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Structure paper

TitleIdentification of Cys255 in HIF-1 alpha as a novel site for development of covalent inhibitors of HIF-1 alpha /ARNT PasB domain protein-protein interaction.
Journal, issue, pagesProtein Sci., Vol. 21, Page 1885-1896, Year 2012
Publish dateSep 19, 2012 (structure data deposition date)
AuthorsCardoso, R. / Love, R. / Nilsson, C.L. / Bergqvist, S. / Nowlin, D. / Yan, J. / Liu, K.K. / Zhu, J. / Chen, P. / Deng, Y.L. ...Cardoso, R. / Love, R. / Nilsson, C.L. / Bergqvist, S. / Nowlin, D. / Yan, J. / Liu, K.K. / Zhu, J. / Chen, P. / Deng, Y.L. / Dyson, H.J. / Greig, M.J. / Brooun, A.
External linksProtein Sci. / PubMed:23033253
MethodsX-ray diffraction
Resolution1.52 Å
Structure data

PDB-4h6j:
Identification of Cys 255 in HIF-1 as a novel site for development of covalent inhibitors of HIF-1 /ARNT PasB domain protein-protein interaction.
Method: X-RAY DIFFRACTION / Resolution: 1.52 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / PAS DOMAIN / HETERODIMER / HYPOXIA INDUCIBLE FACTOR / TRANSCRIPTION FACTOR / ARNT

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