Entry | Database: PDB / ID: 4gs7 |
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Title | Structure of the Interleukin-15 quaternary complex |
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Components | - Cytokine receptor common subunit gamma
- Interleukin-15
- Interleukin-15 receptor subunit alpha
- Interleukin-2 receptor subunit beta
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Keywords | IMMUNE SYSTEM / Cytokine / Cytokine Receptor / Immunoregulatory / anti-tumor / anti-viral / Reductive methylation |
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Function / homology | Function and homology information
NK T cell proliferation / extrathymic T cell selection / positive regulation of protein O-linked glycosylation / natural killer cell proliferation / mature B cell differentiation / interleukin-2 receptor complex / interleukin-2 receptor activity / positive regulation of natural killer cell differentiation / interleukin-15 receptor activity / interleukin-7-mediated signaling pathway ...NK T cell proliferation / extrathymic T cell selection / positive regulation of protein O-linked glycosylation / natural killer cell proliferation / mature B cell differentiation / interleukin-2 receptor complex / interleukin-2 receptor activity / positive regulation of natural killer cell differentiation / interleukin-15 receptor activity / interleukin-7-mediated signaling pathway / interleukin-2 binding / CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation / positive regulation of tissue remodeling / positive regulation of T cell differentiation in thymus / natural killer cell differentiation / Interleukin-9 signaling / Interleukin-21 signaling / interleukin-9-mediated signaling pathway / interleukin-4-mediated signaling pathway / positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation / interleukin-2-mediated signaling pathway / cytokine receptor binding / neutrophil activation / regulation of defense response to virus by host / cellular homeostasis / interleukin-15-mediated signaling pathway / tyrosine phosphorylation of STAT protein / STAT3 nuclear events downstream of ALK signaling / Interleukin-15 signaling / Interleukin-2 signaling / positive regulation of natural killer cell proliferation / negative regulation of cold-induced thermogenesis / cytokine receptor activity / regulation of T cell differentiation / positive regulation of B cell differentiation / positive regulation of interleukin-17 production / cytokine binding / cell surface receptor signaling pathway via JAK-STAT / macrophage differentiation / cell maturation / immunoglobulin mediated immune response / Interleukin receptor SHC signaling / lymph node development / coreceptor activity / positive regulation of T cell proliferation / positive regulation of phagocytosis / positive regulation of tyrosine phosphorylation of STAT protein / Interleukin-7 signaling / response to nutrient levels / positive regulation of cytokine production / cytokine activity / cytoplasmic vesicle membrane / cytokine-mediated signaling pathway / positive regulation of inflammatory response / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of immune response / negative regulation of neuron projection development / cell-cell signaling / RAF/MAP kinase cascade / gene expression / nuclear membrane / T cell differentiation in thymus / protein-containing complex assembly / Interleukin-4 and Interleukin-13 signaling / receptor complex / endosome / nuclear speck / immune response / Golgi membrane / external side of plasma membrane / positive regulation of cell population proliferation / endoplasmic reticulum membrane / positive regulation of gene expression / negative regulation of apoptotic process / protein kinase binding / cell surface / Golgi apparatus / signal transduction / endoplasmic reticulum / extracellular space / extracellular region / nucleoplasm / membrane / plasma membrane / cytoplasm / cytosolSimilarity search - Function Interleukin-15 / Interleukin-15, mammal / Interleukin-15 receptor subunit alpha / Interleukin-15/Interleukin-21 / Interleukin-2 receptor subunit beta, N-terminal / Interleukin-2 receptor subunit beta N-terminal domain 1 / Rubrerythrin, domain 2 - #230 / Interleukin-15/Interleukin-21 family / Interleukin 15 / : ...Interleukin-15 / Interleukin-15, mammal / Interleukin-15 receptor subunit alpha / Interleukin-15/Interleukin-21 / Interleukin-2 receptor subunit beta, N-terminal / Interleukin-2 receptor subunit beta N-terminal domain 1 / Rubrerythrin, domain 2 - #230 / Interleukin-15/Interleukin-21 family / Interleukin 15 / : / : / Cytokine receptor-like factor 2-like, D1 domain / Cytokine receptor-like factor 2-like, D2 domain / Short hematopoietin receptor family 1 signature. / Interleukin-6 receptor alpha chain, binding / Short hematopoietin receptor, family 1, conserved site / Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR) / Sushi/SCR/CCP domain / Sushi/CCP/SCR domain profile. / Sushi/SCR/CCP superfamily / Four-helical cytokine-like, core / Growth Hormone; Chain: A; / Rubrerythrin, domain 2 / Single Sheet / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Immunoglobulins / Immunoglobulin-like fold / Up-down Bundle / Immunoglobulin-like / Sandwich / Mainly Beta / Mainly AlphaSimilarity search - Domain/homology ACETATE ION / Interleukin-2 receptor subunit beta / Cytokine receptor common subunit gamma / Interleukin-15 / Interleukin-15 receptor subunit alphaSimilarity search - Component |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.35 Å |
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Authors | Ring, A.M. / Ozkan, E. / Feng, D. / Garcia, K.C. |
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Citation | Journal: Nat.Immunol. / Year: 2012 Title: Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15. Authors: Ring, A.M. / Lin, J.X. / Feng, D. / Mitra, S. / Rickert, M. / Bowman, G.R. / Pande, V.S. / Li, P. / Moraga, I. / Spolski, R. / Ozkan, E. / Leonard, W.J. / Garcia, K.C. |
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History | Deposition | Aug 27, 2012 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Nov 7, 2012 | Provider: repository / Type: Initial release |
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Revision 1.1 | Nov 14, 2012 | Group: Database references |
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Revision 1.2 | Dec 5, 2012 | Group: Database references |
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Revision 2.0 | Jul 29, 2020 | Group: Atomic model / Data collection ...Atomic model / Data collection / Database references / Derived calculations / Structure summary Category: atom_site / chem_comp ...atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / struct_asym / struct_conn / struct_ref_seq_dif / struct_site / struct_site_gen Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ..._atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.type_symbol / _chem_comp.name / _chem_comp.type / _pdbx_entity_nonpoly.comp_id / _pdbx_entity_nonpoly.entity_id / _pdbx_entity_nonpoly.name / _pdbx_struct_assembly_gen.asym_id_list / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_ref_seq_dif.details Description: Carbohydrate remediation / Provider: repository / Type: Remediation |
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