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- PDB-4dx2: Crystal structure of the human TRPV4 ankyrin repeat domain -

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Basic information

Entry
Database: PDB / ID: 4dx2
TitleCrystal structure of the human TRPV4 ankyrin repeat domain
ComponentsTransient receptor potential cation channel subfamily V member 4
KeywordsTRANSPORT PROTEIN / Ankyrin Repeat / Ion Channel / Membrane
Function / homology
Function and homology information


stretch-activated, monoatomic cation-selective, calcium channel activity / blood vessel endothelial cell delamination / osmosensor activity / vasopressin secretion / positive regulation of macrophage inflammatory protein 1 alpha production / negative regulation of brown fat cell differentiation / positive regulation of striated muscle contraction / calcium ion import into cytosol / positive regulation of microtubule depolymerization / hyperosmotic salinity response ...stretch-activated, monoatomic cation-selective, calcium channel activity / blood vessel endothelial cell delamination / osmosensor activity / vasopressin secretion / positive regulation of macrophage inflammatory protein 1 alpha production / negative regulation of brown fat cell differentiation / positive regulation of striated muscle contraction / calcium ion import into cytosol / positive regulation of microtubule depolymerization / hyperosmotic salinity response / cortical microtubule organization / positive regulation of chemokine (C-X-C motif) ligand 1 production / positive regulation of chemokine (C-C motif) ligand 5 production / cartilage development involved in endochondral bone morphogenesis / cellular hypotonic response / regulation of response to osmotic stress / cellular hypotonic salinity response / osmosensory signaling pathway / multicellular organismal-level water homeostasis / positive regulation of vascular permeability / cellular response to osmotic stress / calcium ion import / positive regulation of monocyte chemotactic protein-1 production / cell volume homeostasis / TRP channels / cell-cell junction assembly / regulation of aerobic respiration / cortical actin cytoskeleton / positive regulation of macrophage chemotaxis / beta-tubulin binding / diet induced thermogenesis / microtubule polymerization / alpha-tubulin binding / cytoplasmic microtubule / response to mechanical stimulus / monoatomic cation channel activity / SH2 domain binding / protein kinase C binding / filopodium / actin filament organization / calcium ion transmembrane transport / adherens junction / positive regulation of JNK cascade / response to insulin / calcium channel activity / cilium / intracellular calcium ion homeostasis / ruffle membrane / positive regulation of inflammatory response / positive regulation of interleukin-6 production / calcium ion transport / actin filament binding / negative regulation of neuron projection development / glucose homeostasis / lamellipodium / cellular response to heat / actin binding / positive regulation of cytosolic calcium ion concentration / growth cone / actin cytoskeleton organization / microtubule binding / positive regulation of ERK1 and ERK2 cascade / response to hypoxia / calmodulin binding / apical plasma membrane / focal adhesion / lipid binding / protein kinase binding / negative regulation of transcription by RNA polymerase II / cell surface / endoplasmic reticulum / ATP binding / membrane / identical protein binding / metal ion binding / plasma membrane
Similarity search - Function
Transient receptor potential cation channel subfamily V member 4 / Transient receptor potential cation channel subfamily V member 1-4 / Ankyrin repeat-containing domain / Transient receptor potential cation channel subfamily V / Ankyrin repeat / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily ...Transient receptor potential cation channel subfamily V member 4 / Transient receptor potential cation channel subfamily V member 1-4 / Ankyrin repeat-containing domain / Transient receptor potential cation channel subfamily V / Ankyrin repeat / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Ion transport domain / Ion transport protein / Alpha Horseshoe / Mainly Alpha
Similarity search - Domain/homology
ADENOSINE-5'-TRIPHOSPHATE / beta-D-glucopyranose / Transient receptor potential cation channel subfamily V member 4
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 2.95 Å
AuthorsInada, H. / Gaudet, R.
CitationJournal: Biochemistry / Year: 2012
Title: Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel.
Authors: Inada, H. / Procko, E. / Sotomayor, M. / Gaudet, R.
History
DepositionFeb 27, 2012Deposition site: RCSB / Processing site: RCSB
Revision 1.0Jul 18, 2012Provider: repository / Type: Initial release
Revision 1.1Dec 19, 2012Group: Database references
Revision 1.2Jul 29, 2020Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Structure summary
Category: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_ref_seq_dif / struct_site / struct_site_gen
Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_ref_seq_dif.details
Description: Carbohydrate remediation / Provider: repository / Type: Remediation
Revision 1.3Feb 28, 2024Group: Data collection / Database references / Structure summary
Category: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2
Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: Transient receptor potential cation channel subfamily V member 4
B: Transient receptor potential cation channel subfamily V member 4
hetero molecules


