登録情報 | データベース: PDB / ID: 4hda |
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タイトル | Crystal structure of human Sirt5 in complex with Fluor-de-Lys peptide and resveratrol |
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要素 | - Fluor-de-Lys peptide
- NAD-dependent protein deacylase sirtuin-5, mitochondrial
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キーワード | HYDROLASE/HYDROLASE ACTIVATOR / NAD-dependent deacetylase / Sirtuin / mitochondrial / activator complex / resveratrol / HYDROLASE-HYDROLASE ACTIVATOR complex |
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機能・相同性 | 機能・相同性情報
protein demalonylation / protein deglutarylation / regulation of ketone biosynthetic process / peptidyl-lysine demalonylation / protein desuccinylation / peptidyl-lysine desuccinylation / protein-glutaryllysine deglutarylase activity / protein-malonyllysine demalonylase activity / protein-succinyllysine desuccinylase activity / NAD-dependent protein lysine deacetylase activity ...protein demalonylation / protein deglutarylation / regulation of ketone biosynthetic process / peptidyl-lysine demalonylation / protein desuccinylation / peptidyl-lysine desuccinylation / protein-glutaryllysine deglutarylase activity / protein-malonyllysine demalonylase activity / protein-succinyllysine desuccinylase activity / NAD-dependent protein lysine deacetylase activity / protein deacetylation / negative regulation of cardiac muscle cell apoptotic process / NAD+ binding / negative regulation of reactive oxygen species metabolic process / 転移酵素; アシル基を移すもの; アミノアシル基以外のアシル基を移すもの / epigenetic regulation of gene expression / response to nutrient levels / mitochondrion organization / Transcriptional activation of mitochondrial biogenesis / mitochondrial intermembrane space / transferase activity / mitochondrial matrix / mitochondrion / zinc ion binding / nucleus / cytosol類似検索 - 分子機能 Sirtuin, class III / SIR2/SIRT2 'Small Domain' / SIR2/SIRT2 'Small Domain' / Sirtuin, catalytic core small domain superfamily / : / Sirtuin family / Sir2 family / Sirtuin family, catalytic core domain / Sirtuin catalytic domain profile. / TPP-binding domain ...Sirtuin, class III / SIR2/SIRT2 'Small Domain' / SIR2/SIRT2 'Small Domain' / Sirtuin, catalytic core small domain superfamily / : / Sirtuin family / Sir2 family / Sirtuin family, catalytic core domain / Sirtuin catalytic domain profile. / TPP-binding domain / DHS-like NAD/FAD-binding domain superfamily / Rossmann fold / 2-Layer Sandwich / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 RESVERATROL / NAD-dependent protein deacylase sirtuin-5, mitochondrial類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 2.601 Å |
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データ登録者 | Gertz, M. / Steegborn, C. |
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引用 | ジャーナル: Plos One / 年: 2012 タイトル: A molecular mechanism for direct sirtuin activation by resveratrol. 著者: Gertz, M. / Nguyen, G.T. / Fischer, F. / Suenkel, B. / Schlicker, C. / Franzel, B. / Tomaschewski, J. / Aladini, F. / Becker, C. / Wolters, D. / Steegborn, C. |
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履歴 | 登録 | 2012年10月2日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2012年12月5日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2013年2月20日 | Group: Database references |
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改定 1.2 | 2024年2月28日 | Group: Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_label_asym_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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