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TitleMechanistic and structural insight into the functional dichotomy between IL-2 and IL-15.
Journal, issue, pagesNat. Immunol., Vol. 13, Page 1187-1195, Year 2012
Publish dateAug 27, 2012 (structure data deposition date)
AuthorsRing, A.M. / Lin, J.X. / Feng, D. / Mitra, S. / Rickert, M. / Bowman, G.R. / Pande, V.S. / Li, P. / Moraga, I. / Spolski, R. ...Ring, A.M. / Lin, J.X. / Feng, D. / Mitra, S. / Rickert, M. / Bowman, G.R. / Pande, V.S. / Li, P. / Moraga, I. / Spolski, R. / Ozkan, E. / Leonard, W.J. / Garcia, K.C.
External linksNat. Immunol. / PubMed:23104097
MethodsX-ray diffraction
Resolution2.35 Å
Structure data

PDB-4gs7:
Structure of the Interleukin-15 quaternary complex
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-ACT:
ACETATE ION

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Cytokine / Cytokine Receptor / Immunoregulatory / anti-tumor / anti-viral / Reductive methylation

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