Theoretical massNumber of molelcules
Total (without water)59,6935
Polymers58,9132
Non-polymers7793
Water1,29772
1
A: Transient receptor potential cation channel subfamily V member 4
hetero molecules


Theoretical massNumber of molelcules
Total (without water)30,1443
Polymers29,4571
Non-polymers6872
Water181
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
MethodPISA
2
B: Transient receptor potential cation channel subfamily V member 4
hetero molecules


Theoretical massNumber of molelcules
Total (without water)29,5492
Polymers29,4571
Non-polymers921
Water181
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
MethodPISA
Unit cell
Length a, b, c (Å)147.890, 147.890, 93.901
Angle α, β, γ (deg.)90.000, 90.000, 120.000
Int Tables number154
Space group name H-MP3221

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Components

#1: Protein Transient receptor potential cation channel subfamily V member 4 / TrpV4 / Osm-9-like TRP channel 4 / OTRPC4 / Transient receptor potential protein 12 / TRP12 / ...TrpV4 / Osm-9-like TRP channel 4 / OTRPC4 / Transient receptor potential protein 12 / TRP12 / Vanilloid receptor-like channel 2 / Vanilloid receptor-like protein 2 / VRL-2 / Vanilloid receptor-related osmotically-activated channel / VR-OAC


Mass: 29456.746 Da / Num. of mol.: 2 / Fragment: N-terminal domain (UNP residues 149-397)
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: TRPV4, VRL2, VROAC / Production host: Escherichia coli (E. coli) / Strain (production host): BL21(DE3) / References: UniProt: Q9HBA0
#2: Sugar ChemComp-BGC / beta-D-glucopyranose / beta-D-glucose / D-glucose / glucose / Glucose


Type: D-saccharide, beta linking / Mass: 180.156 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Formula: C6H12O6
IdentifierTypeProgram
DGlcpbCONDENSED IUPAC CARBOHYDRATE SYMBOLGMML 1.0
b-D-glucopyranoseCOMMON NAMEGMML 1.0
b-D-GlcpIUPAC CARBOHYDRATE SYMBOLPDB-CARE 1.0
GlcSNFG CARBOHYDRATE SYMBOLGMML 1.0
#3: Chemical ChemComp-ATP / ADENOSINE-5'-TRIPHOSPHATE / Adenosine triphosphate


Mass: 507.181 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C10H16N5O13P3 / Comment: ATP, energy-carrying molecule*YM
#4: Chemical ChemComp-GOL / GLYCEROL / GLYCERIN / PROPANE-1,2,3-TRIOL / Glycerol


Mass: 92.094 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C3H8O3
#5: Water ChemComp-HOH / water / Water


Mass: 18.015 Da / Num. of mol.: 72 / Source method: isolated from a natural source / Formula: H2O

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 5.03 Å3/Da / Density % sol: 75.55 %
Crystal growTemperature: 277 K / Method: vapor diffusion, hanging drop / pH: 7.8
Details: 3.5% PEG4000, 0.1M HEPES, 10% glycerol, pH 7.8, VAPOR DIFFUSION, HANGING DROP, temperature 277K

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Data collection

DiffractionMean temperature: 100 K
Diffraction sourceSource: SYNCHROTRON / Site: APS / Beamline: 24-ID-E / Wavelength: 0.9792 Å
DetectorType: ADSC QUANTUM 315 / Detector: CCD / Date: Mar 17, 2010
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.9792 Å / Relative weight: 1
ReflectionResolution: 2.95→40 Å / Num. obs: 25267 / % possible obs: 100 % / Redundancy: 5.5 % / Rmerge(I) obs: 0.099 / Χ2: 1.033 / Net I/σ(I): 17.6
Reflection shell
Resolution (Å)Redundancy (%)Rmerge(I) obsNum. unique allΧ2Diffraction-ID% possible all
2.95-35.60.71412280.9991100
3-3.065.60.7112681.0061100
3.06-3.115.60.50912500.991100
3.11-3.185.60.42512421.0081100
3.18-3.255.70.3512561.0361100
3.25-3.325.60.312381.0771100
3.32-3.415.60.24712471.0491100
3.41-3.55.60.18412721.0721100
3.5-3.65.60.16812391.0741100
3.6-3.725.60.13912391.0681100
3.72-3.855.60.11912621.0681100
3.85-45.60.09412541.0181100
4-4.185.60.08212751.0781100
4.18-4.415.60.07812561.0511100
4.41-4.685.60.07812690.9851100
4.68-5.045.50.09112591.0051100
5.04-5.555.50.09812811.0741100
5.55-6.355.40.09412821.066199.9
6.35-7.995.30.05813031.0191100
7.99-405.20.03113470.918199.7

