登録情報 | データベース: PDB / ID: 4f3l |
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タイトル | Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex |
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要素 | - BMAL1b
- Circadian locomoter output cycles protein kaput
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キーワード | TRANSCRIPTION/ACTIVATOR / bHLH / PAS / Circadian rhythm proteins / TRANSCRIPTION-ACTIVATOR complex |
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機能・相同性 | 機能・相同性情報
CLOCK-BMAL transcription complex / positive regulation of skeletal muscle cell differentiation / regulation of hair cycle / NPAS4 regulates expression of target genes / positive regulation of protein acetylation / negative regulation of glucocorticoid receptor signaling pathway / maternal process involved in parturition / regulation of type B pancreatic cell development / bHLH transcription factor binding / regulation of cellular senescence ...CLOCK-BMAL transcription complex / positive regulation of skeletal muscle cell differentiation / regulation of hair cycle / NPAS4 regulates expression of target genes / positive regulation of protein acetylation / negative regulation of glucocorticoid receptor signaling pathway / maternal process involved in parturition / regulation of type B pancreatic cell development / bHLH transcription factor binding / regulation of cellular senescence / aryl hydrocarbon receptor complex / perichromatin fibrils / chromatoid body / positive regulation of circadian rhythm / negative regulation of TOR signaling / oxidative stress-induced premature senescence / negative regulation of cold-induced thermogenesis / response to redox state / negative regulation of fat cell differentiation / protein acetylation / regulation of protein catabolic process / E-box binding / regulation of insulin secretion / regulation of neurogenesis / histone acetyltransferase activity / histone acetyltransferase / DNA damage checkpoint signaling / cellular response to ionizing radiation / circadian regulation of gene expression / regulation of circadian rhythm / chromatin DNA binding / PML body / autophagy / positive regulation of inflammatory response / circadian rhythm / protein import into nucleus / positive regulation of canonical Wnt signaling pathway / positive regulation of NF-kappaB transcription factor activity / gene expression / spermatogenesis / DNA-binding transcription activator activity, RNA polymerase II-specific / proteasome-mediated ubiquitin-dependent protein catabolic process / transcription regulator complex / sequence-specific DNA binding / nuclear body / protein dimerization activity / transcription cis-regulatory region binding / DNA-binding transcription factor activity, RNA polymerase II-specific / regulation of cell cycle / protein heterodimerization activity / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of DNA-templated transcription / regulation of DNA-templated transcription / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / positive regulation of transcription by RNA polymerase II / DNA binding / nucleoplasm / nucleus / cytoplasm / cytosol類似検索 - 分子機能 : / Helix-loop-helix DNA-binding domain / MYOD Basic-Helix-Loop-Helix Domain, subunit B / Nuclear translocator / Helix-loop-helix DNA-binding domain / PAC motif / Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) / PAS domain / PAS domain / Helix-loop-helix DNA-binding domain superfamily ...: / Helix-loop-helix DNA-binding domain / MYOD Basic-Helix-Loop-Helix Domain, subunit B / Nuclear translocator / Helix-loop-helix DNA-binding domain / PAC motif / Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) / PAS domain / PAS domain / Helix-loop-helix DNA-binding domain superfamily / helix loop helix domain / Myc-type, basic helix-loop-helix (bHLH) domain / Myc-type, basic helix-loop-helix (bHLH) domain profile. / Beta-Lactamase / PAS fold / PAS fold / PAS domain / PAS repeat profile. / PAS domain / PAS domain superfamily / Few Secondary Structures / Irregular / 2-Layer Sandwich / Alpha Beta類似検索 - ドメイン・相同性 Circadian locomoter output cycles protein kaput / BMAL1b / Basic helix-loop-helix ARNT-like protein 1類似検索 - 構成要素 |
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生物種 | ![](img/tx_mammal.gif) Mus musculus (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / 単波長異常分散 / 解像度: 2.268 Å |
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データ登録者 | Huang, N. / Chelliah, Y. / Shan, Y. / Taylor, C. / Yoo, S. / Partch, C. / Green, C.B. / Zhang, H. / Takahashi, J. |
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引用 | ジャーナル: Science / 年: 2012 タイトル: Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex. 著者: Huang, N. / Chelliah, Y. / Shan, Y. / Taylor, C.A. / Yoo, S.H. / Partch, C. / Green, C.B. / Zhang, H. / Takahashi, J.S. |
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履歴 | 登録 | 2012年5月9日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2012年6月6日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2012年8月1日 | Group: Database references |
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改定 1.2 | 2018年12月5日 | Group: Data collection / カテゴリ: diffrn_radiation_wavelength |
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改定 1.3 | 2024年2月28日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details |
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