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- PDB-4dx5: Transport of drugs by the multidrug transporter AcrB involves an ... -

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IDまたはキーワード:

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基本情報

登録情報
データベース: PDB / ID: 4dx5
タイトルTransport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop
要素
  • Acriflavine resistance protein B
  • DARPIN
キーワードMEMBRANE PROTEIN / TRANSPORT PROTEIN / DARPin / multidrug efflux protein
機能・相同性
機能・相同性情報


alkane transmembrane transporter activity / alkane transport / enterobactin transport / enterobactin transmembrane transporter activity / xenobiotic detoxification by transmembrane export across the cell outer membrane / periplasmic side of plasma membrane / efflux pump complex / bile acid transmembrane transporter activity / xenobiotic transport / bile acid and bile salt transport ...alkane transmembrane transporter activity / alkane transport / enterobactin transport / enterobactin transmembrane transporter activity / xenobiotic detoxification by transmembrane export across the cell outer membrane / periplasmic side of plasma membrane / efflux pump complex / bile acid transmembrane transporter activity / xenobiotic transport / bile acid and bile salt transport / efflux transmembrane transporter activity / xenobiotic transmembrane transporter activity / fatty acid transport / response to toxic substance / response to xenobiotic stimulus / response to antibiotic / identical protein binding / membrane / plasma membrane
類似検索 - 分子機能
Multidrug efflux transporter AcrB transmembrane fold / Multidrug efflux transporter AcrB transmembrane domain / Multidrug efflux transporter AcrB pore domain / Multidrug efflux transporter AcrB pore domain like / Multidrug efflux transporter AcrB pore domain / Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains / Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains / Hydrophobe/amphiphile efflux-1 HAE1 / Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains / Acriflavin resistance protein ...Multidrug efflux transporter AcrB transmembrane fold / Multidrug efflux transporter AcrB transmembrane domain / Multidrug efflux transporter AcrB pore domain / Multidrug efflux transporter AcrB pore domain like / Multidrug efflux transporter AcrB pore domain / Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains / Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains / Hydrophobe/amphiphile efflux-1 HAE1 / Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains / Acriflavin resistance protein / AcrB/AcrD/AcrF family / Ankyrin repeat-containing domain / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Alpha Horseshoe / Alpha-Beta Plaits / Up-down Bundle / 2-Layer Sandwich / Mainly Alpha / Alpha Beta
類似検索 - ドメイン・相同性
TETRADECANE / DECANE / DODECANE / nonane / HEXANE / Chem-MIY / N-OCTANE / UNDECANE / Multidrug efflux pump subunit AcrB
類似検索 - 構成要素
生物種Escherichia coli (大腸菌)
SYNTHETIC CONSTRUCT (人工物)
手法X線回折 / シンクロトロン / 分子置換 / 解像度: 1.9 Å
データ登録者Eicher, T. / Cha, H. / Seeger, M.A. / Brandstaetter, L. / El-Delik, J. / Bohnert, J.A. / Kern, W.V. / Verrey, F. / Gruetter, M.G. / Diederichs, K. / Pos, K.M.
引用ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 2012
タイトル: Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop.
著者: Eicher, T. / Cha, H.J. / Seeger, M.A. / Brandstatter, L. / El-Delik, J. / Bohnert, J.A. / Kern, W.V. / Verrey, F. / Grutter, M.G. / Diederichs, K. / Pos, K.M.
履歴
登録2012年2月27日登録サイト: RCSB / 処理サイト: RCSB
改定 1.02012年5月2日Provider: repository / タイプ: Initial release
改定 1.12014年1月29日Group: Source and taxonomy
改定 1.22024年2月28日Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Structure summary
カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / entity / pdbx_entity_nonpoly / struct_ref_seq_dif / struct_site
Item: _chem_comp.name / _database_2.pdbx_DOI ..._chem_comp.name / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id

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構造の表示

構造ビューア分子:
MolmilJmol/JSmol

ダウンロードとリンク

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集合体

登録構造単位
A: Acriflavine resistance protein B
B: Acriflavine resistance protein B
C: Acriflavine resistance protein B
D: DARPIN
E: DARPIN
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)390,62356
ポリマ－380,8445
非ポリマー9,77951
水32,1211783
1


  • 登録構造と同一
  • 登録者が定義した集合体
タイプ名称対称操作数
identity operation1_555x,y,z1
単位格子
Length a, b, c (Å)145.990, 161.720, 245.970
Angle α, β, γ (deg.)90.00, 90.00, 90.00
Int Tables number19
Space group name H-MP212121