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Phasing

PhasingMethod: molecular replacement
Phasing MRRfactor: 48.41 / Model details: Phaser MODE: MR_AUTO
Highest resolutionLowest resolution
Rotation2.95 Å39.64 Å
Translation2.95 Å39.64 Å

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Processing

Software
NameVersionClassificationNB
SCALEPACKdata scaling
PHASER2.1.4phasing
REFMACrefinement
PDB_EXTRACT3.1data extraction
HKL-2000data reduction
RefinementMethod to determine structure: MOLECULAR REPLACEMENT / Resolution: 2.95→38.86 Å / Cor.coef. Fo:Fc: 0.953 / Cor.coef. Fo:Fc free: 0.94 / WRfactor Rfree: 0.208 / WRfactor Rwork: 0.1718 / Occupancy max: 1 / Occupancy min: 0.5 / FOM work R set: 0.8451 / SU B: 23.288 / SU ML: 0.202 / SU R Cruickshank DPI: 0.387 / SU Rfree: 0.2729 / Cross valid method: THROUGHOUT / σ(F): 0 / ESU R: 0.387 / ESU R Free: 0.273 / Stereochemistry target values: MAXIMUM LIKELIHOOD
Details: U VALUES: WITH TLS ADDED. HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT
RfactorNum. reflection% reflectionSelection details
Rfree0.2204 1288 5.1 %RANDOM
Rwork0.1769 ---
obs0.1792 25246 99.92 %-
Solvent computationIon probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å / Solvent model: MASK
Displacement parametersBiso max: 198.66 Å2 / Biso mean: 67.4374 Å2 / Biso min: 33.07 Å2
Baniso -1Baniso -2Baniso -3
1-0.77 Å20.39 Å20 Å2
2--0.77 Å20 Å2
3----1.16 Å2
Refinement stepCycle: LAST / Resolution: 2.95→38.86 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms3926 0 49 72 4047
Refine LS restraints
Refine-IDTypeDev idealDev ideal targetNumber
X-RAY DIFFRACTIONr_bond_refined_d0.0130.0194081
X-RAY DIFFRACTIONr_angle_refined_deg1.81.9835521
X-RAY DIFFRACTIONr_dihedral_angle_1_deg6.8025496
X-RAY DIFFRACTIONr_dihedral_angle_2_deg36.43522.828198
X-RAY DIFFRACTIONr_dihedral_angle_3_deg21.28915720
X-RAY DIFFRACTIONr_dihedral_angle_4_deg23.8541543
X-RAY DIFFRACTIONr_chiral_restr0.1110.2616
X-RAY DIFFRACTIONr_gen_planes_refined0.0070.0213080
LS refinement shellResolution: 2.95→3.026 Å / Total num. of bins used: 20
RfactorNum. reflection% reflection
Rfree0.371 96 -
Rwork0.318 1653 -
all-1749 -
obs--100 %
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
119.56845.76-3.360413.0151-9.80827.44990.4486-0.59650.82470.21080.23430.9667-0.1332-0.2186-0.68290.18350.02510.07210.099-0.04490.2312-68.3841.85515.031
21.69461.3314-2.03945.2433-1.63223.292-0.1672-0.1354-0.0762-0.06640.00630.2821-0.0331-0.19530.16090.08010.1116-0.01690.1679-0.00270.2772-64.36235.43115.721
30.4336-1.71030.68216.7767-2.71221.09180.07510.0405-0.048-0.1917-0.06580.17250.0570.0101-0.00930.2794-0.017-0.0310.3427-0.04590.5215-63.77340.4933.503
411.78254.59983.259518.08613.59372.62980.2738-0.33280.6590.0734-0.32940.4248-0.1873-0.76480.05560.17210.02180.00130.37790.0880.164-62.34649.49410.083
56.472.25830.17016.91761.34423.1018-0.0168-0.49150.0440.3127-0.1626-0.10430.3025-0.04940.17950.0721-0.05990.00940.1356-0.0250.1926-53.08342.96220.957
69.91682.15372.99856.08350.09732.23020.3655-0.0929-0.16840.254-0.4571-0.25070.13340.07780.09160.1183-0.0328-0.00380.11660.02750.2667-54.42235.05415.469
