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- PDB-4dx5: Transport of drugs by the multidrug transporter AcrB involves an ... -

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Basic information

Entry
Database: PDB / ID: 4dx5
TitleTransport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop
Components
  • Acriflavine resistance protein B
  • DARPIN
KeywordsMEMBRANE PROTEIN / TRANSPORT PROTEIN / DARPin / multidrug efflux protein
Function / homology
Function and homology information


xenobiotic detoxification by transmembrane export across the cell outer membrane / efflux pump complex / periplasmic side of plasma membrane / xenobiotic transmembrane transporter activity / efflux transmembrane transporter activity / outer membrane-bounded periplasmic space / membrane / identical protein binding / plasma membrane
Similarity search - Function
Multidrug efflux transporter AcrB transmembrane fold / Multidrug efflux transporter AcrB transmembrane domain / Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains / Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains / Multidrug efflux transporter AcrB pore domain / Multidrug efflux transporter AcrB pore domain like / Multidrug efflux transporter AcrB pore domain / Hydrophobe/amphiphile efflux-1 HAE1 / Acriflavin resistance protein / Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains ...Multidrug efflux transporter AcrB transmembrane fold / Multidrug efflux transporter AcrB transmembrane domain / Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains / Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains / Multidrug efflux transporter AcrB pore domain / Multidrug efflux transporter AcrB pore domain like / Multidrug efflux transporter AcrB pore domain / Hydrophobe/amphiphile efflux-1 HAE1 / Acriflavin resistance protein / Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains / AcrB/AcrD/AcrF family / Ankyrin repeat-containing domain / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Alpha Horseshoe / Alpha-Beta Plaits / Up-down Bundle / 2-Layer Sandwich / Mainly Alpha / Alpha Beta
Similarity search - Domain/homology
TETRADECANE / DECANE / DODECANE / nonane / HEXANE / Chem-MIY / N-OCTANE / UNDECANE / Multidrug efflux pump subunit AcrB
Similarity search - Component
Biological speciesEscherichia coli (E. coli)
SYNTHETIC CONSTRUCT (others)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.9 Å
AuthorsEicher, T. / Cha, H. / Seeger, M.A. / Brandstaetter, L. / El-Delik, J. / Bohnert, J.A. / Kern, W.V. / Verrey, F. / Gruetter, M.G. / Diederichs, K. / Pos, K.M.
CitationJournal: Proc.Natl.Acad.Sci.USA / Year: 2012
Title: Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop.
Authors: Eicher, T. / Cha, H.J. / Seeger, M.A. / Brandstatter, L. / El-Delik, J. / Bohnert, J.A. / Kern, W.V. / Verrey, F. / Grutter, M.G. / Diederichs, K. / Pos, K.M.
History
DepositionFeb 27, 2012Deposition site: RCSB / Processing site: RCSB
Revision 1.0May 2, 2012Provider: repository / Type: Initial release
Revision 1.1Jan 29, 2014Group: Source and taxonomy
Revision 1.2Feb 28, 2024Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Structure summary
Category: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / entity / pdbx_entity_nonpoly / struct_ref_seq_dif / struct_site
Item: _chem_comp.name / _database_2.pdbx_DOI ..._chem_comp.name / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: Acriflavine resistance protein B
B: Acriflavine resistance protein B
C: Acriflavine resistance protein B
D: DARPIN
E: DARPIN
hetero molecules


Theoretical massNumber of molelcules
Total (without water)390,62356
Polymers380,8445
Non-polymers9,77951
Water32,1211783
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Unit cell
Length a, b, c (Å)145.990, 161.720, 245.970
Angle α, β, γ (deg.)90.00, 90.00, 90.00
Int Tables number19
Space group name H-MP212121

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Components

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Protein , 2 types, 5 molecules ABCDE

#1: Protein Acriflavine resistance protein B


Mass: 114736.289 Da / Num. of mol.: 3
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Escherichia coli (E. coli) / Strain: K12 / Gene: acrB, acrE, b0462, JW0451 / Plasmid: pET24 / Production host: Escherichia coli (E. coli) / Strain (production host): C43(DE3) / References: UniProt: P31224
#2: Protein DARPIN /


Mass: 18317.566 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) SYNTHETIC CONSTRUCT (others) / Plasmid: PQE30 / Production host: Escherichia coli (E. coli) / Strain (production host): Xl1blue

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Sugars , 2 types, 9 molecules

#4: Sugar
ChemComp-LMT / DODECYL-BETA-D-MALTOSIDE


Type: D-saccharide / Mass: 510.615 Da / Num. of mol.: 8 / Source method: obtained synthetically / Formula: C24H46O11 / Comment: detergent*YM
#11: Sugar ChemComp-LMU / DODECYL-ALPHA-D-MALTOSIDE


Type: D-saccharide / Mass: 510.615 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C24H46O11 / Comment: detergent*YM

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Non-polymers , 11 types, 1825 molecules

