alpha-ketoglutarate-dependent dioxygenase FTO / FTO, C-terminal domain superfamily / FTO catalytic domain / FTO C-terminal domain / FTO catalytic domain / Alpha-ketoglutarate-dependent dioxygenase AlkB-like / Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily / Methane Monooxygenase Hydroxylase; Chain G, domain 1 / Jelly Rolls / Up-down Bundle / Sandwich / Mainly Beta / Mainly Alpha類似検索 - ドメイン・相同性 CITRATE ANION / Chem-RHN / Alpha-ketoglutarate-dependent dioxygenase FTO類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.6004 Å |
---|
データ登録者 | Aik, W.S. / McDonough, M.A. / Schofield, C.J. |
---|
引用 | ジャーナル: J.Med.Chem. / 年: 2013 タイトル: Structural basis for inhibition of the fat mass and obesity associated protein (FTO) 著者: Aik, W.S. / Demetriades, M. / Hamdan, M.K.K. / Bagg, E.A.L. / Yeoh, K.K. / Lejeune, C. / Zhang, Z. / McDonough, M.A. / Schofield, C.J. |
---|
履歴 | 登録 | 2012年12月13日 | 登録サイト: RCSB / 処理サイト: PDBJ |
---|
改定 1.0 | 2013年4月3日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2013年4月17日 | Group: Database references |
---|
改定 1.2 | 2013年7月31日 | Group: Database references |
---|
改定 1.3 | 2017年11月15日 | Group: Refinement description / カテゴリ: software |
---|
改定 1.4 | 2023年11月8日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
---|
|
---|