741.769331.7199-3.16125.5209-0.10684.2835-0.56730.3839-1.4401-0.54530.3373-1.14220.15280.32870.230.42390.09370.12840.431-0.03060.5052-53.4634.5184.322
84.6316-1.24971.686110.9637-2.22580.94340.1760.35390.0709-0.9581-0.17570.50340.16120.137-0.00030.2439-0.0717-0.02020.2746-0.05290.2341-52.73646.0547.384
91.87661.4168-0.74092.27371.21123.0075-0.23260.17310.2046-0.27170.19220.2301-0.2550.03010.04040.3818-0.027-0.12730.1055-0.02040.3697-50.70654.20812.13
104.93510.22873.53961.77362.44345.79350.0045-0.2884-0.4717-0.09530.0478-0.1023-0.296-0.2291-0.05230.19070.0059-0.19210.1705-0.08830.5352-43.37342.02516.333
1110.4131-8.9864-6.367122.4662-1.53639.8720.62840.06141.5095-1.7460.2895-0.8023-0.94110.2982-0.91780.6203-0.2095-0.07160.4619-0.00980.4183-45.32657.9038.22
1216.0691.25752.193313.9183-1.42010.51030.3372-1.36151.65750.02-0.7696-0.249-0.0737-0.110.43240.68720.0304-0.38960.3096-0.10580.7773-45.21664.77916.59
1313.328-5.19595.72679.7076-2.74142.4949-0.42510.03050.4530.66870.221-0.0897-0.2131-0.00920.20410.2213-0.1282-0.06170.1456-0.03860.3433-41.20757.88615.39
145.78293.0633-0.64729.9267-0.83475.0753-0.06650.1775-0.21040.5911-0.082-0.72280.18620.74190.14850.061-0.0012-0.03370.2189-0.0320.2546-34.48647.24817.535
155.20653.5684-1.843323.67060.56852.3482-0.49950.6352-0.3063-1.32460.4374-0.6513-0.08040.61710.06210.125-0.15670.01040.5448-0.04830.1769-34.25149.3676.351
167.03163.49272.543511.77680.68360.9541-0.58340.42990.5544-0.54290.3322-0.1748-0.20610.15340.25130.1515-0.1771-0.15850.29470.08710.4364-31.38160.95116.712
174.6061.2912-2.193410.04518.094614.5844-0.23420.3806-0.4438-0.0140.2813-0.84450.01011.0308-0.04720.0422-0.0794-0.06850.38130.00410.477-25.17252.19518.558
187.97624.83572.24413.08110.123911.5176-0.23040.8423-0.7354-0.27040.4501-0.48620.49661.3602-0.21970.4411-0.42820.07870.82980.08220.5972-25.03359.2685.115
1912.9926-6.4795.1984.3361-1.06174.2882-0.85150.63570.87450.23260.0904-0.2916-0.64110.86320.76110.2814-0.3085-0.15610.38260.18160.5893-25.51667.06616.315
2043.6501-4.676624.265230.9249-2.097413.498-0.54182.7312-0.7979-0.60721.0114-1.2741-0.31131.5669-0.46960.0824-0.27390.06161.28040.2170.7397-15.77560.02518.646
2148.633112.654-8.610421.98555.83835.0249-0.14630.37881.95572.01740.44460.78590.84750.1679-0.29830.9099-0.379-0.09870.60260.04410.6309-57.11468.024-5.571
226.78942.3022-0.74750.90281.623229.0881-0.4556-1.00760.8802-0.2575-0.39940.3718-1.3321-0.75090.8550.4889-0.0318-0.31670.2461-0.01620.4719-58.2964.961-12.036
2315.303-5.53727.26718.43561.26876.13-0.40330.19841.6875-0.4896-0.0278-1.0514-0.8780.1390.43110.525-0.2531-0.04960.29430.19520.5386-49.71667.47-12.564
2413.81552.718.95340.53323.701626.02030.5523-2.082-0.03970.1799-0.421-0.0750.655-2.764-0.13131.2184-0.7614-0.55140.991-0.22961.6695-45.60766.7180.913
256.77332.71640.75882.8377-1.45587.2749-0.25240.11650.24540.26260.0111-0.0451-0.9534-0.05320.24130.1749-0.0444-0.11140.09650.03280.2627-57.22357.638-3.471
267.9667-3.2009-1.66164.7865-1.35857.25890.17080.6705-0.293-1.584-0.13220.2414-0.2793-0.3225-0.03860.8792-0.065-0.04460.29560.05570.3986-58.38855.779-20.844
