登録情報 | データベース: PDB / ID: 4el1 |
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タイトル | Crystal structure of oxidized hPDI (abb'xa') |
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要素 | Protein disulfide-isomerase |
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キーワード | CHAPERONE / abb'a' domains / "CGHC" active sites / Horseshoe shape / enzyme / a redox-regulated chaperone / Endoplasmic reticulum |
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機能・相同性 | 機能・相同性情報
regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / procollagen-proline 4-dioxygenase complex / VLDL assembly / insulin processing / interleukin-23-mediated signaling pathway / LDL remodeling / procollagen-proline 4-dioxygenase activity / thiol oxidase activity / protein disulfide-isomerase / peptidyl-proline hydroxylation to 4-hydroxy-L-proline ...regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / procollagen-proline 4-dioxygenase complex / VLDL assembly / insulin processing / interleukin-23-mediated signaling pathway / LDL remodeling / procollagen-proline 4-dioxygenase activity / thiol oxidase activity / protein disulfide-isomerase / peptidyl-proline hydroxylation to 4-hydroxy-L-proline / endoplasmic reticulum chaperone complex / Collagen biosynthesis and modifying enzymes / protein folding in endoplasmic reticulum / Chylomicron assembly / Interleukin-23 signaling / interleukin-12-mediated signaling pathway / cellular response to interleukin-7 / Interleukin-12 signaling / protein disulfide isomerase activity / Insulin processing / Detoxification of Reactive Oxygen Species / endoplasmic reticulum-Golgi intermediate compartment / positive regulation of cell adhesion / protein-disulfide reductase activity / endoplasmic reticulum to Golgi vesicle-mediated transport / positive regulation of substrate adhesion-dependent cell spreading / response to endoplasmic reticulum stress / Hedgehog ligand biogenesis / Post-translational protein phosphorylation / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / melanosome / integrin binding / protein folding / lamellipodium / actin binding / cellular response to hypoxia / positive regulation of viral entry into host cell / cytoskeleton / protein heterodimerization activity / endoplasmic reticulum lumen / external side of plasma membrane / focal adhesion / enzyme binding / endoplasmic reticulum / protein-containing complex / RNA binding / extracellular exosome / extracellular region / cytosol類似検索 - 分子機能 Protein disulphide isomerase / Thioredoxin-like domain / Disulphide isomerase / Endoplasmic reticulum targeting sequence. / Thioredoxin / Thioredoxin, conserved site / Thioredoxin family active site. / Thioredoxin domain profile. / Thioredoxin domain / Glutaredoxin ...Protein disulphide isomerase / Thioredoxin-like domain / Disulphide isomerase / Endoplasmic reticulum targeting sequence. / Thioredoxin / Thioredoxin, conserved site / Thioredoxin family active site. / Thioredoxin domain profile. / Thioredoxin domain / Glutaredoxin / Glutaredoxin / Thioredoxin-like superfamily / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.883 Å |
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データ登録者 | Wang, C. / Li, W. / Ren, J. / Ke, H. / Gong, W. / Feng, W. / Wang, C.-C. |
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引用 | ジャーナル: Antioxid Redox Signal / 年: 2013 タイトル: Structural insights into the redox-regulated dynamic conformations of human protein disulfide isomerase 著者: Wang, C. / Li, W. / Ren, J. / Fang, J. / Ke, H. / Gong, W. / Feng, W. / Wang, C.-C. |
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履歴 | 登録 | 2012年4月10日 | 登録サイト: RCSB / 処理サイト: PDBJ |
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改定 1.0 | 2013年4月10日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2013年7月3日 | Group: Database references |
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改定 1.2 | 2023年11月8日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details |
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