#3: Chemical
ChemComp-GOL / GLYCEROL / GLYCERIN / PROPANE-1,2,3-TRIOL / Glycerol


Mass: 92.094 Da / Num. of mol.: 15 / Source method: obtained synthetically / Formula: C3H8O3
#5: Chemical
ChemComp-OCT / N-OCTANE / Octane


Mass: 114.229 Da / Num. of mol.: 7 / Source method: obtained synthetically / Formula: C8H18
#6: Chemical
ChemComp-D10 / DECANE / Decane


Mass: 142.282 Da / Num. of mol.: 6 / Source method: obtained synthetically / Formula: C10H22
#7: Chemical
ChemComp-HEX / HEXANE / Hexane


Mass: 86.175 Da / Num. of mol.: 5 / Source method: obtained synthetically / Formula: C6H14
#8: Chemical
ChemComp-D12 / DODECANE / Dodecane


Mass: 170.335 Da / Num. of mol.: 4 / Source method: obtained synthetically / Formula: C12H26
#9: Chemical ChemComp-MIY / (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE / MINOCYCLINE / Minocycline


Mass: 457.476 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C23H27N3O7 / Comment: medication, antibiotic*YM
#10: Chemical ChemComp-C14 / TETRADECANE / Tetradecane


Mass: 198.388 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C14H30
#12: Chemical ChemComp-DD9 / nonane / Nonane


Mass: 128.255 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C9H20
#13: Chemical ChemComp-SO4 / SULFATE ION / Sulfate


Mass: 96.063 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: SO4
#14: Chemical ChemComp-UND / UNDECANE / LIPID FRAGMENT / Undecane


Mass: 156.308 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C11H24
#15: Water ChemComp-HOH / water / Water


Mass: 18.015 Da / Num. of mol.: 1783 / Source method: isolated from a natural source / Formula: H2O

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 3.81 Å3/Da / Density % sol: 67.73 %
Crystal growTemperature: 290 K / Method: vapor diffusion, hanging drop / pH: 6.5
Details: 0.05M ADA, pH 6.5, 0.2M ammonium sulfate, 7% PEG 4000, 6% glycerol, 0.002M minocycline, VAPOR DIFFUSION, HANGING DROP, temperature 290K

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Data collection

DiffractionMean temperature: 100 K
Diffraction sourceSource: SYNCHROTRON / Site: SLS / Beamline: X06SA / Wavelength: 1 Å
DetectorType: MARRESEARCH / Detector: CCD / Date: Oct 27, 2006
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 1 Å / Relative weight: 1
ReflectionResolution: 1.9→39.47 Å / Num. all: 452134 / Num. obs: 452063 / % possible obs: 99.9 % / Observed criterion σ(F): -3 / Observed criterion σ(I): -3 / Rmerge(I) obs: 0.116 / Net I/σ(I): 12.44
Reflection shell
Resolution (Å)Rmerge(I) obsMean I/σ(I) obsDiffraction-ID% possible all
1.9-2.010.0230.66194.2
2.01-2.150.0231.621100
2.15-2.320.0233.111100
2.32-2.540.0235.361100
2.54-2.840.0239.261100
2.84-3.280.02317.221100
3.28-4.010.02331.871100
4.01-5.640.02345.811100
5.64-39.47350.58198.5

