登録情報 | データベース: PDB / ID: 4ia0 |
---|
タイトル | Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors |
---|
要素 | cGMP-specific 3',5'-cyclic phosphodiesterase |
---|
キーワード | HYDROLASE/HYDROLASE INHIBITOR / HYDROLASE / HYDROLASE-HYDROLASE INHIBITOR complex |
---|
機能・相同性 | 機能・相同性情報
positive regulation of oocyte development / 3',5'-cyclic-GMP phosphodiesterase / regulation of nitric oxide mediated signal transduction / negative regulation of cardiac muscle contraction / oocyte development / RHOBTB1 GTPase cycle / relaxation of cardiac muscle / positive regulation of cardiac muscle hypertrophy / cGMP catabolic process / cGMP effects ...positive regulation of oocyte development / 3',5'-cyclic-GMP phosphodiesterase / regulation of nitric oxide mediated signal transduction / negative regulation of cardiac muscle contraction / oocyte development / RHOBTB1 GTPase cycle / relaxation of cardiac muscle / positive regulation of cardiac muscle hypertrophy / cGMP catabolic process / cGMP effects / 3',5'-cyclic-nucleotide phosphodiesterase activity / cGMP binding / Smooth Muscle Contraction / 3',5'-cyclic-GMP phosphodiesterase activity / 3',5'-cyclic-AMP phosphodiesterase activity / T cell proliferation / negative regulation of T cell proliferation / cAMP-mediated signaling / metal ion binding / cytosol類似検索 - 分子機能 Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase / GAF domain / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase, conserved site / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase domain signature. / 3'5'-cyclic nucleotide phosphodiesterase domain profile. ...Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase / GAF domain / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase, conserved site / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase domain signature. / 3'5'-cyclic nucleotide phosphodiesterase domain profile. / Domain present in phytochromes and cGMP-specific phosphodiesterases. / GAF domain / GAF-like domain superfamily / Metal dependent phosphohydrolases with conserved 'HD' motif. / HD/PDEase domain / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Chem-5BB / cGMP-specific 3',5'-cyclic phosphodiesterase類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.17 Å |
---|
データ登録者 | Ren, J. / Chen, T. / Xu, Y. |
---|
引用 | ジャーナル: Bioorg.Med.Chem.Lett. / 年: 2013 タイトル: Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5. 著者: Gong, X. / Wang, G. / Ren, J. / Liu, Z. / Wang, Z. / Chen, T. / Yang, X. / Jiang, X. / Shen, J. / Jiang, H. / Aisa, H.A. / Xu, Y. / Li, J. |
---|
履歴 | 登録 | 2012年12月5日 | 登録サイト: RCSB / 処理サイト: PDBJ |
---|
改定 1.0 | 2014年1月1日 | Provider: repository / タイプ: Initial release |
---|
|
---|