登録情報 | データベース: PDB / ID: 4g0c |
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タイトル | Neutron structure of acetazolamide-bound human carbonic anhydrase II reveal molecular details of drug binding. |
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要素 | Carbonic anhydrase 2 |
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キーワード | LYASE/LYASE inhibitor / carbonic anhydrase / acetazolamide / hydrogen bonding / LYASE-LYASE inhibitor complex |
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機能・相同性 | 機能・相同性情報
positive regulation of cellular pH reduction / positive regulation of dipeptide transmembrane transport / regulation of monoatomic anion transport / secretion / cyanamide hydratase / cyanamide hydratase activity / arylesterase activity / regulation of chloride transport / Reversible hydration of carbon dioxide / angiotensin-activated signaling pathway ...positive regulation of cellular pH reduction / positive regulation of dipeptide transmembrane transport / regulation of monoatomic anion transport / secretion / cyanamide hydratase / cyanamide hydratase activity / arylesterase activity / regulation of chloride transport / Reversible hydration of carbon dioxide / angiotensin-activated signaling pathway / positive regulation of synaptic transmission, GABAergic / morphogenesis of an epithelium / regulation of intracellular pH / carbonic anhydrase / carbonate dehydratase activity / carbon dioxide transport / Erythrocytes take up oxygen and release carbon dioxide / Erythrocytes take up carbon dioxide and release oxygen / neuron cellular homeostasis / one-carbon metabolic process / apical part of cell / myelin sheath / zinc ion binding / extracellular exosome / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Carbonic Anhydrase II / Alpha carbonic anhydrase / Carbonic anhydrase, alpha-class, conserved site / Alpha-carbonic anhydrases signature. / Carbonic anhydrase, alpha-class / Alpha carbonic anhydrase domain / Alpha carbonic anhydrase domain superfamily / Eukaryotic-type carbonic anhydrase / Alpha-carbonic anhydrases profile. / Eukaryotic-type carbonic anhydrase ...Carbonic Anhydrase II / Alpha carbonic anhydrase / Carbonic anhydrase, alpha-class, conserved site / Alpha-carbonic anhydrases signature. / Carbonic anhydrase, alpha-class / Alpha carbonic anhydrase domain / Alpha carbonic anhydrase domain superfamily / Eukaryotic-type carbonic anhydrase / Alpha-carbonic anhydrases profile. / Eukaryotic-type carbonic anhydrase / Roll / Alpha Beta類似検索 - ドメイン・相同性 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE / DEUTERATED WATER / Carbonic anhydrase 2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 中性子回折 / NUCLEAR REACTOR / 多重同系置換 / 解像度: 2 Å |
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データ登録者 | Fisher, S.Z. / McKenna, R. / Aggarwal, M. |
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引用 | ジャーナル: J.Am.Chem.Soc. / 年: 2012 タイトル: Neutron diffraction of acetazolamide-bound human carbonic anhydrase II reveals atomic details of drug binding. 著者: Fisher, S.Z. / Aggarwal, M. / Kovalevsky, A.Y. / Silverman, D.N. / McKenna, R. |
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履歴 | 登録 | 2012年7月9日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2012年9月19日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2012年11月21日 | Group: Database references |
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改定 1.2 | 2017年11月15日 | Group: Refinement description / Structure summary / カテゴリ: audit_author / software / Item: _audit_author.name / _software.name |
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改定 1.3 | 2018年4月25日 | Group: Data collection / カテゴリ: diffrn_source / Item: _diffrn_source.source |
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改定 1.4 | 2023年9月13日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_seq_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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