登録情報 | データベース: PDB / ID: 4fvt |
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タイトル | Human SIRT3 bound to Ac-ACS peptide and Carba-NAD |
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要素 | - Acetylated ACS2 peptide
- NAD-dependent protein deacetylase sirtuin-3, mitochondrial
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キーワード | HYDROLASE / Sirtuin / Carba-NAD |
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機能・相同性 | 機能・相同性情報
positive regulation of catalase activity / positive regulation of ceramide biosynthetic process / peptidyl-lysine deacetylation / positive regulation of superoxide dismutase activity / NAD-dependent protein lysine deacetylase activity / protein acetyllysine N-acetyltransferase / protein deacetylation / NAD-dependent histone deacetylase activity / Regulation of FOXO transcriptional activity by acetylation / NAD+ binding ...positive regulation of catalase activity / positive regulation of ceramide biosynthetic process / peptidyl-lysine deacetylation / positive regulation of superoxide dismutase activity / NAD-dependent protein lysine deacetylase activity / protein acetyllysine N-acetyltransferase / protein deacetylation / NAD-dependent histone deacetylase activity / Regulation of FOXO transcriptional activity by acetylation / NAD+ binding / negative regulation of reactive oxygen species metabolic process / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / aerobic respiration / Transcriptional activation of mitochondrial biogenesis / positive regulation of insulin secretion / negative regulation of ERK1 and ERK2 cascade / transferase activity / sequence-specific DNA binding / mitochondrial matrix / enzyme binding / protein-containing complex / mitochondrion / zinc ion binding / nucleoplasm / nucleus類似検索 - 分子機能 SIR2/SIRT2 'Small Domain' / SIR2/SIRT2 'Small Domain' / Sirtuin, catalytic core small domain superfamily / Sirtuin family / Sir2 family / Sirtuin family, catalytic core domain / Sirtuin catalytic domain profile. / TPP-binding domain / DHS-like NAD/FAD-binding domain superfamily / Rossmann fold ...SIR2/SIRT2 'Small Domain' / SIR2/SIRT2 'Small Domain' / Sirtuin, catalytic core small domain superfamily / Sirtuin family / Sir2 family / Sirtuin family, catalytic core domain / Sirtuin catalytic domain profile. / TPP-binding domain / DHS-like NAD/FAD-binding domain superfamily / Rossmann fold / 2-Layer Sandwich / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE / NAD-dependent protein deacetylase sirtuin-3, mitochondrial類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.47 Å |
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データ登録者 | Dai, H. |
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引用 | ジャーナル: J.Org.Chem. / 年: 2012 タイトル: Synthesis of Carba-NAD and the Structures of Its Ternary Complexes with SIRT3 and SIRT5. 著者: Szczepankiewicz, B.G. / Dai, H. / Koppetsch, K.J. / Qian, D. / Jiang, F. / Mao, C. / Perni, R.B. |
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履歴 | 登録 | 2012年6月29日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2012年8月15日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2012年9月19日 | Group: Database references |
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