Entry Database : PDB / ID : 4ckr Structure visualization Downloads & linksTitle Crystal structure of the human DDR1 kinase domain in complex with DDR1-IN-1 ComponentsEPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1 Details Keywords TRANSFERASE / COLLAGEN / DISCOIDIN DOMAINFunction / homology Function and homology informationFunction Domain/homology Component
protein tyrosine kinase collagen receptor activity / smooth muscle cell-matrix adhesion / regulation of extracellular matrix disassembly / regulation of cell-matrix adhesion / ear development / collagen-activated tyrosine kinase receptor signaling pathway / branching involved in mammary gland duct morphogenesis / wound healing, spreading of cells / smooth muscle cell migration / neuron projection extension ... protein tyrosine kinase collagen receptor activity / smooth muscle cell-matrix adhesion / regulation of extracellular matrix disassembly / regulation of cell-matrix adhesion / ear development / collagen-activated tyrosine kinase receptor signaling pathway / branching involved in mammary gland duct morphogenesis / wound healing, spreading of cells / smooth muscle cell migration / neuron projection extension / axon development / Non-integrin membrane-ECM interactions / mammary gland alveolus development / peptidyl-tyrosine autophosphorylation / collagen binding / lactation / embryo implantation / transmembrane receptor protein tyrosine kinase activity / regulation of cell growth / receptor protein-tyrosine kinase / positive regulation of neuron projection development / cell population proliferation / protein autophosphorylation / receptor complex / cell adhesion / negative regulation of cell population proliferation / extracellular space / extracellular exosome / ATP binding / metal ion binding / plasma membrane Similarity search - Function : / Discoidin domain-containing receptor 1/2, DS-like domain / Coagulation factors 5/8 type C domain (FA58C) signature 2. / Coagulation factors 5/8 type C domain (FA58C) signature 1. / Coagulation factor 5/8 C-terminal domain, discoidin domain / Coagulation factors 5/8 type C domain (FA58C) profile. / F5/8 type C domain / Coagulation factor 5/8 C-terminal domain / Tyrosine-protein kinase, receptor class II, conserved site / Receptor tyrosine kinase class II signature. ... : / Discoidin domain-containing receptor 1/2, DS-like domain / Coagulation factors 5/8 type C domain (FA58C) signature 2. / Coagulation factors 5/8 type C domain (FA58C) signature 1. / Coagulation factor 5/8 C-terminal domain, discoidin domain / Coagulation factors 5/8 type C domain (FA58C) profile. / F5/8 type C domain / Coagulation factor 5/8 C-terminal domain / Tyrosine-protein kinase, receptor class II, conserved site / Receptor tyrosine kinase class II signature. / Galactose-binding-like domain superfamily / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.2 Å DetailsAuthors Canning, P. / Elkins, J.M. / Goubin, S. / Mahajan, P. / Krojer, T. / Newman, J.A. / Dixon-Clarke, S. / Chaikuad, A. / von Delft, F. / Arrowsmith, C.H. ...Canning, P. / Elkins, J.M. / Goubin, S. / Mahajan, P. / Krojer, T. / Newman, J.A. / Dixon-Clarke, S. / Chaikuad, A. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Bullock, A. CitationJournal : Acs Chem.Biol. / Year : 2013Title : Discovery of a Potent and Selective Ddr1 Receptor Tyrosine Kinase Inhibitor.Authors : Kim, H. / Tan, L. / Weisberg, E.L. / Liu, F. / Canning, P. / Choi, H.G. / Ezell, S.A. / Wu, H. / Zhao, Z. / Wang, J. / Mandinova, A. / Griffin, J.D. / Bullock, A.N. / Liu, Q. / Lee, S.W. / Gray, N.S. History Deposition Jan 7, 2014 Deposition site : PDBE / Processing site : PDBESupersession Jan 15, 2014 ID : 4BKI Revision 1.0 Jan 15, 2014 Provider : repository / Type : Initial releaseRevision 1.1 Sep 6, 2017 Group : Data collection / Category : diffrn_detector / Item : _diffrn_detector.typeRevision 1.2 Dec 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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