Entry | Database: PDB / ID: 4dx5 |
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Title | Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop |
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Components | - Acriflavine resistance protein B
- DARPIN
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Keywords | MEMBRANE PROTEIN / TRANSPORT PROTEIN / DARPin / multidrug efflux protein |
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Function / homology | Function and homology information
xenobiotic detoxification by transmembrane export across the cell outer membrane / efflux pump complex / periplasmic side of plasma membrane / efflux transmembrane transporter activity / xenobiotic transmembrane transporter activity / identical protein binding / membrane / plasma membraneSimilarity search - Function Multidrug efflux transporter AcrB transmembrane fold / Multidrug efflux transporter AcrB transmembrane domain / Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains / Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains / Multidrug efflux transporter AcrB pore domain / Multidrug efflux transporter AcrB pore domain like / Multidrug efflux transporter AcrB pore domain / Hydrophobe/amphiphile efflux-1 HAE1 / Acriflavin resistance protein / Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains ...Multidrug efflux transporter AcrB transmembrane fold / Multidrug efflux transporter AcrB transmembrane domain / Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains / Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains / Multidrug efflux transporter AcrB pore domain / Multidrug efflux transporter AcrB pore domain like / Multidrug efflux transporter AcrB pore domain / Hydrophobe/amphiphile efflux-1 HAE1 / Acriflavin resistance protein / Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains / AcrB/AcrD/AcrF family / Ankyrin repeat-containing domain / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Alpha Horseshoe / Alpha-Beta Plaits / Up-down Bundle / 2-Layer Sandwich / Mainly Alpha / Alpha BetaSimilarity search - Domain/homology TETRADECANE / DECANE / DODECANE / nonane / HEXANE / Chem-MIY / N-OCTANE / UNDECANE / Multidrug efflux pump subunit AcrBSimilarity search - Component |
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Biological species | ![](img/tx_bacteria.gif) Escherichia coli (E. coli) SYNTHETIC CONSTRUCT (others) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.9 Å |
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Authors | Eicher, T. / Cha, H. / Seeger, M.A. / Brandstaetter, L. / El-Delik, J. / Bohnert, J.A. / Kern, W.V. / Verrey, F. / Gruetter, M.G. / Diederichs, K. / Pos, K.M. |
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Citation | Journal: Proc.Natl.Acad.Sci.USA / Year: 2012 Title: Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop. Authors: Eicher, T. / Cha, H.J. / Seeger, M.A. / Brandstatter, L. / El-Delik, J. / Bohnert, J.A. / Kern, W.V. / Verrey, F. / Grutter, M.G. / Diederichs, K. / Pos, K.M. |
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History | Deposition | Feb 27, 2012 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | May 2, 2012 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jan 29, 2014 | Group: Source and taxonomy |
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Revision 1.2 | Feb 28, 2024 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Structure summary Category: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / entity / pdbx_entity_nonpoly / struct_ref_seq_dif / struct_site Item: _chem_comp.name / _database_2.pdbx_DOI ..._chem_comp.name / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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