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Processing

Software
NameVersionClassificationNB
XSCALEdata scaling
PHENIX1.7.3_928refinement
PDB_EXTRACT3.1data extraction
XDSdata scaling
XDSdata reduction
MOLREPphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT / Resolution: 1.9→39.468 Å / Occupancy max: 1 / Occupancy min: 1 / SU ML: 0.29 / σ(F): 1.99 / Phase error: 26.1 / Stereochemistry target values: ML
RfactorNum. reflection% reflection
Rfree0.2312 22549 5 %
Rwork0.2002 --
obs0.2018 450987 99.35 %
all-450986 -
Solvent computationShrinkage radii: 0.98 Å / VDW probe radii: 1.2 Å / Solvent model: FLAT BULK SOLVENT MODEL / Bsol: 44.532 Å2 / ksol: 0.34 e/Å3
Displacement parameters
Baniso -1Baniso -2Baniso -3
1--4.8686 Å20 Å2-0 Å2
2--6.475 Å2-0 Å2
3----1.6064 Å2
Refinement stepCycle: LAST / Resolution: 1.9→39.468 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms25969 0 671 1783 28423
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.00727101
X-RAY DIFFRACTIONf_angle_d1.136674
X-RAY DIFFRACTIONf_dihedral_angle_d15.4149841
X-RAY DIFFRACTIONf_chiral_restr0.0844317
X-RAY DIFFRACTIONf_plane_restr0.0044620
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
1.9-1.92160.45886810.44113022X-RAY DIFFRACTION91
1.9216-1.94420.44977140.424213574X-RAY DIFFRACTION95
1.9442-1.96790.39687310.399513856X-RAY DIFFRACTION97
1.9679-1.99290.38777410.375614133X-RAY DIFFRACTION99
1.9929-2.01910.37267510.349214217X-RAY DIFFRACTION100
2.0191-2.04670.33867510.322914268X-RAY DIFFRACTION100
2.0467-2.0760.31527540.294414309X-RAY DIFFRACTION100
2.076-2.1070.30967500.272614230X-RAY DIFFRACTION100
2.107-2.13990.29037520.255714290X-RAY DIFFRACTION100
2.1399-2.1750.27477530.244214297X-RAY DIFFRACTION100
2.175-2.21250.26067530.228314311X-RAY DIFFRACTION100
2.2125-2.25270.27567540.228814315X-RAY DIFFRACTION100
2.2527-2.2960.25737510.211614280X-RAY DIFFRACTION100
2.296-2.34290.24857540.209414327X-RAY DIFFRACTION100
2.3429-2.39380.25057520.204314296X-RAY DIFFRACTION100
2.3938-2.44950.24957560.201214354X-RAY DIFFRACTION100
2.4495-2.51070.24327530.200114309X-RAY DIFFRACTION100
2.5107-2.57860.24367530.189514310X-RAY DIFFRACTION100
2.5786-2.65450.22427580.183714404X-RAY DIFFRACTION100
2.6545-2.74010.23127530.18614305X-RAY DIFFRACTION100
2.7401-2.8380.23327570.184714380X-RAY DIFFRACTION100
2.838-2.95160.2137550.174114353X-RAY DIFFRACTION100
2.9516-3.08590.22077590.181914410X-RAY DIFFRACTION100
3.0859-3.24850.21327600.175514447X-RAY DIFFRACTION100
3.2485-3.4520.20397590.174114424X-RAY DIFFRACTION100
3.452-3.71830.19547610.164814442X-RAY DIFFRACTION100
3.7183-4.09210.19137630.162114507X-RAY DIFFRACTION100
4.0921-4.68350.18337660.156914549X-RAY DIFFRACTION100
4.6835-5.89750.19747710.174514657X-RAY DIFFRACTION100
5.8975-39.47690.2017830.185914862X-RAY DIFFRACTION99
Refinement TLS params.Method: refined / Origin x: 40.538 Å / Origin y: -31.3127 Å / Origin z: -30.7368 Å
111213212223313233
T0.0053 Å20.0167 Å2-0.0358 Å2-0.0491 Å2-0.0285 Å2--0.0367 Å2
L0.4869 °20.0729 °2-0.1261 °2-0.2495 °2-0.1091 °2--0.4191 °2
S0.068 Å °0.0507 Å °0.0701 Å °-0.0014 Å °-0.0422 Å °0.0493 Å °-0.071 Å °-0.0272 Å °-0.0016 Å °
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )A1 - 1044
2X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )A1102
3X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )A1103
4X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )A1104
5X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )A1106
6X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )A1105
7X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )A1107
8X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )A1201 - 1741
9X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )A1108
10X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )A1109
11X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )A1110
12X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1 - 1033
13X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1102
14X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1103
15X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1201 - 1780
16X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1105
17X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1104
18X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1107
19X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1106
20X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1108
21X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1109
22X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1110
23X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1112
24X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1111
25X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1114
26X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1113
27X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1115
28X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1116
29X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1117
30X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1118
31X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1119
32X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )C1120
33X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1 - 1033
34X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1103
35X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1104
36X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1106
37X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1105
38X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1201 - 1732
39X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1107
40X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1108
41X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1109
42X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1111
43X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1110
44X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1113
45X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1112
46X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1114
47X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1115
48X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1116
49X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1117
50X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )B1118
51X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )E15 - 166
52X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )E301 - 342
53X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )D11 - 166
54X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )D301 - 388
55X-RAY DIFFRACTION1( CHAIN A AND ( RESID 1:1044 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1107:1107 OR RESID 1201:1740 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 ) ) OR ( CHAIN C AND ( RESID 1:1033 OR RESID 1102:1102 OR RESID 1103:1103 OR RESID 1201:1780 OR RESID 1105:1105 OR RESID 1104:1104 OR RESID 1107:1107 OR RESID 1106:1106 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1110:1110 OR RESID 1112:1112 OR RESID 1111:1111 OR RESID 1114:1114 OR RESID 1113:1113 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 OR RESID 1118:1118 OR RESID 1119:1119 OR RESID 1120:1120 ) ) OR ( CHAIN B AND ( RESID 1:1033 OR RESID 1103:1103 OR RESID 1104:1104 OR RESID 1106:1106 OR RESID 1105:1105 OR RESID 1201:1731 OR RESID 1107:1107 OR RESID 1108:1108 OR RESID 1109:1109 OR RESID 1111:1111 OR RESID 1110:1110 OR RESID 1113:1113 OR RESID 1112:1112 OR RESID 1114:1114 OR RESID 1115:1115 OR RESID 1116:1116 OR RESID 1117:1117 ) ) OR ( CHAIN E AND ( RESID 15:166 OR RESID 301:342 ) ) OR ( CHAIN D AND ( RESID 11:166 OR RESID 301:387 OR RESID 202:202 ) )D202

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