登録情報 データベース : PDB / ID : 4do0 構造の表示 ダウンロードとリンクタイトル Crystal Structure of human PHF8 in complex with Daminozide 要素Histone lysine demethylase PHF8 詳細 キーワード METAL BINDING PROTEIN / JMJC DOMAIN / Histone demethylase / Epigenetics / Daminozide / Structural Genomics / Structural Genomics Consortium / SGC機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
histone H4K20 demethylase activity / histone H3K36me/H3K36me2 demethylase activity / [histone H3]-dimethyl-L-lysine36 demethylase / histone H3K9me/H3K9me2 demethylase activity / [histone H3]-dimethyl-L-lysine9 demethylase / histone H3K27me2/H3K27me3 demethylase activity / negative regulation of rDNA heterochromatin formation / histone H3K36 demethylase activity / 2-oxoglutarate-dependent dioxygenase activity / positive regulation of transcription by RNA polymerase I ... histone H4K20 demethylase activity / histone H3K36me/H3K36me2 demethylase activity / [histone H3]-dimethyl-L-lysine36 demethylase / histone H3K9me/H3K9me2 demethylase activity / [histone H3]-dimethyl-L-lysine9 demethylase / histone H3K27me2/H3K27me3 demethylase activity / negative regulation of rDNA heterochromatin formation / histone H3K36 demethylase activity / 2-oxoglutarate-dependent dioxygenase activity / positive regulation of transcription by RNA polymerase I / histone H3K9 demethylase activity / histone demethylase activity / methylated histone binding / Condensation of Prophase Chromosomes / transcription coregulator activity / HDMs demethylate histones / brain development / G1/S transition of mitotic cell cycle / nuclear membrane / iron ion binding / chromatin binding / nucleolus / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / positive regulation of transcription by RNA polymerase II / zinc ion binding / nucleoplasm / nucleus 類似検索 - 分子機能 Methane Monooxygenase Hydroxylase; Chain G, domain 1 - #1360 / Jumonji, helical domain / Jumonji helical domain / Cupin / JmjC domain, hydroxylase / A domain family that is part of the cupin metalloenzyme superfamily. / JmjC domain / JmjC domain profile. / Zinc finger, PHD-type, conserved site / PHD-finger ... Methane Monooxygenase Hydroxylase; Chain G, domain 1 - #1360 / Jumonji, helical domain / Jumonji helical domain / Cupin / JmjC domain, hydroxylase / A domain family that is part of the cupin metalloenzyme superfamily. / JmjC domain / JmjC domain profile. / Zinc finger, PHD-type, conserved site / PHD-finger / Zinc finger PHD-type signature. / Methane Monooxygenase Hydroxylase; Chain G, domain 1 / Zinc finger PHD-type profile. / Zinc finger, PHD-finger / Zinc finger, PHD-type / PHD zinc finger / Zinc finger, FYVE/PHD-type / Jelly Rolls / Up-down Bundle / Sandwich / Mainly Beta / Mainly Alpha 類似検索 - ドメイン・相同性 ACETATE ION / DAMINOZIDE / Histone lysine demethylase PHF8 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.55 Å 詳細データ登録者 Krojer, T. / Daniel, M. / Ng, S.S. / Walport, L.J. / Chowdhury, R. / Arrowsmith, C.H. / Edwards, A. / Bountra, C. / Kawamura, A. / Muller-Knapp, S. ...Krojer, T. / Daniel, M. / Ng, S.S. / Walport, L.J. / Chowdhury, R. / Arrowsmith, C.H. / Edwards, A. / Bountra, C. / Kawamura, A. / Muller-Knapp, S. / McDonough, M.A. / von Delft, F. / Schofield, C.J. / Oppermann, U. / Structural Genomics Consortium (SGC) 履歴 登録 2012年2月9日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2012年3月14日 Provider : repository / タイプ : Initial release改定 1.1 2020年2月26日 Group : Data collection / Database references / カテゴリ : reflns / reflns_shell / struct_ref_seq_difItem : _reflns.pdbx_Rmerge_I_obs / _reflns_shell.Rmerge_I_obs / _struct_ref_seq_dif.details改定 1.2 2023年9月13日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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