272.04153.48820.537410.20643.52821.75430.0166-0.11320.26850.55170.5505-0.72030.37520.4794-0.56710.45710.0250.08091.01230.31260.8839-46.42457.993-12.921
2817.68062.959510.927523.0856-13.257416.8304-0.05390.37150.5956-0.6383-0.5137-0.16530.37240.66070.56750.0628-0.00190.01230.8241-0.08340.6954-47.44551.041-5.407
291.45171.0473-1.66462.8303-1.52331.9708-0.06870.0909-0.13950.1234-0.15-0.33690.0831-0.03660.21870.2301-0.0093-0.03330.20030.01550.3215-62.25547.606-5.918
302.0834-2.7579-4.537931.322433.40537.0135-0.52260.05710.2037-1.0489-1.22761.9021-0.5705-1.26341.75020.72510.0541-0.21660.3750.05320.6979-60.91146.564-20.276
3114.05896.9422-4.279322.168510.29559.5244-0.02161.2127-0.2102-1.3360.568-1.0458-0.8701-0.3318-0.54640.13550.00940.19640.63370.06960.4611-49.70746.807-19.352
324.9745-0.38310.11887.74771.19243.3594-0.3467-0.0558-0.27490.4640.18250.12560.58920.5530.16420.17290.0794-0.00290.11080.0820.172-61.70241.233-6.892
3316.8608-1.3554-4.34766.4416-1.04959.1915-0.0967-0.75510.2557-0.45860.09480.5010.5681-0.24490.00190.1398-0.0016-0.09420.0645-0.04310.1632-70.08937.979-10.739
3411.37642.97971.77675.4014-0.49048.7282-0.19980.8936-0.7253-1.06450.2799-0.63320.57880.9369-0.08010.33870.060.13590.1732-0.06010.1854-54.79336.511-21.074
3512.33133.4666-7.084314.5142-2.66864.12620.553-0.9529-0.92370.4093-1.0365-1.9371-0.31020.58280.48350.37930.2639-0.2490.53740.13590.7345-51.42131.711-11.409
367.47522.3385-2.99936.3987-1.6111.2856-0.43230.4975-0.5105-0.77920.28850.49780.2821-0.2030.14390.57760.0932-0.06510.09540.02060.3304-68.94730.056-19.431
3718.8876-8.09121.70969.3804-1.810.86880.02310.9382-0.7393-0.8099-0.1215-0.85540.36260.73340.09840.89590.16640.18351.0123-0.1520.6852-56.46325.657-22.634
382.3378-4.1738-3.608215.21640.179810.7686-1.00990.085-0.45450.879-0.4466-0.47272.29490.01331.45640.95670.0868-0.10260.08580.05030.969-60.07920.246-11.141
399.43572.15268.677210.70281.73418.44360.2789-0.8308-0.4384-0.2408-0.20050.11790.8814-0.7444-0.07840.9514-0.02510.2510.07990.09290.5448-72.58422.298-15.166
4017.8581-3.07565.290235.99943.074920.75870.70630.851-1.5697-0.47210.4254-1.36330.9073-0.3968-1.13160.756-0.0104-0.0880.0783-0.06160.5732-68.59516.908-25.58
Refinement TLS group
IDRefine-IDRefine TLS-IDAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1A148 - 154
2X-RAY DIFFRACTION2A155 - 176
3X-RAY DIFFRACTION3A177 - 183
4X-RAY DIFFRACTION4A184 - 192
5X-RAY DIFFRACTION5A193 - 206
6X-RAY DIFFRACTION6A207 - 217
7X-RAY DIFFRACTION7A218 - 224
8X-RAY DIFFRACTION8A225 - 231
9X-RAY DIFFRACTION9A232 - 246
10X-RAY DIFFRACTION10A247 - 264
11X-RAY DIFFRACTION11A265 - 271
12X-RAY DIFFRACTION12A272 - 280
13X-RAY DIFFRACTION13A281 - 288
14X-RAY DIFFRACTION14A289 - 305
15X-RAY DIFFRACTION15A306 - 321
16X-RAY DIFFRACTION16A322 - 334
17X-RAY DIFFRACTION17A335 - 358
18X-RAY DIFFRACTION18A359 - 368
19X-RAY DIFFRACTION19A369 - 388
20X-RAY DIFFRACTION20A389 - 393
21X-RAY DIFFRACTION21B148 - 152
22X-RAY DIFFRACTION22B153 - 159
23X-RAY DIFFRACTION23B160 - 173
24X-RAY DIFFRACTION24B174 - 178
25X-RAY DIFFRACTION25B179 - 196
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