Entry Database : PDB / ID : 4h6j Structure visualization Downloads & linksTitle Identification of Cys 255 in HIF-1 as a novel site for development of covalent inhibitors of HIF-1 /ARNT PasB domain protein-protein interaction. ComponentsARYL HYDROCARBON NUCLEAR TRANSLOCATOR HYPOXIA INDUCIBLE FACTOR 1-ALPHA DetailsKeywords TRANSCRIPTION / PAS DOMAIN / HETERODIMER / HYPOXIA INDUCIBLE FACTOR / TRANSCRIPTION FACTOR / ARNTFunction / homology Function and homology informationFunction Domain/homology Component
epithelial cell differentiation involved in mammary gland alveolus development / neural fold elevation formation / iris morphogenesis / positive regulation of chemokine-mediated signaling pathway / hypoxia-inducible factor-1alpha signaling pathway / elastin metabolic process / glandular epithelial cell maturation / nuclear aryl hydrocarbon receptor complex / regulation of transforming growth factor beta2 production / connective tissue replacement involved in inflammatory response wound healing ... epithelial cell differentiation involved in mammary gland alveolus development / neural fold elevation formation / iris morphogenesis / positive regulation of chemokine-mediated signaling pathway / hypoxia-inducible factor-1alpha signaling pathway / elastin metabolic process / glandular epithelial cell maturation / nuclear aryl hydrocarbon receptor complex / regulation of transforming growth factor beta2 production / connective tissue replacement involved in inflammatory response wound healing / cardiac ventricle morphogenesis / negative regulation of mesenchymal cell apoptotic process / hemoglobin biosynthetic process / Aryl hydrocarbon receptor signalling / positive regulation of hormone biosynthetic process / mesenchymal cell apoptotic process / positive regulation of mitophagy / retina vasculature development in camera-type eye / Cellular response to hypoxia / intestinal epithelial cell maturation / aryl hydrocarbon receptor complex / negative regulation of growth / regulation of protein neddylation / collagen metabolic process / PTK6 Expression / intracellular oxygen homeostasis / negative regulation of bone mineralization / B-1 B cell homeostasis / positive regulation of protein sumoylation / vascular endothelial growth factor production / transcription regulator activator activity / dopaminergic neuron differentiation / Xenobiotics / negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / lactate metabolic process / STAT3 nuclear events downstream of ALK signaling / positive regulation of cytokine production involved in inflammatory response / Phase I - Functionalization of compounds / negative regulation of thymocyte apoptotic process / positive regulation of vascular endothelial growth factor receptor signaling pathway / motile cilium / positive regulation of signaling receptor activity / insulin secretion involved in cellular response to glucose stimulus / negative regulation of TOR signaling / response to iron ion / response to muscle activity / neural crest cell migration / Regulation of gene expression by Hypoxia-inducible Factor / regulation of glycolytic process / embryonic hemopoiesis / DNA-binding transcription repressor activity / DNA-binding transcription activator activity / PTK6 promotes HIF1A stabilization / regulation of aerobic respiration / digestive tract morphogenesis / muscle cell cellular homeostasis / positive regulation of neuroblast proliferation / axonal transport of mitochondrion / positive regulation of epithelial cell migration / bone mineralization / heart looping / outflow tract morphogenesis / E-box binding / intracellular glucose homeostasis / positive regulation of insulin secretion involved in cellular response to glucose stimulus / aryl hydrocarbon receptor binding / positive regulation of vascular endothelial growth factor production / neuroblast proliferation / TOR signaling / negative regulation of reactive oxygen species metabolic process / embryonic placenta development / positive regulation of blood vessel endothelial cell migration / epithelial to mesenchymal transition / cellular response to interleukin-1 / Endogenous sterols / cis-regulatory region sequence-specific DNA binding / chondrocyte differentiation / positive regulation of chemokine production / axon cytoplasm / positive regulation of endothelial cell proliferation / NPAS4 regulates expression of target genes / lactation / positive regulation of glycolytic process / negative regulation of miRNA transcription / positive regulation of erythrocyte differentiation / positive regulation of nitric-oxide synthase activity / response to reactive oxygen species / nuclear receptor binding / RNA polymerase II transcription regulatory region sequence-specific DNA binding / Hsp90 protein binding / euchromatin / visual learning / Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha / PPARA activates gene expression / NOTCH1 Intracellular Domain Regulates Transcription / cerebral cortex development / cellular response to virus / transcription coactivator binding / positive regulation of miRNA transcription / negative regulation of inflammatory response Similarity search - Function Hypoxia-inducible factor-1 alpha / HIF-1 alpha, transactivation domain, C-terminal / HIF-1 alpha C terminal transactivation domain / Hypoxia-inducible factor, alpha subunit-like / Hypoxia-inducible factor-1 / Nuclear translocator / PAS fold-3 / PAS fold / Helix-loop-helix DNA-binding domain / PAC motif ... Hypoxia-inducible factor-1 alpha / HIF-1 alpha, transactivation domain, C-terminal / HIF-1 alpha C terminal transactivation domain / Hypoxia-inducible factor, alpha subunit-like / Hypoxia-inducible factor-1 / Nuclear translocator / PAS fold-3 / PAS fold / Helix-loop-helix DNA-binding domain / PAC motif / Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) / PAS domain / PAS domain / Helix-loop-helix DNA-binding domain superfamily / helix loop helix domain / Myc-type, basic helix-loop-helix (bHLH) domain / Myc-type, basic helix-loop-helix (bHLH) domain profile. / Beta-Lactamase / PAS fold / PAS fold / PAS domain / PAS repeat profile. / PAS domain / PAS domain superfamily / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.52 Å DetailsAuthors Cardoso, R. / Love, R.A. / Nilsson, C. / Bergqvist, S. / Nowlin, D. / Yan, J. / Liu, K. / Zhu, J. / Chen, P. / Deng, Y.-L. ...Cardoso, R. / Love, R.A. / Nilsson, C. / Bergqvist, S. / Nowlin, D. / Yan, J. / Liu, K. / Zhu, J. / Chen, P. / Deng, Y.-L. / Dyson, H.J. / Greig, M.J. / Brooun, A. CitationJournal : Protein Sci. / Year : 2012Title : Identification of Cys255 in HIF-1 alpha as a novel site for development of covalent inhibitors of HIF-1 alpha /ARNT PasB domain protein-protein interaction.Authors : Cardoso, R. / Love, R. / Nilsson, C.L. / Bergqvist, S. / Nowlin, D. / Yan, J. / Liu, K.K. / Zhu, J. / Chen, P. / Deng, Y.L. / Dyson, H.J. / Greig, M.J. / Brooun, A. History Deposition Sep 19, 2012 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Dec 5, 2012 Provider : repository / Type : Initial releaseRevision 1.1 Aug 28, 2013 Group : Database referencesRevision 1.2 Jan 24, 2018 Group : Structure summary / Category : audit_author / Item : _audit_author.nameRevision 1.3 Feb 28, 2024 Group : Data collection / Database referencesCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details
Show all Show less