- PDB-4fbk: Crystal structure of a covalently fused Nbs1-Mre11 complex with o... -
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基本情報
登録情報
データベース: PDB / ID: 4fbk
タイトル
Crystal structure of a covalently fused Nbs1-Mre11 complex with one manganese ion per active site
要素
DNA repair and telomere maintenance protein nbs1,DNA repair protein rad32 CHIMERIC PROTEIN
キーワード
HYDROLASE / PROTEIN BINDING / DNA double-strand break repair / Nuclease / Schizosaccharomyces pombe
機能・相同性
機能・相同性情報
Cytosolic sensors of pathogen-associated DNA / DNA Damage/Telomere Stress Induced Senescence / HDR through MMEJ (alt-NHEJ) / Sensing of DNA Double Strand Breaks / Processing of DNA double-strand break ends / mitochondrial double-strand break repair via homologous recombination / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / Mre11 complex / chromosome, telomeric repeat region / meiotic DNA double-strand break formation ...Cytosolic sensors of pathogen-associated DNA / DNA Damage/Telomere Stress Induced Senescence / HDR through MMEJ (alt-NHEJ) / Sensing of DNA Double Strand Breaks / Processing of DNA double-strand break ends / mitochondrial double-strand break repair via homologous recombination / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / Mre11 complex / chromosome, telomeric repeat region / meiotic DNA double-strand break formation / phosphorylation-dependent protein binding / DNA end binding / Y-form DNA binding / chromatin-protein adaptor activity / double-strand break repair involved in meiotic recombination / DNA double-strand break processing / nuclease activity / single-stranded DNA endodeoxyribonuclease activity / double-stranded DNA 3'-5' DNA exonuclease activity / telomere maintenance via recombination / single-stranded DNA 3'-5' DNA exonuclease activity / reciprocal meiotic recombination / mitotic intra-S DNA damage checkpoint signaling / DNA duplex unwinding / protein localization to chromosome, telomeric region / mitotic G2 DNA damage checkpoint signaling / telomere maintenance / double-strand break repair via homologous recombination / double-strand break repair via nonhomologous end joining / double-strand break repair / site of double-strand break / manganese ion binding / damaged DNA binding / molecular adaptor activity / 加水分解酵素; エステル加水分解酵素 / DNA repair / nucleus 類似検索 - 分子機能
A: DNA repair and telomere maintenance protein nbs1,DNA repair protein rad32 CHIMERIC PROTEIN B: DNA repair and telomere maintenance protein nbs1,DNA repair protein rad32 CHIMERIC PROTEIN ヘテロ分子
温度: 293 K / 手法: 蒸気拡散法, ハンギングドロップ法 詳細: 100 MM Tri Na Citrate pH 5.0, 200 mM ammonium sulfate, 13% PEG 4000, VAPOR DIFFUSION, HANGING DROP, temperature 293K