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要素

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タンパク質 , 2種, 5分子 ABCDE

#1: タンパク質 Acriflavine resistance protein B


分子量: 114736.289 Da / 分子数: 3 / 由来タイプ: 組換発現 / 由来: (組換発現) Escherichia coli (大腸菌) / 株: K12 / 遺伝子: acrB, acrE, b0462, JW0451 / プラスミド: pET24 / 発現宿主: Escherichia coli (大腸菌) / 株 (発現宿主): C43(DE3) / 参照: UniProt: P31224
#2: タンパク質 DARPIN


分子量: 18317.566 Da / 分子数: 2 / 由来タイプ: 組換発現 / 由来: (組換発現) SYNTHETIC CONSTRUCT (人工物) / プラスミド: PQE30 / 発現宿主: Escherichia coli (大腸菌) / 株 (発現宿主): Xl1blue

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糖 , 2種, 9分子

#4: 糖
ChemComp-LMT / DODECYL-BETA-D-MALTOSIDE / ドデシルβ-D-マルトシド


タイプ: D-saccharide / 分子量: 510.615 Da / 分子数: 8 / 由来タイプ: 合成 / 式: C24H46O11 / コメント: 可溶化剤*YM
#11: 糖 ChemComp-LMU / DODECYL-ALPHA-D-MALTOSIDE


タイプ: D-saccharide / 分子量: 510.615 Da / 分子数: 1 / 由来タイプ: 合成 / 式: C24H46O11 / コメント: 可溶化剤*YM

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非ポリマー , 11種, 1825分子

#3: 化合物
ChemComp-GOL / GLYCEROL / GLYCERIN / PROPANE-1,2,3-TRIOL / グリセロ-ル


分子量: 92.094 Da / 分子数: 15 / 由来タイプ: 合成 / 式: C3H8O3
#5: 化合物
ChemComp-OCT / N-OCTANE / オクタン


分子量: 114.229 Da / 分子数: 7 / 由来タイプ: 合成 / 式: C8H18
#6: 化合物
ChemComp-D10 / DECANE / デカン


分子量: 142.282 Da / 分子数: 6 / 由来タイプ: 合成 / 式: C10H22
#7: 化合物
ChemComp-HEX / HEXANE / ヘキサン


分子量: 86.175 Da / 分子数: 5 / 由来タイプ: 合成 / 式: C6H14
#8: 化合物
ChemComp-D12 / DODECANE / ドデカン


分子量: 170.335 Da / 分子数: 4 / 由来タイプ: 合成 / 式: C12H26
#9: 化合物 ChemComp-MIY / (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE / MINOCYCLINE / ミノサイクリン


分子量: 457.476 Da / 分子数: 1 / 由来タイプ: 合成 / 式: C23H27N3O7 / コメント: 薬剤, 抗生剤*YM
#10: 化合物 ChemComp-C14 / TETRADECANE / テトラデカン


分子量: 198.388 Da / 分子数: 1 / 由来タイプ: 合成 / 式: C14H30
#12: 化合物 ChemComp-DD9 / nonane / ノナン


分子量: 128.255 Da / 分子数: 1 / 由来タイプ: 合成 / 式: C9H20
#13: 化合物 ChemComp-SO4 / SULFATE ION / 硫酸ジアニオン


分子量: 96.063 Da / 分子数: 1 / 由来タイプ: 合成 / 式: SO4
#14: 化合物 ChemComp-UND / UNDECANE / LIPID FRAGMENT / ウンデカン


分子量: 156.308 Da / 分子数: 1 / 由来タイプ: 合成 / 式: C11H24
#15: 水 ChemComp-HOH / water


分子量: 18.015 Da / 分子数: 1783 / 由来タイプ: 天然 / 式: H2O

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実験情報

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実験

実験手法: X線回折 / 使用した結晶の数: 1

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試料調製

結晶マシュー密度: 3.81 Å3/Da / 溶媒含有率: 67.73 %
結晶化温度: 290 K / 手法: 蒸気拡散法, ハンギングドロップ法 / pH: 6.5
詳細: 0.05M ADA, pH 6.5, 0.2M ammonium sulfate, 7% PEG 4000, 6% glycerol, 0.002M minocycline, VAPOR DIFFUSION, HANGING DROP, temperature 290K

