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TitleA molecular mechanism for direct sirtuin activation by resveratrol.
Journal, issue, pagesPlos One, Vol. 7, Page e49761-e49761, Year 2012
Publish dateOct 2, 2012 (structure data deposition date)
AuthorsGertz, M. / Nguyen, G.T. / Fischer, F. / Suenkel, B. / Schlicker, C. / Franzel, B. / Tomaschewski, J. / Aladini, F. / Becker, C. / Wolters, D. / Steegborn, C.
External linksPlos One / PubMed:23185430
MethodsX-ray diffraction
Resolution2.3 - 2.601 Å
Structure data

PDB-4hd8:
Crystal structure of human Sirt3 in complex with Fluor-de-Lys peptide and piceatannol
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-4hda:
Crystal structure of human Sirt5 in complex with Fluor-de-Lys peptide and resveratrol
Method: X-RAY DIFFRACTION / Resolution: 2.601 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-PIT:
PICEATANNOL

ChemComp-IPA:
ISOPROPYL ALCOHOL / alkaloid*YM

ChemComp-HOH:
WATER

ChemComp-STL:
RESVERATROL

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / NAD-dependent deacetylase / Sirtuin / mitochondrial / inhibitor complex / piceatannol / resveratrol-like compound / HYDROLASE-HYDROLASE INHIBITOR complex / HYDROLASE/HYDROLASE ACTIVATOR / activator complex / resveratrol / HYDROLASE-HYDROLASE ACTIVATOR complex

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