Entry Database : PDB / ID : 4cj2 Structure visualization Downloads & linksTitle Crystal structure of HEWL in complex with affitin H4 Components Details Keywords HYDROLASE/DE NOVO PROTEIN / HYDROLASE-DE NOVO PROTEIN COMPLEX / GLYCOSIDASEFunction / homology Function and homology informationFunction Domain/homology Component
RNA endonuclease activity / Lactose synthesis / Antimicrobial peptides / Neutrophil degranulation / beta-N-acetylglucosaminidase activity / cell wall macromolecule catabolic process / lysozyme / lysozyme activity / defense response to Gram-negative bacterium / killing of cells of another organism ... RNA endonuclease activity / Lactose synthesis / Antimicrobial peptides / Neutrophil degranulation / beta-N-acetylglucosaminidase activity / cell wall macromolecule catabolic process / lysozyme / lysozyme activity / defense response to Gram-negative bacterium / killing of cells of another organism / defense response to Gram-positive bacterium / defense response to bacterium / endoplasmic reticulum / DNA binding / extracellular space / identical protein binding / cytoplasm Similarity search - Function DNA-binding 7kDa protein / 7kD DNA-binding domain / OB fold (Dihydrolipoamide Acetyltransferase, E2P) - #40 / Chromo-like domain superfamily / Lysozyme - #10 / Glycoside hydrolase, family 22, lysozyme / Glycoside hydrolase family 22 domain / Glycosyl hydrolases family 22 (GH22) domain signature. / Glycoside hydrolase, family 22 / C-type lysozyme/alpha-lactalbumin family ... DNA-binding 7kDa protein / 7kD DNA-binding domain / OB fold (Dihydrolipoamide Acetyltransferase, E2P) - #40 / Chromo-like domain superfamily / Lysozyme - #10 / Glycoside hydrolase, family 22, lysozyme / Glycoside hydrolase family 22 domain / Glycosyl hydrolases family 22 (GH22) domain signature. / Glycoside hydrolase, family 22 / C-type lysozyme/alpha-lactalbumin family / Glycosyl hydrolases family 22 (GH22) domain profile. / Alpha-lactalbumin / lysozyme C / Lysozyme / OB fold (Dihydrolipoamide Acetyltransferase, E2P) / Lysozyme-like domain superfamily / Beta Barrel / Orthogonal Bundle / Mainly Beta / Mainly Alpha Similarity search - Domain/homologyBiological species SULFOLOBUS ACIDOCALDARIUS (acidophilic)GALLUS GALLUS (chicken)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.5 Å DetailsAuthors Correa, A. / Pacheco, S. / Mechaly, A.E. / Obal, G. / Behar, G. / Mouratou, B. / Oppezzo, P. / Alzari, P.M. / Pecorari, F. CitationJournal : Plos One / Year : 2014Title : Potent and Specific Inhibition of Glycosidases by Small Artificial Binding Proteins (Affitins)Authors : Correa, A. / Pacheco, S. / Mechaly, A.E. / Obal, G. / Behar, G. / Mouratou, B. / Oppezzo, P. / Alzari, P.M. / Pecorari, F. History Deposition Dec 18, 2013 Deposition site : PDBE / Processing site : PDBERevision 1.0 May 21, 2014 Provider : repository / Type : Initial releaseRevision 1.1 May 28, 2014 Group : Database referencesRevision 1.2 May 16, 2018 Group : Data collection / Category : diffrn_source / Item : _diffrn_source.pdbx_synchrotron_beamlineRevision 1.3 Dec 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_ncs_dom_lim / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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