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データ収集

回折平均測定温度: 100 K
放射光源由来: シンクロトロン / サイト: SLS / ビームライン: X06SA / 波長: 1 Å
検出器タイプ: MARRESEARCH / 検出器: CCD / 日付: 2006年10月27日
放射プロトコル: SINGLE WAVELENGTH / 単色(M)・ラウエ(L): M / 散乱光タイプ: x-ray
放射波長波長: 1 Å / 相対比: 1
反射解像度: 1.9→39.47 Å / Num. all: 452134 / Num. obs: 452063 / % possible obs: 99.9 % / Observed criterion σ(F): -3 / Observed criterion σ(I): -3 / Rmerge(I) obs: 0.116 / Net I/σ(I): 12.44
反射 シェル
解像度 (Å)Rmerge(I) obsMean I/σ(I) obsDiffraction-ID% possible all
1.9-2.010.0230.66194.2
2.01-2.150.0231.621100
2.15-2.320.0233.111100
2.32-2.540.0235.361100
2.54-2.840.0239.261100
2.84-3.280.02317.221100
3.28-4.010.02331.871100
4.01-5.640.02345.811100
5.64-39.47350.58198.5

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解析

ソフトウェア
名称バージョン分類NB
XSCALEデータスケーリング
PHENIX1.7.3_928精密化
PDB_EXTRACT3.1データ抽出
XDSデータスケーリング
XDSデータ削減
MOLREP位相決定
精密化構造決定の手法: 分子置換 / 解像度: 1.9→39.468 Å / Occupancy max: 1 / Occupancy min: 1 / SU ML: 0.29 / σ(F): 1.99 / 位相誤差: 26.1 / 立体化学のターゲット値: ML
Rfactor反射数%反射
Rfree0.2312 22549 5 %
Rwork0.2002 --
obs0.2018 450987 99.35 %
all-450986 -
溶媒の処理減衰半径: 0.98 Å / VDWプローブ半径: 1.2 Å / 溶媒モデル: FLAT BULK SOLVENT MODEL / Bsol: 44.532 Å2 / ksol: 0.34 e/Å3
原子変位パラメータ
Baniso -1Baniso -2Baniso -3
1--4.8686 Å20 Å2-0 Å2
2--6.475 Å2-0 Å2
3----1.6064 Å2
精密化ステップサイクル: LAST / 解像度: 1.9→39.468 Å
タンパク質核酸リガンド溶媒全体
原子数25969 0 671 1783 28423
拘束条件
Refine-IDタイプDev ideal数
X-RAY DIFFRACTIONf_bond_d0.00727101
X-RAY DIFFRACTIONf_angle_d1.136674
X-RAY DIFFRACTIONf_dihedral_angle_d15.4149841
X-RAY DIFFRACTIONf_chiral_restr0.0844317
X-RAY DIFFRACTIONf_plane_restr0.0044620
LS精密化 シェル
解像度 (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
1.9-1.92160.45886810.44113022X-RAY DIFFRACTION91
1.9216-1.94420.44977140.424213574X-RAY DIFFRACTION95
1.9442-1.96790.39687310.399513856X-RAY DIFFRACTION97
1.9679-1.99290.38777410.375614133X-RAY DIFFRACTION99
1.9929-2.01910.37267510.349214217X-RAY DIFFRACTION100
2.0191-2.04670.33867510.322914268X-RAY DIFFRACTION100
2.0467-2.0760.31527540.294414309X-RAY DIFFRACTION100
2.076-2.1070.30967500.272614230X-RAY DIFFRACTION100
2.107-2.13990.29037520.255714290X-RAY DIFFRACTION100
2.1399-2.1750.27477530.244214297X-RAY DIFFRACTION100
2.175-2.21250.26067530.228314311X-RAY DIFFRACTION100
2.2125-2.25270.27567540.228814315X-RAY DIFFRACTION100
2.2527-2.2960.25737510.211614280X-RAY DIFFRACTION100
2.296-2.34290.24857540.209414327X-RAY DIFFRACTION100
2.3429-2.39380.25057520.204314296X-RAY DIFFRACTION100
2.3938-2.44950.24957560.201214354X-RAY DIFFRACTION100
2.4495-2.51070.24327530.200114309X-RAY DIFFRACTION100
2.5107-2.57860.24367530.189514310X-RAY DIFFRACTION100
2.5786-2.65450.22427580.183714404X-RAY DIFFRACTION100
2.6545-2.74010.23127530.18614305X-RAY DIFFRACTION100
2.7401-2.8380.23327570.184714380X-RAY DIFFRACTION100
2.838-2.95160.2137550.174114353X-RAY DIFFRACTION100
2.9516-3.08590.22077590.181914410X-RAY DIFFRACTION100
3.0859-3.24850.21327600.175514447X-RAY DIFFRACTION100
3.2485-3.4520.20397590.174114424X-RAY DIFFRACTION100
3.452-3.71830.19547610.164814442X-RAY DIFFRACTION100
3.7183-4.09210.19137630.162114507X-RAY DIFFRACTION100
4.0921-4.68350.18337660.156914549X-RAY DIFFRACTION100
4.6835-5.89750.19747710.174514657X-RAY DIFFRACTION100
5.8975-39.47690.2017830.185914862X-RAY DIFFRACTION99
精密化 TLS手法: refined / Origin x: 40.538 Å / Origin y: -31.3127 Å / Origin z: -30.7368 Å
111213212223313233
T0.0053 Å20.0167 Å2-0.0358 Å2-0.0491 Å2-0.0285 Å2--0.0367 Å2
L0.4869 °20.0729 °2-0.1261 °2-0.2495 °2-0.1091 °2--0.4191 °2
S0.068 Å °0.0507 Å °0.0701 Å °-0.0014 Å °-0.0422 Å °0.0493 Å °-0.071 Å °-0.0272 Å °-0.0016 Å °
精密化 TLSグループ
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )A1 - 1044
2X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )A1102
3X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )A1103
4X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )A1104
5X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )A1106
6X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )A1105
7X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )A1107
8X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )A1201 - 1741
9X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )A1108
10X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )A1109
11X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )A1110
12X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1 - 1033
13X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1102
14X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1103
15X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1201 - 1780
16X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1105
17X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1104
18X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1107
19X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1106
20X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1108
21X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1109
22X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1110
23X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1112
24X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1111
25X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1114
26X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1113
27X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1115
28X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1116
29X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1117
30X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1118
31X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1119
32X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1120
33X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1 - 1033
34X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1103
35X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1104
36X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1106
37X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1105
38X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1201 - 1732
39X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1107
40X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1108
41X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1109
42X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1111
43X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1110
44X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1113
45X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1112
46X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1114
47X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1115
48X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1116
49X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1117
50X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1118
51X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )E15 - 166
52X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )E301 - 342
53X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )D11 - 166
54X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )D301 - 388
55X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )D202

