- PDB-4e4v: The crystal structure of the dimeric human importin alpha 1 at 2.... -
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基本情報
登録情報
データベース: PDB / ID: 4e4v
タイトル
The crystal structure of the dimeric human importin alpha 1 at 2.5 angstrom resolution.
要素
Importin subunit alpha-2
キーワード
TRANSPORT PROTEIN / armadillo repeat / karyopherin / importin / nuclear import / host-virus interaction / nucleus / phosphoprotein / protein transport / transport
機能・相同性
機能・相同性情報
Sensing of DNA Double Strand Breaks / regulation of DNA recombination / entry of viral genome into host nucleus through nuclear pore complex via importin / positive regulation of viral life cycle / NS1 Mediated Effects on Host Pathways / NLS-dependent protein nuclear import complex / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / nuclear import signal receptor activity / DNA metabolic process / CaMK IV-mediated phosphorylation of CREB ...Sensing of DNA Double Strand Breaks / regulation of DNA recombination / entry of viral genome into host nucleus through nuclear pore complex via importin / positive regulation of viral life cycle / NS1 Mediated Effects on Host Pathways / NLS-dependent protein nuclear import complex / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / nuclear import signal receptor activity / DNA metabolic process / CaMK IV-mediated phosphorylation of CREB / nuclear localization sequence binding / NLS-bearing protein import into nucleus / positive regulation of type I interferon production / ISG15 antiviral mechanism / histone deacetylase binding / protein import into nucleus / SARS-CoV-1 activates/modulates innate immune responses / host cell / nuclear membrane / Estrogen-dependent gene expression / Golgi membrane / endoplasmic reticulum membrane / SARS-CoV-2 activates/modulates innate and adaptive immune responses / RNA binding / nucleoplasm / membrane / nucleus / cytosol / cytoplasm 類似検索 - 分子機能