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万見について

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お知らせ

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2022年2月9日: EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

  • EMDBのヘッダファイルのバージョン3が、公式のフォーマットとなりました。
  • これまでは公式だったバージョン1.9は、アーカイブから削除されます。

関連情報:EMDBヘッダ

外部リンク:wwPDBはEMDBデータモデルのバージョン3へ移行します

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2020年8月12日: 新型コロナ情報

新型コロナ情報

URL: https://pdbj.org/emnavi/covid19.php

新ページ: EM Navigatorに新型コロナウイルスの特設ページを開設しました。

関連情報:Covid-19情報 / 2020年3月5日: 新型コロナウイルスの構造データ

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2020年3月5日: 新型コロナウイルスの構造データ

新型コロナウイルスの構造データ

関連情報:万見生物種 / 2020年8月12日: 新型コロナ情報

外部リンク:COVID-19特集ページ - PDBj / 今月の分子2020年2月：コロナウイルスプロテーアーゼ

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2019年1月31日: EMDBのIDの桁数の変更

EMDBのIDの桁数の変更

  • EMDBエントリに付与されているアクセスコード(EMDB-ID)は4桁の数字(例、EMD-1234)でしたが、間もなく枯渇します。これまでの4桁のID番号は4桁のまま変更されませんが、4桁の数字を使い切った後に発行されるIDは5桁以上の数字(例、EMD-12345)になります。5桁のIDは2019年の春頃から発行される見通しです。
  • EM Navigator/万見では、接頭語「EMD-」は省略されています。

関連情報:Q: 「EMD」とは何ですか？ / 万見/EM NavigatorにおけるID/アクセスコードの表記

外部リンク:EMDB Accession Codes are Changing Soon! / PDBjへお問い合わせ

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2017年7月12日: PDB大規模アップデート

PDB大規模アップデート

  • 新バージョンのPDBx/mmCIF辞書形式に基づくデータがリリースされました。
  • 今回の更新はバージョン番号が4から5になる大規模なもので、全エントリデータの書き換えが行われる「Remediation」というアップデートに該当します。
  • このバージョンアップで、電子顕微鏡の実験手法に関する多くの項目の書式が改定されました(例：em_softwareなど)。
  • EM NavigatorとYorodumiでも、この改定に基づいた表示内容になります。

外部リンク:wwPDB Remediation / OneDepデータ基準に準拠した、より強化された内容のモデル構造ファイルが、PDBアーカイブで公開されました。

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万見 (Yorodumi)

幾万の構造データを、幾万の視点から

  • 万見(Yorodumi)は、EMDB/PDB/SASBDBなどの構造データを閲覧するためのページです。
  • EM Navigatorの詳細ページの後継、Omokage検索のフロントエンドも兼ねています。

関連情報:EMDB / PDB / SASBDB / 3つのデータバンクの比較 / 万見検索 / 2016年8月31日: 新しいEM Navigatorと万見 / 万見文献 / Jmol/JSmol / 機能・相同性情報 / 新しいEM Navigatorと万見の変更点

他の情報も見る